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Oral composition containing Ectoine and hyaluronic acid and application of oral composition

An oral composition and hyaluronic acid technology, applied in the field of oral care, can solve the problems of large use restrictions, poor effect, and single function, and achieve the effects of promoting healing, lasting and accurate wound care, and high biological safety

Active Publication Date: 2019-08-23
BLOOMAGE BIOTECHNOLOGY CORP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention selects hyaluronic acid or its salts with different molecular weights, ectoine, tea polyphenols and xylitol as active ingredients, uses ectoine as the main functional component, and ectoine as a small molecule cyclic amino acid Derivatives have multiple functions such as moisturizing, protecting biomolecules and cells, anti-inflammation, and repairing. They have high biological safety and remarkable anti-inflammatory and repairing effects. The ingredients complement each other and have a synergistic effect with each other. Combining together can maximize the advantages of each ingredient, which can well solve the current oral care products that have single functions, poor effects, or relatively large toxic side effects. , large use restrictions and other problems, with unexpected effects

Method used

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  • Oral composition containing Ectoine and hyaluronic acid and application of oral composition
  • Oral composition containing Ectoine and hyaluronic acid and application of oral composition
  • Oral composition containing Ectoine and hyaluronic acid and application of oral composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Prepare oral composition gel, and carry out efficacy research to it, specific method is as follows:

[0039](1) Prepare 6 groups of oral composition gel samples according to the formula in Table 1 below. During preparation, mix each component uniformly according to the prescribed dosage to obtain the oral composition gel;

[0040] Table 1 oral composition gel each component composition (wt%)

[0041]

[0042]

[0043] (2) 77 rabbits weighing 2.0kg to 3.0kg were selected, fasted on the first day of the experiment, and anesthetized by injecting 3 wt% pentobarbital into the ear vein. After anesthesia, retract the upper lip to expose the lip mucosa, use a prefabricated filter paper sheet with a diameter of 5 mm to soak with glacial acetic acid with a volume fraction of 40%, place it on both sides of the upper lip of the rabbit, and take it out for 60 seconds to see a 5.5 mm white lesion in the area; 48 hours Ulcers with a diameter of about 5.5mm;

[0044] (3) The ra...

Embodiment 2

[0052] Prepare the oral composition film containing ectoine and hyaluronic acid, the method is as follows:

[0053] 1. Formula: 1.5% of 2000kDa sodium hyaluronate, 5% of 200kDa sodium hyaluronate, 0.01% of tea polyphenols, 1% of xylitol, 1% of ectoine, and the balance of purified water.

[0054] 2. According to the above formula, add 2000kDa sodium hyaluronate, 200kDa sodium hyaluronate, tea polyphenols, xylitol and ectoine into purified water, mix and dissolve fully; pour the mixed solution into two groups of molds respectively, and cast Molding, in which group A molds are placed in an oven, dried at a constant temperature of 37°C for molding, group B molds are placed in vacuum freeze-drying equipment, and vacuum freeze-dried for molding; after drying, terminal irradiation sterilization, two groups of A and B containing Oral composition film of ectoine and hyaluronic acid.

[0055] 50 patients with oral ulcers (35 males and 15 females) were selected for observation within th...

Embodiment 3

[0062] Preparation of oral composition spray containing ectoine and hyaluronic acid:

[0063] 1. Formula: 0.1% of 3000kDa sodium hyaluronate, 0.1% of 800kDa sodium hyaluronate, 1% of tea polyphenol, 3% of xylitol, 1% of ectoine, and the balance of purified water.

[0064] 2. Add 3000kDa sodium hyaluronate, 800kDa sodium hyaluronate, tea polyphenols, xylitol and ectoine into the purified water, fully mix and dissolve; filter and sterilize the mixed solution and pour it into a spray bottle to obtain a spray . The spray is more convenient to use and easy to carry with you.

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Abstract

The invention discloses an oral composition containing Ectoine and hyaluronic acid and application of the oral composition. The oral composition is prepared from, by mass, 0.1-5% of high molecular weight hyaluronic acid or salt thereof, 0.1-5% of low molecular weight hyaluronic acid or salt thereof, 0.01-1% of tea polyphenol, 1-3% of xylitol, 0.1-1% of Ectoine and the balance water, and the totalpercentage is 100%. Accordingly, the Ectoine, different molecular weights of hyaluronic acid or salt thereof, tea polyphenol and xylitol are compounded, the bio-safety is high, the synergetic effect is achieved, the effects of nursing wound surfaces, diminishing inflammation, promoting healing and the like are achieved, and the oral composition is applicable to oral care application such as oral care after cancer chemotherapy and oral ulcer care and can also be applied to the field of medical products, medical equipment and disinfection products.

Description

technical field [0001] The invention relates to an oral composition containing ectoine and hyaluronic acid and application thereof, belonging to the technical field of oral care. Background technique [0002] Ectoin, also known as "halal-tolerant bacteria extract", is derived from Halomonas Elongata. It is a small molecule cyclic amino acid derivative, which is mostly synthesized by microorganisms in extreme environments under osmotic stress. Osmotic pressure compensating solutes can protect halophilic bacteria from damage under extreme conditions of high salt, high temperature, and high ultraviolet radiation. At present, the main effects and mechanisms of ectoine that have been studied are: [0003] 1. Moisturizing effect [0004] Mechanism: The dense charge distribution on the surface of Ectoin molecules enables it to further strengthen the hydrogen bond between water molecules through the electrostatic interaction with water molecules, reduce water activity, and promote...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/34A61K8/49A61Q11/00A61K31/728A61P1/02A61K31/353A61K31/047A61K31/505
CPCA61K8/4953A61K8/735A61K8/498A61K8/345A61Q11/00A61K31/728A61K31/353A61K31/047A61K31/505A61P1/02A61K2800/592A61K2300/00
Inventor 冯晓毅宋永民宫衍革刘栋姜秀敏甄文博郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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