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Biogastrone acid prosome liposome with long circulation function and preparation method thereof
InactiveCN101366698AAchieve long cycleSmall particle sizeOrganic active ingredientsMetabolism disorderFreeze-dryingCholesterol
The invention belongs to the new technical field of a drug preparation and in particular relates to a precursor liposome containing a glycyrrhetinic acid and a method for preparing the same. The precursor liposome containing the glycyrrhetinic acid consists of glycyrrhetinic acid, phospholipids, cholesterol, a surfactant and a water-soluble material; a suspension solution of the glycyrrhetinic acid liposome is prepared by an ethanol injection method or a thin-film dispersion method; and solid liposome powder is prepared by a freeze drying method or a spray drying method. The precursor liposome has simple process and good repeatability, is suitable for industrialized production; through drug administration by intravenous injection, the precursor liposome has long-circulating function, can remarkably reduce the toxicity of drug and achieve the function of prolonging the drug effect; and through oral administration, a solid preparation of the liposome can increase absorption and improve bioavailability by three to five times.
Owner:CHINA PHARM UNIV
Preparation method and application of RGD-modified ultra-small magnetic iron oxide nanoparticles
ActiveCN104258425AStrong reducing propertiesHigh crystallinityNMR/MRI constrast preparationsEmulsion deliveryCyclic peptideActive agent
The invention discloses a preparation method of RGD-modified ultra-small magnetic iron oxide nanoparticles. The preparation method comprises the following steps: preparing ultra-small magnetic iron oxide nanoparticles by taking ferric acetylacetonate as a reaction raw material and a precursor, taking oleylamine as a surfactant and a reducing agent and taking dibenzyl ether as a solvent; replacing oleylamine molecules wrapped on the surfaces of the nanoparticles by utilizing dopamine-modified HOOC-PEG-COOH to realize PEG-modification of the surfaces of the nanoparticles; and finally, chemically coupling RGD cyclic peptide by virtue of free carboxyl at the tail end of the PEG to obtain the RGD-modified ultra-small magnetic iron oxide nanoparticles. The method of synthesizing the ultra-small magnetic iron oxide nanoparticles has the characteristics of a simple process, a high raw material conversion ratio, strong repeatability and the like. The synthesized magnetic iron oxide nanoparticles have the characteristics of a regular morphology, an ultra-small dimension, good stability, good monodispersity, high biocompatibility, and tumor specific targeting, and the like, and can be used as a T1-weighted imaging high-performance magnetic resonance imaging contrast agent with a tumor active targeting function.
Owner:SOUTHEAST UNIV
Liposome-modified spermine derivative and liposome prepared by derivative
ActiveCN104876831AHas the effect of silenceImprove accumulation abilityCarbamic acid derivatives preparationOrganic compound preparationCholesterolSulfur
The invention provides a liposome-modified spermine derivative and a liposome prepared by the derivative. The spermine derivative is directly applied or is mixed with one or more selected from cholesterol, neutral lipids and polyethylene glycol (PEG)-modified lipids, which can be adopted as a carrier for entrapping or absorbing bioactive molecular drugs to be loaded into cells. In this way, the effect of regulation, intervention or treatment is realized. In a general formula (1), X1 represents -(CH2)- or carbonyl group, wherein n represents 1, 2 or 3; X2 represents -(CH2)-, ester group, amide group, oxygen, or sulfur; R1 and R2 independently represent C6-C18 alkyl group or lipophilic cholesterol molecules, respectively.
Owner:GUANGZHOU NANOTIDES PHARMA
Preparation method for Silicate-1 molecular sieve catalyst, catalyst and method for preparing caprolactam
ActiveCN107335464AImprove conversion rateExtend your lifeLactams preparationMolecular sieve catalystsMolecular sieveNitrogen
The invention discloses a preparation method for a Silicate-1 molecular sieve catalyst, the Silicate-1 molecular sieve catalyst prepared by the method and a method for preparing caprolactam from cyclohexanone oxime. The preparation method for the Silicate-1 molecular sieve catalyst comprises the steps: a. mixing a silicon source, a metal ion source, an organic template agent and water, so as to obtain a colloidal mixture; b. subjecting the colloidal mixture obtained in the step a to hydrothermal crystallization, so as to obtain a crystallized product; c. subjecting the crystallized product obtained in the step b to washing and separating treatment, so as to obtain metal ion containing Silicate-1 molecular sieves; and d. subjecting the metal ion containing Silicate-1 molecular sieves obtained in the step c to forming treatment, roasting treatment and aftertreatment by an alkaline buffer solution of a nitrogen containing compound, and carrying out washing, separating and drying, thereby obtaining the Silicate-1 molecular sieve catalyst containing trace metal ions. By adopting the method, the performance of the Silicate-1 molecular sieve catalyst can be effectively changed; and by applying the catalyst to the production of the caprolactam, an unexpected result can be achieved.
Owner:CHINA PETROLEUM & CHEM CORP +1
Antineoplastic prodrug with P-glycoprotein inhibition function
InactiveCN102935236AImprove solubilityImprove stabilityPharmaceutical non-active ingredientsAntineoplastic agentsPolyethylene glycolGlycoprotein i
The invention relates to an antineoplastic prodrug with a P-glycoprotein inhibition function. The antineoplastic prodrug is an amphiphilic substance formed by connecting antineoplastic drugs and chitosan-polyethlyene glycols-succinate with the P-glycoprotein inhibition function through a connector in a covalent mode. The connector comprises a sensitive bond and at least two reaction functional groups respectively used for connecting the antineoplastic drugs and the chitosan-polyethlyene glycols-succinate in a covalent mode, wherein the sensitive bond is a chemical bond which is easily broken under a reducing environment or an acid environment in a tumor cell. The antineoplastic prodrug with the P-glycoprotein inhibition function is expected to effectively treat tumors and drug-fast tumors.
Owner:WUHAN PINGHUA BIOMEDICAL TECH
Near infrared laser-driven mitochondrial targeting fluorescent polymer and preparation method and application thereof
ActiveCN107033283ALow optical damageGood optical damagePhotodynamic therapyPharmaceutical non-active ingredientsMethacrylateAcrylonitrile
Disclosed is a near infrared laser-driven mitochondrial targeting fluorescent polymer and a preparation method and application thereof. A nano-scale photosensitizer, which is prepared from a polymer of poly-(2Z, 2'Z)-3,3'-(2, 5-bis(diphenylamino)-1, 4-phenyl) bis(2-(3, 5-bis(trifluoromethyl) phenyl) acrylonitrile-copolymer (N-(2-hydroxypropyl) methacrylamide)-copolymer (2-dimethylamino ethyl methacrylate) and an inorganic upconversion nano-scale particle of ytterbium and thulium codoped sodium yttrium fluoride in aqueous solution; when irradiated by laser of a wavelength of 980 nm, the nano-scale photosensitizer can produce reactive oxygen to effectively kill cells. The invention provides a novel and effective nano-scale photosensitive material for research and application of photodynamic therapy of tumor cells in the future.
Owner:深圳市丰用实业集团有限公司
Amphiphilic waterborne segmented copolymer medicament carrier with pH responsiveness and biodegradability and preparation thereof
InactiveCN102807657AGood biocompatibilityPromote degradationSolution deliveryPharmaceutical non-active ingredientsBiocompatibility TestingPolymer chemistry
The invention discloses an amphiphilic waterborne segmented copolymer medicament carrier with pH responsiveness and biodegradability and a preparation method thereof. An amphiphilic waterborne segmented copolymer consists of a chain segment which is modified with polyphosphoester and polymethacrylate hydroxyethyl and contains carboxyl. A polyanion chain segment can be reversely converted into a hydrophilic or hydrophobic chain segment by adjusting the pH value of a medium. The amphiphilic polymer is self-assembled into a micelle under the condition of certain PH, and a shell of the micelle formed by a hydrophilic polyphosphoester chain segment can be used for better stabilizing the micelle. A hydrophobic polyanionic chain segment is used for forming an inner core of the micelle, is used for coating a hydrophobic medicament, and serves as a medicament carrier. The polyphosphoester chain segment has high biocompatibility and high biodegradability, and long in-vivo circulation of a medicament-carrying micelle can be realized. Under a weakly alkaline condition, the aims of dissociating the micelle, releasing a medicament and realizing controllable release are fulfilled.
