85 results about "Coumarin Compound" patented technology

The invention discloses a coumarin KRAS-G12C inhibitor as well as preparation and application of the coumarin KRAS-G12C inhibitor. The coumarin compound disclosed by the invention has a remarkable inhibition effect on non-small cell lung cancer cells (NCI-H23 and NCI-H358) with high expression of KRAS-G12C and pancreatic cancer cells (MIAPaCa-2), is particularly used for preparing medicines for treating and / or preventing non-small cell lung cancer and pancreatic cancer, and has a good prospect of development and application of antitumor medicines.

This invention discloses an acaricide targeting calcium ion channels and its application, belonging to the field of pesticides. Specifically, it relates to an acaricide based on the L-type calcium ion channel (L-VGCC) target and its application in the control of agricultural mites. The acaricide, artemisinin [Formula (I)], is a natural coumarin compound that is highly effective against agricultural mites and safe against predatory mites. It is a targeted, natural, and environmentally friendly acaricide with minimal harm to humans and the environment, and has the potential to be developed into a selective acaricide.

This invention relates to the field of natural product separation technology, specifically to coumarin compounds isolated from *Hypericum perforatum*, their preparation methods, and applications. The preparation method of these coumarin compounds includes alcohol extraction from *Hypericum perforatum*, followed by macroporous resin adsorption separation and column separation. The coumarin compounds of this invention can be used for anti-inflammatory purposes, exhibiting inhibitory activity against RAW264.7 cells and the expression of TNF-α, IL-1β, and IL-6 proteins.

The invention relates to a preparation method of an all-solid-state lithium metal battery, which comprises the following steps: S1, adding a high-molecular polymer, a lithium salt and a coumarin compound in a mass ratio of 1: (1-6) into an organic solvent, and uniformly mixing to obtain a mixed system, the mass of the coumarin compound accounts for 5wt%-80wt% of the total mass of the whole mixed system, and preparing the solid electrolyte membrane by adopting a solution pouring method; and S2, assembling the solid electrolyte membrane into the all-solid-state lithium metal battery. The invention also relates to the all-solid-state lithium metal battery obtained by the preparation method. According to the all-solid-state lithium metal battery and the preparation method thereof disclosed by the invention, the ionic conductivity of the electrolyte can be effectively improved, and the component structure of the interface layer between the electrolyte and the electrode is optimized to meet the all-solid-state battery requirements of high capacity, good rate capability, long cycle performance, relatively good stability and high safety.

The application belongs to the technical field of medicine, and relates to 3-benzylamino coumarin compounds and application thereof. Experimental results show that the compounds can significantly increase the survival rate of HUVEC cells in a high-sugar environment, and resist blood vessel injury caused by high sugar. The compounds can increase the release amount of NO in HUVEC cells damaged by high sugar, reduce the generation of malondialdehyde, and reduce the generation of tumor necrosis factor alpha.

The application discloses application of a coumarin compound or a composition thereof in inhibition of a plant Huanglongbing pathogen, prevention of plant Huanglongbing, improvement of plant resistance to Huanglongbing, inhibition of a plant pathogenic bacterium and preparation of a product for preventing and treating plant Huanglongbing, improving plant Huanglongbing resistance, inhibiting a plant Huanglongbing pathogen and inhibiting a plant pathogenic bacterium. The coumarin compound is isofraxidiformin or ostruthin. By applying the coumarin compound or the composition thereof to a receptor plant or a growth medium thereof, the content of the coumarin compound or the composition thereof in the receptor plant is increased, and then the citrus Huanglongbing pathogen in the plant body is significantly reduced C Las quantity. Under field application conditions, the coumarin compound or the composition thereof also shows good prevention and treatment potential. In addition, the coumarin compound shows broad-spectrum bacteriostatic activity on a plurality of other plant pathogenic bacteria, and shows good plant antibacterial prevention and treatment potential.

The application discloses a porphyrin-eugenol derivative with antitumor activity, uses DPBF to detect the yield of singlet oxygen, and in-vitro antitumor activity test shows that the compound has good activity. The porphyrin-coumarin compound can realize the synergistic treatment of phototherapy and chemotherapy, in addition, the insertion of metal Zn in the porphyrin can also enhance the antitumor activity of the compound. Thus, the compound can be used as an active ingredient of an antitumor drug, and has good development and application prospect.

