7,4'-di(mono succinate)o-ethoxy-daidzein and novel medical uses thereof

A technology of succinic acid monoester and daidzein, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of restricting widespread use, low bioavailability, and poor water solubility of isoflavones
CN101255149AInactive Publication Date: 2008-09-03SHENYANG PHARMA UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHENYANG PHARMA UNIVERSITY
Publication Date
2008-09-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses new pharmaceutical uses of 7, 4'- di(mono succinate) oxyethoxypropyl daidzein. Pharmacological activity research is carried out to DZ5 by an experimental model for mice under atmospheric hypoxia tolerance, an experimental model for mice acute cerebral ischemia, an experimental model for bilateral common carotid arteries and vagus nerve ligation, an experimental model for mice KCN poisoning, an experimental model for mice NaNO2 poisoning and experimental model for learning and remembering, an action model for rat cortical neuron damage caused by anoxia of DZ5, an effect model for rat myocardial ischemia caused by hypophysin, an experimental model for vitro anti platelet aggregation, an experimental model for vivo anti platelet aggregation, and an effect model for arterial thrombosis in rabbits. Proved by the result, DZ5 has the functions of anti-cerebral ischemia and anoxia, anti-myocardial ischemia and anoxia, antagonistic memory disorders, anti-platelet aggregation and thrombosis, and protection of rat cortical neuron damage caused by anoxia. DZ5 can be mixed with a pharmacologically acceptable carrier or excipient to prepare medicine compositions.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and relates to 7,4'-bis(succinic acid monoester)oxyethoxy-pueraria daidzein (DZ5) and its new application in medicine, in particular to 7,4'-bis(succinic acid monoester) Ester) oxyethoxy-didzein in the preparation of anti-cerebral ischemia, hypoxia, anti-myocardial ischemia, hypoxia, antagonism memory impairment, anti-platelet aggregation and anti-thrombosis, protection of rat cortical nerves caused by hypoxia Application of meta-damaging drugs. Background technique

[0002] Cardiovascular and cerebrovascular diseases are major diseases that endanger human health and life. According to the World Health Report of the World Health Organization in 2000, the number of deaths from cardiovascular and cerebrovascular diseases in the world is 16.97 million, accounting for 30.3% of the total death population. In my country, the morbidity and mortality of cardiovascular and cerebrovascular diseases rank ...

Claims

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