Amphiphilic waterborne segmented copolymer medicament carrier with pH responsiveness and biodegradability and preparation thereof
A block copolymer and degradability technology, applied in the field of dual hydrophilic block copolymer drug carrier and preparation thereof
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Example Embodiment
[0074] Example 1: Preparation of macromolecular ATRP initiator PEEP 32 The specific synthesis method of -Br:
[0075] (1) After drying the round-bottomed flask with the branch tube in the stirring bar for at least 24 hours in an oven at 120 °C, plug it with a glass stopper, connect it with an oil pump through a latex tube and pump it to room temperature, then pass in high-purity argon gas, and pump it again. Vacuum, and so on three times.
[0076] (2) inject a certain amount of initiator bromoisobutyric acid-2-hydroxyethyl ester (HEBI) (0.14g, 0.66mmol), 2-ethoxy-2-oxo-1 from the branch pipe in turn with a dry syringe , 3,2-dioxaphosphalane (EEP) monomer (4g, 26mmol) and Sn(Oct) 2 (EEP monomer: Sn(Oct) 2 =1:0.002, mass ratio), anhydrous tetrahydrofuran (15 mL) was used as solvent. After the reaction flask was filled with argon, the reaction was stirred for 1 h in an oil bath at 40°C.
[0077] (3) after the reaction finishes, most solvent tetrahydrofuran is removed by rota...
Example Embodiment
[0080] Example 2: Diblock copolymer PEEP 32 -b-PHEMA 128 The specific preparation method:
[0081] (a) After the branched round-bottomed flask is treated according to the above method, it is filled with argon, and PEEP is quickly weighed and added. 32 -Br (2.25g, 0.45mmol), cuprous bromide (0.06g, 0.45mmol) and bipyridine (0.14g, 0.45mmol) (the molar ratio of the three is 1:1:1), after repeated three times of evacuation , inject 5 mL of solvent anhydrous methanol, stir until the mixture is completely dissolved, and the solution is brown.
[0082] (b) The round-bottomed flask was moved to the oil bath, and the monomer hydroxyethyl methacrylate (HEMA) (8.7 g, 67.5 mmol) was added with a dry syringe, and PEEP was used. 32 The terminal bromine in the -Br homopolymer was used as an initiator to initiate the ATRP reaction, and the reaction was stirred in an oil bath at 30 °C for 6 h.
[0083] (c) after the completion of the reaction, contact with air to terminate the reaction, t...
Example Embodiment
[0084] Example 3: pH-responsive dual hydrophilic block copolymer PEEP 32 -b-PSEMA 128 The specific synthesis method:
[0085] (1) After the branched round-bottomed flask was treated according to the above method, it was filled with argon, and the above-mentioned two-block polymer PEEP dissolved in 10 mL of anhydrous pyridine was rapidly added 32 -b-PHEMA 128 (3g, the mole number of hydroxyl (HO-) is 16.64mmol), add succinic anhydride under magnetic stirring (3.328g, 33.28mmol) (the molar ratio of hydroxyl group and succinic anhydride is 1:2), and reacted at room temperature for 48h.
[0086] (2) after the reaction finishes, the reaction solution is precipitated in 150mL ice anhydrous ether to remove solvent and unreacted monomer, after repeated precipitation 3 times, the product obtained after the precipitation is dissolved in deionized water and dialyzed (select dialysis Bag retention 3500g mol -1 ) 2 to 3 days, and finally the dialysis solution was freeze-dried to obta...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap