47results about How to "Achieve long cycle" patented technology

The invention belongs to the new technical field of a drug preparation and in particular relates to a precursor liposome containing a glycyrrhetinic acid and a method for preparing the same. The precursor liposome containing the glycyrrhetinic acid consists of glycyrrhetinic acid, phospholipids, cholesterol, a surfactant and a water-soluble material; a suspension solution of the glycyrrhetinic acid liposome is prepared by an ethanol injection method or a thin-film dispersion method; and solid liposome powder is prepared by a freeze drying method or a spray drying method. The precursor liposome has simple process and good repeatability, is suitable for industrialized production; through drug administration by intravenous injection, the precursor liposome has long-circulating function, can remarkably reduce the toxicity of drug and achieve the function of prolonging the drug effect; and through oral administration, a solid preparation of the liposome can increase absorption and improve bioavailability by three to five times.

The invention discloses a preparation method of RGD-modified ultra-small magnetic iron oxide nanoparticles. The preparation method comprises the following steps: preparing ultra-small magnetic iron oxide nanoparticles by taking ferric acetylacetonate as a reaction raw material and a precursor, taking oleylamine as a surfactant and a reducing agent and taking dibenzyl ether as a solvent; replacing oleylamine molecules wrapped on the surfaces of the nanoparticles by utilizing dopamine-modified HOOC-PEG-COOH to realize PEG-modification of the surfaces of the nanoparticles; and finally, chemically coupling RGD cyclic peptide by virtue of free carboxyl at the tail end of the PEG to obtain the RGD-modified ultra-small magnetic iron oxide nanoparticles. The method of synthesizing the ultra-small magnetic iron oxide nanoparticles has the characteristics of a simple process, a high raw material conversion ratio, strong repeatability and the like. The synthesized magnetic iron oxide nanoparticles have the characteristics of a regular morphology, an ultra-small dimension, good stability, good monodispersity, high biocompatibility, and tumor specific targeting, and the like, and can be used as a T1-weighted imaging high-performance magnetic resonance imaging contrast agent with a tumor active targeting function.

The invention discloses a preparation method for a Silicate-1 molecular sieve catalyst, the Silicate-1 molecular sieve catalyst prepared by the method and a method for preparing caprolactam from cyclohexanone oxime. The preparation method for the Silicate-1 molecular sieve catalyst comprises the steps: a. mixing a silicon source, a metal ion source, an organic template agent and water, so as to obtain a colloidal mixture; b. subjecting the colloidal mixture obtained in the step a to hydrothermal crystallization, so as to obtain a crystallized product; c. subjecting the crystallized product obtained in the step b to washing and separating treatment, so as to obtain metal ion containing Silicate-1 molecular sieves; and d. subjecting the metal ion containing Silicate-1 molecular sieves obtained in the step c to forming treatment, roasting treatment and aftertreatment by an alkaline buffer solution of a nitrogen containing compound, and carrying out washing, separating and drying, thereby obtaining the Silicate-1 molecular sieve catalyst containing trace metal ions. By adopting the method, the performance of the Silicate-1 molecular sieve catalyst can be effectively changed; and by applying the catalyst to the production of the caprolactam, an unexpected result can be achieved.

The invention relates to an antineoplastic prodrug with a P-glycoprotein inhibition function. The antineoplastic prodrug is an amphiphilic substance formed by connecting antineoplastic drugs and chitosan-polyethlyene glycols-succinate with the P-glycoprotein inhibition function through a connector in a covalent mode. The connector comprises a sensitive bond and at least two reaction functional groups respectively used for connecting the antineoplastic drugs and the chitosan-polyethlyene glycols-succinate in a covalent mode, wherein the sensitive bond is a chemical bond which is easily broken under a reducing environment or an acid environment in a tumor cell. The antineoplastic prodrug with the P-glycoprotein inhibition function is expected to effectively treat tumors and drug-fast tumors.

