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Method for preparing quick temperature response semi-interpenetration network hydrogel

A semi-interpenetrating network and temperature-responsive technology, which is applied in the field of rapid temperature-responsive semi-interpenetrating network hydrogel preparation, can solve problems such as difficult application, uneven cross-linking of the gel network, and difficult control, and achieve easy controllability , fast temperature response, and easy-to-operate effects

Inactive Publication Date: 2005-03-02
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, Zhang et al. (Langmuir, 2002, 18: 2538-2542) used a mixed solution of water and tetrahydrofuran as the reaction medium, according to monomer N-isopropylacrylamide (NIPAAm) and poly-N-isopropylacrylamide (PNIPAAm) The solubility difference in the mixed solution, during the polymerization reaction, the generated poly N-isopropylacrylamide polymer is not dissolved by the reaction medium but is precipitated and fixed in the entire gel network, so that the entire gel network is not crosslinked. Uniformity, resulting in more pore structures in the gel network, resulting in an increase in the corresponding rate of the gel, but this heterogeneous structure is difficult to control and difficult to apply in practice

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Dissolve 9.2mmol (1.04g) monomer NIPAAm, 0.25mmol (0.039g) N,N'-methylenebisacrylamide in 13ml deionized water, add 0.26g 4 Sodium alginate, 0.15g NaCl, stirred and blown nitrogen for 20 minutes. Add 0.039g of ammonium persulfate, stir and blow nitrogen for 5 minutes, then add 40 μL of catalyst N, N, N', N'-tetramethylethylenediamine, mix well, continue blowing nitrogen for 5 minutes, and then quickly pour into Put the test tube in a test tube, seal it and place it in an ice water bath for 24 hours, then place the test tube in a water bath at 45°C until the gel completely shrinks, take it out, soak it in deionized water for 6 days, and change the water regularly to remove unreacted monomers and Electrolyte in the reaction system, the PNIPAAm hydrogel with good elasticity and fast shrinkage rate can be obtained.

[0025] Using the method disclosed in the literature (Zhang J T et al. Colloid Polym Sci, 2003, 281: 582-589) (the size of the gel response rate is characteriz...

Embodiment 2

[0027] Dissolve 11.5mmol (1.3g) monomer NIPAAm, 0.169mmol (0.026g) N,N'-methylenebisacrylamide in 13ml deionized water, add 5 0.52 g of sodium alginate and 0.61 g of NaCl were stirred and passed through nitrogen for 15 minutes. Add 0.026g of ammonium persulfate, stir and blow nitrogen for 6 minutes, then add 30 μL of catalyst N, N, N', N'-tetramethylethylenediamine, mix well, continue blowing nitrogen for 5 minutes, and then quickly pour into a 10cm-diameter Place the test tube in a sealed test tube in an ice-water bath for 24 hours, then place the test tube in a 45°C water bath until the gel completely shrinks, take it out, soak it in deionized water for 6 days, and change the water regularly to remove unreacted monomers And the electrolyte in the reaction system, the PNIPAAm hydrogel with good elasticity and fast shrinkage rate can be obtained.

[0028] Using the method disclosed in the literature (Zhang J T et al. Colloid Polym Sci, 2003, 281: 582-589) (the size of the gel...

Embodiment 3

[0030] Dissolve 17.25mmol (1.95g) monomer NIPAAm, 0.38mmol (0.0585g) cross-linking agent ethylene glycol bisacrylate in 13ml deionized water, add molecular weight 2.0×10 50.16 g of carboxymethylcellulose sodium salt and 0.30 g of KCl were stirred and nitrogen gas was passed for 30 minutes. Add 0.029g of ammonium persulfate, stir and blow nitrogen for 5 minutes, then add 60 μL of catalyst N, N, N', N'-tetramethylethylenediamine, mix well, continue blowing nitrogen for 8 minutes, and then quickly pour into a 10cm-diameter Put the test tube in a test tube, seal it and place it in an ice water bath for 24 hours, then place the test tube in a water bath at 45°C until the gel completely shrinks, take it out, soak it in deionized water for 6 days, and change the water regularly to remove unreacted monomers and Electrolyte in the reaction system, the PNIPAAm hydrogel with good elasticity and fast shrinkage rate can be obtained.

[0031] Using the method disclosed in the literature (Z...

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Abstract

The preparation process of semi-interpenetration network hydrogel with quick temperature response includes the following steps: dissolving the monomer and cross-linking agent in deionized water; adding polyeleectrolyte, electrolyte and initiator through stirring under inertial atmosphere for 5-10 min, reaction at 0-30 deg.c for 2-48 hr, and collecting semi-interpenetration network hydrogel with quick temperature response. The hydrogel has not only quick temperature response, but also great gel strength, and its response speed may be regulated via altering the consumption and molecular weight of the polyeleectrolyte and salt concentration in the reaction liquid. The hydrogel has 90 sec dehydration rate over 95 % at the temperature over its phase conversion point, can reach dehydration balance in 2 min, and has good pH response and thus expanded application range, especially in biological and medicine fields.

Description

technical field [0001] The invention relates to a preparation method of a rapid temperature response semi-interpenetrating network hydrogel. Background of the invention [0002] Smart hydrogels are currently the most attractive class of hydrogels. Poly N-isopropylacrylamide (PNIPAAm) hydrogel is a typical representative of this type of gel. PNIPAAm hydrogel has a volume phase transition temperature (VPTT, around 32°C). When the ambient temperature is lower than VPTT, PNIPAAm hydrogel absorbs water and swells; when the ambient temperature is higher than VPTT, PNIPAAm hydrogel shrinks violently and loses water. . Based on the temperature-sensitive nature of PNIPAAm hydrogel, it has been applied in the fields of controlled release of drugs, immobilization of enzymes and circulating absorbents. [0003] However, the response rate of traditional PNIPAAm hydrogel is slow, which greatly limits its application in some aspects, such as chemical sensors, artificial muscles and chem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/14
Inventor 张高奇梁伯润查刘生周美华马敬红石艳丽
Owner DONGHUA UNIV
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