The invention belongs to the technical field of green biological prevention and control of plant diseases, and particularly relates to a biopesticide based on coumarin metabolites and application of the biopesticide in green prevention and control of litchi downy blight. A novel litchi downy blight prevention and control method is developed based on coumarin compounds, and the method passes through in-vitro bacteriostasis experiments, fresh leaf bacteriostasis experiments and comprehensive evaluation of the prevention and control effect. According to the present invention, it is found that the three coumarins such as Scopoletin, Esculin and Esculin can significantly inhibit the growth of peronophythora litchii on a culture medium and a living body leaf, and have good prevention and control effects, and the Scopoletin and Esculin have the most significant antibacterial effect, and can synergistically enhance the inhibition effect on peronophythora litchii, such that the Scopoletin, Esculin and Esculin can significantly inhibit the growth of peronophythora litchii. The method has the advantages of environmental protection, high efficiency, safety and economy, is suitable for large-scale application, and provides a new solution for the prevention and treatment of the litchi downy blight.

The present invention discloses a coumarin HDAC6 inhibitor and its preparation method and application, belonging to the field of chemical medicine technology. The present invention provides coumarin compounds shown in Formula I, Formula II and Formula III. Based on the structure of coumarin, the characteristic group of HDAC6 inhibitor hydroxamic acid is introduced to achieve good homologous selectivity for HDAC1 / 6; at the enzyme level, cell level and animal experiment level, it is verified that the compound has excellent target inhibition effect; by studying the example of HDAC6-NF-κB participating in the inflammatory response of colonic tissue, a new practical basis is provided for the treatment of ulcerative colitis. The compound provided by the present invention can be used as a new HDAC6 inhibitor to prevent and treat HDAC6-related diseases, especially it is expected to solve the shortcomings of some current small molecule drugs for the treatment of ulcerative colitis, such as poor relief effect and large side effects.

The invention discloses a synthesis method of pyrido [3, 2-c] coumarin compounds, and belongs to the technical field of organic synthesis. According to the technical scheme, the method is characterized by comprising the following steps: dissolving an aromatic aldehyde compound, a 4-amino coumarin compound and a tertiary aliphatic amine compound in a solvent, adding an oxidant, and reacting at 120-140 DEG C to obtain the target product pyridino [3, 2-c] coumarin compound. The synthesis process is simple and efficient, the pyrido [3, 2-c] coumarin compound is directly prepared in one step through one-pot cascade reaction, no catalyst or additive is needed in the synthesis process, heating is only needed under the air condition, operation is convenient, raw materials are simple, the reaction condition is mild, and the substrate application range is wide.

This invention discloses a coumarin compound and its uses, belonging to the field of chemical and pharmaceutical technology. This invention provides coumarin compounds represented by Formula I, particularly some specific coumarin compounds. These compounds and their compositions can inhibit the MEK or Ras-MAPK signaling pathway, providing a new approach for treating diseases related to the MEK or Ras-MAPK signaling pathway.

The present disclosure addresses the problem of providing a resin composition, a cured product of which has a high glass transition temperature and good desmear resistance, wherein a solder resist formed on a printed wiring board including the cured product has good small-diameter opening properties. This resin composition contains a thermosetting resin (A), a coumarin compound (B), and an inorganic filler (C). The thermosetting resin (A) contains an epoxy resin (A1) and a maleimide resin (A2). The content of the maleimide resin (A2) is 8-60 mass% with respect to the total amount of the thermosetting resin (A).

The invention discloses an antihypertensive beverage formula and a preparation method thereof, and the antihypertensive beverage formula comprises the following components in parts by weight: 0.01-10 parts of saffron, 0.1-100 parts of sophora flower bud, 0.1-100 parts of huanglongcao, 0.1-100 parts of corn stigma, 0.1-100 parts of cassia occidentalis, 0.1-100 parts of white chrysanthemum and 0.1-100 parts of cistanche. According to the invention, the huanglongcao contains baicalin, baicalin, baicalein, scutellaria baicalensis enzyme and the like; the common selfheal fruit-spike contains triterpenoids, flavonoids, steroid glucoside and coumarin compounds, and the cassia seed contains anthraquinones and naphthopyrone compounds; when the components act in the human body, the CAMP (cyclic adenosine monophosphate) level of the human body is increased, so that the platelet accumulation is obviously reduced, the resistance of blood circulation is reduced, the pressure of blood on vascular walls is reduced, and the effects of reducing blood pressure, improving eyesight, inducing diuresis and inhibiting cholesterol synthesis are achieved, so that the purpose of reducing blood pressure is achieved.

The invention discloses a method for extracting 7-hydroxy-8-O-beta-D-glucopyranoside-coumarin from apple peel, a compound extracted by the method and application of the compound. The invention belongs to the field of extraction and separation of natural products, and relates to a coumarin compound found in apple peel. The invention further provides a separation and identification method of the novel compound. Methanol extraction, ethyl acetate elution and a high performance liquid chromatograph are sequentially adopted for separation, purification and preparation. The structure of the compound is determined to be the compound found in apple peel for the first time by adopting nuclear magnetic identification of hydrogen spectrum and carbon spectrum. The compound has a protective effect on vascular endothelial dysfunction caused by hyperlipidemia, has no toxic effect on cells, and can be used as a raw material for drug development and pharmacological activity research.

