46 results about "Neuroma" patented technology

The invention discloses a generalized neural radiation field reconstruction method based on multi-modal information fusion, and the method specifically comprises the following steps: 1, constructing a luminosity feature body and a geometric feature body based on unstructured multiple views, and constructing a multi-modal neural coding body through progressive complementary fusion; step 2, converting the multi-modal neural coding body and the original RGB pixel body of the unstructured multi-view into volume density and radiation brightness; 3, sampling light rays, and fusing context features of the sampled light rays to obtain context features of the light rays; and step 4, decoding the volume density and the radiation brightness by using the light context features, rendering to generate a free view angle RGB-D image, and then guiding dense reconstruction of a low texture scene by combining photometric supervision and sparse geometric supervision. According to the method, the problem of shape radiation ambiguity can be solved, high-quality three-dimensional reconstruction and two-dimensional rendering are realized, and the surface reconstruction precision of the generalized neural radiation field is improved.

The invention discloses a septal medical image segmentation method based on deep learning, and the method comprises the steps: collecting user-defined data sets of different types of medical images, and carrying out the data cleaning, preprocessing and marking, and obtaining a sample data set; wherein the different types of medical images comprise three-dimensional CT images of patients with germ cell tumor, lymphadenoma, neuroma, teratoma and thymoma; the sample data set comprises a 2D slice generated by cutting the three-dimensional CT image and a corresponding mask file; dividing the sample data set into a training set, a verification set and a test set according to a proportion of 8: 1: 1; inputting the training set into a pre-training MedSAM model in batches, and obtaining a prediction segmentation result of voxels in the training sample through forward calculation; determining target loss based on the predicted segmentation result and a prior label corresponding to the mask file, and reversely updating parameters of the pre-trained MedSAM model until convergence to obtain a medical image semantic segmentation model; and evaluating the performance of the medical image semantic segmentation model by using the verification set and the test set.

Methods, devices and systems are described for gel-based modulation of neural tissue, including prevention of nerve regeneration and neuroma formation. The gel can be delivered to selected target locations within or proximate nerves, including interfascicularly and intrafascicularly. Gel delivery associated with an operative procedure for the treatment of pain and other indications is also disclosed.

Methods, devices and systems are described for gel-based modulation of neural tissue, including prevention of nerve regeneration and neuroma formation. The gel can be delivered to selected target locations within or proximate nerves, including interfascicularly and intrafascicularly. Gel delivery associated with an operative procedure for the treatment of pain and other indications is also disclosed.

The invention relates to nerve conduits for connecting a lesioned nerve end to a target site. In particular, the invention relates to nerve conduits supporting repair of a nerve lesion and motor control and / or reducing risk of the development of a neuroma at the lesioned nerve end. Accordingly, a nerve conduit (10) for connecting a nerve end to a target site is suggested, comprising an elongate body (12) formed by a wall (22) defining an inner cavity (16) and comprising a central portion (14), wherein the inner cavity (1 6) extends through the central portion (14), and two end portions (18, 19) defining respective openings (20, 21) to the inner cavity (16), wherein one end portion (18) is an insertion portion configured for inserting a respective nerve end (26) and the other end portion (19) is a nerve end outlet portion. According to the invention, the end portions (18, 19) are arranged such that the cross-sections of the openings (20, 21) are oriented at an angle to each other.

The utility model discloses a face sagging prevention mask structure for facial paralysis after an auditory neuroma operation, and particularly relates to the field of medical care, the face sagging prevention mask structure comprises a mask, bandages are fixedly mounted on two sides of the mask, a binding buckle is arranged on one side of each of the two bandages, a pushing and pressing mechanism is arranged on the outer wall of the mask, and the pushing and pressing mechanism comprises fixed plates fixedly mounted on two sides of the mask. The two fixed plates are symmetrically arranged, a first rotating roller is fixedly installed on the outer walls of the two fixed plates, the first rotating roller is arranged in a vertical state, a position supporting plate is rotatably installed on the outer wall of the first rotating roller, and the position supporting plate and the outer wall of the mask are arranged in parallel; according to the utility model, the pushing and pressing mechanism is arranged, and structures capable of performing pressing and rolling massage are arranged on the two sides of the mask, so that a patient presses the face position by himself to perform pushing and pressing massage on the face, the facial muscles of the patient are relieved, and the situation that the face of the patient is tightened for a long time and consequently the face is stiff is avoided.