Owner:SUZHOU UNIV
Ligustrazine microcosmic salt liposome medicine and preparing method
InactiveCN101176720ASmall doseGood curative effectOrganic active ingredientsPharmaceutical non-active ingredientsAdditive ingredientPhosphate
The invention relates to a tetramethylpyrazine phosphate liposome drug and a preparation method; wherein, the drug is characterized in that: the effective efficacy components and weight accounts of the liposome drug are as following: a mixture 200 to330 with a weight ratio 4 to 1 of egg yolk lecithin and sheep cerebral lecithin, a mixture 170 to 280 with a weight ratio 3 to 1of stigmasterol and campestrol, reduction glutathione 2.5 to 10, tetramethylpyrazine phosphate 15 to 25, a mixture 720 to 1200 with a weight ratio 1 : 0.01 to 0.05 : 0.02 to 0.07 of tert-butyl alcohol, ethanol, acetone, a mixture 140 to 160 with a weight ratio 4:05 to 1 of polyethylene glycol-2000 and tween 801, and hydroxyl propyl methyl cellulose 100 to 120. The invention also provides the preparation method for the liposome drugs. The invention has the advantages of adopting the provided drugs, enabling to decrease the drug dosage by two third and once a day, and improving the efficacy above fifteen percent.
Owner:HUNAN KANGDU PHARMA
Medicine carrying polymer micelle and preparation method thereof
InactiveCN101766562AGood particle propertiesImprove performancePharmaceutical delivery mechanismPharmaceutical non-active ingredientsPolyethylene glycolCopolymer
The invention discloses medicine carrying polymer micelle which is methyl polyethylene glycol polylactic acid segmented copolymer micelle carried with hydrophobicity drugs; the grain size is 50-100nm, and the dispersion coefficient PI of the grains is more than or equal to 0.05 and is less than or equal to 0.09; the invention further discloses a preparation method of the medicine carrying polymer micelle; the grain size of the medicine carrying polymer micelle is small, the grain size distribution range is centralized, the stability is good, and the in vitro releasing experiment and the in vitro macrophagocyte cytophagy experiment can reach good effect. The preparation method of the medicine carrying polymer micelle has the following characteristics: the operation is simple and convenient; the encapsulating rate is high, and the highest encapsulating rate can be up to more than 90%; in addition, the prepared medicine carrying polymer micelle has good performance.
Owner:SHANGHAI INST OF PHARMA IND CO LTD
Synthesis method of sodium titanate nanoribbon/titanium carbide nanosheet compound
ActiveCN108134055AImprove electrochemical performanceHigh magnificationMaterial nanotechnologyHybrid capacitor electrodesSynthesis methodsBarium titanate
Owner:TONGJI UNIV
Anti-tumor prodrug with P-glycoprotein inhibition function and preparation method
ActiveCN108245683AImprove solubilityAvoid effluxOrganic active ingredientsPharmaceutical non-active ingredientsPolyethylene glycolTumor cells
The invention discloses an anti-tumor prodrug with a P-glycoprotein inhibition function and a preparation method. The prodrug comprises a part formed by covalently connecting an anti-tumor drug and polyethylene glycol vitamin E succinate through a connecting arm, wherein the connecting arm comprises a sensitive bond; the sensitive bond is a chemical bond which is broken in an oxidization or reduction environment. The free polyethylene glycol vitamin E succinate and the active anti-tumor drug are dissociated; the polyethylene glycol vitamin E succinate is combined with P-glycoprotein; the expression of a P-glycoprotein efflux pump is inhibited, the activity of the P-glycoprotein is inhibited, the excretion of the anti-tumor drug is reduced and the intracellular concentration of the drug isimproved, so that the multi-drug drug resisting property of tumor cells is inhibited, the intracellular concentration of the active anti-tumor drug is greatly improved and a remarkable anti-tumor effect is obtained. The released active drug can be combined with a specific target spot in the cells and the growth of the tumor cells is inhibited.
Owner:HUAZHONG UNIV OF SCI & TECH
Silicon-carbon negative electrode material, preparation method and application
PendingCN113659122AImprove first-time efficiencyWide variety of sourcesCell electrodesSecondary cellsCarbon coatingCarbon layer
The invention discloses a silicon-carbon negative electrode material. The composite material is of a core-shell structure, and the core-shell structure sequentially comprises a silicon core, a cavity layer, a lithium silicate layer and a carbon layer from inside to outside; the silicon core is micron silicon, micropores are distributed in the lithium silicate layer, and the carbon layer coats the lithium silicate layer. The micron silicon is wide in source, low in cost, high in controllability of the preparation process and suitable for large-scale production, the hollow layer and the micropore structure provide a space for volume expansion and shrinkage in the charging and discharging process, the expansion rate of the powder is greatly reduced, structural collapse is avoided, the structure is stable, the reversible capacity is high, and the cycle performance is good. The material has a wide application prospect as a negative electrode material of a lithium ion battery. Through oxidation, heat treatment, etching and carbon coating, the preparation method is simple and feasible in process, free of pollution, simple in equipment, small in investment and suitable for large-scale production.