The invention discloses an amphiphilic waterborne segmented copolymer medicament carrier with pH responsiveness and biodegradability and a preparation method thereof. An amphiphilic waterborne segmented copolymer consists of a chain segment which is modified with polyphosphoester and polymethacrylate hydroxyethyl and contains carboxyl. A polyanion chain segment can be reversely converted into a hydrophilic or hydrophobic chain segment by adjusting the pH value of a medium. The amphiphilic polymer is self-assembled into a micelle under the condition of certain PH, and a shell of the micelle formed by a hydrophilic polyphosphoester chain segment can be used for better stabilizing the micelle. A hydrophobic polyanionic chain segment is used for forming an inner core of the micelle, is used for coating a hydrophobic medicament, and serves as a medicament carrier. The polyphosphoester chain segment has high biocompatibility and high biodegradability, and long in-vivo circulation of a medicament-carrying micelle can be realized. Under a weakly alkaline condition, the aims of dissociating the micelle, releasing a medicament and realizing controllable release are fulfilled.

The invention discloses medicine carrying polymer micelle which is methyl polyethylene glycol polylactic acid segmented copolymer micelle carried with hydrophobicity drugs; the grain size is 50-100nm, and the dispersion coefficient PI of the grains is more than or equal to 0.05 and is less than or equal to 0.09; the invention further discloses a preparation method of the medicine carrying polymer micelle; the grain size of the medicine carrying polymer micelle is small, the grain size distribution range is centralized, the stability is good, and the in vitro releasing experiment and the in vitro macrophagocyte cytophagy experiment can reach good effect. The preparation method of the medicine carrying polymer micelle has the following characteristics: the operation is simple and convenient; the encapsulating rate is high, and the highest encapsulating rate can be up to more than 90%; in addition, the prepared medicine carrying polymer micelle has good performance.

The invention relates to a synthesis method of a sodium titanate nanoribbon/titanium carbide nanosheet compound. The method comprises the following steps: slowly adding Ti3AlC2 powder into a hydrofluoric acid solution, and then stirring under the condition of heating for carrying out a reaction; after the reaction is finished, cooling, washing, carrying out ultrasonic treatment, and freeze-dryingto obtain two-dimensional layered Ti3C2; adding the obtained two-dimensional layered Ti3C2 into a strong alkaline solution with a certain concentration, enabling the mixed solution to react at the room temperature under the condition of magnetic stirring, washing, centrifuging, and carrying out vacuum drying to obtain the sodium titanate nanoribbon/titanium carbide nanosheet compound. The sodium titanate nanoribbon/titanium carbide nanosheet compound is simple in preparation method, high in controllability, novel in morphology, uniform in size distribution, stable in structure and good in repeatability; furthermore, sodium titanate grows on titanium carbide nanosheets in situ and is in good electrical contact with the titanium carbide nanosheets, so that rapid electron transfer is facilitated. When being used as an electrode material for lithium ion batteries and sodium ion batteries, the sodium titanate nanoribbon/titanium carbide nanosheet compound shows good electrochemical performance.

The invention discloses a silicon-carbon negative electrode material. The composite material is of a core-shell structure, and the core-shell structure sequentially comprises a silicon core, a cavity layer, a lithium silicate layer and a carbon layer from inside to outside; the silicon core is micron silicon, micropores are distributed in the lithium silicate layer, and the carbon layer coats the lithium silicate layer. The micron silicon is wide in source, low in cost, high in controllability of the preparation process and suitable for large-scale production, the hollow layer and the micropore structure provide a space for volume expansion and shrinkage in the charging and discharging process, the expansion rate of the powder is greatly reduced, structural collapse is avoided, the structure is stable, the reversible capacity is high, and the cycle performance is good. The material has a wide application prospect as a negative electrode material of a lithium ion battery. Through oxidation, heat treatment, etching and carbon coating, the preparation method is simple and feasible in process, free of pollution, simple in equipment, small in investment and suitable for large-scale production.

The invention provides a genetic engineering subunit vaccine for preventing a new variant of a chicken infectious bursal disease virus. The new variant is an IBDV FJ-1812 strain. The effective component of the genetic engineering subunit vaccine is VP2 protein expressed after codon optimization and transformation of the gene sequence of the variant, and a nucleotide sequence of the VP2 protein isshown as SEQ ID NO. 1; a genetically engineered bacterium with a VP2 protein expression region as shown in SEQ ID NO.1 of an IBDV FJ-1812 strain is constructed, and induced expression and purificationare carried out to obtain VP2 protein, and the VP2 protein with a pharmaceutically acceptable adjuvant are uniformly mixed to prepare the genetic engineering subunit vaccine of the IBDV new variant.According to the invention, the new variant IBDV FJ-1812 strain is discovered for the first time, an expression vector and engineering bacteria capable of expressing the VP2 protein are constructed for the variant, and the expressed VP2 protein is the soluble and antigenic protein.

