37 results about "Coumarin Compound" patented technology

This invention discloses an acaricide targeting calcium ion channels and its application, belonging to the field of pesticides. Specifically, it relates to an acaricide based on the L-type calcium ion channel (L-VGCC) target and its application in the control of agricultural mites. The acaricide, artemisinin [Formula (I)], is a natural coumarin compound that is highly effective against agricultural mites and safe against predatory mites. It is a targeted, natural, and environmentally friendly acaricide with minimal harm to humans and the environment, and has the potential to be developed into a selective acaricide.

This invention relates to the field of natural product separation technology, specifically to coumarin compounds isolated from *Hypericum perforatum*, their preparation methods, and applications. The preparation method of these coumarin compounds includes alcohol extraction from *Hypericum perforatum*, followed by macroporous resin adsorption separation and column separation. The coumarin compounds of this invention can be used for anti-inflammatory purposes, exhibiting inhibitory activity against RAW264.7 cells and the expression of TNF-α, IL-1β, and IL-6 proteins.

The application belongs to the technical field of medicine, and relates to 3-benzylamino coumarin compounds and application thereof. Experimental results show that the compounds can significantly increase the survival rate of HUVEC cells in a high-sugar environment, and resist blood vessel injury caused by high sugar. The compounds can increase the release amount of NO in HUVEC cells damaged by high sugar, reduce the generation of malondialdehyde, and reduce the generation of tumor necrosis factor alpha.

The application discloses application of a coumarin compound or a composition thereof in inhibition of a plant Huanglongbing pathogen, prevention of plant Huanglongbing, improvement of plant resistance to Huanglongbing, inhibition of a plant pathogenic bacterium and preparation of a product for preventing and treating plant Huanglongbing, improving plant Huanglongbing resistance, inhibiting a plant Huanglongbing pathogen and inhibiting a plant pathogenic bacterium. The coumarin compound is isofraxidiformin or ostruthin. By applying the coumarin compound or the composition thereof to a receptor plant or a growth medium thereof, the content of the coumarin compound or the composition thereof in the receptor plant is increased, and then the citrus Huanglongbing pathogen in the plant body is significantly reduced C Las quantity. Under field application conditions, the coumarin compound or the composition thereof also shows good prevention and treatment potential. In addition, the coumarin compound shows broad-spectrum bacteriostatic activity on a plurality of other plant pathogenic bacteria, and shows good plant antibacterial prevention and treatment potential.

This invention discloses a coumarin compound and its uses, belonging to the field of chemical and pharmaceutical technology. This invention provides coumarin compounds represented by Formula I, particularly some specific coumarin compounds. These compounds and their compositions can inhibit the MEK or Ras-MAPK signaling pathway, providing a new approach for treating diseases related to the MEK or Ras-MAPK signaling pathway.

The invention discloses a method for extracting 7-hydroxy-8-O-beta-D-glucopyranoside-coumarin from apple peel, a compound extracted by the method and application of the compound. The invention belongs to the field of extraction and separation of natural products, and relates to a coumarin compound found in apple peel. The invention further provides a separation and identification method of the novel compound. Methanol extraction, ethyl acetate elution and a high performance liquid chromatograph are sequentially adopted for separation, purification and preparation. The structure of the compound is determined to be the compound found in apple peel for the first time by adopting nuclear magnetic identification of hydrogen spectrum and carbon spectrum. The compound has a protective effect on vascular endothelial dysfunction caused by hyperlipidemia, has no toxic effect on cells, and can be used as a raw material for drug development and pharmacological activity research.

This invention provides a method for detecting copper oxide content in a gas generator using a chemical sensor. During copper ion detection, the test solution contains coumarin compounds with phenylhydrazone groups. These compounds, acting as a chemical sensor, can complex with copper ions. This complexation weakens the carbon-nitrogen double bonds in the phenylhydrazone compound molecules, promoting the hydrolysis of the phenylhydrazone groups to generate corresponding aldehyde compounds. The solution then emits a strong green fluorescence. When used for copper ion detection in aqueous solutions, the chemical sensor of this invention exhibits a significant fluorescence enhancement response, high detection sensitivity, and a detection limit as low as 150 nM. It demonstrates extremely high selectivity for copper ions with almost no interference from other common metal ions, and is particularly effective in accurately quantifying the content and distribution of copper oxide in gas generators.

This invention discloses a coumarin analogue, its synthesis method, and its application, belonging to the field of agricultural pest control technology. The structural formula of the coumarin compound is shown in formula (I), denoted as COUM-L; in formula (I), R is hydrogen, halogen, hydroxide, or 1-(methoxymethyl)-3-methylbenzene; it is a target-type natural product environmentally friendly acaricide with high acaricidal efficiency and low harm to humans and the environment.

