197 results about "Nerve fibre" patented technology

Various aspects of this disclosure relate to a layered polymer substrate with electrodes and conductive ink embedded in the substrate. In some embodiments, a prosthetic liner may be bonded onto the polymer substrate. The substrate may include an interconnect coupled to the electrodes via the conductive ink. The system may include a controller (e.g., an electrode controller) in communication with the electrodes via the conductive ink. The electrodes may be activated such that they may stimulate nerve fibers in a user's residual limb.

Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and / or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and / or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and / or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

The subject invention pertains to deep learning (DL) systems and methods for the binary classification of Alzheimer's Disease. Optical coherence tomography (OCT) generated reports were used, and the images were grouped into 3 different inputs: (1) an optic nerve head (ONH) model including a retinal nerve fiber layer (RNFL) thickness map, a RNFL deviation map, and an ONH-centered en face image; (2) a Macula model including a ganglion cell inner plexiform layer (GCIPL) thickness map, a GCIPL deviation map, a macular thickness map, and a macula-centered en face image; and (3) a General model including all images of (1) and (2). A fusion network is provided to analyze the plurality of images from a single eye for classification. The fusion network includes Feature Extraction, Feature Fusion, and Feature Reconstruction. Ensemble learning is provided to advantageously combine several baseline models to build a single but more powerful model.

Various aspects of this disclosure relate to a layered polymer substrate with electrodes and conductive ink embedded in the substrate. In some embodiments, a prosthetic liner may be bonded onto the polymer substrate. The substrate may include an interconnect coupled to the electrodes via the conductive ink. The system may include a controller (e.g., an electrode controller) in communication with the electrodes via the conductive ink. The electrodes may be activated such that they may stimulate nerve fibers in a user's residual limb.

The invention discloses a retina thickness prediction method and system based on a multi-modal image, and the method and system achieve the effective estimation of the retina thickness under a low-cost condition through feature alignment and fusion modeling, and improve the basic screening and follow-up visit capability. According to the invention, through fusion of the multi-mode retina image data, the structure and function information of the optic nerve can be more comprehensively obtained, and the prediction accuracy of the thickness of the retina nerve fiber layer (RNFL) is improved. The OCT high-resolution hierarchical structure and the wide-view texture features of the eye fundus image are combined, so that anatomy and pathological states of optic nerves can be truly restored. The method can be used as an auxiliary method for early screening and early warning of optic neurodegenerative diseases such as glaucoma, and provides support for low-cost and high-efficiency primary screening and clinical auxiliary decision making.

The invention discloses a quantitative detection method for sweat gland cholinergic nerves of a neuron intracellular inclusion body disease. Belongs to the technical field of biological science. Performing immunohistochemical staining; scanning a slide; and calculating the density of the cholinergic nerve fiber. The invention relates to a simple and feasible method for quantitatively evaluating cholinergic nerve fibers of a neuron intracellular inclusion body disease. The method comprises the following steps: carrying out skin biopsy on control receptors of a neuron intranuclear inclusion body disease and a nervous system-free disease, slicing, carrying out immunofluorescent staining by using a VIP antibody, quantitatively calculating the density of cholinergic nerve fibers labeled by the sweat gland VIP antibody in dermis by using Image J software, analyzing whether the cholinergic nerve fibers have differences in the two groups of receptors, and if so, determining whether the cholinergic nerve fibers have differences in the two groups of receptors. Evaluating the nervous injury and severity of the cholinergic nerve; the invention provides a new way for accurately evaluating the autonomic nerve injury and severity of the neuronal intracellular inclusion body disease.

The invention relates to a medical implant with an electrode arrangement designed as a wrapping cuff, or cuff electrode for short, suitable for extravascular or extraneuronal attachment along an intracorporeal vessel or nerve fiber bundle, and an electrical supply and drainage arrangement having a longitudinal extension, which electrically connects the cuff electrode to an implantable supply unit designed separately from the cuff electrode, wherein the electrical supply and drainage arrangement is surrounded along a section in its longitudinal extension by an elastic sheath, which connects the electrical supply and drainage arrangement to an intracorporeal tissue area in a fixed position via a fastening means that can be brought into operative contact with the elastic sheath. The invention is characterized in that the elastic sheathing has a longitudinal extension and a circumferential edge oriented radially around the longitudinal extension, and that at least one tunnel-like opening contour is arranged on the circumferential edge of the sheathing along at least one cross-sectional plane oriented orthogonally to its longitudinal extension, which is suitable for the local insertion of the fastening element designed as a medical thread.

