Preparation method of pH response type carboxymethyl chitosan/sodium alginate hydrogel ball

A technology of carboxymethyl chitosan and sodium alginate, which is applied in the directions of non-active ingredient medical preparations, pharmaceutical formulations, aerosol delivery, etc., can solve the problems of calcium ion health effects, health effects, chemical residues, etc., Achieve the effect of easy to achieve large-scale production, convenient cleaning and low cost

Pending Publication Date: 2021-09-10
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of cross-linking agents like glutaraldehyde can cause chemical residues and affect health; CaCl 2 It will also cause the intake of too much calcium ion, which will also affect health; the price of genipin is relatively high, which also limits its application

Method used

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  • Preparation method of pH response type carboxymethyl chitosan/sodium alginate hydrogel ball
  • Preparation method of pH response type carboxymethyl chitosan/sodium alginate hydrogel ball
  • Preparation method of pH response type carboxymethyl chitosan/sodium alginate hydrogel ball

Examples

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Effect test

Embodiment 1

[0044] A preparation method of pH-responsive carboxymethyl chitosan / sodium alginate hydrogel balls, the specific steps are:

[0045] (1) Dissolve 1.0 g of carboxymethyl chitosan in 100 mL of water, stir rapidly to form a homogeneous carboxymethyl chitosan solution, filter, remove insoluble matter, and ultrasonically degas for 30 minutes;

[0046] (2) Dissolve 0.6g of sodium alginate in 100mL of water, stir rapidly to form a uniform sodium alginate solution, filter, remove insoluble substances, and ultrasonically degas for 30 minutes;

[0047] (3) Mix carboxymethyl chitosan solution and sodium alginate solution at a volume ratio of 1:1, stir rapidly to form a uniform carboxymethyl chitosan / sodium alginate mixed solution, and ultrasonically degas for 30 minutes;

[0048] (4) At room temperature, use a 1mL disposable syringe to add the homogeneous mixed solution obtained in step (3) dropwise into a citric acid solution with a concentration of 0.05M for cross-linking, and take out...

Embodiment 2

[0050] A preparation method of pH-responsive carboxymethyl chitosan / sodium alginate hydrogel balls, the specific steps are:

[0051] (1) Dissolve 4.0g carboxymethyl chitosan in 100mL water, stir rapidly to form a uniform carboxymethyl chitosan solution, filter, remove insoluble matter, and ultrasonically degas for 30min;

[0052] (2) Dissolve 1.5g of sodium alginate in 100mL of water, stir rapidly to form a uniform sodium alginate solution, filter, remove insoluble substances, and ultrasonically degas for 30 minutes;

[0053] (3) Mix the carboxymethyl chitosan solution and the sodium alginate solution at a volume ratio of 2:1, stir rapidly to form a uniform carboxymethyl chitosan / sodium alginate mixed solution, and ultrasonically degas for 30 minutes;

[0054] (4) At room temperature, use a 1mL disposable syringe to drop the homogeneous mixed solution obtained in step (3) into a hydrochloric acid solution with a concentration of 0.02M for cross-linking, and take out the cured ...

Embodiment 3

[0056] A preparation method of pH-responsive carboxymethyl chitosan / sodium alginate hydrogel balls, the specific steps are:

[0057] (1) Dissolve 2.5g carboxymethyl chitosan in 100mL water, stir rapidly to form a uniform carboxymethyl chitosan solution, filter, remove insoluble matter, and ultrasonically degas for 30min;

[0058] (2) Dissolve 1.0 g of sodium alginate in 100 mL of water, stir rapidly to form a uniform sodium alginate solution, filter, remove insoluble substances, and degas with ultrasound for 30 minutes;

[0059] (3) Mix carboxymethyl chitosan solution and sodium alginate solution at a volume ratio of 1:2, stir rapidly to form a uniform carboxymethyl chitosan / sodium alginate mixed solution, and ultrasonically degas for 30 minutes;

[0060] (4) At room temperature, use a 1mL disposable syringe to add the homogeneous mixed solution obtained in step (3) dropwise into an aqueous solution of acetic acid with a concentration of 0.07M for cross-linking, and take out t...

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Abstract

The invention belongs to the field of high-molecular polymer hydrogel, and relates to a preparation method of a pH response type carboxymethyl chitosan / sodium alginate hydrogel ball. The preparation method of the hydrogel ball comprises the following steps: respectively dissolving carboxymethyl chitosan and sodium alginate in water under stirring at room temperature, carrying out filtering to remove insoluble substances, and performing ultrasonic degassing to respectively obtain transparent carboxymethyl chitosan and sodium alginate solutions; adding a certain amount of the carboxymethyl chitosan solution into the sodium alginate solution, carrying out quick stirring to form a uniform solution, and conducting degassing; and dropwise adding a mixed solution obtained in the previous step into a cross-linking agent by using a disposable syringe with a volume of 1 mL, conducting curing, taking out the hydrogel ball, and washing the hydrogel ball with water. According to the invention, release of protein in simulated gastric juice can be effectively reduced; a preparation process is simple, safe and non-toxic; raw materials are low in price; the hydrogel ball is stable in structure and good in pH response characteristics, and wide application prospects are achieved in the aspect of oral protein and water-soluble drug delivery.

Description

technical field [0001] The invention belongs to the field of polymer hydrogel, and relates to a preparation method of pH-responsive carboxymethyl chitosan / sodium alginate hydrogel balls. Background technique [0002] Hydrogel is a kind of hydrophilic polymer network polymer that can swell but not dissolve in water. It has good swelling performance and is widely used in medicine, agriculture and other fields. Among them, the pH-sensitive smart hydrogel can control the release of a small amount of drug in the stomach or even not release it in the intestinal tract, so as to achieve the purpose of protecting the drug sensitive to the gastric juice environment, and has important research in the field of oral drug delivery. value. Hydrogels prepared from natural raw materials have attracted extensive attention due to their non-toxic, biodegradable, and good biocompatibility properties. [0003] Carboxymethyl chitosan is a chitosan derivative of chitosan. It has good water solubi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/08C08L5/04A61K9/06A61K47/36
CPCC08J3/075C08J3/246A61K9/06A61K47/36C08J2305/08C08J2405/04C08J2305/04C08J2405/08
Inventor 王洪新荆慧娟杜晓静马朝阳吕文平
Owner JIANGNAN UNIV
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