3D-printed high-conductivity healing-promoting multichannel nerve conduit and preparation method and application thereof

A nerve conduit and 3D printing technology, which is applied in medical science, prosthesis, additive processing, etc., can solve the problems of little research, achieve reduced adverse reactions, high biological safety, and eliminate long-term inflammation-related side effects Effect

Active Publication Date: 2022-08-05
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because of its excellent electrochemical energy storage performance and excellent conductivity as an electrode material for supercapacitors, it has won the research interest of many researchers around the world. Titanium dicarbide (Ti 3 C 2 T x ) is currently the most researched two-dimensional MXene material, which has good biocompatibility and has applications in the fields of osteogenesis and repair, but there is little research on nerve repair engineering

Method used

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  • 3D-printed high-conductivity healing-promoting multichannel nerve conduit and preparation method and application thereof
  • 3D-printed high-conductivity healing-promoting multichannel nerve conduit and preparation method and application thereof
  • 3D-printed high-conductivity healing-promoting multichannel nerve conduit and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1, the preparation of PLA-PTMC catheter

[0032] (1) Weigh N,N-dimethylformamide and dichloromethane in a mass ratio of 7:3, and mix them evenly.

[0033] (2) Weigh the PLA-PTMC copolymer particles, and dissolve them in the mixed solution obtained in step (1) according to a mass ratio of 45:100 to obtain a PLA-PTMC mixed gel solution;

[0034] (3) Fill the PLA-PTMC gel obtained in step (2) into the 3D printer barrel, and the 3D printer prints, and the 3D printing content is one 3mm*12mm flat plate and four 8mm*12mm flat plates, each of which is 8mm*12mm. The content of the flatbed printing is that the two layers of mechanical layers and the guiding long axis are at 45° and perpendicular to each other, the fiber spacing in the layers is 1.0mm, and the inner spacing of one guiding layer is 0.3mm.

[0035] (4) After printing, the sample prepared in step (3) is placed in a refrigerator for pre-freezing for half an hour for shaping, and then freeze-dried for 4-6 ...

Embodiment 2

[0038] Example 2. Preparation of MXPLT-15% catheter

[0039] (1) Weigh N,N-dimethylformamide and dichloromethane according to the mass ratio of 7:3, and mix them evenly;

[0040] (2) Weigh Ti 3 C 2 T x The powder is dissolved in the mixed solution obtained in step (1) according to a mass ratio of 2:1000 to obtain a mixed solution of MXene;

[0041] (3) Weigh the PLA-PTMC copolymer particles, and dissolve them in the mixed solution obtained in step (2) according to a mass ratio of 15:100 to obtain a MXPLT mixed gel solution;

[0042] (4) Filling the MXPLT mixed gel solution obtained in step (3) into the 3D printer barrel, and the 3D printer prints, the 3D printing content is one 3mm*12mm flat plate and four 8mm*12mm flat plates, each The content of the flatbed printing is that the two mechanical layers and the guiding long axis are at 45° and perpendicular to each other, the fiber spacing in the layers is 1.0mm, and the inner spacing of one guiding layer is 0.3mm;

[0043]...

Embodiment 3

[0046] Example 3. Preparation of MXPLT-25% catheter

[0047] The preparation method of this embodiment is the same as that of embodiment 2, except that the mass ratio of PLA-PTMC to mixed solvent in step (3) is 25:100, to obtain a mixed gel solution of MXPLT. Prepared nerve conduits such as figure 1 (b).

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Abstract

The invention discloses a preparation method and application of a high-conductivity healing-promoting multichannel nerve conduit based on a 3D printing technology, the nerve conduit comprises raw materials of polylactide-poly (trimethylene carbonate) and trititanium dicarbide, and also comprises solvents of N, N-dimethylformamide and dichloromethane, the prepared MXPLT conduit has quite high ductility, and the healing-promoting multichannel nerve conduit is suitable for being used in the field of medical instruments, such as medical instruments, medical instruments, medical instruments, medical instruments, medical instruments, medical instruments, medical instruments, medical instruments, medical instruments and medical instruments. The material can deal with catheter deformation caused by muscle human body movement in the nerve repairing process and is suitable for being used as a nerve repairing material for repairing nerve broken ends. The MXPLT catheter is more beneficial to electrical signal conduction, and is more beneficial to repairing of a nerve broken end, meanwhile, the MXPLT catheter has excellent shape memory ability and can recover to an initial shape within a short time when deformation is generated due to the influence of external force in the repairing process, the repairing effect of the MXPLT catheter group is closest to that of autotransplantation repairing, and the MXPLT catheter group has an excellent repairing effect.

Description

technical field [0001] The invention belongs to the technical field of medical biological materials, and in particular relates to a preparation method and application of a high-conductivity and healing-promoting multi-channel nerve conduit based on 3D printing technology. Background technique [0002] Due to the characteristics of highly differentiated nerve tissue and low regeneration ability, the repair effect of peripheral nerve injury is still not ideal. How to promote the regeneration of peripheral nerve fibers, induce the growth of regenerated nerve fibers into target tissues, and reduce the inflammatory response associated with nerve regeneration has always been a difficult problem in the field of nerve injury repair research. Among them, the non-directional regeneration of axons at the injured site is one of the main problems. Therefore, researchers pay more and more attention to the role of repair conditions in regulating the regeneration of axonal directivity duri...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/02A61L27/50A61L27/56A61L27/54B33Y70/10B33Y80/00B33Y10/00A61F2/02
CPCA61L27/18A61L27/025A61L27/50A61L27/56A61L27/54B33Y70/10B33Y80/00B33Y10/00A61F2/02A61L2430/32A61L2400/16A61L2300/404A61L2300/102C08L69/005
Inventor 范增杰乔梁梁家琛叶茜王志龙
Owner LANZHOU UNIVERSITY
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