Achyranthes bidentata polypeptide, preparing process and uses

Achyranthes bidentata and ammonium sulfate technology, which is applied in the field of Achyranthes bidentata polypeptide and its production and application, can solve the problems of unsatisfactory clinical patients, neurodegeneration is rare, etc., and achieve the prevention of neuron apoptosis, significant pharmacological effects, and technological innovation. reasonable effect

Inactive Publication Date: 2008-09-24
NANTONG UNIVERSITY
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Problems solved by technology

However, so far there are few new traditional Chinese medicines that can effectively promote nerve regeneration and prevent neurodegeneration clinically, and cannot meet the needs of clinical patients.

Method used

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Experimental program
Comparison scheme
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Embodiment Construction

[0017] An extract of Achyranthes bidentata (protein) from a traditional Chinese medicine is obtained by the following method: extracting slices of Achyranthes bidentata single herb with an aqueous solution for three times, and combining the extracts to obtain an aqueous solution of Achyranthes bidentata. Then adopt the following method to obtain Achyranthes bidentata (protein) extract from Achyranthes bidentata aqueous solution: (1) extraction of polypeptide (protein): Achyranthes bidentata aqueous solution adds ammonium sulfate to 50% at 4 ℃, centrifugal half an hour at 15000rpm, the upper part after centrifugal Add ammonium sulfate to the supernatant to 80% at 4°C, centrifuge at 15,000 rpm for half an hour, transfer the precipitate to a dialysis bag with a minimum molecular weight cut-off of 1,000, dialyze with pure water, and freeze-dry after dialyzing. (2) Separation of polypeptide (protein): use diethylaminoethyl (DEAE) preparative column and quaternary linear gradient elu...

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Abstract

The present invention discloses achyranthes bidentata polypeptide, a production method and applications, and the achyranthes bidentata polypeptide is produced with the steps including polypeptide extraction, polypeptide separation, etc. The achyranthes bidentata polypeptide is used to the preparation of drugs and health products for treating peripheral nerve injuries, cerebrovascular accidents, ischemic brain injuries, cerebral traumas, optic nerve injuries, spinal cord injuries and central nervous system injuries, antiaging and preventing neurodegenerative diseases. Experiments prove that the extracted achyranthes bidentata polypeptide (protein) of the present invention has the effects of promoting the growth of nerves, preventing the fading of nerve cells and promoting the regeneration of injured nerves, the source of medicinal materials is single, the preparation method is advanced, the technique is reasonable, the ingredients of preparations are definite, safety is high, and pharmacological action is obvious.

Description

Technical field: [0001] The invention relates to a polypeptide (protein) extracted from traditional Chinese medicine Achyranthes bidentata and its extraction method and use. Background technique: [0002] With the development of modern society, traffic accidents, wars, natural disasters, population aging and other factors, the incidence of nerve damage and degenerative diseases of the nervous system is on the rise. Find ways to promote the repair of damaged nerves, prevent and treat nervous system degeneration Effective medicine for sex change is a topic that attracts attention in current medical research. [0003] Traditional Chinese medicine is a great treasure house of Chinese medical science. It has the advantages of definite curative effect and less toxic and side effects. It is valued not only by domestic medical circles but also by colleagues in the world. Traditional Chinese medicine has accumulated a lot of experience in treating nerve injury and neurodegenerative ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K1/14C07K14/415A61K38/16A61P25/02A61P25/00A61P25/28A61P39/06A61P9/10
CPCC07K14/415A61K38/00A61P9/10A61P25/00A61P25/02A61P25/28A61P39/06
Inventor 顾晓松丁斐袁颖杨宇民程琼
Owner NANTONG UNIVERSITY
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