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Metal polyphenol collagen membrane material as well as preparation method and application thereof

A polyphenol collagen and collagen technology, which is used in medical science, bandages and other directions to achieve the effects of inhibiting bacterial growth, promoting healing, and excellent repairing effects.

Active Publication Date: 2021-02-05
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But in the field of collagen, responsiveness has been less studied

Method used

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  • Metal polyphenol collagen membrane material as well as preparation method and application thereof
  • Metal polyphenol collagen membrane material as well as preparation method and application thereof
  • Metal polyphenol collagen membrane material as well as preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0035] This example is an example of preparing complexes of polyphenols and metal ions. This example prepares 3 groups of complexes. The first group chelates epigallocatechin gallate with magnesium ions, and the second group chelates dopamine Chelated with iron ions, the third group chelates quercetin with copper ions.

[0036] The preparation method is as follows:

[0037] Dissolving polyphenols in water to obtain a polyphenol solution, adding ammonia water to adjust the pH of the polyphenol solution to 8-10, and stirring at room temperature for 24 hours to obtain polyphenol nanoparticles. Slowly add an aqueous solution of metal ions (such as an aqueous solution of magnesium chloride, aqueous ferric chloride, or aqueous copper chloride) dropwise into the polyphenol solution, wherein the amounts of metal ions and polyphenols are 10-20 parts by weight and 100-120 parts by weight, respectively; Add ammonia water to adjust the pH to 8-10, and stir at room temperature for 24 hour...

Embodiment 2

[0040] This embodiment is an embodiment of preparing collagen gel.

[0041] The collagen is completely dissolved in acetic acid solution, and then freeze-dried into a gel. Gained collagen gel is carried out electron microscope observation, electron microscope figure sees Figure 4 , it can be seen from the figure that the particle size of the collagen gel is on the order of μm, and it has a porous structure, which can well load nano-complex particles.

Embodiment 3

[0043] 85 parts by weight of collagen were dissolved in acetic acid solution, and stirred at room temperature overnight until completely dissolved. Add 15 parts by weight of epigallocatechin gallate (EGCG) nanoparticles into the collagen solution, adjust the pH to 7.4-8.0, and incubate in an oven at 35° C. to 37° C. for 24 hours until gelling. The hydrogel was freeze-dried in a freezer for 2 days to prepare a freeze-dried sponge, and the freeze-dried sponge was rolled into a film with a plexiglass frame mold.

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Abstract

The invention discloses a metal polyphenol collagen membrane material as well as a preparation method and application thereof. The metal polyphenol collagen membrane material is a hydrogel material and comprises collagen and a nano complex loaded on a porous structure of the collagen, and the nano complex is obtained by chelating metal ions and polyphenol. The metal polyphenol collagen membrane material has good pH responsiveness, has antibacterial and hemostatic effects at the same time under response conditions, has an excellent skin wound repairing effect, and can be applied to skin wound repairing materials.

Description

technical field [0001] The invention relates to a responsive membrane material, in particular to a metal polyphenol collagen membrane material, a preparation method and application thereof. Background technique [0002] Collagen is a common protein in mammals. There are many kinds of collagen, which often come from skin, bones, tendons, blood vessels, internal organs and other organs. Among them, collagen plays a role in stabilizing the structure and participating in metabolic processes. In addition, collagen often has a three-dimensional helical structure, mainly composed of amino acids such as glycine, proline, and lysine, and more amino groups, carboxyl groups, and hydroxyl groups are exposed in the molecular structure. Compared with other polymers, the current research on collagen mainly focuses on the stability of synthetic collagen and its conformation and cross-linking structure, and the research on its intelligent behavior is still rare. Chemical modification of co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0033A61L26/0066A61L26/008A61L26/0085A61L2300/102A61L2300/216A61L2300/404A61L2300/41A61L2300/412A61L2300/418A61L2300/602
Inventor 顾志鹏张恒杰李乙文
Owner SICHUAN UNIV
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