Described herein are peptides that can be used to treat pain or increase pain sensitivity in subject in need of treatment. Additionally, peptides of the present disclosure can be administered with an analgesic agent and / or anesthetic agent. Peptides of the present disclosure are suitable for use when a subject in need of treatment has an injury, a chronic disease, a chronic inflammation, Morton's neuroma, operative / post-operative pain, or a combination thereof.

The subject invention provides devices and methods for alleviating discomfort associated with neuroma formation. The devices and methods of the invention effectively use the body's natural response of reconstructing implanted biomaterials to minimize the size of, isolate, and protect a neuroma. In preferred embodiments, the subject device is a cylindrical cap, wherein the internal chamber of the cylindrical cap physically partitions the nerve to enable an arrangement of nerve fibers (as opposed to haphazardly arranged nerve fibers often produced in neuromas). Tabs arranged on the outside of the cap can be used to manipulate the cap into place on a nerve. The open end can also be configured with flaps that can be used to widen the open end for easier insertion of the nerve into the cap. In addition, the cap's material remodels into a tissue cushion after implantation, which protects the neuroma from being stimulated and inducing pain.

The present disclosure relates to a method of treating a brain tumor or neuroblastoma in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a substituted azaquinolone compound having activity as a poly(ADP-ribose) polymerase (PARP) inhibitor.

The invention provides a method for in-vitro detection of exogenous gene expression activity of AAV virus in nerve cells and an evaluation system. The method comprises the following steps: infecting N2A cranial nerve tumor cells by using AAV carrying a neuron-specific promoter or a glial cell-specific promoter and a reporter gene driven by the neuron-specific promoter or the glial cell-specific promoter; and detecting the level of a reporter gene transcript or a protein expressed by the reporter gene in the infected N2A cranial nerve tumor cell so as to detect the activity of the AAV expressing the exogenous gene. According to the method disclosed by the invention, the target gene expression driven by the CamKII promoter of the AAV9 serotype is tested by utilizing the N2A cranial nerve tumor cells, the problem that a suitable cell model is lacked in the prior art is solved, and a new tool and a new method are provided for AAV activity test in neurobiology research.

The application discloses a waterproof and breathable type brain and spinal cord nerve injury wound protection dressing, which is sequentially stacked and arranged from inside to outside as a wound adhesion inner layer, a functional sustained-release middle layer and a waterproof and breathable outer layer; the three-layer synergistic dressing structure of the wound adhesion inner layer, the functional sustained-release middle layer and the waterproof and breathable outer layer is constructed, waterproof sealing and the dynamic adaptation of the air permeability performance of the brain and spinal cord nerve injury wound are realized, the target anti-scar polypeptide is covalently bonded on the inner layer, the effective inhibition of excessive scar hyperplasia and neuroma formation is realized, the matching regulation of the gradient degradation drug-loaded microsphere system and the air permeation pore size of the middle layer is realized, the accurate release of active factors in the whole cycle of nerve repair is realized, the long-acting waterproof and breathable protection in a dynamic scene is realized through the design of the outer layer of super-hydrophobic nanofiber membrane, the risk of postoperative complications is reduced, and the integration and synergy of the physical protection of the wound and the nerve function repair are realized.

The invention relates to a nerve conduit for connecting an impaired nerve ending to a target site. In particular, the present invention relates to nerve conduits that support nerve injury repair and motion control and / or reduce the risk of developing a neuroma at an impaired nerve ending. Thus, a nerve conduit (10) for connecting a nerve ending to a target site is proposed, comprising an elongated body (12) formed by a wall (22) defining an internal cavity (16), and comprising: a central portion (14) wherein the internal cavity (16) extends through the central portion (14); and two end portions (18, 19) defining respective openings (20, 21) to the lumen (16), one end portion (18) being an insertion portion configured for insertion into a respective nerve ending and the other end portion (19) being a nerve ending exit portion. According to the invention, the end portions (18, 19) are arranged such that the cross-sections of the openings (20, 21) are oriented at an angle to one another.

The present invention relates to the therapeutic use of non-classical human major histocompatibility complex (MHC) molecules (also referred to as MHC class Ib molecules) in combination with peptide antigens for the treatment of neuromyelitis optica (NMO). The present invention more specifically relates to recombinant polypeptides comprising a peptide antigen and one or more domains of a non-classical MHC class Ib molecule. The present invention also relates to methods for producing such recombinant polypeptides, pharmaceutical compositions comprising same, and their use for treating neuromyelitis optica (NMO).

The invention provides a Janus membrane with tissue adhesiveness, a preparation method of the Janus membrane and application of the Janus membrane to neural restoration. The Janus membrane with the tissue adhesiveness comprises an electrospun fiber layer and an oriented hydrogel fiber layer with the tissue adhesiveness. The electrospun fiber layer is used as a non-viscous isolation layer, has good mechanical properties and air permeability, and can effectively avoid adhesion and compression of surrounding tissues; the oriented hydrogel fiber layer has unique tissue adhesiveness and an oriented structure, the tissue adhesiveness characteristic of the oriented hydrogel fiber layer can ensure that the oriented hydrogel fiber layer is tightly attached to nervous tissues, and the oriented structure can guide directional regeneration of nerves, so that the nerve regeneration efficiency is remarkably improved, directional adhesion and migration of cells can be induced, axons are promoted to extend in a specific direction, and the nerve regeneration effect is improved. Therefore, the formation of neuroma is effectively prevented. The Janus membrane and a nerve broken end are bonded without tension and curled to form an exclusive catheter which is adaptive to various nerve diameters and complex branch structures.

A composition comprising a liquid plasma according to the present invention can induce growth inhibition and death of brain tumor cells through the combined effect of radicals, ionic species, and pH effect, and thus can be effectively used for preventing or treating brain tumors. In addition, the present invention is a non-invasive physical and chemical treatment approach with low drug dependence, can exhibit a synergistic effect when used in combination with existing anticancer drugs, and has a high potential for application to the treatment of various nervous system tumors or metastatic brain diseases including glioblastoma and auditory nerve tumors.

Provided are an upstream Open Reading Frame (uORF) of a Phosphatase and Tensin homolog (PTEN) gene and a protein coded by the uORF. A potential ORF of 138 bases (45aa-uORF) in the 5′UTR of the PTEN, coding an oligopeptide of 45 amino acids (named PTEN-45aa) plays an important role in the development and progression progress of tumors. Further provided are a new diagnostic and therapeutic method and a drug screening platform for PTEN expression regulation related diseases, in particular neuroglioma. Also provided is a polypeptide for treatment of PTEN expression regulation related diseases.

The invention relates to the technical field of bioengineering, in particular to a culture medium and a method for constructing auditory neuroma organs. According to the culture medium, Neurobase Medium and DMEM (Dulbecco Modified Eagle Medium) / F12 are used as a basic culture medium; the feed additive comprises a N2 additive, a B27 additive, L-alanyl-L-glutamine, an antibiotic, HEPES, glucose, beta-mercaptoethanol, a cell growth factor, MEM NEAA and a TGF-beta inhibitor. The cell growth factor is EGF (Epidermal Growth Factor) or FGF-2. The culture medium provided by the invention can effectively improve the construction efficiency of the auditory neuroma organoid, and the constructed auditory neuroma organoid can be used as a reliable in-vitro substitution model, is used for marker detection, drug screening and individualized medical exploration in basic research and clinical transformation research, and has important application value.

The invention belongs to the technical field of in-vitro drug evaluation model construction, and particularly relates to bio-ink, an in-vitro humanized neural model and application of the bio-ink in construction of an opioid drug classification prediction model and a dose-effect relationship. The bio-ink comprises a neuroma cell line, methacrylated gelatin, a photoinitiator and a basement membrane matrix. The in-vitro humanized neural model prepared on the basis of the bio-ink provided by the invention has cell-cell and cell-matrix microenvironment interaction characteristics, the complexity of in-vivo tissues can be more truly reduced, and the structure and function of human neurons can be highly biomimetic simulated on the cellular level; the biomimetic property is obviously superior to that of traditional two-dimensional culture and animal experiments, and the accuracy and reliability of drug toxicity and dependency evaluation are improved.

