76 results about "Pulpa dentis" patented technology

The invention belongs to the technical field of dental pulp blood supply reconstruction, and relates to a multi-omics data fusion analysis method for EDTA (Ethylene Diamine Tetraacetic Acid) induced cell differentiation in dental pulp blood supply reconstruction. A space-time matched multi-level data basis is provided for analyzing a dynamic rule; then through standardization processing and difference analysis, screening out differential molecules which realize corresponding modes and are strongly related to phenotypes, focusing on core regulation and control candidate objects, and avoiding limitation of single omics; the method comprises the following steps: constructing a dynamic multi-layer regulation and control network comprising a transcription layer, a protein layer, a metabolism layer and interlayer connections thereof, finally identifying key nodes and modules through network topology analysis, tracking a time evolution rule in combination with dynamic trajectory analysis, and finally screening a core regulation and control module and predicting a cross-level key path. System analysis from multi-omics data to a hierarchical regulation and control mechanism and a dynamic rule is realized, and the limitation of single-dimension research is effectively broken through.

A method and apparatus for detecting a distance of a probe contacting a tooth surface to a pulp of a tooth by determining an indication of a thickness of a dentin of the tooth is provided. The method includes illuminating tooth tissue of the tooth with the probe and then receiving data indicative of scattered light from the tooth tissue. A spectrum of the scattered light is then acquired and analyzed to further acquire a spectral analysis result. An indication of the thickness of the dentin of the tooth is then determined based on the spectral analysis result. The method can help prevent accidental exposure of the pulp during dental treatments such as drilling.

Embodiments of the present application disclose a method and device for extracting root canal feature morphology based on CBCT data, equipment and medium, belong to the field of oral medicine and medical image technology, wherein the method comprises: filtering and denoising CBCT images and performing pulp segmentation processing, and performing surface rendering three-dimensional reconstruction on tooth root canals to generate a three-dimensional model; based on the regular point cloud data in the three-dimensional model, a point-surface method is used to realize surface reconstruction to generate a root canal entity model; the root canal entity model is subjected to coordinate alignment processing in a three-dimensional space, and the approximate center line of the fitted root canal is used to measure the root canal length, root canal opening direction, root canal curvature and pulp depth. The present application quickly reconstructs the corresponding three-dimensional model based on the CBCT tomographic images obtained by scanning the teeth of a patient, and obtains relevant data such as pulp depth and root canal opening size from the three-dimensional model of the teeth to assist the performance of oral surgery.

The invention discloses a female vaginal mucosa cell maintenance preparation and a preparation method and application thereof, and belongs to the technical field of biological agents, the female vaginal mucosa cell maintenance preparation is prepared from dental pulp mesenchymal stem cells, portulaca oleracea polysaccharide, lactic acid, quercitrin, glycerin and stem cell carriers, and vaginal injection paste is obtained by evenly mixing the dental pulp mesenchymal stem cells, the portulaca oleracea polysaccharide, the lactic acid, the quercitrin, the glycerin and the stem cell carriers through a proper amount of deionized water. The purslane polysaccharide and the dental pulp mesenchymal stem cells form a unique synergistic effect, through physical wrapping, the survival rate and delivery efficiency of the stem cells in a vaginal cavity are improved, local inflammatory response is inhibited, a microenvironment is optimized to support directional differentiation of the stem cells into epithelial cells, paracrine activity of the stem cells is enhanced, and repairable factors are released to promote cell-level regeneration. The problem of hormone dependence is solved, deep maintenance of targeted mucous membrane cells is achieved, limitation of an existing therapy is broken through by directly nourishing cells, activating and regenerating, enhancing barrier integrity and maintaining an acidic microenvironment, and an ideal treatment effect is achieved.

The invention relates to the technical field of biological medicine, and provides application of a dental pulp stem cell exosome in preparation of a medicine for treating and preventing osteoarthritis, a preparation method of the dental pulp stem cell exosome comprises the following steps: S1, obtaining dental pulp tissue from a dental pulp cavity of an in-vitro tooth; s2, pretreating dental pulp tissues, adding digestive juice, digesting, centrifuging, discarding supernatant, adding a complete culture medium containing antibiotics into precipitates, mixing, filtering and centrifuging to obtain dental pulp stem cells; and S3, culturing the dental pulp stem cells by using a complete culture medium, when the confluence degree of the dental pulp stem cells reaches 60-80%, replacing the serum-free culture medium for continuous culture, collecting the dental pulp stem cell conditioned culture medium, and performing differential centrifugation to obtain the dental pulp stem cell exosome. According to the technical scheme, the regulating effect of the dental pulp stem cell exosome on endoplasmic reticulum stress and the mechanism of the dental pulp stem cell exosome for improving cartilage cell degeneration are explored.

