5results about How to "Good pH responsiveness" patented technology

The invention discloses a hyperbranched nano POSS (Polyhedral Oligomeric Silsesquioxane) material, a hyperbranched nano POSS active material as well as a preparation method and application of the hyperbranched nano POSS material and the hyperbranched nano POSS active material, the hyperbranched nano POSS material is grafted and modified on the basis of a polyhedral oligomeric silsesquioxane nano material matrix and is used as a base material, and the base material, organic amine and a surfactant are prepared into a hyperbranched response type oily sludge circulating cleaning material NM-POSS. The NM-POSS has excellent pH response performance, and the state of the emulsion can be changed by adjusting the pH, so that the NM-POSS can be recycled after being cleaned; the cleaning agent also has excellent cleaning performance, and the oil content of bottom mud can be reduced to 2% or below when different oily sludge is cleaned, so that the requirement for cleaning different oily sludge is met.

The present invention proposes an acid-reducing and fertilizing improver for red soil rice fields, a preparation method and an improvement method thereof, and belongs to the technical field of soil improvement. After the straw is carbonized, it is added to a urea solution, sodium alginate and carboxymethyl chitosan are added, and an injection pump is dripped into a calcium chloride solution drop by drop to obtain a gel ball, the surface of which is modified by a silane coupling agent, hydrolyzed, added to a solution containing microorganisms and biological enzymes, and freeze-dried to obtain an acid-reducing and fertilizing improver for red soil rice fields. The acid-reducing and fertilizing improver for red soil rice fields prepared by the present invention can not only effectively increase the soil pH value, improve soil fertility, improve soil structure, and promote the downward leaching of salt-damaging ions, but the straw powder can also improve the soil CO2 bias, soil air, and soil quality, and has a good slow-release effect and broad application prospects.

The present invention provides a preparation method of a pH-responsive chitosan-citral-p-coumaric acid zinc complex with anti-vibrio and antioxidant activity, belonging to the field of biomedicine. The preparation method of the present invention is: a citral solution is slowly added dropwise to a chitosan dispersion, heated and stirred; after the system is stabilized, a chitosan-citral dispersion is obtained by reaction under supercritical carbon dioxide conditions; a p-coumaric acid solution is slowly added dropwise to a zinc salt solution, heated and stirred to react, and concentrated to dryness, and then a solvent is added to produce a precipitate, the precipitate is removed, and further concentrated to obtain a p-coumaric acid zinc solution. The obtained chitosan-citral dispersion is slowly added dropwise to the obtained p-coumaric acid zinc solution, heated and stirred evenly; after the system is stabilized, a precipitate is obtained by reaction under supercritical carbon dioxide conditions, and a chitosan-citral-p-coumaric acid zinc complex is obtained after solvent washing and drying. The complex has anti-vibrio, antioxidant activity and pH responsiveness.

The application discloses an oxygen-enhanced pH-responsive magnetic targeting photosensitizer delivery system, which is recorded as Fe3O4@mSiO2@MnO2@PS@PEG-b-PAsp, and the delivery system takes the superparamagnetic Fe3O4 core as a magnetic targeting matrix, is covered with mesoporous silica outside, and is crosslinked with polyethylene glycol-polyaspartic acid after being modified by amino on the surface of the mesoporous silica, so that the loading of the photosensitizer is realized. The oxygen-enhanced pH-responsive magnetic targeting photosensitizer delivery system provided by the application realizes the magnetic targeting property and the pH responsiveness, and realizes the effect of increasing the concentration of intracellular reactive oxygen species.

This invention discloses a ZIF-8 nanomedicine delivery system co-loaded with doxorubicin and siTDRKH, its preparation method, and its applications, belonging to the fields of biomedicine and nanomaterials technology. The nanomedicine delivery system uses the zeolite imidazole ester framework material ZIF-8 as a carrier. Its porous structure encapsulates the chemotherapeutic drug doxorubicin within the framework, and small interfering RNA targeting the TDRKH gene is loaded onto the surface through electrostatic adsorption. This structure exhibits high pH responsiveness: it remains stable under normal physiological conditions (pH 7.4), preventing premature drug leakage; upon entering the slightly acidic environment of a tumor (pH 6.5) or a lysosomal environment (pH 5.0), the ZIF-8 framework immediately disintegrates, achieving targeted and synergistic release of the loaded drug.