Owner:四川金汇能新材料股份有限公司
Genetic engineering subunit vaccine for preventing new variant of chicken infectious bursal disease virus and preparation method thereof
InactiveCN110665010AGood curative effectAvoid clearingPowder deliveryDigestive systemAdjuvantGenetic engineering
The invention provides a genetic engineering subunit vaccine for preventing a new variant of a chicken infectious bursal disease virus. The new variant is an IBDV FJ-1812 strain. The effective component of the genetic engineering subunit vaccine is VP2 protein expressed after codon optimization and transformation of the gene sequence of the variant, and a nucleotide sequence of the VP2 protein isshown as SEQ ID NO. 1; a genetically engineered bacterium with a VP2 protein expression region as shown in SEQ ID NO.1 of an IBDV FJ-1812 strain is constructed, and induced expression and purificationare carried out to obtain VP2 protein, and the VP2 protein with a pharmaceutically acceptable adjuvant are uniformly mixed to prepare the genetic engineering subunit vaccine of the IBDV new variant.According to the invention, the new variant IBDV FJ-1812 strain is discovered for the first time, an expression vector and engineering bacteria capable of expressing the VP2 protein are constructed for the variant, and the expressed VP2 protein is the soluble and antigenic protein.
Owner:ZHEJIANG UNIV
Medicine composition of alprostadil and Chuanhuning/Yanhuning liposome and its prepn
InactiveCN101019869AImprove curative effectLower dosePowder deliveryOrganic active ingredientsPediatricsLiposome
The present invention relates to medicine composition of alprostadil and Chuanhuning / Yanhuning liposome and its preparation process. The nanometer liposome medicine contains the mixture of alprostadil and Chuanhuning / Yanhuning in the weight ratio of 0.1-1.0 to 50-300 in 10.1-80.2 weight portions, the mixture of soybean lecithin and yolk lecithin in the weight ratio of 4 to 1 in 88-440 weight portions, the mixture of cholesterol and beta-sitosterol n the weight ratio of 9 to 1 in 40-200, polyethylene glycol in 4000 15-40 weight portions, sodium glucuronate in 100 -280 weight portions and vitamin C in 160-800 weight portions. The medicine of the present invention may be used in antagonizing pneumonia adenovirus and influenza virus.
Owner:江苏德伦生物制药有限公司
Preparation method of trace rear earth ion-containing spherical MFI topological structured all-silicon molecular sieve catalyst and preparation method of caprolactam
ActiveCN109833898ASolve the problem of difficult access to molecular sieve frameworkLow costLactams preparationMolecular sieve catalystsMolecular sieveRare earth ions
The invention relates to the field of all-silicon molecular sieves and discloses a preparation method of a trace rear earth ion-containing spherical MFI topological structured all-silicon molecular sieve catalyst and a preparation method of caprolactam. The preparation method of the spherical MFI topological structured all-silicon molecular sieve catalyst comprises the following steps: a, mixing asilicon source, a rare earth ion source, an organic template and water to obtain a colloid admixture; b, carrying out two-stage variable-temperature hydrothermal crystallization on the colloid admixture to obtain a crystallization product; c, washing the crystallization product and carrying out separation treatment to obtain rare earth ion-containing all-silicon molecular sieve; and d, moulding the rare earth ion-containing all-silicon molecular sieve, roasting and postprocessing with a nitrogen compound-containing alkaline buffer solution, washing, separating, and drying to obtain the spherical all-silicon molecular sieve catalyst containing trace rear earth ions. By the method, performance of the all-silicon molecular sieve catalyst can be changed effectively. By applying the catalyst to production of caprolactam, a good effect can be achieved.
Owner:ZHEJIANG HENGYI PETROCHEMICAL RES INST CO LTD
Preparation and application of cotransport system of Mn<2+> donor and chloroquine drugs
ActiveCN106344925AReduce the use effectEliminate side effectsOrganic active ingredientsInorganic non-active ingredientsDispersitySolubility
The invention relates to preparation and application of a cotransport system of a Mn<2+> donor and chloroquine drugs. According to the preparation and the application, the problems of low pesticide effect, large required dosage, poor targeting ability and serious toxic and side effects of tumor treating drugs can be effectively solved. According to the technical scheme, double-layer hollow mesoporous manganese sesquioxide nanoparticles are synthesized by virtue of a hydrothermal method, hyaluronic acid and the double-layer hollow mesoporous manganese sesquioxide nanoparticles are linked through chemical bonds so as to spontaneously form a nano-layer in a water medium, and then a chloroquine anti-tumor drug enters mesoporous structures of the double-layer hollow mesoporous manganese sesquioxide nanoparticles through a physical effect. According to the drug-cooperated cotransport system, the dosage and toxic and side effects of the drug can be effectively reduced, the treating efficiency of the drug can be improved, the solubility problem of the drug can be effectively solved, and the effective loading of the drug and the controlled release of the drug at target sites of tumors can be realized; the dispersity and biocompatibility of magnetic carriers are improved, the long circle, the active targeting and the fixed-point gate-controlled release of the drug are realized; and furthermore, the preparation process is simple, energy saving, environmentally friendly and low in cost, the industrial production can be realized, and the preparation process is the innovation of the tumor treating drugs.