Apparatuses and methods are provided for displaying the position of a dental file during endodontic treatment. Data showing the morphology of a tooth is obtained. In one embodiment, the data is X-ray image data. A three-dimensional representation of the dental file positioned in the tooth is generated, and a length that the dental file extends from an upper surface of the tooth is determined from the three-dimensional representation. A representation of the dental file is provided in the image of the tooth obtained from the data showing the tooth morphology, with the representation of the dental file being depicted such that a part of the representation of the dental file extends from the upper surface of the tooth in proportion to the length that the dental file extends from the upper surface of the tooth as determined from the three-dimensional representation and such that a remaining part of the representation of the dental file extends into the tooth, with a part of the remaining part of the representation of the dental file being positioned in the root of the tooth in the image. The image of tooth and representation of the dental file may be displayed.

The utility model discloses a special intramedullary file of minimally invasive, relates to the technical field of intramedullary file, including file main part, the one end fixed connection of file main part has micro motor, the outer wall fixed connection of micro motor has handle, the outer wall movable joint of handle has heat dissipation mechanism, and heat dissipation mechanism includes ring, water pipe and transmission strip, and the both sides fixed mounting of ring have protruding block, and the one side of protruding block is fixedly connected with the one end of transmission strip, the utility model discloses the special structure design of heat dissipation mechanism, can utilize water pipe to radiate heat when intramedullary file works, reduces the heat damage risk of heat of the generation of filing to dental pulp tissue, guarantees postoperative recovery, and simultaneously, the connection and sliding relation among each part make heat dissipation mechanism can move flexibly, and the different filing operation demand of adaptation.

The invention discloses an oral cavity teaching training model for dental pulp blood supply reconstruction, and the model comprises a model body which is provided with a puncture channel for simulating a root canal; the puncture seat is arranged at the lower end of the puncture channel, and a bleeding hole communicated with the puncture channel is formed in the puncture seat; the simulation film is arranged between the puncture channel and the bleeding hole; the driving mechanism is connected with the simulation thin film, and the driving mechanism is used for driving the simulation thin film to move so as to adjust the puncture area, corresponding to the bleeding hole, of the simulation thin film; the liquid supply device is connected with the bleeding hole, the liquid supply device is used for conveying simulated plasma to the bleeding hole, or the liquid supply device is used for conveying simulated plasma in the bleeding hole outwards, the simulated film is matched with the bleeding hole to achieve high simulation of bleeding after puncture, and meanwhile dynamic simulation of different bleeding amounts is achieved in cooperation with the liquid supply device; through cooperation of the driving mechanism and the simulation thin film, rapid switching of the puncture areas corresponding to the simulation thin film is achieved, and repeated training is facilitated.

The invention relates to the technical field of oral medicine, in particular to a DNMTi and ZIF-8 nano-complex and application thereof.The DNMTi and ZIF-8 nano-complex is technically characterized in that in-situ synthesized zeolite imidaze-8 (ZIF-8) is adopted for delivering a DNA methyltransferase inhibitor (DNMTi), dental pulp stem cell (DPSC) cell spheres are combined, the DNMTi and ZIF-8 nano-complex can be used for bionic therapy, the activity of medicine is prolonged, and the effect of treating dental pulp stem cells is achieved. And zinc ions are continuously released to activate a PI3K-AKT signal channel, so that the dentin differentiation of stem cells and the generation of blood vessels are promoted. Through accurate simulation of a tooth development microenvironment, the biomimetic therapy can realize regeneration of a dental pulp-dentin complex. The therapy for simulating the tooth development process not only solves the key problems in the dental tissue engineering, but also opens up a new direction for treating the dental pulp and periapical diseases, and highlights the wide application prospect in regenerative medicine.