The present invention relates to the field of neurology technology, and discloses a lifting device for neurology examination, comprising: a support and guide mechanism, the surface of which is provided with an extension and folding mechanism, and the number of the extension and folding mechanisms is two, and the two extension and folding mechanisms are relatively distributed, a lifting and hoisting mechanism is fixedly provided between the two extension and folding mechanisms, and the surfaces of the two extension and folding mechanisms are both provided with a buffering support mechanism. The lifting device for neurology examination can ensure that the patient can relatively conveniently place the lower limbs on the support surface of the main cushion surface through the buffering support mechanism with a shorter lifting length during use, and push the buffering support mechanism to unfold through the extension and folding mechanism after the lower limbs are placed, so as to ensure that a wider lifting length is provided by the unfolded main cushion, auxiliary cushion and docking soft cloth during testing, so as to prevent the patient's lower limbs from easily bouncing off the support surface during testing.

Tissue grafts with reduced regenerative potential, methods of preparing such grafts, and related kits and methods of treatment are described. The method may include treating tissue with a digestion solution comprising trypsin, alpha-chymotrypsin (ACT) and optionally ethylenediaminetetraacetic acid (EDTA) to substantially remove one or more susceptible proteins from the tissue. The method may also include washing the treated tissue with a buffer solution and / or with a serine-containing serum. Nerve grafts prepared according to the disclosed methods may inhibit, or lessen (e.g., provide for reduced) neuroma formation and / or axonal outgrowth after implantation.

Tissue grafts with reduced regenerative potential, methods of preparing such grafts, and related kits and methods of treatment are described. The method may include treating tissue with a digestion solution comprising trypsin, alpha-chymotrypsin (ACT) and optionally ethylenediaminetetraacetic acid (EDTA) to substantially remove one or more susceptible proteins from the tissue. The method may also include washing the treated tissue with a buffer solution and / or with a serine-containing serum. Nerve grafts prepared according to the disclosed methods may inhibit, or lessen (e.g., provide for reduced) neuroma formation and / or axonal outgrowth after implantation.

The invention provides a nerve conduit, which comprises a cannula, one end of the cannula is provided with an opening, and the other end of the cannula is provided with a folding part; the shape of the filling block is matched with the internal shape of the sleeve; when the filling block is assembled in the sleeve, the distance between one end, close to the opening, of the filling block and one end of the opening of the sleeve is preset; wherein a plurality of through holes are formed in the side wall of the sleeve, and the through holes are configured to provide passages for permeation of tissue fluid; and the filling block is made of a degradable biomedical material. According to the nerve conduit provided by the invention, a protective envelope is formed through the sleeve, replaces an adventitia, coats and limits the growth of nerve tracts, and nerves can be subjected to the action of relative mechanical stress along with the narrowing of the surrounding growth environment, so that the formation of neuroma is more quickly and stably prevented, the extrusion of surrounding muscles in a body is resisted, and the terminal nerves are protected. The nerve conduit is simple in structure and has good mechanical properties, and industrial mass production can be achieved.

The subject invention provides devices and methods for alleviating discomfort associated with neuroma formation. The devices and methods of the invention effectively use the body's natural response of reconstructing implanted biomaterials to minimize the size of, isolate, and protect a neuroma. In preferred embodiments, the subject device is a cylindrical cap, wherein the internal chamber of the cylindrical cap physically partitions the nerve to enable an arrangement of nerve fibers (as opposed to haphazardly arranged nerve fibers often produced in neuromas). Tabs arranged on the outside of the cap can be used to manipulate the cap into place on a nerve. The open end can also be configured with flaps that can be used to widen the open end for easier insertion of the nerve into the cap. In addition, the cap's material remodels into a tissue cushion after implantation, which protects the neuroma from being stimulated and inducing pain.

The present invention discloses a differentiated interface nerve conduit that can be customized, including a hollow outer sheath and an inner core filler arranged inside the hollow outer sheath; the surface of the hollow outer sheath is distributed with nano-scale micropores, and the inner core filler is a micron-scale lamellar loose filler arranged in an axial orientation. The nerve conduit structure meets the two different requirements of the internal and external repair microenvironments, respectively, and realizes the important functions of "inner affinity and outer sparseness, inner promotion and outer resistance". The conduit can not only promote the directional myelination of nerves and the directional growth of axons, but also avoid the formation of neuromas. The present invention also uses digital modeling combined with a template leaching method to customize nerve conduits. The preparation process is convenient, and the product parameters are adjustable and controllable. It provides a reliable personalized treatment plan for nerve defects with complex structures such as multiple branches, filling the gap of the current lack of precise repair products for complex nerve defects in clinical practice.

