159 results about "Neuroregeneration" patented technology

The present invention provides compounds of the following structure, wherein R₁, R₂, R₄, R_4′, R₆, R₇, and R₁₅ are defined above:

These compounds are useful in treating neurological disorders or complications due to stroke or head injury; benign or malignant neoplastic disease, carcinomas and adenocarcinomas; proliferative disorders; and inflammatory disorders. The compounds are therefore useful as neuroprotective and neuroregenerative, anti-proliferative, and anti-inflammatory agents.

Methods and compositions are disclosed for enhancing neurogenesis, resolving neuropathy and improving neurological health and functioning using fungal extracts and their active ingredients, including species of mushrooms and mycelia containing psilocybin and psilocin, combined with erinacines and hericenones or fungal extracts containing those active ingredients, with the addition of nicotinic acid. The compositions may optionally be combined with nervine plants.

The present invention generally relates to improved medical devices, systems, and methods. In many embodiments, devices, systems, and methods for amputating a limb of a patient are provided. In many embodiments, devices, systems, and methods may provide chronic denervation of one or more nerves of a patient as part of a therapeutic treatment. The methods may employ cold for the prevention of neuromas or fibromas associated with amputation of a limb of a patient. Embodiments of the invention include needles that can be advanced through skin or other tissues to cause axonotmesis of a target nerve of the patient and to repeatedly interrupt a regeneration of the nerve so as to provide therapeutic chronic denervation of the target nerve. The therapeutic chronic denervation may delay the formation of neuromas or fibromas in a patient's residual limb and/or may provide long lasting and permanent pain relief associated with the target nerve.

The present invention provides an isolated population of perineurium derived adult stem cells and cells derived thereof. The cells of the invention are obtained from the perineurium of peripheral nerves and demonstrate the ability to expand and differentiate in response to BMP2. The invention also provides methods of using the cells of the invention, for example in methods to promote neuroregeneration and bone formation.

The invention provides a nerve conduit. The nerve conduit is characterized by comprising an inner layer, an outer layer and a cavity; the outer surface of the inner layer is wrapped with the outer layer; the cavity is formed between the inner layer and the outer layer; the inner layer is a hydrophilic cytoskeleton layer manufactured by the electrostatic spinning method; the outer layer is a hydrophobic nerve conduit skeleton layer by the electrostatic spinning method; the cavity is used for storing a bioactive factor solution. The nerve conduit has the characteristics of being proper in strength and hardness, degradable, capable of providing proper neurotrophic active substances, ideal in double-layer or multi-layer structure, semi-permeable, low in cost, short in production cycle, easy to be stored and transported, free of viruses, free of immunological rejection or extremely small in immunological rejection, and wide in applicable scope; the requirement on nerve regeneration process can be met well.

The invention discloses a preparation technology of a novel nerve conduit, and belongs to the technical field of tents of biological tissue engineering. The preparation technology sequentially comprises a preparation technology of GDNF (glial-derived neurotrophic factor)-carried gelatin microspheres, a synthesizing technology of gelatin-methacrylamide hydrogel, a preparation method of polycaprolactone/gelatin electricity texture nerve conduits, and a combining method of the electricity texture nerve conduits and the GDNF-carried gelatin microspheres. The preparation technology has the advantages that a tent structure with good degradability, biological compatibility and biological safety is realized, and the GDNF is controlled and released by the GDNF-carried gelatin microspheres; compared with blank groups and collagen conduit groups, the regeneration of peripheral nerves is effectively promoted, and the structure and function of restoring damaged nerves can reach the effect similar to the effect of autotransplantation groups; the defect nerves can be bridged, and the stability of axon regeneration environment can be maintained; the invasion of peripheral connective tissues is prevented; the saturing of near and far-heart breaking ends of smaller nerve defect is solved, and the restoration of larger nerve defect is solved.