Owner:ZHENGZHOU UNIV
Nano preparation loaded with anti-pulmonary fibrosis medicament and immunomodulator and preparation method thereof
ActiveCN110339168AEfficient releaseEncapsulationOrganic active ingredientsRespiratory disorderMedicineImmunomodulations
The invention discloses a nano preparation loaded with an anti-pulmonary fibrosis medicament and an immunomodulator and a preparation method thereof. The nanometer preparation is loaded with the anti-pulmonary fibrosis medicament and the immunomodulator at the same time, and the two medicaments are adopted to synergistically regulate and control the pulmonary fibrosis microenvironment to achieve the purpose of strengthening pulmonary fibrosis treatment through immunomodulation. Additionally, a nano preparation modified by a metalloproteinase-2(MMP-2) specific sensitive peptide segment and a carrier of the nano preparation are utilized to realize rapid massive release of therapeutic medicaments including the immunomodulator and the anti-pulmonary fibrosis medicament by means of the MMP-2 specific sensitive peptide segment, and therefore a new way and strategy for strengthening the treatment of pulmonary fibrosis are provided.
Owner:燃点(南京)生物医药科技有限公司
Preparation method of long-circulation multifunctional metal organic framework nano preparation
PendingCN114732795AGood stealthGood targetingOrganic active ingredientsMaterial nanotechnologyChemistryPoly ethylene
The invention relates to a preparation method of a long-circulation multifunctional metal organic framework nano-preparation, which comprises the following steps: preparing a GA / Fe nano-composite with moderate particle size by taking PVP (Polyvinyl Pyrrolidone) as a mineralizer, and then obtaining white nano-particles; white nano-particles are dissolved and soaked in a hyaluronic acid solution for incubation, and the multifunctional metal organic framework nano-preparation is prepared; the preparation has excellent biocompatibility, tumor targeting ability, bimodal imaging function and combined CDT / hunger therapy / chemotherapy ability, in-situ imaging and treatment of tumors can be realized at the same time, stealth can be realized in vivo due to doping of polyethylene glycol, long circulation is realized, the preparation has good targeting ability, and the preparation has good application prospects. A PVA / Fe nano-composite based on polyvinylpyrrolidone is packaged, so that the preparation simultaneously realizes a T2 imaging effect based on Fe < 3 + >, the spatial position of a tumor can be accurately obtained, and gallic acid can reduce Fe < 3 + > generated by a Fenton reaction and accelerate the Fenton reaction to generate. OH to effectively kill tumor cells; good application prospects are realized in tumor treatment.
Owner:SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
Application of pH sensitive polyethylene glycol derivative and small molecule drug conjugate polymer micelle in inflammatory targeting drug delivery system
ActiveCN106139159AAvoid the defects of being degraded in advanceIncrease concentrationOrganic active ingredientsAntipyreticDiseasePolyethylene glycol
The invention provides an application of pH (potential of hydrogen) sensitive polyethylene glycol derivative and small molecule drug conjugate in a formula (I) and polymer micelle thereof as an inflammatory targeting delivery system and a preparation method of the pH sensitive polyethylene glycol derivative and small molecule drug conjugate. A portion B includes a small molecule drug D with inflammatory disease treating activity, and a portion A includes a polyethylene glycol derivative carrier system. The pH sensitive polyethylene glycol derivative and small molecule drug conjugate polymer micelle has good inflammatory targeting property, the concentration of the drug in the portion B at a low-pH inflammatory site can be remarkably increased, or staying time of the drug at the low-pH inflammatory site can be prolonged, or the anti-inflammatory effect of the drug can be enhanced.
