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Medicine composition of alprostadil and Chuanhuning/Yanhuning liposome and its prepn

A technology of alprostadil and Yanhuning, applied in the field of alprostadil and Chuanhuning/Yanhuning liposome combination medicine and preparation thereof, can solve the problems of pyrogen-like reaction, allergic reaction, liver function damage, etc. Use dose, improve the therapeutic index, and promote the effect of hepatocyte regeneration

Inactive Publication Date: 2007-08-22
江苏德伦生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing Chuanhuning and Yanhuning drugs have liver function damage, allergic reactions, and pyrogen-like reactions

Method used

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  • Medicine composition of alprostadil and Chuanhuning/Yanhuning liposome and its prepn
  • Medicine composition of alprostadil and Chuanhuning/Yanhuning liposome and its prepn
  • Medicine composition of alprostadil and Chuanhuning/Yanhuning liposome and its prepn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] This embodiment provides a kind of nano liposome drug, comprising alprostadil and Chuanhuning / Yanhuning, comprising the following raw materials in parts by weight:

[0031] Alprostadil and Chuanhuning / Yanhuning

[0032] Mixture 80.2 in a weight ratio of 0.1:300;

[0033] 4:1 mixture of soybean lecithin and egg yolk lecithin in weight ratio 440;

[0034] Cholesterol and β-sitosterol weight ratio 9: 1 mixture 200;

[0035] Macrogol 4000 40;

[0036] Sodium Glucuronate 280;

[0037] Vitamin C 800.

[0038] The Chuanhuning / Yanhuning refers to the mixture of Chuanhuning and Yanhuning in a weight ratio of 3:1 or Chuanhuning alone.

[0039] The preparation method of above-mentioned medicine, the steps are as follows:

[0040] (1) Get the mixture of Alprostadil and Chuanhuning / Yanhuning weight ratio 0.1: 300, soybean lecithin and egg yolk lecithin mixture, cholesterol and β-sitosterol weight ratio 9: 1 mixture dissolved in ethanol or ether In, make a solution;

[0041] ...

Embodiment 2

[0052] This embodiment provides a kind of nano liposome drug, comprising alprostadil and Chuanhuning / Yanhuning, comprising the following raw materials in parts by weight:

[0053] Alprostadil and Chuanhuning / Yanhuning

[0054] Mixture 10.1 in a weight ratio of 0.1:500;

[0055] 4:1 mixture of soybean lecithin and egg yolk lecithin by weight 88;

[0056] 9:1 ​​mixture of cholesterol and β-sitosterol by weight 40;

[0057] Polyethylene glycol 4000 15;

[0058] Sodium Glucuronate 100;

[0059] Vitamin C 160.

[0060] The Chuanhuning / Yanhuning refers to the mixture of Chuanhuning and Yanhuning in a weight ratio of 2:1 or Chuanhuning alone.

[0061] The preparation method of above-mentioned medicine refers to embodiment 1.

[0062] The curative effect verification of the medicine prepared in the present embodiment is as follows:

[0063] Induce pneumonia model mice with A1 type influenza virus, 18-20 grams in weight, with 20μg / kg alprostadil / 10mg / kg Yanhuning / Chuanhuning (trea...

Embodiment 3

[0067] This embodiment provides a kind of nano liposome drug, comprising alprostadil and Chuanhuning / Yanhuning, comprising the following raw materials in parts by weight:

[0068] Alprostadil and Chuanhuning / Yanhuning

[0069] Mixture 80.2 in weight ratio 1.0:266;

[0070] 4:1 mixture of soybean lecithin and egg yolk lecithin by weight 88;

[0071] Cholesterol and β-sitosterol weight ratio 9: 1 mixture 200;

[0072] Polyethylene glycol 4000 15;

[0073] Sodium Glucuronate 100;

[0074] Vitamin C 800.

[0075] The Chuanhuning / Yanhuning refers to the mixture of Chuanhuning and Yanhuning in a weight ratio of 3:1 or Yanhuning alone.

[0076] The preparation method of above-mentioned medicine refers to embodiment 1.

[0077] The curative effect verification of the medicine prepared in the present embodiment is as follows:

[0078] Induce pneumonia model mice with A1 type influenza virus, 18-20 grams in weight, with 300μg / kg alprostadil 80mg / kg Yanhuning / Chuanhuning (treatmen...

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Abstract

The present invention relates to medicine composition of alprostadil and Chuanhuning / Yanhuning liposome and its preparation process. The nanometer liposome medicine contains the mixture of alprostadil and Chuanhuning / Yanhuning in the weight ratio of 0.1-1.0 to 50-300 in 10.1-80.2 weight portions, the mixture of soybean lecithin and yolk lecithin in the weight ratio of 4 to 1 in 88-440 weight portions, the mixture of cholesterol and beta-sitosterol n the weight ratio of 9 to 1 in 40-200, polyethylene glycol in 4000 15-40 weight portions, sodium glucuronate in 100 -280 weight portions and vitamin C in 160-800 weight portions. The medicine of the present invention may be used in antagonizing pneumonia adenovirus and influenza virus.

Description

technical field [0001] The invention relates to a combination medicine of alprostadil and Chuanhuning / Yanhuning liposome and a preparation method thereof. Background technique [0002] Chuanhuning / Yanhuning are the first-choice anti-pneumonia adenovirus and influenza virus drugs for adults and children in clinical practice. The active metabolites of Chuanhuning / Yanhuning in the body are the same substance, because Yanhuning is the extract of the plant Andrographis paniculata - andrographolide Dehydrated andrographolide succinate half-ester potassium and sodium salt refined through esterification, dehydration, and salt formation, while Chuanhuning is the monopotassium salt of andrographolide half-ester. The existing Chuanhuning and Yanhuning drugs have liver function damage, allergic reaction, and pyrogen-like reaction. After eliminating or improving their adverse reactions, both have broad prospects for clinical application. Contents of the invention [0003] In order to...

Claims

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Application Information

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IPC IPC(8): A61K31/5575A61K9/127A61K9/19A61K9/20A61K9/48A61K9/72A61K47/24A61K47/34A61P31/16A61P31/20A61P11/00A61K31/365A61K47/10
Inventor 蔡海德
Owner 江苏德伦生物制药有限公司
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