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Preparation method of pH responsive cation nanogel

A nanogel and cation technology, applied in the field of preparation of cationic nanogels, can solve the problems of low charge density, weak pH response of microgels, limited application range, etc. good stability

Inactive Publication Date: 2013-09-04
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cationic monomer DMAEMA used in this process only accounts for 25% of the total molar number of monomers, and the pH response of the microgel is relatively weak, and the charge density on the surface of the microgel particles is small, thus limiting Its scope of application

Method used

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  • Preparation method of pH responsive cation nanogel
  • Preparation method of pH responsive cation nanogel
  • Preparation method of pH responsive cation nanogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 0.15g of SDS into 45mL of water, sonicate for 10min to fully dissolve, add to a 100mL four-necked flask, add 0.35g of a stabilizer PEGMA with a relative molecular weight of 2000, blow in nitrogen, stir and pre-emulsify for 30min to obtain an aqueous phase solution.

[0026] Weigh 0.05g EGDMA, mix it with 5g DEA in a small flask, and ultrasonically mix it evenly to obtain a monomer mixture, add it to a constant pressure dropping funnel, and drop it into the water in a four-necked flask at a speed of 0.03mL / min. phase solution, stirred for 2 to 3 hours to obtain a microemulsion.

[0027] The temperature of the microemulsion was raised to 65°C and stabilized for 10 minutes. Mix 0.05 g of initiator V-50 and 5 mL of water into a constant-pressure funnel, and dropwise added to the microemulsion at an average speed of 0.25 mL / min. After the dropwise addition, react for 20 hours to generate a white PDEA nanogel emulsion with bluish light. Placed in deionized water and di...

Embodiment 2

[0034] Weigh 0.07g of SDS and add it into 45mL of water, sonicate for 10min to fully dissolve it, add it into a 100mL four-necked flask, add 0.15g of a stabilizer PEGMA with a relative molecular weight of 2000, blow in nitrogen, stir and pre-emulsify for 30min to obtain an aqueous phase solution.

[0035] Weigh 0.02g EGDMA, mix it with 3g DPA in a small flask, and ultrasonically mix it evenly to obtain a monomer mixture, add it to a constant pressure dropping funnel, and drop it into the water in a four-necked flask at a speed of 0.03mL / min. phase solution, stirred for 2 to 3 hours to obtain a microemulsion.

[0036] The temperature of the microemulsion was raised to 65°C and stabilized for 10 min. Mix 0.015 g of initiator V-50 and 5 mL of water into a constant pressure funnel, and drop into the microemulsion at an average speed of 0.25 mL / min. After the dropwise addition, react for 20 hours to generate a white emulsion of PDPA nanogel with bluish light. Placed in deionized w...

Embodiment 3

[0038] Weigh 0.06g EGDMA and put it into a small flask, mix it with 5g DEA, and ultrasonically mix it evenly. Others are the same as in Example 1.

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Abstract

The invention discloses a preparation method of pH responsive cation nanogel. The preparation method comprises the following steps: lauryl sodium sulfate and polyethylene glycol dimethyl acrylic ester are sufficiently dissolved in water to prepare a water-phase solution, ethylene glycol dimethacrylate and cationic monomer methylacrylic acid-(N, N-diethyl amine) ethyl ester or 2-(diisopropyl amino) ethyl methacrylate are uniformly mixed to obtain a mixture, and then the mixture is added into the water-phase solution to prepare microemulsion, and a water solution with an initiator is added in the microemulsion to react for 20-24 h to obtain the pH responsive cation nanogel dispersion liquid. The nanogel prepared has good pH responsiveness and dispersion stability, can be placed stably for more than 3 months, and the number-average grain size of the nanogel is smaller than 100 nm.

Description

technical field [0001] The invention belongs to the technical field of macromolecular chemical materials, and relates to a preparation method of a nanogel, in particular to a preparation method of a pH-responsive cationic nanogel synthesized from a hydrophobic monomer. Background technique [0002] pH-responsive microgel refers to a type of microgel that swells or shrinks in volume with changes in the pH value of the environment, and various properties also change in response. It is used in drug separation, release, catalyst carrier, and tissue engineering. has great application potential. [0003] According to the ionizable weakly acidic or weakly basic groups contained in the molecular chain, pH-responsive microgels can be divided into anionic and cationic. Usually, there are certain carboxyl groups, sulfonic acid groups and other groups distributed on the surface of anionic microgels, while groups such as amino groups and pyridines are distributed on the surface of catio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/34C08F222/14C08F2/26
Inventor 申迎华杨振芳叶丹峰刘成岑杜海燕
Owner TAIYUAN UNIV OF TECH
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