59 results about "Coumarin Compound" patented technology

The invention discloses a coumarin KRAS-G12C inhibitor as well as preparation and application of the coumarin KRAS-G12C inhibitor. The coumarin compound disclosed by the invention has a remarkable inhibition effect on non-small cell lung cancer cells (NCI-H23 and NCI-H358) with high expression of KRAS-G12C and pancreatic cancer cells (MIAPaCa-2), is particularly used for preparing medicines for treating and / or preventing non-small cell lung cancer and pancreatic cancer, and has a good prospect of development and application of antitumor medicines.

This invention discloses an acaricide targeting calcium ion channels and its application, belonging to the field of pesticides. Specifically, it relates to an acaricide based on the L-type calcium ion channel (L-VGCC) target and its application in the control of agricultural mites. The acaricide, artemisinin [Formula (I)], is a natural coumarin compound that is highly effective against agricultural mites and safe against predatory mites. It is a targeted, natural, and environmentally friendly acaricide with minimal harm to humans and the environment, and has the potential to be developed into a selective acaricide.

This invention relates to the field of natural product separation technology, specifically to coumarin compounds isolated from *Hypericum perforatum*, their preparation methods, and applications. The preparation method of these coumarin compounds includes alcohol extraction from *Hypericum perforatum*, followed by macroporous resin adsorption separation and column separation. The coumarin compounds of this invention can be used for anti-inflammatory purposes, exhibiting inhibitory activity against RAW264.7 cells and the expression of TNF-α, IL-1β, and IL-6 proteins.

The application belongs to the technical field of medicine, and relates to 3-benzylamino coumarin compounds and application thereof. Experimental results show that the compounds can significantly increase the survival rate of HUVEC cells in a high-sugar environment, and resist blood vessel injury caused by high sugar. The compounds can increase the release amount of NO in HUVEC cells damaged by high sugar, reduce the generation of malondialdehyde, and reduce the generation of tumor necrosis factor alpha.

The application discloses application of a coumarin compound or a composition thereof in inhibition of a plant Huanglongbing pathogen, prevention of plant Huanglongbing, improvement of plant resistance to Huanglongbing, inhibition of a plant pathogenic bacterium and preparation of a product for preventing and treating plant Huanglongbing, improving plant Huanglongbing resistance, inhibiting a plant Huanglongbing pathogen and inhibiting a plant pathogenic bacterium. The coumarin compound is isofraxidiformin or ostruthin. By applying the coumarin compound or the composition thereof to a receptor plant or a growth medium thereof, the content of the coumarin compound or the composition thereof in the receptor plant is increased, and then the citrus Huanglongbing pathogen in the plant body is significantly reduced C Las quantity. Under field application conditions, the coumarin compound or the composition thereof also shows good prevention and treatment potential. In addition, the coumarin compound shows broad-spectrum bacteriostatic activity on a plurality of other plant pathogenic bacteria, and shows good plant antibacterial prevention and treatment potential.

The application discloses a porphyrin-eugenol derivative with antitumor activity, uses DPBF to detect the yield of singlet oxygen, and in-vitro antitumor activity test shows that the compound has good activity. The porphyrin-coumarin compound can realize the synergistic treatment of phototherapy and chemotherapy, in addition, the insertion of metal Zn in the porphyrin can also enhance the antitumor activity of the compound. Thus, the compound can be used as an active ingredient of an antitumor drug, and has good development and application prospect.

The invention discloses a synthesis method of pyrido [3, 2-c] coumarin compounds, and belongs to the technical field of organic synthesis. According to the technical scheme, the method is characterized by comprising the following steps: dissolving an aromatic aldehyde compound, a 4-amino coumarin compound and a tertiary aliphatic amine compound in a solvent, adding an oxidant, and reacting at 120-140 DEG C to obtain the target product pyridino [3, 2-c] coumarin compound. The synthesis process is simple and efficient, the pyrido [3, 2-c] coumarin compound is directly prepared in one step through one-pot cascade reaction, no catalyst or additive is needed in the synthesis process, heating is only needed under the air condition, operation is convenient, raw materials are simple, the reaction condition is mild, and the substrate application range is wide.

This invention discloses a coumarin compound and its uses, belonging to the field of chemical and pharmaceutical technology. This invention provides coumarin compounds represented by Formula I, particularly some specific coumarin compounds. These compounds and their compositions can inhibit the MEK or Ras-MAPK signaling pathway, providing a new approach for treating diseases related to the MEK or Ras-MAPK signaling pathway.