According to the three-dimensional electric field coupling modeling method for analgesia provided by the invention, the propagation process of an electric field in each physiological tissue is accurately simulated by constructing a multi-layer bionic tissue model, so that the accuracy and effect of analgesia treatment are improved; calculating the conductivity and dielectric constant of each layer of tissue, performing numerical simulation on electric field distribution by using a finite element analysis technology, optimizing electrode configuration and electrical stimulation parameters, and ensuring the uniformity and stability of the electric field of a target area; a neurophysiology model is integrated, the conduction law of nerve fiber action potential is dynamically simulated, the stimulation effect of electric field intensity on nerve fibers is quantitatively analyzed, analgesia parameters are further optimized, and accurate control over pain signal transmission is achieved. The problems that in an existing electrical stimulation technology, electric field distribution is not uniform, electrode contact is not stable, and the stimulation effect is difficult to last are effectively solved, wide clinical application prospects are achieved, and an efficient, stable and accurate solution is provided especially in non-invasive treatment of chronic pain.

The invention belongs to the field of medicines, and discloses application of a stress-induced stem cell extract in treatment of cerebral apoplexy. The inventor finds that stem cells are cultured under proper stress conditions through screening, and the separated stem cell extract (also known as Alritoin) can increase the axon length and dendritic length of normal primary neurons and is beneficial to growth and conduction of nerve fibers; in a pdMCAO model, the volume of cerebral infarction in the acute stage of ischemia of a mouse can be remarkably reduced, the neurological function score can be improved, and a relatively good improvement trend is achieved in the aspect of cognition; in the acute stage of cerebral ischemia reperfusion, the pharmaceutical composition has remarkable effects on reducing the cerebral infarction volume of a mouse, reducing relative edema and improving the neurological function, and is relatively long in medication time window; in a cerebral ischemia reperfusion model, the trend of improving local cerebral blood flow is shown. The allitoin is expected to be developed into a promising drug for cerebral apoplexy, especially a drug for treating ischemic cerebral apoplexy.

Methods and apparatus disclosed for treating pain and mobility impairments include synergistic application of various stimuli to a patient. These stimuli can comprise serial and sequential combinations of predetermined subatmospheric pressure values, time-varying voltage waveforms applied to electrodes in contact with different portions of a patient's skin in a matter that produces currents which stimulate nerve fibers that activate muscles, and direct practitioner-assisted mechanical movement of tissue. Apparatus and systems for applying the treatment methods are disclosed.

The invention relates to an ablation control method, system and device, computer equipment, a computer readable storage medium and a computer program product. The method comprises the following steps: acquiring ablation input power corresponding to a to-be-ablated area; an ablation signal is provided for the target electrode so as to apply ablation energy to the to-be-ablated area, and the initial power of the ablation signal is smaller than the ablation input power; in the process of applying ablation energy to the to-be-ablated area, physiological parameters are obtained. Target output power of ablation energy corresponding to the ablation signal is determined according to the physiological parameters, the ablation input power and the ablation progress, the influence degree of the physiological parameters on the target output power is in negative correlation with the ablation progress, and the influence degree of the ablation input power on the target output power is in positive correlation with the ablation progress. The power of the ablation signal is adjusted. By the adoption of the method, the sympathetic nerves in the to-be-ablated area can be ablated on the premise that the nerve fibers are prevented from being irreversibly damaged in the ablation process.

Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and / or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary, receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and / or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and / or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

The present disclosure relates to an apparatus, neurostimulation device, system, and computer program for stimulating and / or recording signals travelling along nerve fibers of a spinal cord. According to aspects of the present disclosure, the apparatus comprises one or more first electrode arrangements arranged on an elongated and non- conducting base material, each first electrode arrangement comprising: an elongated first central reference electrode extending along a longitudinal direction of the elongated base material; and a plurality of first electrodes arranged on both sides of the elongated first central reference electrode; wherein a length of the elongated first central reference electrode is at least two times larger or at least three times larger than an average length of the plurality of first electrodes; and wherein the elongated first central reference electrode is configured to provide a counter potential for stimulating and / or a reference potential for recording of the nerve fibers of the spinal cord via the plurality of first electrodes.

The embodiment of the invention discloses a brain operation path determination method and device, equipment, a medium and a medical system. The brain operation path determination method comprises the steps that a brain structure model and at least one target spot of a target user are obtained; based on the brain structure model, determining an information transfer relationship between each nuclear group sub-model and each nerve fiber sub-model; determining a plurality of candidate operation schemes based on the plurality of preset path starting points, the target group sub-model to which the at least one target point belongs and the information transfer relationship; for each candidate operation plan, performing quality evaluation on the candidate operation plan based on a quantitative evaluation model under at least one evaluation dimension, and determining a path quality attribute corresponding to each candidate operation plan; according to the method, at least one target recommended operation scheme is determined based on each path quality attribute, a plurality of candidate paths conforming to nerve conduction characteristics are automatically generated, and an optimal scheme is screened through a quantitative evaluation model, so that the brain tissue injury risk and the operation complexity are effectively reduced while the operation precision is improved.

Systems and methods of neurofeedback intervention reduce the negative effects of neurological disorders, including Parkinson's disease, essential tremor, dystonia, epilepsy, dysfunction following stroke, obsessive-compulsive disorder, Tourette syndrome, dementia, complex regional pain syndrome, and the like. Haptic devices, including eccentric-mass actuators and computer-controlled tightening haptic straps provide haptic sensation to a body. The haptic sensations are controlled by a haptic control signal determined by a control program. The control program may determine the haptic control signal from a neurological signal from an EEG, an electrode detecting a signal in a nerve fiber, or an accelerometer. Haptic therapy un-trains and desynchronizes abnormal neuron synchrony, to reduce the negative effects of neurological disorders.

Systems, devices, and methods for promoting a patient's volume return to the heart and cardiac pre-load by inducing constriction of at least a portion of the splanchnic bed of the patient are described herein. Constriction of at least a portion of the splanchnic bed is induced via electrical stimulation to splanchnic nerve fibers of one or more splanchnic nerves. Electrical stimulation to splanchnic nerve fibers is delivered using at least one intravenous electrode disposed within a vein of the patient proximate to the splanchnic nerve fibers.

Methods and systems for stimulating nerve fibers to treat a condition in a patient are disclosed herein. Such methods can include stimulating, via an electrode device, afferent fibers associated with baroreceptors and / or a carotid sinus nerve of a patient; sensing a heart rate of the patient; and adjusting a stimulation frequency of the afferent fibers based on the sensed heart rate. The heart rate can be indicative of an activity level of the patient, and an increase in the sensed heart rate can cause an increase in the stimulation frequency.

Apparatus and methods for treating back pain are provided, in which an implantable stimulator is configured to communicate with an external control system, the implantable stimulator providing a neuromuscular electrical stimulation therapy designed to cause muscle contraction to rehabilitate the muscle, restore neural drive and restore spinal stability; the implantable stimulator further including one or more of a number of additional therapeutic modalities, including a module that provides analgesic stimulation; a module that monitors muscle performance and adjusts the muscle stimulation regime; and / or a module that provides longer term pain relief by selectively and repeatedly ablating nerve fibers. In an alternative embodiment, a standalone implantable RF ablation system is described.