The present invention relates to the technical field of chemicals and pharmaceuticals. Disclosed are a coumarin compound and a use thereof. The present invention provides a coumarin compound represented by formula I, and some specific coumarin compounds. The compound and composition can effectively inhibit MEK or Ras-MAPK signaling pathways, can be used for preparing MEK or Ras-MAPK signaling pathway inhibitors, and provide a new way for treating MEK or Ras-MAPK signaling pathway-related diseases.

The application discloses a curcuminoid xanthene compound shown in formula I, a preparation method of the curcuminoid xanthene compound and application of the curcuminoid xanthene compound as a photodiagnosis and treatment agent. The compound has the characteristics of long absorption and emission wavelength, good stability, high phototoxicity, large Stokes shift, good biocompatibility and good cell membrane permeability. Compared with curcumin, the photosensitizer has a longer absorption wavelength, lower dark toxicity and can generate ROS under type-I and type-II synergistic action, and is expected to be applied to PDT in an anaerobic tumor microenvironment.

The invention provides an electrolyte membrane and a preparation method and application thereof, and relates to the technical field of electrolyte. The preparation method of the electrolyte membrane comprises the following steps: S1, uniformly mixing a polymer solution and a coumarin compound solution to obtain a mixed solution; s2, adding lithium salt and a solvent into the mixed solution, heating and stirring to obtain slurry; and blade-coating the slurry, and drying to form a membrane to obtain the electrolyte membrane. The electrolyte membrane provided by the invention not only has self-healing performance, but also has high conductivity.

This invention belongs to the field of pharmaceutical technology, specifically relating to a simple coumarin obtained from *Pseudoflavinus*, its preparation method, and its applications. The compound is shown in Formula 1 and its pharmaceutically acceptable salts and isomers; R 1 It is hydrogen, hydroxyl, or C1-C8 alkoxy; R 2 The group is composed of hydrogen, hydroxyl, C1-C8 alkoxy, aldehyde, fragment A, fragment B, or a 6-membered ring containing at least one heteroatom formed with an adjacent hydroxyl group, and the heterocycle is substituted by at least one substituent, which may be the same or different and selected from hydroxyl and C1-C3 alkyl groups; R 3 The compounds are hydrogen, hydroxyl, C2-C8 alkenyl, or fragment C. The structures of the simple coumarin compounds, their preparation methods, and their applications in the preparation of drugs for the prevention and treatment of neurodegenerative diseases are described.

The invention discloses a coumarin compound as well as a preparation method and a medicinal composition thereof. Compared with the prior art, the coumarin compound shown in the formula (I) can inhibit the interaction of lncRNA-PSF and increase the expression of p53 protein so as to change the cell cycle, has a sensitization effect on an immune checkpoint inhibitor, improves the treatment effect of the immune checkpoint inhibitor on tolerant tumors, and has very good popularization and application values.

The application discloses a coumarin derivative, a preparation method and application thereof, and has a structure as shown in formula (I) and / or (II). The method for preparing the coumarin derivative is simple and efficient, and the application is that the prepared coumarin derivative has good in-vitro inhibitory activity on four common plant pathogenic fungi of Botrytis cinerea, Fusarium oxysporum, Alternaria alternata and Alternaria solani. The compound has good application in a plant-derived fungus inhibitor, is more environmentally friendly, and meets the green chemistry concept.

A composition is disclosed comprising a coumarin or a derivative thereof for use in a method of treating a disease or disorder associated with cell senescence. Alternatively or additionally, the composition may comprise a plant extract comprising a coumarin or a derivative thereof . Also disclosed is a cosmetic method for preventing, minimising or reducing cell senescence, comprising contacting the skin of an individual with said composition. Preferred coumarin compounds used in the composition include osthole, xanthotoxin, bergapten, isopimpinellin, umbelliferone and imperatorin. The compounds may be sourced from extracts of Umbelliferae, in particular Angelica or Cnidium. The compounds are especially useful in the treatment of skin aging where they preserve, maintain or improve epidermal thickness, function and / or quality.

The application belongs to the technical field of medicine, and relates to a monoamine oxidase B inhibitor and a pharmaceutical application thereof. The monoamine oxidase B is a coumarin compound, and has the characteristics of high activity, high selectivity, high blood-brain barrier permeability and low neurocyte toxicity. The monoamine oxidase B can be clinically used for treating Parkinson's disease, Alzheimer's disease, neurodegenerative disease and depression.