The invention belongs to the field of biological medicine, and particularly relates to a Nogo-A receptor binding peptide as well as a derivative and an application thereof. The amino acid residue sequence of the Nogo-A receptor binding peptide is HIYTALV or GFATITG. The derivative of the binding peptide is a product obtained through conventional modification of an amino terminal or a carboxyl terminal of a Nogo-A receptor binding peptide fragment on a Nogo-A receptor binding peptide amino acid side chain group or a product obtained by connecting a label used for peptide or protein detection or purification on the Nogo-A receptor binding peptide. The binding peptide and the derivative of the binding peptide can be bound with NgR in vitro, nerve regeneration is promoted by preventing binding of NgR and Nogo-A, nerve regeneration barriers caused by central nervous injury diseases can be treated, recovery of a central nervous function is promoted, and the binding peptide and the derivative can be widely applied in the medical and biological fields.

The present invention discloses achyranthes bidentata polypeptide, a production method and applications, and the achyranthes bidentata polypeptide is produced with the steps including polypeptide extraction, polypeptide separation, etc. The achyranthes bidentata polypeptide is used to the preparation of drugs and health products for treating peripheral nerve injuries, cerebrovascular accidents, ischemic brain injuries, cerebral traumas, optic nerve injuries, spinal cord injuries and central nervous system injuries, antiaging and preventing neurodegenerative diseases. Experiments prove that the extracted achyranthes bidentata polypeptide (protein) of the present invention has the effects of promoting the growth of nerves, preventing the fading of nerve cells and promoting the regeneration of injured nerves, the source of medicinal materials is single, the preparation method is advanced, the technique is reasonable, the ingredients of preparations are definite, safety is high, and pharmacological action is obvious.

The present invention discloses compositions and methods for the treatment of injury or disease of the nervous system CNS. In a particular embodiment, the invention provides methods of treatment using non-recombinant activated antiself T-cells that recognize an antigen of the NS or a peptide derived therefrom or a derivative thereof to promote nerve regeneration or to prevent or inhibit axonal degeneration within the NS. The invention also provides methods of treatment using a NS-specific antigen or peptide derived therefrom or a derivative thereof or a nucleotide sequence encoding said antigen or peptide to promote nerve regeneration or to prevent or inhibit axonal degeneration in NS, i.e., the CNS and/or PNS. The NS-specific antiself activated T-cells may be administered alone or in combination with NS-specific antigen or peptide derived therefrom or a derivative thereof or a nucleotide sequence encoding said antigen or peptide or any combination thereof.

The present invention is directed to a device and method for a nanofiber wrap to minimize inflation and scarring of nerve tissue and maximize the nutrient transport. More particularly, the present invention is directed to a novel semi-permeable nanofiber construct prepared from biocompatible materials. The nanofiber construct is applied around a nerve repair site following end-to-end anastomosis. The nanofiber construct is porous and composed of randomly oriented nanofibers prepare using an electrospinning method. The nanofiber construct has a wall that is approximately 50-100 μm thick with pores smaller than 25 μm. The nanofiber construct prevents inflammatory cells from migrating into the nerve coaption site, while still permitting the diffusion of growth factors and essential nutrients. The nanofiber construct allows for enhanced neuroregeneration and optimal function outcomes.

The invention discloses a nerve regeneration gel as well as a preparation method and application thereof. The matrix of the nerve regeneration gel is formed by fibrinogen, thrombin, laminin and fibronectin; the nerve regeneration gel contains procyanidine, sonic hedgehog, an epidermal growth factor, neurenergen-3 and a vascular endothelial growth factor. In-vitro test and animal test show that thegel is capable of accelerating neuron regeneration and neurite extension and repairing the injured nerve tissue. The matrix of the gel comprises fibrin, laminin and fibronectin and is capable of reducing formation of cavities and accelerating adhesion and proliferation of endogenous neural stem cells; the procyanidine in the gel is capable of resisting oxidation and inhibiting inflammation; the sonic hedgehog, the epidermal growth factor and the neurenergen-3 are capable of accelerating proliferation of the stem cells and differentiation to neurons of the stem cells; the vascular endothelialgrowth factor is capable of accelerating generation of blood vessels. The gel can be formed in situ on injured parts and can be used for treating nervous system injury.