This invention provides a treatment system for promoting dental pulp repair using oral stem cells, belonging to the field of oral treatment technology. The system utilizes a dynamic gene regulation module, an adaptive intelligent scaffold, and a bio-digital fusion interface in synergy. Through the dynamic gene regulation module and the adaptive intelligent scaffold, the efficiency and therapeutic effect of dental pulp regeneration are significantly improved. The dynamic gene regulation module employs a light-controlled CRISPR system to perform real-time gene editing on dental pulp stem cells, dynamically adjusting according to the needs of the regeneration stage. The adaptive intelligent scaffold, based on 3D printing technology and manufactured using a digital model of the patient's teeth, can dynamically release growth factors and optimize the microenvironment. This combination of personalized design and dynamic regulation allows for adaptive adjustments to meet the specific needs of the patient, not only improving the repair efficiency of dental pulp tissue but also enhancing the success rate of functional reconstruction. This provides patients with dental pulp injury with a more efficient and precise treatment option, promoting the personalized development of oral regenerative medicine.

The utility model provides a dental pulp root canal auxiliary positioning device which comprises a handle, a mounting box, a triangular block, a supporting plate and a butt joint shaft, the lower end of the handle is sleeved with a roller bearing, the outer ring of the roller bearing is fixedly connected with an anti-skid sleeve, guide grooves are formed in the front side and the rear side of the right end of the mounting box respectively, and a rotating shaft is mounted at the lower end in the mounting box; the annular side face of the rotating shaft is fixedly sleeved with a plurality of second rolling wheels, a notch column is movably connected to the upper portion of the installation box in an inserted mode, a first rolling wheel is rotatably installed at the lower end of the notch column, a circular ring is fixedly connected to the side face of the notch column in a sleeved mode, and a spring is installed on the side of the upper portion of the circular ring and connected with the notch column in a sleeved mode. The handle placing device is reasonable in structure, good in practicability, convenient to use and suitable for popularization and application, the handle is limited by utilizing the telescopic characteristic of the spring, and the stability of the handle during placing is greatly improved.

The invention discloses a preparation method and application of a graded delivery system which takes a pH response type metal organic framework material NH2-MIL-101 (Fe) as a carrier and takes antibacterial peptide AMP and irisin as active ingredients. The graded delivery system comprises a metal organic framework material NH2-MIL-101 (Fe), AMP (adenosine monophosphate) and Irisin, wherein the AMP and the Irisin are loaded on the pH (potential of hydrogen) response type metal organic framework material NH2-MIL-101 (Fe). According to the system, aiming at periodontal and dental pulp infectious diseases, early-stage AMP rapid release for precise bacteriostasis and middle-stage Irisin synergistic release are realized through time sequence regulation and control to achieve anti-inflammatory and anti-oxidation effects, so that alveolar bone tissue / dentin regeneration is further promoted, and an excellent'antibacterial-anti-inflammatory-hard tissue regeneration 'cascade treatment effect is shown. The invention provides a new strategy and theoretical basis for precise treatment of periodontitis and pulpitis.

The invention provides an auxiliary positioning device for an oral dental pulp root canal, and relates to the technical field of root canal treatment equipment. Comprising a positioning platform and a positioning frame, and the positioning platform is arranged on the positioning frame; a positioning clamp is arranged on the positioning platform, a positioning sleeve is connected to the positioning clamp through an induction line, and an inductance device is arranged on the positioning sleeve; displacement assemblies are arranged at the tail ends of the positioning clamps; the displacement assembly comprises an outer pipe and an inner pipe, and one end of the outer pipe is sleeved with one end of the inner pipe. A first motor is arranged in the outer pipe, a driving screw rod is arranged on an output shaft of the first motor, and threads are arranged on the inner side of the inner pipe and are in threaded connection with the driving screw rod; a limiting groove is formed in the inner side of the outer pipe, and a limiting protrusion matched with the limiting groove is arranged on the outer side of the inner pipe. Compared with the prior art, the device is convenient to use and adjust, accurate in positioning and capable of effectively avoiding blocking the surgical field.