The invention discloses an intracranial electrode lead track generation method, device and system, a medium and a product. The method comprises the following steps: acquiring medical image data of the brain of a patient after an electrode lead is implanted into the intracranial of the patient; extracting a feature point set corresponding to the electrode lead from the medical image data; according to trajectory features of the electrode lead in the cranium of the patient, a target feature point set implanted into the cranium of the patient is screened out from the feature point set, and the trajectory features at least represent that the bending degree of the electrode lead in the cranium of the patient does not exceed a preset bending value; and according to the target feature point set, simulating to obtain an intracranial electrode lead track of the patient. According to the method, the intracranial electrode lead wire part can be accurately identified by utilizing the intracranial trend of the electrode lead wire, and accurate three-dimensional visual rendering is performed on the intracranial electrode lead wire through the point corresponding to the intracranial electrode lead wire part, so that a doctor can better understand the position relationship between the intracranial electrode lead wire and the surrounding nerve fiber bundle, and the accuracy and the reliability of the system are improved. Doctors can optimize program control parameters, and the treatment effect is improved.

The invention discloses an exosome and optic nerve injury prognosis evaluation method and system, and relates to the field of data processing and artificial intelligence, and the method comprises the steps: carrying out the collection and prognosis grade labeling of optic nerve MRI data; carrying out adaptive processing on the three-dimensional MRI voxel data by adopting anisotropic Gaussian interpolation so as to retain a micron-sized structure of an optic nerve fiber layer; constructing a double-branch gating classification network, extracting axonal injury and fusion prognosis related features through independent branches, and training by combining a dynamic focus loss function with confidence loss; and finally, the prognosis probability distribution of the patient is output through the model. According to the method, multi-modal information can be effectively fused, tiny damage feature characterization is enhanced, and the accuracy and interpretability of prognosis evaluation are improved.

Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and / or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) are provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves within a wall of (e.g., within adventitia surrounding a lumen of) an artery or other blood vessel, such as the common hepatic artery.

Disclosed herein are of systems, methods, and computer-program products for determining if a response is an electrically evoked compound action potential (eCAP), refining raw data of an eCAP amplitude growth function (AGF) and utilizing maximum (i.e., steepest) slope from moving linear regression to effectively estimate cochlear nerve function, and determining quality of an electrode-neuron interface (ENI) using a model developed from eCAP attributes.

Systems and methods of applying electrical stimulation to achieve sustained relief of chronic pain that comprise a coiled wire percutaneous lead configured for insertion into a portion of a body that is proximal to a region of pain and an electrode formed integrally on the coiled wire percutaneous lead, wherein the electrode is configured to be positioned inside the body and at a therapeutically effective distance from a portion of at least one peripheral nerve that innervates the region of pain. The systems and method may also include an electrical stimulation device operatively coupled to the lead to apply electrical stimulation through the at least one electrode to at least one peripheral nerve that innervates the region of pain, to activate target peripheral nerve fibers while preventing activation of non-target peripheral nerve fibers and avoiding changing or blocking neural activity in off-target peripheral nerve fibers in the at least one peripheral nerve to create comfortable sensations in the region of pain and produce pain relief by modulating central nervous system plasticity associated with the pain.

Differential charge-balancing can be used in high-frequency neural stimulation. For example, a neural stimulation apparatus can have first and second electrodes configured to be coupled proximate to a nerve fiber to implement a neural stimulation procedure. A neural stimulation circuit can be electrically coupled to the first and second electrodes. The neural stimulation circuit can apply stimulation currents to the nerve fiber through the first and second electrodes during a first stimulation phase of the neural stimulation procedure. The neural stimulation circuit can also apply a modified stimulation current to the nerve fiber through the first electrode during a second stimulation phase of the neural stimulation procedure. The modified stimulation current can be generated based on a difference between (i) a voltage at the first electrode, and (ii) a reference voltage derived from voltages on the first and second electrodes.

Systems, devices, and methods for affecting a patient's organ function by innervating one or more organs of the patient are described herein. Innervating one or more organs of the patient is induced via electrical stimulation to nerve fibers, such as afferent nerve fibers, of one or more of the patient's dorsal roots. Electrical stimulation to dorsal root nerve fibers is delivered using at least one intravenous electrode disposed within a vein of the patient proximate to the dorsal root nerve fibers.

