High-strength responsive hydrogel based on block copolymer and preparation method thereof

A block copolymer, high-strength technology, applied in the field of high-strength responsive hydrogel and its preparation, can solve problems such as no public reports on research, and achieve a green and safe preparation process, short time consumption, and fewer by-products. Effect

Inactive Publication Date: 2019-10-08
XI'AN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the development of hydrogels based on amphiphilic triblock copolymers is of great significance for realizing their applications in many fields, but the specific research has not yet been published.

Method used

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  • High-strength responsive hydrogel based on block copolymer and preparation method thereof
  • High-strength responsive hydrogel based on block copolymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Step 1: Dissolve 10g of completely dry F108 in a three-neck flask filled with 200mL of dichloromethane, and blow nitrogen gas while stirring. After F108 is completely dissolved, add 1.4g of triethylamine, and slowly add 1.2g of it dropwise with a dropping funnel Acryloyl chloride (at this time, the amount of triethylamine and acryloyl chloride used is 10 times that of the hydroxyl group in F108), and the total dropping time is controlled to be 30min. After the dropwise addition, the reaction solution was stirred at room temperature for 10 h, and the entire reaction was controlled to proceed under anhydrous conditions. After completion of the reaction, the reaction solution was filtered several times to remove triethylamine hydrochloride generated in the reaction. The remaining liquid was poured into petroleum ether and filtered several times, and the obtained solid was dried in a vacuum oven at 30° C. for 2 hours to obtain double-terminal acryloyl F108 (F108DA).

[003...

Embodiment 2

[0036]Step 1: Dissolve 10g of completely dry P123 in a three-necked flask containing 200mL of dichloromethane, and blow nitrogen gas while stirring. After P123 is completely dissolved, add 3.5g of triethylamine, and slowly add 3.1g of it dropwise with a dropping funnel Acryloyl chloride (at this time, the amount of triethylamine and acryloyl chloride used is 10 times that of the hydroxyl group in P123), and the total dropping time is controlled to be 30min. After the dropwise addition, the reaction solution was stirred at room temperature for 48 h, and the entire reaction was controlled to proceed under anhydrous conditions. After completion of the reaction, the reaction solution was filtered several times to remove triethylamine hydrochloride generated in the reaction. The remaining liquid was poured into petroleum ether and filtered several times, and then the obtained solid was dried in a vacuum oven at 25° C. for 20 h to obtain double-terminal acryloyl P123 (P123DA).

[0...

Embodiment 3

[0039] Step 1: Dissolve 10g of completely dry F68 in a three-necked flask filled with 100mL of dichloromethane, and blow nitrogen gas while stirring. After F68 is completely dissolved, add 1.2g of triethylamine, and slowly add 1.1g of it with a dropping funnel Acryloyl chloride (at this time, the amount of triethylamine and acryloyl chloride used is 5 times that of the hydroxyl group in F68), and the total dropping time is controlled to be 15 min. After the dropwise addition, the reaction solution was stirred at room temperature for 24 h, and the whole reaction was controlled to proceed under anhydrous conditions. After completion of the reaction, the reaction solution was filtered several times to remove triethylamine hydrochloride generated in the reaction. The remaining liquid was poured into petroleum ether and filtered several times, and the obtained solid was dried in a vacuum oven at 20° C. for 48 hours to obtain double-terminated acryloyl F68 (F68DA).

[0040] Step 2:...

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Abstract

The invention discloses high-strength responsive hydrogel based on a block copolymer and a preparation method thereof, and belongs to the technical field of preparation of materials. A reactive amphiphilic triblock copolymer capable of self-assembling in water to form micelles is subjected as an intra-system macromolecular crosslinking point instead of the traditional crosslinker N,N-methylene diacrylamide to free radical polymerization with a monomer so as to obtain high-strength hydrogel having uniform crosslinking density. The reactive amphiphilic triblock copolymer is not electrically charged; the size and stability of the reactive amphiphilic triblock copolymer are scarcely influenced by ion strength or charge in a solution; therefore, the reactive amphiphilic triblock copolymer is applicable to most free radical polymerized monomers, and synthesis of intelligent functional hydrogel is facilitated. The preparation method herein is simple to perform; preparing is easy; the raw materials are good in safety and stability and are easy to store; the preparation process is green and safe, has short time and low byproduct production; a means is provided to prepare multifunctional high-strength hydrogel. The prepared hydrogel has excellent pH response and mechanical properties.

Description

technical field [0001] The invention belongs to the technical field of material preparation and environmental treatment, and in particular relates to a high-strength responsive hydrogel based on a block copolymer and a preparation method thereof. Background technique [0002] Responsive hydrogels can be widely used in drug delivery, tissue engineering, biosensors and underwater robots because of their ability to sense and respond to external stimuli. However, the high water content of traditional responsive hydrogels and the widespread use of chemical cross-linking agents will lead to inhomogeneity of the gel network, making it easy to stress concentration when the gel is stressed, so the toughness of traditional hydrogels is relatively low. Low (<10Jm -2 ). From the perspective of molecular and network structure design, how to combine the strengthening and toughening mechanism of high-performance hydrogels with the response mechanism to prepare high-strength hydrogels ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F283/06C08F220/56C08F220/34
CPCC08F283/06C08F220/56
Inventor 孙元娜李青山赵小亮张彩宁王琛
Owner XI'AN POLYTECHNIC UNIVERSITY
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