The invention relates to a three-platinum-root-rehmannia root gargle and a preparation method and application thereof, and belongs to the technical field of oral medicine and traditional Chinese medicine application. The invention provides a three-platinum radix rehmanniae gargle. The three-platinum radix rehmanniae gargle comprises the following components in parts by mass: 1-10 parts of rhizoma bletillae, 1-10 parts of radix angelicae, 1-10 parts of rhizoma corydalis, 1-10 parts of cortex dictamni, 1-10 parts of fructus kochiae, 1-10 parts of honeysuckle, 1-5 parts of borneol and 1-5 parts of pseudo-ginseng. The three-platinum-radix rehmanniae gargle provided by the invention locally acts on sensitive areas of diseased teeth and is gargled after treatment, so that the three-platinum-radix rehmanniae gargle has the effects of diminishing inflammation, inhibiting bacteria, resisting tooth sensitivity, dispersing blood stasis, stopping bleeding, promoting tissue regeneration, relieving pain, clearing away heat and toxic materials and the like, effectively relieves tooth pain or sensitivity and protects dental pulp. When being used for preparing the deep caries pulp-protecting treatment medicine, the compound can permeate into dentin or dental pulp in the deep caries pulp-protecting treatment process and after operation, and plays the roles of relieving pain, desensitizing, clearing away heat and toxic materials and the like, so that the dental pulp is protected, and toothache and tooth sensitivity are avoided.

This invention proposes a method for preparing dental pulp stem cell exosomes and their applications, belonging to the field of exosome technology. Dental pulp stem cells from exfoliated deciduous teeth are seeded into serum-free α-MEM medium containing microparticles, insulin-like growth factor, transforming growth factor-β1, penicillin, and streptomycin for culture. Exosomes are isolated, dispersed in PBS solution, and incubated with microparticles, propylene glycol, and rhodioloside to obtain highly active dental pulp stem cell exosomes. The surface of these exosomes is then modified with shikonin and interferon to obtain dental pulp stem cell exosomes. The dental pulp stem cell exosomes prepared by this invention exhibit good affinity for titanium implant-mediated osteointegration repair materials, demonstrating good anti-inflammatory, immunomodulatory, osteogenic, and damage-reducing effects. Furthermore, the preparation method is simple, yields high output, and operates under mild conditions, showing broad application prospects.

The present invention relates to a three-dimensional biomaterial comprising particles that encapsulate at least one complementary active fragment dispersed therein. The invention also relates to a process for manufacturing said biomaterial. This biomaterial is useful for tissue regeneration, especially of dental pulp, dentin, periodontal and gingival tissues, as well as bone tissues.

The utility model discloses automatic external diameter measuring equipment, which comprises a clamping device, a moving device, a positioning device and a measuring device, the positioning device is arranged between the clamping device and the measuring device, the clamping device is connected to the moving device in a sliding mode, the clamping device can move in the direction close to or away from the positioning device and the measuring device, and when the clamping device moves in the direction close to the positioning device and the measuring device, the clamping device can move in the direction close to the positioning device and the measuring device. And then the measuring device is moved to the positioning device. The outer diameter automatic measuring equipment measures the outer diameter of the root canal file by fitting the actual application scene, the measuring result is infinitely close to the size of a hole drilled in dental pulp during actual rotation of the root canal file, the measuring result is accurate, the measuring period is short, the result can be obtained at each point in about 1.5 seconds, and the measuring efficiency is high. The method has the beneficial effects of high measurement precision and high efficiency.

The application discloses a pile channel preparation guide device and a manufacturing method thereof, and belongs to the technical field of oral cavity restoration. The application aims to manufacture a pile channel preparation guide device which can guide a doctor to accurately and simply realize the direction preparation and depth control of a predetermined pile channel. The pile channel preparation guide device manufactured by the manufacturing method has a retainer which can be embedded in a target dental pulp chamber. A guide structure is arranged in the retainer, and the guide structure has a direction which is extremely suitable for the preparation of a target root channel. The guide structure can effectively ensure the accuracy of the direction of the pile channel preparation. The length of the guide structure is equal to the working length recorded during the preparation of the root channel, minus the length of the target root channel from the target root channel opening to the root tip of the target root channel, and plus the reserved root tip sealing length. Therefore, the guide structure has a length which is extremely suitable for the preparation of the target root channel. It can be seen that the doctor can accurately and simply realize the preparation of the direction of the predetermined pile channel and the control of the depth by using the pile channel preparation guide device manufactured by the manufacturing method.

The present application provides a kind of dentin inducer for enhancing histone succinylation and its application, wherein the dentin inducer is dimethyl succinate.The present application finds that Wnt3a protein with clear odontogenic differentiation effect promotes odontogenic differentiation of dental pulp stem cells by increasing intracellular succinic acid content to induce histone succinic acid, and direct addition of succinic acid or succinic acid derivatives such as dimethyl succinate can play a Wnt3a replacement role, enhance stem cell histone succinylation and promote odontogenic differentiation of dental pulp stem cells.Furthermore, compared with Wnt3a protein class inducer, succinic acid or succinic acid derivative has the advantages of stable preparation and clear target, and is more suitable for clinical operation, which has important practical significance for promoting the clinical transformation of dental pulp dentin complex regeneration technology.

