The invention discloses application of
hyperoside to treatment of
endometriosis, and aims to evaluate whether
hyperoside has an anti-
fibrosis effect when applied to a rat
endometriosis model by taking
fibrosis as a treatment target. The method comprises the following steps: constructing a rat
endometriosis model through an
autotransplantation method, dividing molded rats into a low-
dose group, a medium-
dose group, a high-
dose group, a model group and a
western medicine control group 4 weeks after successful modeling, and laparotomizing and taking out ectopic lesions after respectively taking medicines for 4 weeks. HE
staining and masson
staining methods are used for mutually proving the
fibrosis degree, the expression conditions of fibrosis indexes a-SMA, Co-1,
CTGF and Fn are detected in an immunohistochemical mode, and the anti-fibrosis effect of
hyperoside is evaluated. As a result, hyperoside can prevent the development of fibrosis in endometriosis, and thus hyperoside can be used as a
drug for treating or preventing fibrosis in endometriosis.