The invention discloses a nerve cryoablation puncture needle suite with a nerve stimulation module, and relates to the technical field of medical equipment, the nerve cryoablation puncture needle suite comprises an ultrasonic easy-to-develop puncture needle main body, and the puncture needle main body is connected with a three-way valve; the probe body is connected with the needle body, the delivery pipe is arranged on the surface of the outer end of the needle body, and the other end of the delivery pipe is communicated with the three-way valve and can be used for drug delivery. After the tail end of the needle core is connected with the nerve stimulation module, current can be quantitatively output, the tip of the needle core can stimulate nerve fibers with the diameters from small to large, nerve sensation or movement reaction can be induced, focus-related nervous tissue can be accurately targeted, tissue specificity in the treatment process is ensured, and accuracy and safety of pain treatment are improved. The refrigerating pipe is arranged at the middle end in the needle body, the vacuum cavity is formed in the inner wall of the needle body, when the refrigerating fluid is vaporized and discharged through the outlet, the refrigerating fluid which is not vaporized completely makes contact with the outlet, the filler is cooled and expands to block the outlet, and the refrigerating fluid is effectively prevented from overflowing at low temperature.

The invention provides a method for removing noise signals in a brain-computer interface through a force-electric decoupling method, and the method comprises the steps: collecting signals generated in the brain-computer interface, including electric signals transmitted by nerve fibers, interference electric signals and electric signals caused by force signals of various loads in the brain; electric signals caused by action potential are removed through the force-electricity constitutive relation of the liquid-containing porous material, electric signals caused by force signals of various loads in the brain are decoupled, and electric signals conducted by nerve fibers are reserved. According to the method, noise signals generated due to the electrokinetic effect in the brain-computer interface can be effectively removed, and electric signals conducted by nerve fibers can be accurately obtained.

The invention discloses an implantable electrode and a system for treating hypertension by adopting the same. The implantable electrode for treating hypertension comprises a catheter, a stimulating electrode slice, a guide wire and an insulating film, the two stimulating electrode plates are arranged on the two sides of the exterior of the catheter respectively, are connected with the exterior through guide wires arranged in the catheter respectively and are used for emitting current to stimulate nerves according to external signals; one end of the insulating film is arranged outside the catheter and located between the two stimulating electrode slices and used for wrapping the stimulating electrode slices making contact with the nerves and the outside of the nerves so that the stimulating electrode slices can be insulated from the outside. The invention discloses a system for treating hypertension by adopting an implantable electrode. The system comprises an implantable electrical stimulation device, a blood pressure monitoring device and a remote analysis monitoring platform. According to the implantable electrode and the system for treating hypertension by adopting the implantable electrode disclosed by the invention, extremely low-intensity electrical stimulation is given to renal sympathetic nerve introduced nerve fibers in dorsal root nerves through the stimulation electrode to inhibit the activity of the nerve fibers, so that the blood pressure of a patient is kept relatively stable, and the risk of complications caused by blood pressure fluctuation is reduced; the medicine taking amount of a hypertensive patient can be greatly reduced, and even the hypertensive patient may stop taking hypertensive medicines.

A method of activating a piezoelectric neuroconduit guide scaffold including a plurality of aligned piezoelectric polymer nanofibers, the method including mechanically stimulating the piezoelectric neuroconduit guide scaffold with hydro-acoustic waves or shockwaves to remotely activate a piezoelectric effect of the nanofibrous scaffolds that induces a mechano-electrical stimulus on neural cells cultured on the scaffold, wherein the mechano-electrical stimulus promotes nerve fiber outgrowth from the neuronal cells. Some aspects relate to seeding individual components of neural tissues on the piezoelectric neuroconduit guide scaffold, wherein the hydro-acoustic stimulation induces neural tissue formation. In other aspects, the piezoelectric neuroconduit guide scaffold is implanted in a damaged neural tissue, wherein stimulating the piezoelectric neuroconduit guide scaffold by the application of shockwaves promotes nerve fiber outgrowth that bridges a nerve gap to induce nerve regeneration or reinnervation of the damaged neural tissue.