The application particularly relates to an adaptive dental pulp file, comprising: a mounting seat configured to be detachably connected with a rotating end of an electric rotating tool; a gum cleaning shaft comprising a shaft body and a first gum cleaning part made of a flexible material, one end of the shaft body being connected with an end face of one end of the mounting seat, and one end of the first gum cleaning part being connected with the other end of the shaft body; the first gum cleaning part comprising: a cluster of first gum cleaning hairs coaxially arranged with the shaft body; from the direction of the mounting seat to the direction of the first gum cleaning part, the cross-sectional area of the first gum cleaning hairs gradually decreases until the end of the first gum cleaning hairs away from the mounting seat is in a pointed structure; and a guide spring connected with the mounting seat and sleeved on the gum cleaning shaft; the adaptive dental pulp file is configured to rotate at a speed of 8000 RPM to 12000 RPM to facilitate the first gum cleaning hairs to clean the dental pulp in the root canal.

In some embodiments, the distal end of the endodontic brush is uneven (e.g., not along a line perpendicular to the axis of the brush). Optionally, the uneven strands will contact the walls of the canal more evenly and / or will have an increased agitation effect compared to a uniformly cut end that can be cut with an abrasive cutter (e.g., a grinding wheel) and / or a laser cutter and / or an electrical discharge machining (EDM) cutter. Optionally, the grinding wheel will rotate counter to the winding of the line. Optionally, a rounded end can be formed on the line. In some embodiments, the coupling between the endodontic brush and the handpiece is configured to be rotatably retained to the handpiece by friction and / or to be longitudinally locked into the handpiece by interference elements. In some embodiments, the edge of the brush is roughened. Optionally, the brush can be curved and / or off-center.

The invention provides a dental pulp stem cell exosome-loaded acellular tissue engineering nerve conduit as well as a preparation method and application thereof, relates to the technical field of biomedical engineering and nerve regeneration medicine, and aims to solve the problems of poor mechanical property, low bionic degree, high degradation rate, insufficient biological activity and the like of an existing nerve conduit. The technical key point of the invention is as follows: the dental pulp stem cell exosome-loaded acellular tissue engineering nerve conduit is provided, and the nerve conduit is obtained by loading a nanofiber conduit with enhanced function of over-expressing let-7i-5p, the porous nanofiber catheter is a porous catheter which is obtained after a polyvinyl alcohol (PVA)-chitosan (CS)-graphene (G) electrostatic spinning membrane is subjected to pipe reeling and crosslinking, and the nucleotide sequence of let-7i-5p in DPSC-Exo is shown as SEQ NO.1. The invention further discloses a preparation method of the porous nanofiber catheter.

The application discloses a YWHAH active polypeptide and a preparation method and application thereof, and belongs to the field of biological medicine and tissue engineering. The polypeptide sequence is LRDNLTLWTSDQQDE or TLWTSDQQDEEAGEG, which can target and block the GREM1 / YWHAH protein complex, and release the inhibition of GERM1 on the BMP signal pathway. Experiments prove that the polypeptide can significantly improve the osteogenic and dentinogenic differentiation ability of dental pulp mesenchymal stem cells, up-regulate the alkaline phosphatase activity and cell mineralization level, promote the expression of osteogenic and dentinogenic marker genes, and induce the formation of bone-like and dentin-like new tissues in vivo. The polypeptide has the advantages of small molecular weight, convenient chemical synthesis, good physicochemical stability, weak immunogenicity and the like, and can be used in stem cell culture preparations, composite tissue engineering scaffolds, local injection drugs and various dosage forms, and has a wide application prospect in various hard tissue defect repair scenes.