This invention provides a method for detecting copper oxide content in a gas generator using a chemical sensor. During copper ion detection, the test solution contains coumarin compounds with phenylhydrazone groups. These compounds, acting as a chemical sensor, can complex with copper ions. This complexation weakens the carbon-nitrogen double bonds in the phenylhydrazone compound molecules, promoting the hydrolysis of the phenylhydrazone groups to generate corresponding aldehyde compounds. The solution then emits a strong green fluorescence. When used for copper ion detection in aqueous solutions, the chemical sensor of this invention exhibits a significant fluorescence enhancement response, high detection sensitivity, and a detection limit as low as 150 nM. It demonstrates extremely high selectivity for copper ions with almost no interference from other common metal ions, and is particularly effective in accurately quantifying the content and distribution of copper oxide in gas generators.

The invention discloses a double-target inhibitor of 1, 2, 4-triazole-coumarin alpha-glucosidase and protein tyrosine phosphatase 1B (PTP1B) as well as a preparation method and application of the double-target inhibitor. The chemical structure of the alpha-glucosidase and PTP1B double-target inhibitor is as shown in formula (I): # imgabs0. The 1, 2, 4-triazole-coumarin compound provided by the invention has obvious effects of inhibiting the activity of alpha-glucosidase and PTP1B and reducing postprandial blood sugar, and can be used as a novel lead compound for antidiabetic research; the 1, 2, 4-triazole-coumarin compound provided by the invention is mild in preparation condition, simple to operate, low in price and easy to popularize.

This invention discloses a coumarin analogue, its synthesis method, and its application, belonging to the field of agricultural pest control technology. The structural formula of the coumarin compound is shown in formula (I), denoted as COUM-L; in formula (I), R is hydrogen, halogen, hydroxide, or 1-(methoxymethyl)-3-methylbenzene; it is a target-type natural product environmentally friendly acaricide with high acaricidal efficiency and low harm to humans and the environment.

The present invention relates to the technical field of chemicals and pharmaceuticals. Disclosed are a coumarin compound and a use thereof. The present invention provides a coumarin compound represented by formula I, and some specific coumarin compounds. The compound and composition can effectively inhibit MEK or Ras-MAPK signaling pathways, can be used for preparing MEK or Ras-MAPK signaling pathway inhibitors, and provide a new way for treating MEK or Ras-MAPK signaling pathway-related diseases.

The invention belongs to the technical field of shape memory high-molecular polymers, and particularly relates to coumarin-based light / heat dual response type shape memory polyurethane as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out a ring-opening polymerization reaction on 2, 2-bis (4-epoxypropoxyphenyl) propane and 3-amino-1-propanol as raw materials in a liquid phase to prepare a prepolymer, and carrying out a polymerization addition reaction on the prepolymer, an isocyanate monomer and a coumarin compound as raw materials in the liquid phase under a catalytic action to prepare the coumarin-modified polyurethane. Light / heat dual response type shape memory polyurethane based on coumarin is prepared; according to the invention, the photoresponse characteristic of the coumarin compound and the temperature response characteristic of the prepolymer are ingeniously combined, so that the dual response to photostimulation and temperature stimulation is realized, and the stimulation response speed and the programming precision controllability of the coumarin-based optical / thermal dual response type shape memory polyurethane are improved.

The invention discloses a hydrogen sulfide prodrug of a coumarin compound and application of the hydrogen sulfide prodrug, the hydrogen sulfide prodrug of the coumarin compound is shown as a formula (I), the coumarin compound is used as a lead compound, the structure of the coumarin compound is modified and transformed, and release of hydrogen sulfide can be monitored through the fluorescence property of the coumarin compound; according to the invention, release-monitoring is integrated, hydrogen sulfide can be released while the hydrogen sulfide is converted into an active compound in vivo, and the physiological function of the hydrogen sulfide is exerted to regulate oxidative stress of a body and reduce toxic and side effects of the drug while the drug effect of the active compound is exerted, so that the effects of reducing toxicity and enhancing efficacy are achieved. # imgabs0 #

The invention provides a mass spectrum imaging method for visually analyzing terpenoid and coumarin components in ferula asafetida stems, and belongs to the technical field of molecular imaging. The method comprises the following steps: embedding a to-be-detected sample of a ferula ferulaeoides stem, freezing and slicing the to-be-detected sample with the thickness of 30 microns, performing matrix-assisted laser desorption ionization mass spectrometry imaging on the obtained slice in a positive ion mode, and obtaining the spatial distribution information of terpenoids and coumarins in the to-be-detected tissue sample in situ according to the accurate mass-to-charge ratio of ions in an imaging picture. The slice under specific conditions has a relatively complete tissue structure, the established mass spectrum imaging method does not need complex sample pretreatment, basically does not change the spatial distribution information of active components in a sample to be detected, and can accurately position the spatial distribution information of a plurality of compounds at the same time; therefore, the visualization of the internal active ingredients of the ferula ferulaeoides stems is realized. The invention provides a new technical support for researching the anabolic pathway and physiological function of terpenoid and coumarin compounds in ferula plants in the future, and has important significance in improving the separation and extraction rate of active ingredients in ferula and the utilization rate of ferula stem tissues.