The invention discloses a biological adhesive tape for nerve stumps after amputation and a preparation method thereof.The biological adhesive tape comprises an outer layer and an inner layer, the outer layer and the inner layer are connected through a layer of PEG-based adhesive, and the outer surface of the outer layer is coated with a PDMS hydrophobic coating; the inner surface of the inner layer is also coated with a PEG-based adhesive layer; wherein the outer layer is prepared from recombinant human-derived I-type collagen and contains dexamethasone drug-loaded microspheres; and the inner layer is prepared from recombinant human I-type collagen and contains gabapentin drug-loaded microspheres. According to the biological adhesive tape, the outer layer inhibits inflammatory reaction and reduces foreign body reaction by slowly releasing glucocorticoid, and the inner layer prevents and relieves neuralgia by slowly releasing gabapentin; the physical fitting effect of the adhesive tape can prevent nerve fibers from growing outwards, so that the risk of neuroma formation is reduced. The biological adhesive tape is high in application flexibility, suitable for nerve stumps with different diameters and shapes and suitable for complex trauma conditions.

The invention relates to nerve conduits for connecting a lesioned nerve end to a target site. In particular, the invention relates to nerve conduits supporting repair of a nerve lesion and motor control and / or reducing risk of the development of a neuroma at the lesioned nerve end. Accordingly, a nerve conduit (10) for connecting a nerve end to a target site is suggested, comprising an elongate body (12) formed by a wall (22) defining an inner cavity (16) and comprising a central portion (14), wherein the inner cavity (16) extends through the central portion (14), and two end portions (18, 19) defining respective openings (20, 21) to the inner cavity (16), wherein one end portion (18) is an insertion portion configured for inserting a respective nerve end (26) and the other end portion (19) is a nerve end outlet portion. According to the invention, the end portions (18, 19) are arranged such that the cross-sections of the openings (20, 21) are oriented at an angle to each other.

The invention provides a nerve conduit, which comprises a sleeve, one end of the sleeve is provided with an opening, and the other end of the sleeve is provided with a fixing part; the supporting frame comprises one or more supporting plates; when the supporting frame is assembled in the sleeve, the interior of the sleeve is divided into a plurality of axial limiting channels by the supporting plates, and the limiting channels are configured to provide a preset growth path; a plurality of through holes are formed in the side wall of the sleeve, and the through holes are configured to provide passages for permeation of tissue fluid. According to the nerve conduit provided by the invention, a protective envelope is formed through the sleeve, replaces an adventitia, coats and limits the growth of nerve tracts, and nerves can be subjected to the action of relative mechanical stress along with the narrowing of the surrounding growth environment, so that the formation of neuroma is more quickly and stably prevented, the extrusion of surrounding muscles in a body is resisted, and the terminal nerves are protected. The nerve conduit is simple in structure and has good mechanical properties, and industrial mass production can be achieved.

The present disclosure provides a mechanically-actuated tool for cutting a tissue graft having a hollow core and methods for use thereof. A portion of a biological structure, such as a nerve, is attached to the hollow core to form an implantable neural graft assembly. The tool has a cutter mechanism and a grasper mechanism. The grasper mechanism has one or more component(s) that open and close via an actuation mechanism, like a handle, and rotate via a controller component, like a rotatable wheel. The cutter mechanism may be a cutting tube component that harvests the tissue graft. The tool may also have an ejector mechanism to remove the tissue graft as part of the implantable neural graft assembly. Such devices and methods are particularly suitable for treating neuromas and other neural regeneration procedures.

Disclosed is an individualized nerve conduit with differentiated interfaces, including a hollow outer sheath and an inner core filler disposed inside the hollow outer sheath; wherein a surface of the hollow outer sheath is distributed with nano-scale micropores, and the inner core filler is a loose filler of micron-scale sheets with axially oriented arrangement. The structure of such nerve conduit satisfies the repair microenvironment with different needs, both internal and external, and realizes the important function of “internal affinition and external alienation, internal promotion and external resistance”. The conduit not only promotes directional myelination of nerve and directional ingrowth of axon, but also prevents neuroma formation.