The present invention relates to medicine composition of alprostadil and Chuanhuning/Yanhuning liposome and its preparation process. The nanometer liposome medicine contains the mixture of alprostadil and Chuanhuning/Yanhuning in the weight ratio of 0.1-1.0 to 50-300 in 10.1-80.2 weight portions, the mixture of soybean lecithin and yolk lecithin in the weight ratio of 4 to 1 in 88-440 weight portions, the mixture of cholesterol and beta-sitosterol n the weight ratio of 9 to 1 in 40-200, polyethylene glycol in 4000 15-40 weight portions, sodium glucuronate in 100 -280 weight portions and vitamin C in 160-800 weight portions. The medicine of the present invention may be used in antagonizing pneumonia adenovirus and influenza virus.

The invention relates to the field of all-silicon molecular sieves and discloses a preparation method of a trace rear earth ion-containing spherical MFI topological structured all-silicon molecular sieve catalyst and a preparation method of caprolactam. The preparation method of the spherical MFI topological structured all-silicon molecular sieve catalyst comprises the following steps: a, mixing asilicon source, a rare earth ion source, an organic template and water to obtain a colloid admixture; b, carrying out two-stage variable-temperature hydrothermal crystallization on the colloid admixture to obtain a crystallization product; c, washing the crystallization product and carrying out separation treatment to obtain rare earth ion-containing all-silicon molecular sieve; and d, moulding the rare earth ion-containing all-silicon molecular sieve, roasting and postprocessing with a nitrogen compound-containing alkaline buffer solution, washing, separating, and drying to obtain the spherical all-silicon molecular sieve catalyst containing trace rear earth ions. By the method, performance of the all-silicon molecular sieve catalyst can be changed effectively. By applying the catalyst to production of caprolactam, a good effect can be achieved.

The invention relates to preparation and application of a cotransport system of a Mn<2+> donor and chloroquine drugs. According to the preparation and the application, the problems of low pesticide effect, large required dosage, poor targeting ability and serious toxic and side effects of tumor treating drugs can be effectively solved. According to the technical scheme, double-layer hollow mesoporous manganese sesquioxide nanoparticles are synthesized by virtue of a hydrothermal method, hyaluronic acid and the double-layer hollow mesoporous manganese sesquioxide nanoparticles are linked through chemical bonds so as to spontaneously form a nano-layer in a water medium, and then a chloroquine anti-tumor drug enters mesoporous structures of the double-layer hollow mesoporous manganese sesquioxide nanoparticles through a physical effect. According to the drug-cooperated cotransport system, the dosage and toxic and side effects of the drug can be effectively reduced, the treating efficiency of the drug can be improved, the solubility problem of the drug can be effectively solved, and the effective loading of the drug and the controlled release of the drug at target sites of tumors can be realized; the dispersity and biocompatibility of magnetic carriers are improved, the long circle, the active targeting and the fixed-point gate-controlled release of the drug are realized; and furthermore, the preparation process is simple, energy saving, environmentally friendly and low in cost, the industrial production can be realized, and the preparation process is the innovation of the tumor treating drugs.

The invention discloses a nano preparation loaded with an anti-pulmonary fibrosis medicament and an immunomodulator and a preparation method thereof. The nanometer preparation is loaded with the anti-pulmonary fibrosis medicament and the immunomodulator at the same time, and the two medicaments are adopted to synergistically regulate and control the pulmonary fibrosis microenvironment to achieve the purpose of strengthening pulmonary fibrosis treatment through immunomodulation. Additionally, a nano preparation modified by a metalloproteinase-2(MMP-2) specific sensitive peptide segment and a carrier of the nano preparation are utilized to realize rapid massive release of therapeutic medicaments including the immunomodulator and the anti-pulmonary fibrosis medicament by means of the MMP-2 specific sensitive peptide segment, and therefore a new way and strategy for strengthening the treatment of pulmonary fibrosis are provided.