Owner:SICHUAN UNIV
Trace rare earth ion containing all silicon-1 molecular sieve based catalyst with microspheric MFI topological structure and spray shaping preparation method thereof
ActiveCN109772426ASolve the problem of difficult access to the skeletonLow costLactams preparationMolecular sieve catalystsBeckmann rearrangementMolecular sieve
The invention relates to the field of all silicon-1 molecular sieves and discloses a trace rare earth ion containing all silicon-1 molecular sieve based catalyst with a microspheric MFI topological structure and a spray shaping preparation method thereof. The trace rare earth ion containing all silicon-1 molecular sieve based catalyst with the microspheric MFI topological structure comprises 70-95wt% of all silicon-1 molecular sieve and containing an extremely trace amount of rare earth ions and 5-30 wt% of an adhesive according to the dry basis weight percentage; the particle size of the trace rare earth ion containing all silicon-1 molecular sieve based catalyst with the microspheric MFI topological structure is 20-400 (m, and the abrasion index K of the catalyst is less than 5; the BETspecific surface area of the all silicon-1 molecular sieve is 400-500 square meters / g; and the weight ratio of silicon oxide and the rare earth ions is (10000-200000):1. The trace rare earth ion containing all silicon-1 molecular sieve based catalyst with the microspheric MFI topological structure, disclosed by the invention, has the advantages that the abrasion index of the catalyst is low, andthe technological economy of a new process can be effectively improved when the catalyst is used for vapor phase Beckmann rearrangement reaction of cyclohexanone-oxime in a fluidized bed process.
Owner:ZHEJIANG HENGYI PETROCHEMICAL RES INST CO LTD
Derivative of amphoteric chitosan, preparation method, and application in pharmacy
InactiveCN100503646CNo toxicityGood biocompatibilityPharmaceutical non-active ingredientsPolymer scienceDehydrogenation
The invention belongs to the technical field of polymer materials, in particular to an amphiphilic chitosan derivative, a preparation method thereof and an application in pharmacy. The acid-chlorinated long-chain fatty acid is connected to the hydroxyl group of chitosan through esterification reaction, and then the end-activated polybenzyl malate is connected to O-long-chain alkyl chitosan through amide bond, and finally the hydrogenation dehydrogenation is carried out. Remove the protecting group to prepare amphiphilic O-long chain alkyl-N-polymalic acid chitosan graft copolymer. It can form nanoparticles of 100-300nm in aqueous solution. Compared with the prior art, the polymer is completely biodegradable, has good biocompatibility, and has easily modified functional groups.
Owner:FUDAN UNIV
Preparation method of active targeting adriamycin amycin-amphipathic chondroitin sulfate micelle
InactiveCN104368005AIncrease profitAvoid damageOrganic active ingredientsPharmaceutical non-active ingredientsFolate targetingDouble bond
The invention discloses a preparation method of an amphipathic polysaccharide-folic acid-fatty acyl-chondroitin sulfate which contains a folate-targeted group and takes an amphipathic of chondroitin sulfate as a hydrophilic chain segment and a long-chain fatty acid as a hydrophobic chain segment as well as an application thereof in the aspect of adriamycin amycin antitumor pharmaceutical preparations. The average molecular weight (Mw) of the folic acid-fatty acyl-chondroitin sulfate is 3100-53000Da. The general formula of the folic acid-fatty acyl-chondroitin sulfate is shown in the specification, wherein x which is the number of carbon atoms is an integer ranging from 10 to 22; y which is the number of double bonds is an integer ranging from 0 to 6; n is an integer ranging from 8 to 150; O-alkyl substitution degree is 5-50%; folic acid substitution degree is 0.5-2%.
Owner:TAISHAN MEDICAL UNIV
Bifunctional polyethylene glycol and adriamycin conjugate and preparation method thereof
InactiveCN103357022BSmall toxicityGood water solubilityOrganic active ingredientsPharmaceutical non-active ingredientsCancer cellKetone
The invention relates to a bifunctional polyethylene glycol and adriamycin conjugate and a preparation method thereof. The bifunctional polyethylene glycol and adriamycin conjugate is prepared in the following steps: modifying methoxy polyethylene glycol which serves as a raw material through hydroformylation, carrying out a reductive amination reaction on the modified methoxy polyethylene glycol and disulfide-bond containing dihydrazide to generate terminal-hydrazide polyethylene glycol, and carrying out a reaction on the terminal hydrazide of the terminal-hydrazide polyethylene glycol and the ketone carbonyl of the adriamycin to generate a hydrazone bond to obtain the bifunctional polyethylene glycol and adriamycin conjugate. The bifunctional polyethylene glycol and adriamycin conjugate provided by the invention can adapt to the reductive acidic environment in a cancer cell to release drugs rapidly to improve the cancer treatment effect and reduce the drug resisting possibility of the cancer cell, and in addition, the bifunctional polyethylene glycol and adriamycin conjugate can be self-assembled into a nano particle in a water phase to be able to circulate for a long time in blood to improve the pharmacokinetics of the doxorubicin. The method for preparing the bifunctional polyethylene glycol and adriamycin conjugate has the advantages of simple process, mild reaction conditions, high drug carrying rate and low cost, and the raw materials are easy to obtain. The bifunctional polyethylene glycol and adriamycin conjugate has potential application values in the aspects of targeted delivery of drugs, controlled release of drugs and improvement of clinical cancer resisting and treating effects.