The present disclosure addresses the problem of providing a resin composition, a cured product of which has a high glass transition temperature and good desmear resistance, wherein a solder resist formed on a printed wiring board including the cured product has good small-diameter opening properties. This resin composition contains a thermosetting resin (A), a coumarin compound (B), and an inorganic filler (C). The thermosetting resin (A) contains an epoxy resin (A1) and a maleimide resin (A2). The content of the maleimide resin (A2) is 8-60 mass% with respect to the total amount of the thermosetting resin (A).

The invention discloses a method for extracting 7-hydroxy-8-O-beta-D-glucopyranoside-coumarin from apple peel, a compound extracted by the method and application of the compound. The invention belongs to the field of extraction and separation of natural products, and relates to a coumarin compound found in apple peel. The invention further provides a separation and identification method of the novel compound. Methanol extraction, ethyl acetate elution and a high performance liquid chromatograph are sequentially adopted for separation, purification and preparation. The structure of the compound is determined to be the compound found in apple peel for the first time by adopting nuclear magnetic identification of hydrogen spectrum and carbon spectrum. The compound has a protective effect on vascular endothelial dysfunction caused by hyperlipidemia, has no toxic effect on cells, and can be used as a raw material for drug development and pharmacological activity research.

This invention provides a method for detecting copper oxide content in a gas generator using a chemical sensor. During copper ion detection, the test solution contains coumarin compounds with phenylhydrazone groups. These compounds, acting as a chemical sensor, can complex with copper ions. This complexation weakens the carbon-nitrogen double bonds in the phenylhydrazone compound molecules, promoting the hydrolysis of the phenylhydrazone groups to generate corresponding aldehyde compounds. The solution then emits a strong green fluorescence. When used for copper ion detection in aqueous solutions, the chemical sensor of this invention exhibits a significant fluorescence enhancement response, high detection sensitivity, and a detection limit as low as 150 nM. It demonstrates extremely high selectivity for copper ions with almost no interference from other common metal ions, and is particularly effective in accurately quantifying the content and distribution of copper oxide in gas generators.

This invention discloses a coumarin analogue, its synthesis method, and its application, belonging to the field of agricultural pest control technology. The structural formula of the coumarin compound is shown in formula (I), denoted as COUM-L; in formula (I), R is hydrogen, halogen, hydroxide, or 1-(methoxymethyl)-3-methylbenzene; it is a target-type natural product environmentally friendly acaricide with high acaricidal efficiency and low harm to humans and the environment.

The present invention relates to the technical field of chemicals and pharmaceuticals. Disclosed are a coumarin compound and a use thereof. The present invention provides a coumarin compound represented by formula I, and some specific coumarin compounds. The compound and composition can effectively inhibit MEK or Ras-MAPK signaling pathways, can be used for preparing MEK or Ras-MAPK signaling pathway inhibitors, and provide a new way for treating MEK or Ras-MAPK signaling pathway-related diseases.

The invention belongs to the technical field of shape memory high-molecular polymers, and particularly relates to coumarin-based light / heat dual response type shape memory polyurethane as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out a ring-opening polymerization reaction on 2, 2-bis (4-epoxypropoxyphenyl) propane and 3-amino-1-propanol as raw materials in a liquid phase to prepare a prepolymer, and carrying out a polymerization addition reaction on the prepolymer, an isocyanate monomer and a coumarin compound as raw materials in the liquid phase under a catalytic action to prepare the coumarin-modified polyurethane. Light / heat dual response type shape memory polyurethane based on coumarin is prepared; according to the invention, the photoresponse characteristic of the coumarin compound and the temperature response characteristic of the prepolymer are ingeniously combined, so that the dual response to photostimulation and temperature stimulation is realized, and the stimulation response speed and the programming precision controllability of the coumarin-based optical / thermal dual response type shape memory polyurethane are improved.

The application discloses a curcuminoid xanthene compound shown in formula I, a preparation method of the curcuminoid xanthene compound and application of the curcuminoid xanthene compound as a photodiagnosis and treatment agent. The compound has the characteristics of long absorption and emission wavelength, good stability, high phototoxicity, large Stokes shift, good biocompatibility and good cell membrane permeability. Compared with curcumin, the photosensitizer has a longer absorption wavelength, lower dark toxicity and can generate ROS under type-I and type-II synergistic action, and is expected to be applied to PDT in an anaerobic tumor microenvironment.