The invention provides application of acellular nerve hydrogel to preparation of a peripheral nerve injury repairing composition. The peripheral nerve injury repairing composition is prepared by using the acellular nerve hydrogel, so the peripheral nerve regeneration microenvironment can be simulated well, extension and myelination of axon can be promoted, the PSD95 expression level of nerve cells is reduced, and occurrence of pathological neuralgia and neuroma is inhibited. An electrophysiological experiment proves that although the acellular nerve hydrogel inhibits formation of cynapse between the nerve cells, the acellular nerve hydrogel does not influence generation of action potential and conduction along axion and can repair peripheral nerve injury well.

Disclosed are therapeutic treatment methods, compositions and devices for maintaining neural pathways in a mammal, including enhancing survival of neurons at risk of dying, inducing cellular repair of damaged neurons and neural pathways, and stimulating neurons to maintain their differentiated phenotype. In one embodiment, the invention provides means for stimulating CAM expression in neurons. The invention also provides means for evaluating the status of nerve tissue, including means for detecting and monitoring neuropathies in a mammal. The methods, devices and compositions include a morphogen or morphogen-stimulating agent provided to the mammal in a therapeutically effective concentration.

The invention relates to a construction method of an artificial neural network sample catheter for repairing spinal cord injury, in particular to a method for constructing a functional artificial neural network sample catheter by using a porous gelatin sponge cylindrical stand and application thereof. When applied, the functional artificial neural network sample catheter is transplanted to an injured part of complete transverse or semi-transverse spinal cord so as to better promote the injured central nervous regeneration and functional repair. The method has significance for enhancing protection of injured neurons after spinal cord injury, promoting reconstruction of a neural network, improving the quality of life of the wounded and sick, lightening the social and family burden and promoting the social and economic development of China at a biological tissue engineering level.

The invention provides peptides and analogs of INGAP and HIP peptides. The peptides and analogs can be used in methods for treating various diseases and conditions. Such diseases and conditions can include impaired pancreatic function, treating a metabolic disease, for example, diabetes, both type 1 and type 2 diabetes, islets induction, expansion and proliferation for trans plantation, promoting neuroprotection or nerve regeneration, promoting liver regeneration or inhibiting inflammation.

The invention discloses a Chinese medicinal composition for promoting nerve regeneration and a preparation method and use thereof. The Chinese medicinal composition for promoting nerve regeneration consists of 2 to 10 parts of multiflower knotweed root, 1 to 10 parts of ginseng and 1 to 10 parts of ginkgo leaves; and the Chinese medicinal composition for promoting nerve regeneration also may consist of commercial multiflower knotweed root extract, ginseng extract and ginkgo leaf extract in a ratio. Besides the conventional preparation method, the invention also provides a preparation method of the Chinese medicinal composition, which comprises: subjecting the raw materials to C1 to C1 alcohol extraction respectively to obtain C1 to C3 alcohol extracts; concentrating, passing through a macroporous adsorption resin column, eluting with ethanol, collecting eluent, recovering ethanol, and drying; or recovering ethanol, concentrating to obtain thick paste, drying, grinding, obtaining the final extracts, and mixing to obtain the Chinese medicinal composition. The Chinese medicinal compostion has an obvious nerve regeneration promoting effect, and has the effects of resisting cerebral ischemia injury, protecting nerves, improving learning and memory and resisting senile dementia; the main active ingredients are definite, the quality is stable, and the dosage is small; and the Chinesemedicinal composition is a high-quality natural medicine or health-care food.

The invention relates to the field of medicine, and discloses a novel application of 3-methoxyl mangiferin in the field of pharmacy, and a medicine composition comprising 3-methoxyl mangiferin. 3-methoxyl mangiferin can promote hippocampus dentate gyrus neuron 5-hydroxytryptamine 1A receptor gene and protein expressions, and can induce neurotrophic effects such as hippocampus remodeling performed by 5-hydroxytryptamine. Therefore, post-stroke hippocampus nerve aregeneratory can be substantially ameliorated, 5-HT re-uptake of nerve presynaptic membrane can be selectively inhibited, 5-HT positive cell expression at hypothalamus can be reduced, exhaustion of 5-HT can be relieved, and anxiety and depression symptoms caused by 5-HT exhaustion can be relieved. Therefore, 3-methoxyl mangiferin can be used in preparing medicines used for treating post-stroke depression.