Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Medicine composition of alprostadil and Chuanhuning/Yanhuning liposome and its prepn

A technology of alprostadil and Yanhuning, applied in the field of alprostadil and Chuanhuning/Yanhuning liposome combination medicine and preparation thereof, can solve the problems of pyrogen-like reaction, allergic reaction, liver function damage, etc. Use dose, improve the therapeutic index, and promote the effect of hepatocyte regeneration

Inactive Publication Date: 2007-08-22
江苏德伦生物制药有限公司
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing Chuanhuning and Yanhuning drugs have liver function damage, allergic reactions, and pyrogen-like reactions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicine composition of alprostadil and Chuanhuning/Yanhuning liposome and its prepn
  • Medicine composition of alprostadil and Chuanhuning/Yanhuning liposome and its prepn
  • Medicine composition of alprostadil and Chuanhuning/Yanhuning liposome and its prepn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] This embodiment provides a kind of nano liposome drug, comprising alprostadil and Chuanhuning / Yanhuning, comprising the following raw materials in parts by weight:

[0031] Alprostadil and Chuanhuning / Yanhuning

[0032] Mixture 80.2 in a weight ratio of 0.1:300;

[0033] 4:1 mixture of soybean lecithin and egg yolk lecithin in weight ratio 440;

[0034] Cholesterol and β-sitosterol weight ratio 9: 1 mixture 200;

[0035] Macrogol 4000 40;

[0036] Sodium Glucuronate 280;

[0037] Vitamin C 800.

[0038] The Chuanhuning / Yanhuning refers to the mixture of Chuanhuning and Yanhuning in a weight ratio of 3:1 or Chuanhuning alone.

[0039] The preparation method of above-mentioned medicine, the steps are as follows:

[0040] (1) Get the mixture of Alprostadil and Chuanhuning / Yanhuning weight ratio 0.1: 300, soybean lecithin and egg yolk lecithin mixture, cholesterol and β-sitosterol weight ratio 9: 1 mixture dissolved in ethanol or ether In, make a solution;

[0041] ...

Embodiment 2

[0052] This embodiment provides a kind of nano liposome drug, comprising alprostadil and Chuanhuning / Yanhuning, comprising the following raw materials in parts by weight:

[0053] Alprostadil and Chuanhuning / Yanhuning

[0054] Mixture 10.1 in a weight ratio of 0.1:500;

[0055] 4:1 mixture of soybean lecithin and egg yolk lecithin by weight 88;

[0056] 9:1 ​​mixture of cholesterol and β-sitosterol by weight 40;

[0057] Polyethylene glycol 4000 15;

[0058] Sodium Glucuronate 100;

[0059] Vitamin C 160.

[0060] The Chuanhuning / Yanhuning refers to the mixture of Chuanhuning and Yanhuning in a weight ratio of 2:1 or Chuanhuning alone.

[0061] The preparation method of above-mentioned medicine refers to embodiment 1.

[0062] The curative effect verification of the medicine prepared in the present embodiment is as follows:

[0063] Induce pneumonia model mice with A1 type influenza virus, 18-20 grams in weight, with 20μg / kg alprostadil / 10mg / kg Yanhuning / Chuanhuning (trea...

Embodiment 3

[0067] This embodiment provides a kind of nano liposome drug, comprising alprostadil and Chuanhuning / Yanhuning, comprising the following raw materials in parts by weight:

[0068] Alprostadil and Chuanhuning / Yanhuning

[0069] Mixture 80.2 in weight ratio 1.0:266;

[0070] 4:1 mixture of soybean lecithin and egg yolk lecithin by weight 88;

[0071] Cholesterol and β-sitosterol weight ratio 9: 1 mixture 200;

[0072] Polyethylene glycol 4000 15;

[0073] Sodium Glucuronate 100;

[0074] Vitamin C 800.

[0075] The Chuanhuning / Yanhuning refers to the mixture of Chuanhuning and Yanhuning in a weight ratio of 3:1 or Yanhuning alone.

[0076] The preparation method of above-mentioned medicine refers to embodiment 1.

[0077] The curative effect verification of the medicine prepared in the present embodiment is as follows:

[0078] Induce pneumonia model mice with A1 type influenza virus, 18-20 grams in weight, with 300μg / kg alprostadil 80mg / kg Yanhuning / Chuanhuning (treatmen...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to medicine composition of alprostadil and Chuanhuning / Yanhuning liposome and its preparation process. The nanometer liposome medicine contains the mixture of alprostadil and Chuanhuning / Yanhuning in the weight ratio of 0.1-1.0 to 50-300 in 10.1-80.2 weight portions, the mixture of soybean lecithin and yolk lecithin in the weight ratio of 4 to 1 in 88-440 weight portions, the mixture of cholesterol and beta-sitosterol n the weight ratio of 9 to 1 in 40-200, polyethylene glycol in 4000 15-40 weight portions, sodium glucuronate in 100 -280 weight portions and vitamin C in 160-800 weight portions. The medicine of the present invention may be used in antagonizing pneumonia adenovirus and influenza virus.

Description

technical field [0001] The invention relates to a combination medicine of alprostadil and Chuanhuning / Yanhuning liposome and a preparation method thereof. Background technique [0002] Chuanhuning / Yanhuning are the first-choice anti-pneumonia adenovirus and influenza virus drugs for adults and children in clinical practice. The active metabolites of Chuanhuning / Yanhuning in the body are the same substance, because Yanhuning is the extract of the plant Andrographis paniculata - andrographolide Dehydrated andrographolide succinate half-ester potassium and sodium salt refined through esterification, dehydration, and salt formation, while Chuanhuning is the monopotassium salt of andrographolide half-ester. The existing Chuanhuning and Yanhuning drugs have liver function damage, allergic reaction, and pyrogen-like reaction. After eliminating or improving their adverse reactions, both have broad prospects for clinical application. Contents of the invention [0003] In order to...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/5575A61K9/127A61K9/19A61K9/20A61K9/48A61K9/72A61K47/24A61K47/34A61P31/16A61P31/20A61P11/00A61K31/365A61K47/10
Inventor 蔡海德
Owner 江苏德伦生物制药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com