The invention relates to a preparation method of a long-circulation multifunctional metal organic framework nano-preparation, which comprises the following steps: preparing a GA/Fe nano-composite with moderate particle size by taking PVP (Polyvinyl Pyrrolidone) as a mineralizer, and then obtaining white nano-particles; white nano-particles are dissolved and soaked in a hyaluronic acid solution for incubation, and the multifunctional metal organic framework nano-preparation is prepared; the preparation has excellent biocompatibility, tumor targeting ability, bimodal imaging function and combined CDT/hunger therapy/chemotherapy ability, in-situ imaging and treatment of tumors can be realized at the same time, stealth can be realized in vivo due to doping of polyethylene glycol, long circulation is realized, the preparation has good targeting ability, and the preparation has good application prospects. A PVA/Fe nano-composite based on polyvinylpyrrolidone is packaged, so that the preparation simultaneously realizes a T2 imaging effect based on Fe < 3 + >, the spatial position of a tumor can be accurately obtained, and gallic acid can reduce Fe < 3 + > generated by a Fenton reaction and accelerate the Fenton reaction to generate. OH to effectively kill tumor cells; good application prospects are realized in tumor treatment.

The invention provides an application of pH (potential of hydrogen) sensitive polyethylene glycol derivative and small molecule drug conjugate in a formula (I) and polymer micelle thereof as an inflammatory targeting delivery system and a preparation method of the pH sensitive polyethylene glycol derivative and small molecule drug conjugate. A portion B includes a small molecule drug D with inflammatory disease treating activity, and a portion A includes a polyethylene glycol derivative carrier system. The pH sensitive polyethylene glycol derivative and small molecule drug conjugate polymer micelle has good inflammatory targeting property, the concentration of the drug in the portion B at a low-pH inflammatory site can be remarkably increased, or staying time of the drug at the low-pH inflammatory site can be prolonged, or the anti-inflammatory effect of the drug can be enhanced.

The invention relates to the field of all silicon-1 molecular sieves and discloses a trace rare earth ion containing all silicon-1 molecular sieve based catalyst with a microspheric MFI topological structure and a spray shaping preparation method thereof. The trace rare earth ion containing all silicon-1 molecular sieve based catalyst with the microspheric MFI topological structure comprises 70-95wt% of all silicon-1 molecular sieve and containing an extremely trace amount of rare earth ions and 5-30 wt% of an adhesive according to the dry basis weight percentage; the particle size of the trace rare earth ion containing all silicon-1 molecular sieve based catalyst with the microspheric MFI topological structure is 20-400 (m, and the abrasion index K of the catalyst is less than 5; the BETspecific surface area of the all silicon-1 molecular sieve is 400-500 square meters/g; and the weight ratio of silicon oxide and the rare earth ions is (10000-200000):1. The trace rare earth ion containing all silicon-1 molecular sieve based catalyst with the microspheric MFI topological structure, disclosed by the invention, has the advantages that the abrasion index of the catalyst is low, andthe technological economy of a new process can be effectively improved when the catalyst is used for vapor phase Beckmann rearrangement reaction of cyclohexanone-oxime in a fluidized bed process.

The invention discloses a preparation method of an amphipathic polysaccharide-folic acid-fatty acyl-chondroitin sulfate which contains a folate-targeted group and takes an amphipathic of chondroitin sulfate as a hydrophilic chain segment and a long-chain fatty acid as a hydrophobic chain segment as well as an application thereof in the aspect of adriamycin amycin antitumor pharmaceutical preparations. The average molecular weight (Mw) of the folic acid-fatty acyl-chondroitin sulfate is 3100-53000Da. The general formula of the folic acid-fatty acyl-chondroitin sulfate is shown in the specification, wherein x which is the number of carbon atoms is an integer ranging from 10 to 22; y which is the number of double bonds is an integer ranging from 0 to 6; n is an integer ranging from 8 to 150; O-alkyl substitution degree is 5-50%; folic acid substitution degree is 0.5-2%.