Owner:XI AN JIAOTONG UNIV
Microsphere silicate-1 molecular sieve catalyst and preparation method thereof and method for preparing caprolactam
ActiveCN109718828BChange performanceHigh strengthLactams preparationMolecular sieve catalystsBeckmann rearrangementMolecular sieve
The present disclosure relates to a Silicate-1 microsphere molecular sieve catalyst containing trace metal ions, a preparation method thereof, and a method for preparing caprolactam from cyclohexanone oxime. ~95% by weight of Silicate-1 molecular sieve containing trace metal ions, and 5-30% by weight of binder; the particle size of the catalyst is 20-100 μm, and the wear index K is less than 10; BET specific surface area of 400‑500 m 2 / g, the weight ratio of silicon oxide to metal ions is (5000‑200000):1. The catalyst has a low attrition index and can effectively improve the selectivity of caprolactam when used in the gas-phase Beckmann rearrangement reaction of cyclohexanone oxime in a fluidized bed process.
Owner:CHINA PETROLEUM & CHEM CORP +1
Preparation method of spherical MFI topological structure all-silicon molecular sieve catalyst containing trace rare earth ions and preparation method of caprolactam
ActiveCN109833898BImprove conversion rateImprove performanceLactams preparationMolecular sieve catalystsMolecular sievePtru catalyst
The invention relates to the field of all-silicon molecular sieves, and discloses a preparation method of a spherical MFI topological structure all-silicon molecular sieve catalyst containing trace rare earth ions and a caprolactam preparation method. The preparation method of the spherical MFI topological structure all-silicon molecular sieve catalyst comprises: a. Silicon source, rare earth ion source, organic template and water are mixed to obtain a colloidal mixture; b. The colloidal mixture is subjected to two-stage variable temperature hydrothermal crystallization to obtain a crystallization product; c. Washing and separation of the crystallization product to obtain a rare earth-containing ionic all-silicon molecular sieve; d, the all-silicon molecular sieve containing rare earth ions is shaped, roasted, and post-treated with an alkaline buffer solution of nitrogen-containing compounds, and then washed, separated, and dried to obtain a spherical all-silicon molecular sieve containing a very small amount of rare earth ions Silicon molecular sieve catalyst. The method can effectively change the performance of the all-silicon molecular sieve catalyst, and the application of the catalyst in the production of caprolactam can achieve better results.
Owner:ZHEJIANG HENGYI PETROCHEMICAL RES INST CO LTD
Ligustrazine microcosmic salt liposome medicine and preparing method
InactiveCN100586421CSmall doseGood curative effectOrganic active ingredientsPharmaceutical non-active ingredientsAdditive ingredientPhosphate
The invention relates to a tetramethylpyrazine phosphate liposome drug and a preparation method; wherein, the drug is characterized in that: the effective efficacy components and weight accounts of the liposome drug are as following: a mixture 200 to330 with a weight ratio 4 to 1 of egg yolk lecithin and sheep cerebral lecithin, a mixture 170 to 280 with a weight ratio 3 to 1of stigmasterol and campestrol, reduction glutathione 2.5 to 10, tetramethylpyrazine phosphate 15 to 25, a mixture 720 to 1200 with a weight ratio 1 : 0.01 to 0.05 : 0.02 to 0.07 of tert-butyl alcohol, ethanol, acetone, amixture 140 to 160 with a weight ratio 4:05 to 1 of polyethylene glycol-2000 and tween 801, and hydroxyl propyl methyl cellulose 100 to 120. The invention also provides the preparation method for theliposome drugs. The invention has the advantages of adopting the provided drugs, enabling to decrease the drug dosage by two third and once a day, and improving the efficacy above fifteen percent.