The application discloses a furan coumarin compound and a preparation method and application thereof, and the molecular formula of the furan coumarin compound is C 21 H 20 O6; the furan coumarin compound can reduce the inflammatory reaction of RAW264.7 macrophages induced by lipopolysaccharide (LPS), can reduce the NO production of RAW264.7 macrophages induced by LPS, and can significantly inhibit the production of inflammatory factors such as TNF-alpha, interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta).

This invention relates to the field of organic synthesis technology, and particularly to a dual-fluorescent probe for Bodipy and NBD, its synthesis method, and its application. The method includes: first, synthesizing NBD coumarin compound 6; then, using nitrobenzaldehyde f and dimethylpyrrole as starting materials, undergoing a four-step one-pot cascade reaction with catalytic amounts of trifluoroacetic acid, DDQ oxidation, and excess triethylamine and Lewis acid boron trifluoride diethyl ether to obtain the fluorescent compound Bodipy h; finally, subjecting the fluorescent compound Bodipy h to reduction and acylation to obtain Bodipy fluorescent probe 8; and finally, after lithium hydroxide demethylation of Bodipy fluorescent probe 8 to obtain a carboxylic acid, which is then amidated with the deBoc-protected NBD compound 6 by trifluoroacetic acid to obtain the target product, dual-fluorescent probe 9. This invention anticipates that the fluorescence of coumarin and naphthalimide, through this dual quenching process, can efficiently achieve the quenching strategy, and can be applied to the simultaneous detection of H2S and hNQO1 in vivo or in vitro.

The application discloses a furan coumarin compound and application thereof in preparation of a drug for treating osteoporosis, and belongs to the technical field of drug research and development. 50 The furan coumarin compound has an IC of 37.86 nM, has no obvious cytotoxicity and systemic toxicity, can inhibit a key path of RANKL-induced osteoclast differentiation, and can be used for preparing the drug for treating osteoporosis.

The invention provides a preparation method for simultaneously synthesizing four coumarin natural products, which comprises the following steps: by taking cheap and easily available 2-hydroxy-4-methoxybenzaldehyde as a raw material, carrying out selective bromination reaction in the presence of Lewis acid, cyclizing the product through Perkin reaction to obtain a brominated coumarin compound, and then carrying out palladium-catalyzed Heck dehydration reaction to obtain the four coumarin natural products. The preparation method comprises the following steps of: obtaining trans-Dehydrostol under a reflux condition, and carrying out epoxidation on the trans-Dehydrostol to generate Phebalosin; and carrying out ring opening and rearrangement on the Phebalosin to synthesize the natural products, namely Murraxocin, Murrangitin and Murralongin, wherein the natural products are Murraxocin, Murrangitin and Murralongin. The method has the advantages of simple synthetic route, simple and easily available raw materials, simple operation, low preparation cost and high yield, and is suitable for large-scale production.

The application discloses coumarin compounds, and a preparation method and application thereof. The coumarin compound is selected from a compound shown in formula (A-A); wherein R1 is selected from a group shown in the formula, H or C1-C10 alkyl, wherein R 1′ oxalyl chloride ester selected from H or C1-C10, R 1” substituted or unsubstituted aryl; R2 is selected from a group shown in the formula or H, wherein R 2′ substituted or unsubstituted aryl; R3 is selected from a group shown in the formula, H or hydroxyl, wherein R 3′ C1-C10 carboxylic acid, R 3” substituted or unsubstituted aryl; and when R1 of the coumarin compound is selected from hydrogen, R3 cannot be selected from hydroxyl. The coumarin compound has simple structure, small molecular weight and good biological activity, can inhibit test bacteria in different degrees, and can be used as a potential new antibacterial agent.

The present application relates to a 3-formylformic acid coumarin compound of formula (I), a preparation method and uses thereof, a photoinitiator composition and a photocurable composition comprising the same, a cured material obtainable from the photocurable composition, and a method for preparing a photocured material. The compound of the present application can be used as an oil-soluble photoinitiator and an aqueous photoinitiator, has obvious advantages in photosensitivity, is suitable for use as a photoinitiator for UV-VIS LED light source curing, can initiate free radical polymerization, and can also sensitize onium salt compounds such as iodonium salt or sulfonium salt to initiate cationic polymerization of epoxy monomers or oxetane monomers.

