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1042 results about "Stem like cell" patented technology

Multi-channel nerve repair conduit with tissue induced function and mold

The invention discloses a multi-channel nerve repair conduit with a tissue induced function and a mold; chitosan-coated salidroside microspheres and composite type salidroside slow-release microspheres are prepared, the drug cumulative release amount is calculated, the composite type salidroside slow-release microspheres with different contents are mixed with I-type collagen, and salidroside slow-release microspheres/I-type collagen is obtained; a multi-aperture cylindrical nerve conduit core layer is prepared by using the mold, a nano fiber nerve conduit shell layer is prepared by a high-pressure electrostatic spinning technology, the core layer and the shell layer are nested, and thus the multi-channel nerve repair conduit with the tissue induced function is prepared. The shell layer of the conduit has a good role in exchanging with a tissue fluid, and has a function of guiding nerve growth; the core layer has the functions of guiding nerve fiber orientation growth, promoting stem cells to directionally differentiate to schwann cells and accelerating the nerve fiber growth and function recovery, effectively repairs peripheral nerve defects, has good degradation and biocompatibility, and meets the requirements of a tissue engineering scaffold material.
Owner:甘肃伯骊江3D打印科技有限公司

Microfluidic diffusion and open intervening cell culture array chip and fabrication method and application thereof

The invention relates to a microfluidic diffusion and open intervening cell culture array chip and a fabrication method and application thereof. The cell culture array chip is suitable for cell culture, stem cell proliferation, drug screening, regenerative medicine and the like. The cell culture array chip comprises a base and a substrate fixed on the base, wherein a plurality of hole-like cell culture unit are distributed on the substrate; and a microfluidic main channel and a microfluidic diffusion channel, which are intercommunicated with each other, are arranged on the substrate and are communicated with each cell culture unit and the external environment. The cell culture array chip provided by the invention has the following advantages: (1) the required culture solution, growth factors and the like are supplied through a microfluidic diffusion network, so as to result in a zero cell shearing force and ensure the gas and moisture environment required for cell growth; (2) the in vivo microenvironment multichannel microfluidic concentration gradient of cells is simulated, and the quantitative drug release at a fixed time and other functions are realized; (3) the chip is suitable for high-throughput drug screening research on cell phenotype; and (4) the chip has a compact structure and low cost, and is suitable for batch production.
Owner:武汉介观生物科技有限责任公司

Oxidized graphene doped nano-fibers, as well as preparation method and application thereof

The invention discloses oxidized graphene doped nano-fibers, as well as a preparation method and application thereof. The nano-fibers are continuous nano-fibers with smooth surfaces and mainly formed by oxidized graphene and poly(lactic-co-glycolic acid) using an electrostatic spinning method. The nano-fibers provided by the invention can be used to form a porous three-dimensional structured nano-fiber scaffold material for tissue engineering. The scaffold material for tissue engineering simulates cell natural extracellular matrix, wherein the diameter of the nano-fiber ranges from a dozen nanometers to several micrometers, and the nano-fiber is similar with the collagen fiber in the extracellular matrix; the scaffold material provided by the invention has a porous topology structure with a high specific surface area and simulating the extracellular matrix, can provide better growth environment for the cells, can remarkably promote the adhesion, proliferation and differentiation of the stem cells; at the same time, the preparation technology of the nano-fibers is simple without using complicated equipment; mass production can be achieved, and the manufacturing cost is low.
Owner:SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI

Stem cell heat insulation and moisturizing transport box

The invention discloses a stem cell heat insulation and moisturizing transport box. The transport box comprises a box body, a box cover arranged at the top of the box body and a handle arranged at thetop of the box cover, and further comprises a stem cell cryopreservation tube fixing device, a temperature control device, an ultrasonic humidifying device, a control panel, a wireless communicationmodule and a controller. A miniature camera device is arranged at the bottom of the box cover, and protective layers wrap the outer side of the box body and the outer side of the box cover; a first horizontal partition plate is arranged in the box body, the box body is divided into two chambers, a stem cell storage chamber is arranged above the first horizontal partition plate, a humidifying chamber is arranged below the first horizontal partition plate, the ultrasonic humidifying device is arranged in the humidifying chamber, and the stem cell cryopreservation tube fixing device and the temperature control device are arranged in the stem cell storage chamber; and the control panel, the wireless communication module and the controller are all arranged at the top of the box cover. The transport box is simple in structure and convenient to use, the heat insulation and moisturizing effects are excellent, transportation of stem cells is facilitated, it is ensured that the state of the cells in the transportation process is good, and users can monitor the state in the box in real time.
Owner:上海美致臻心生物医学科技有限公司

Preparation method of hair follicle stem cells

The invention discloses a preparation method of hair follicle stem cells. The method comprises the following steps: cutting roots of hair follicles of volunteers, performing cleaning, adding 0.25% Dispase enzyme, and performing digesting at 37 DEG C for 0.5-1.5 hours; after enzyme digestion, and inoculating the obtained material into a hair follicle stem cell culture medium, wherein the culture conditions are that the temperature is 37 DEG C, the CO2 content is 5 percent, and a liquid is changed once every 1 to 2 days; subjecting hair follicle stem cells to amplification: transferring the hairfollicle stem cells obtained in the step S2 into a hair follicle stem cell amplification culture medium for continuous culture, wherein the hair follicle stem cell amplification culture medium comprises the following components: a DMEM basal culture medium, FBS, T-beta, hEGF, VEGF and Rho related kinase; and subjecting the hair follicle stem cells to purification. The hair follicle stem cells prepared by the method disclosed by the invention can be subjected to long-term in-vitro subculture, have very high regeneration and differentiation capacities, lay a foundation for being applied to treatment of skin defects, and have a very good clinical application prospect.
Owner:浙江卫未生物医药科技有限公司
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