The invention provides an electrolyte membrane and a preparation method and application thereof, and relates to the technical field of electrolyte. The preparation method of the electrolyte membrane comprises the following steps: S1, uniformly mixing a polymer solution and a coumarin compound solution to obtain a mixed solution; s2, adding lithium salt and a solvent into the mixed solution, heating and stirring to obtain slurry; and blade-coating the slurry, and drying to form a membrane to obtain the electrolyte membrane. The electrolyte membrane provided by the invention not only has self-healing performance, but also has high conductivity.

The present invention provides a compound extracted and isolated from the herb Rhizoma Coptidis, with a structure shown in Formula I. It is a new coumarin compound that has the activity of inhibiting the growth of lung cancer cells, and provides a new strategy for the further development of the herb Rhizoma Coptidis and the further research and development of cancer therapeutics. #imgabs0#

This invention belongs to the field of pharmaceutical technology, specifically relating to a simple coumarin obtained from *Pseudoflavinus*, its preparation method, and its applications. The compound is shown in Formula 1 and its pharmaceutically acceptable salts and isomers; R 1 It is hydrogen, hydroxyl, or C1-C8 alkoxy; R 2 The group is composed of hydrogen, hydroxyl, C1-C8 alkoxy, aldehyde, fragment A, fragment B, or a 6-membered ring containing at least one heteroatom formed with an adjacent hydroxyl group, and the heterocycle is substituted by at least one substituent, which may be the same or different and selected from hydroxyl and C1-C3 alkyl groups; R 3 The compounds are hydrogen, hydroxyl, C2-C8 alkenyl, or fragment C. The structures of the simple coumarin compounds, their preparation methods, and their applications in the preparation of drugs for the prevention and treatment of neurodegenerative diseases are described.

The application discloses a class of sulfonyl fluoride coumarin compounds, a preparation method and application thereof. The sulfonyl fluoride coumarin compound has broad-spectrum and high-efficiency bactericidal activity, especially has better antibacterial activity on plant pathogenic bacteria, and has better prevention and treatment effect on diseases caused by the plant pathogenic bacteria.

The invention discloses a coumarin compound as well as a preparation method and a medicinal composition thereof. Compared with the prior art, the coumarin compound shown in the formula (I) can inhibit the interaction of lncRNA-PSF and increase the expression of p53 protein so as to change the cell cycle, has a sensitization effect on an immune checkpoint inhibitor, improves the treatment effect of the immune checkpoint inhibitor on tolerant tumors, and has very good popularization and application values.

The application discloses a coumarin derivative, a preparation method and application thereof, and has a structure as shown in formula (I) and / or (II). The method for preparing the coumarin derivative is simple and efficient, and the application is that the prepared coumarin derivative has good in-vitro inhibitory activity on four common plant pathogenic fungi of Botrytis cinerea, Fusarium oxysporum, Alternaria alternata and Alternaria solani. The compound has good application in a plant-derived fungus inhibitor, is more environmentally friendly, and meets the green chemistry concept.

A composition is disclosed comprising a coumarin or a derivative thereof for use in a method of treating a disease or disorder associated with cell senescence. Alternatively or additionally, the composition may comprise a plant extract comprising a coumarin or a derivative thereof . Also disclosed is a cosmetic method for preventing, minimising or reducing cell senescence, comprising contacting the skin of an individual with said composition. Preferred coumarin compounds used in the composition include osthole, xanthotoxin, bergapten, isopimpinellin, umbelliferone and imperatorin. The compounds may be sourced from extracts of Umbelliferae, in particular Angelica or Cnidium. The compounds are especially useful in the treatment of skin aging where they preserve, maintain or improve epidermal thickness, function and / or quality.

The application belongs to the technical field of medicine, and relates to a monoamine oxidase B inhibitor and a pharmaceutical application thereof. The monoamine oxidase B is a coumarin compound, and has the characteristics of high activity, high selectivity, high blood-brain barrier permeability and low neurocyte toxicity. The monoamine oxidase B can be clinically used for treating Parkinson's disease, Alzheimer's disease, neurodegenerative disease and depression.