This invention discloses a protein with O-isopentenyltransferase activity, related biomaterials, and applications, belonging to the field of biotechnology. This invention screened and cloned an O-isopentenyltransferase gene (GlOPT), which can be used to prepare O-isopentenyltransferase. Experiments have confirmed that this O-isopentenyltransferase can catalyze the in vitro conversion of 8-hydroxybergamot lactone to arugulatin; catalyze the conversion of bergamotol to isoimperatorin; and catalyze the conversion of xanthotoxin to imperatorin. This provides technical support for the production of isopentenyl furanocoumarin-like active ingredients from arugula, lays the foundation for research on the biosynthetic pathways of coumarin compounds, and has significant theoretical and practical implications.

The invention relates to a coumarin compound and application thereof, in particular to a coumarin compound as well as a preparation method and application thereof, the coumarin compound is 3, 3 '-(4-iodobenzene methylene)-bis-4-hydroxycoumarin, and the structural formula of the compound is as shown in formula I. According to the technical scheme, the 3, 3 '-(4-iodobenzene)-bis-4-hydroxycoumarin is a novel compound which is not researched, can accurately target periodontal key pathogenic microorganisms including porphyromonas gingivalis, actinomyces viscosus, actinomyces naeslundii, streptococcus gordoni and the like at a relatively low concentration, and can be used for preparing a target drug for treating periodontal diseases, such as periodontal diseases, periodontal diseases and periodontal diseases. The blank that the activity of selective inhibition of periodontal pathogenic bacteria is not reported in the prior art is filled.

The invention belongs to the field of medicinal chemistry, and discloses a quinazoline-coumarin compound as well as a preparation method and application thereof. The compound has a structural general formula shown in the specification, wherein R1 and R2 are defined in the specification. Preliminary pharmacological experiments show that the compound has the activity of inhibiting tumor cells of gastric cancer, prostatic cancer, lung cancer and the like, and can be used for research and development of antitumor drugs or development of inhibitors such as PI3K and the like.

The application provides a feruloyl-CoA 6'-hydroxylase pocket mutant and application. The feruloyl-CoA 6'-hydroxylase pocket mutant is obtained by amino acid mutation of the amino acid sequence shown in SEQ ID NO. 1, and includes at least one of the following amino acid mutations: L141N, L141G, A142N, Q144D, F156Y, V157T, N311G. The application also provides an engineering bacterium for synthesizing coumarin compounds by using the feruloyl-CoA 6'-hydroxylase mutant. The feruloyl-CoA 6'-hydroxylase mutant has good enzyme activity and stability, so that the engineering bacterium can not only realize efficient synthesis of coumarin compounds such as scopoletin, aesculin, aesculin glycoside and anisodamine, but also realize efficient de novo biosynthesis of the coumarin compounds, thereby providing a reference for microbial synthesis of the coumarin compounds.

The application provides feruloyl-CoA 6'-hydroxylase surface mutants and applications thereof. The feruloyl-CoA 6'-hydroxylase surface mutant is obtained by amino acid mutation of an amino acid sequence shown in SEQ ID NO. 1, and includes at least one of the following amino acid mutations: D102E, E163K, E190K, L196F, K199N. The application also provides an engineered bacterium for synthesizing coumarin compounds, which is constructed by using the feruloyl-CoA 6'-hydroxylase mutant. The feruloyl-CoA 6'-hydroxylase mutant has good enzyme activity and stability, and the enzyme activity is increased by more than 1.7 times, and can even be increased by 8.4 times. Therefore, the engineered bacterium can realize high-efficiency biosynthesis of scopoletin, fraxidin, fraxin, scopolin, fraxidin, fraxin A or chicoricin, and provides a reference for microbial synthesis of coumarin compounds.

The application belongs to the technical field of biological medicine, and particularly relates to a coumarin hydrazone derivative with antioxidant activity and application thereof. The chemical structural formula of the coumarin derivative is shown as formula (I), wherein R is an aromatic ring containing different substituents. The in vitro antioxidant experiment results show that most of the derivatives exhibit certain scavenging capacity on DPPH, ABTS, superoxide anion and hydroxyl radicals, and have certain reducing capacity. Notably, the derivatives 5a-5d, 5i-5k, 5m and 5n have better scavenging effect on superoxide anion radicals than or equivalent to vitamin C. The method for preparing the coumarin hydrazone derivative has the advantages of simple operation, convenient post-treatment, high product separation yield and the like. The coumarin compound can be used for preparing an antioxidant.

The application discloses a coumarin derivative, a preparation method and application thereof, and belongs to the technical field of agricultural pest control. The coumarin compound has a structural formula shown in formula (I) and is recorded as COUM-N. In the formula (I), R is hydrogen, halogen, methoxy or hydroxyl. The coumarin compound is a target type natural environment-friendly compound for killing whitefly, and has little harm to human bodies and the environment.