Owner:HUNAN KANGDU PHARMA
A solanesol derivative with tumor tissue reduction sensitivity, its preparation method and application
InactiveCN107090082BAchieve long cycleAchieving passive targetingPharmaceutical non-active ingredientsEmulsion deliverySide effectTumor targeting
The invention discloses a solanesol ramification of reductive sensibility of tumor tissue. The ramification structure is shown in the prediction. While serving as a micelle for carrying medicine, the solanesol ramification is characterized in that (1) the nano-scale grain size is smaller than 1000 nm, and the granulometric distribution is even and stable; (2) by means of the hydrophilic shell of polyethylene glycol and the nano-scale grain size, the long circulation of nano particles and passive targeting of EPR are achieved; (3) in the effect of the active targeting capable of reducing sensibility, the reductive material GSH which is richly contained in tumour cytoplasm can be utilized to achieve triggered-type drug release in tumor tissue portions; (4) the solanesol ramification has an excellent ability of loading hydrophobic anti-cancer drugs, a high drug loading capacity and great stability;(5) since the solanesol ramification has a great tumor targeting, medicine is more released in tumor tissue and less released in normal tissue, therefore the toxic and side effect performed on the normal tissue is decreased;(6) since the hydrophobic solanesol has an effect of inhibiting tumor cells and sensibilization of anti-cancer medicine, the inhibiting effect of tumor cells in anti-cancer medicine is enhanced.
Owner:HENAN UNIVERSITY
A kind of multi-component low-carbon hydrocarbon adsorption and desorption evaluation device and method
ActiveCN110940752BAchieve pressurizationAchieve long cycleComponent separationSorbentPhysical chemistry
The present invention discloses a diversified low -carbon hydrocarbon adsorption and absorbing evaluation device and method. Its devices include gas supply systems, dual -channel switching system I, adsorption and absorbing system, dual -channel switching system II, chromatography analysis system, tail gas emissions system, relieving inhalation absorbing absorbing systemSystems, adsorbent discharge and analysis systems, adsorbent online feeding systems and blowing conveyor gas source systems; the present invention uses advanced dual -channel switching systems, gas supply systems, high temperature inert gas relieving adsorption systems and adsorbent analysis systems.The pressurization of various sample gas and adsorbents, long cycle, and dual -channel adsorption and absorbing evaluation have the characteristics of simple operation and online reading results, and have good expansion and market prospects.
Owner:SHAANXI YANCHANG PETROLEUM GRP
Medicine composition of alprostadil and Chuanhuning/Yanhuning liposome and its preparation
InactiveCN101019869BInhibition of reproductionIncrease oxygen capacityOrganic active ingredientsPowder deliveryYolkVitamin C
The present invention relates to medicine composition of alprostadil and Chuanhuning / Yanhuning liposome and its preparation process. The nanometer liposome medicine contains the mixture of alprostadil and Chuanhuning / Yanhuning in the weight ratio of 0.1-1.0 to 50-300 in 10.1-80.2 weight portions, the mixture of soybean lecithin and yolk lecithin in the weight ratio of 4 to 1 in 88-440 weight portions, the mixture of cholesterol and beta-sitosterol n the weight ratio of 9 to 1 in 40-200, polyethylene glycol in 4000 15-40 weight portions, sodium glucuronate in 100 -280 weight portions and vitamin C in 160-800 weight portions. The medicine of the present invention may be used in antagonizing pneumonia adenovirus and influenza virus.
Owner:江苏德伦生物制药有限公司
Use of Polyethylene Glycol Derivatives-Small Molecule Drug Conjugate Polymer Micelle in Inflammation Targeted Drug Delivery System
ActiveCN106139159BImprove stabilityAchieve long cycleOrganic active ingredientsAntipyreticDrug conjugationPolyethylene glycol
The invention provides an application of pH (potential of hydrogen) sensitive polyethylene glycol derivative and small molecule drug conjugate in a formula (I) and polymer micelle thereof as an inflammatory targeting delivery system and a preparation method of the pH sensitive polyethylene glycol derivative and small molecule drug conjugate. A portion B includes a small molecule drug D with inflammatory disease treating activity, and a portion A includes a polyethylene glycol derivative carrier system. The pH sensitive polyethylene glycol derivative and small molecule drug conjugate polymer micelle has good inflammatory targeting property, the concentration of the drug in the portion B at a low-pH inflammatory site can be remarkably increased, or staying time of the drug at the low-pH inflammatory site can be prolonged, or the anti-inflammatory effect of the drug can be enhanced.
Owner:SICHUAN UNIV
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