The application discloses a curcuminoid xanthene compound shown in formula I, a preparation method of the curcuminoid xanthene compound and application of the curcuminoid xanthene compound as a photodiagnosis and treatment agent. The compound has the characteristics of long absorption and emission wavelength, good stability, high phototoxicity, large Stokes shift, good biocompatibility and good cell membrane permeability. Compared with curcumin, the photosensitizer has a longer absorption wavelength, lower dark toxicity and can generate ROS under type-I and type-II synergistic action, and is expected to be applied to PDT in an anaerobic tumor microenvironment.

The invention provides an electrolyte membrane and a preparation method and application thereof, and relates to the technical field of electrolyte. The preparation method of the electrolyte membrane comprises the following steps: S1, uniformly mixing a polymer solution and a coumarin compound solution to obtain a mixed solution; s2, adding lithium salt and a solvent into the mixed solution, heating and stirring to obtain slurry; and blade-coating the slurry, and drying to form a membrane to obtain the electrolyte membrane. The electrolyte membrane provided by the invention not only has self-healing performance, but also has high conductivity.

The present invention provides a compound extracted and isolated from the herb Rhizoma Coptidis, with a structure shown in Formula I. It is a new coumarin compound that has the activity of inhibiting the growth of lung cancer cells, and provides a new strategy for the further development of the herb Rhizoma Coptidis and the further research and development of cancer therapeutics. #imgabs0#

This invention belongs to the field of pharmaceutical technology, specifically relating to a simple coumarin obtained from *Pseudoflavinus*, its preparation method, and its applications. The compound is shown in Formula 1 and its pharmaceutically acceptable salts and isomers; R 1 It is hydrogen, hydroxyl, or C1-C8 alkoxy; R 2 The group is composed of hydrogen, hydroxyl, C1-C8 alkoxy, aldehyde, fragment A, fragment B, or a 6-membered ring containing at least one heteroatom formed with an adjacent hydroxyl group, and the heterocycle is substituted by at least one substituent, which may be the same or different and selected from hydroxyl and C1-C3 alkyl groups; R 3 The compounds are hydrogen, hydroxyl, C2-C8 alkenyl, or fragment C. The structures of the simple coumarin compounds, their preparation methods, and their applications in the preparation of drugs for the prevention and treatment of neurodegenerative diseases are described.

The invention relates to the field of pharmacy, in particular to a benzofuran coumarin compound as well as a preparation method and application thereof. The benzofuran coumarin compound is an optical isomer, a crystal and a pharmaceutically available salt as shown in the following structural formula: # imgabs0 #, wherein R1 is selected from hydrogen and C1-C6 alkoxy. The benzofuran coumarin compound disclosed by the invention has anti-hepatitis activity and a potential liver protection effect, and a new preparation method of direct C3 alkylation of the benzofuran coumarin compound is provided.

The application discloses a class of sulfonyl fluoride coumarin compounds, a preparation method and application thereof. The sulfonyl fluoride coumarin compound has broad-spectrum and high-efficiency bactericidal activity, especially has better antibacterial activity on plant pathogenic bacteria, and has better prevention and treatment effect on diseases caused by the plant pathogenic bacteria.

The invention discloses a coumarin compound as well as a preparation method and a medicinal composition thereof. Compared with the prior art, the coumarin compound shown in the formula (I) can inhibit the interaction of lncRNA-PSF and increase the expression of p53 protein so as to change the cell cycle, has a sensitization effect on an immune checkpoint inhibitor, improves the treatment effect of the immune checkpoint inhibitor on tolerant tumors, and has very good popularization and application values.

The application discloses a coumarin derivative, a preparation method and application thereof, and has a structure as shown in formula (I) and / or (II). The method for preparing the coumarin derivative is simple and efficient, and the application is that the prepared coumarin derivative has good in-vitro inhibitory activity on four common plant pathogenic fungi of Botrytis cinerea, Fusarium oxysporum, Alternaria alternata and Alternaria solani. The compound has good application in a plant-derived fungus inhibitor, is more environmentally friendly, and meets the green chemistry concept.