The invention discloses a photosensitive response type composite fresh-keeping composition, a fruit fresh-keeping agent and a preparation method of the photosensitive response type composite fresh-keeping composition, and the photosensitive response type composite fresh-keeping composition comprises the following components in parts by mass: 1-40 parts of shaddock peel extract and 10-60 parts of algal polysaccharide. According to the fruit preservative disclosed by the invention, the natural shaddock peel extract and the algal polysaccharide are used as main components, so that the use of synthetic chemical additives is avoided. Compared with traditional chemical preservatives (such as preservatives and antioxidants), the coating provided by the invention is more environment-friendly, non-toxic and harmless, has no negative influence on human health, and meets the requirements of food safety and environmental protection. The shaddock peel extract is rich in coumarin compounds, the components can be subjected to photosensitive reaction under the irradiation of ultraviolet light or visible light to play antibacterial activity, and a lasting and efficient fresh-keeping effect can be shown in the storage and transportation process.

The application discloses a furan coumarin compound and a preparation method and application thereof, and the molecular formula of the furan coumarin compound is C 21 H 20 O6; the furan coumarin compound can reduce the inflammatory reaction of RAW264.7 macrophages induced by lipopolysaccharide (LPS), can reduce the NO production of RAW264.7 macrophages induced by LPS, and can significantly inhibit the production of inflammatory factors such as TNF-alpha, interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta).

This invention relates to the field of organic synthesis technology, and particularly to a dual-fluorescent probe for Bodipy and NBD, its synthesis method, and its application. The method includes: first, synthesizing NBD coumarin compound 6; then, using nitrobenzaldehyde f and dimethylpyrrole as starting materials, undergoing a four-step one-pot cascade reaction with catalytic amounts of trifluoroacetic acid, DDQ oxidation, and excess triethylamine and Lewis acid boron trifluoride diethyl ether to obtain the fluorescent compound Bodipy h; finally, subjecting the fluorescent compound Bodipy h to reduction and acylation to obtain Bodipy fluorescent probe 8; and finally, after lithium hydroxide demethylation of Bodipy fluorescent probe 8 to obtain a carboxylic acid, which is then amidated with the deBoc-protected NBD compound 6 by trifluoroacetic acid to obtain the target product, dual-fluorescent probe 9. This invention anticipates that the fluorescence of coumarin and naphthalimide, through this dual quenching process, can efficiently achieve the quenching strategy, and can be applied to the simultaneous detection of H2S and hNQO1 in vivo or in vitro.

The application discloses a furan coumarin compound and application thereof in preparation of a drug for treating osteoporosis, and belongs to the technical field of drug research and development. 50 The furan coumarin compound has an IC of 37.86 nM, has no obvious cytotoxicity and systemic toxicity, can inhibit a key path of RANKL-induced osteoclast differentiation, and can be used for preparing the drug for treating osteoporosis.

The invention provides a preparation method for simultaneously synthesizing four coumarin natural products, which comprises the following steps: by taking cheap and easily available 2-hydroxy-4-methoxybenzaldehyde as a raw material, carrying out selective bromination reaction in the presence of Lewis acid, cyclizing the product through Perkin reaction to obtain a brominated coumarin compound, and then carrying out palladium-catalyzed Heck dehydration reaction to obtain the four coumarin natural products. The preparation method comprises the following steps of: obtaining trans-Dehydrostol under a reflux condition, and carrying out epoxidation on the trans-Dehydrostol to generate Phebalosin; and carrying out ring opening and rearrangement on the Phebalosin to synthesize the natural products, namely Murraxocin, Murrangitin and Murralongin, wherein the natural products are Murraxocin, Murrangitin and Murralongin. The method has the advantages of simple synthetic route, simple and easily available raw materials, simple operation, low preparation cost and high yield, and is suitable for large-scale production.

The application provides a coumarin tertiary alcohol compound containing bistrifluoromethyl and a preparation method and application thereof, and belongs to the technical field of organic synthesis chemistry, and aims to solve the technical problems of single structure and poor bactericidal activity of existing trifluoro tertiary alcohol compounds.The structural formula of the coumarin tertiary alcohol compound is shown in the following formula: in the formula, R is Me, OMe, OEt, F, Cl, Br or Ph.The preparation method is as follows: a trifluoroacetyl coumarin compound, a trifluoromethyl silane compound, a catalyst and a solvent are mixed to prepare a reaction solution, the reaction solution is fully reacted, and after purification, the coumarin tertiary alcohol compound is prepared.The application widens the synthesis of bistrifluoromethyl tertiary alcohol and tertiary alcohol siloxane compound products, the compound has excellent antibacterial activity, has a good effect on more plant fungal diseases, is worth further exploration, and has a wide exploration and application space in the field of pesticides.