The invention particularly relates to a self-adaptive dental pulp file, which comprises a mounting seat, which is configured to be detachably connected with a rotating end of an electric rotating tool; the glue removing shaft comprises a shaft body part and a first glue removing part made of a flexible material, one end of the shaft body part is connected with the end face of one end of the mounting seat, and one end of the first glue removing part is connected with the other end of the shaft body part; the first glue cleaning part comprises a cluster of first glue cleaning hairs which are coaxially arranged with the shaft body part; from the direction of the mounting seat to the direction of the first glue cleaning part, the cross sectional area of the first glue cleaning hair is gradually reduced until one end, far away from the mounting seat, of the first glue cleaning hair is of a sharp structure; one end of the guide spring is connected with the mounting seat, and the glue cleaning shaft is sleeved with the guide spring; the self-adaptive dental pulp file is configured at the rotating speed of 8000 RPM to 12000 RPM so as to promote the first gutta-percha cleaning hair to clean the gutta-percha in the root canal.

In a method and system for performing a treatment on a tooth, ultrasonic energy is generated and transmitted by an ultrasonic instrument to a fluid located in the interior of the tooth. The amplitude and frequency of the ultrasonic energy causes inertial cavitation of gas vesicles located in bacteria present in the fluid to assist in cleaning, disinfecting, and / or delivering a payload to the fluid and interior of the tooth but is below the safety limit for ultrasonic imaging.

The invention discloses a multifunctional probe for tooth pulp activity detection, and relates to the technical field of oral medicine. Comprising arc-shaped side plates and a supporting plate, the supporting plate is connected between the two arc-shaped side plates, and a mounting block is arranged on one arc-shaped side plate; a blood oxygen probe transmitting end and a blood oxygen probe receiving end are arranged at the middle lower part of the outer side of the mounting block, the blood oxygen probe transmitting end is used for transmitting infrared light, the blood oxygen probe receiving end is used for receiving light reflected by a to-be-tested tooth, an electric activity testing electrode is arranged at the upper part of the inner side of the mounting block, and the inner side surface of the electric activity testing electrode is in contact with the tooth surface of the to-be-tested tooth; and the radian of the arc-shaped side plate is consistent with that of a dental arch curve of the to-be-detected tooth area. The multifunctional probe disclosed by the invention not only can complete an electric activity test, but also can detect the blood oxygen saturation of the dental pulp in real time, can structurally adapt to the anatomic form of the tooth surface, can obtain qualitative and quantitative activity information in single operation, and provides a more objective, comprehensive and quantifiable detection basis for judging the activity of the dental pulp.

The invention discloses a deciduous tooth pulp mesenchymal stem cell population, a separation and extraction method and a proliferation potential identification method. According to the separation method, SHED is efficiently separated from dental pulp tissues of deciduous teeth through an optimized mixed enzyme digestion method (3 mg / mL of neutral protease and 4 mg / mL of II type collagenase), and the separation success rate reaches 76% or above. According to the identification method, a proliferation-function-aging three-in-one evaluation system is constructed, and the method comprises the following steps: quantitatively evaluating proliferation potential through a clone formation rate (greater than or equal to 10%), an S-phase cell proportion (greater than or equal to 20%) and a Ki-67 positive rate (greater than or equal to 60%); the migration and paracrine capabilities are evaluated through a scratch experiment (the healing rate in 24 hours is greater than or equal to 35%) and a conditioned medium function experiment; the aging trend is evaluated through SA-beta-gal staining (the positive rate is lt; 10%). The quantitative standard of the high-quality SHED is defined for the first time, and reliable technical support is provided for quality control and standardized application of the high-quality SHED in regenerative medicine.

The invention belongs to the technical field of oral medical instruments, and provides an adjustable positioning exploring and diagnosing device and a bracket positioning method. The arc-shaped probe is detachably connected to one end of the probing handle; the sickle-shaped curettage device is detachable and can be replaced with the arc-shaped probe; and the depth probe is arranged at one end, deviating from the arc-shaped probe, of the probing handle. In the aspect of orthodontics, the depth probe is matched with the abutting piece, so that the accuracy of positioning the bracket can be improved, the bracket can be conveniently positioned through the depth probe and the abutting piece, and the bracket can be axially adjusted and an overflowing adhesive can be removed through the arc-shaped probe or the sickle-shaped scaler; in the periodontal aspect, the depth of a periodontal pocket can be measured through a depth probe, and dental calculi can be simply removed through the sickle-type scaler end. In the aspect of tooth body and dental pulp, the arc-shaped probe can meet the requirement of caries exploration, and the number of replacement times of tools in an operation is reduced. The efficiency of diagnosing and treating the oral cavity condition of the patient by medical personnel is improved.

A peptide composed of an amino acid sequence of the following General Formula 1: K—Y-R1-R2-R3-R4-R5-R6-R7-R8 (General Formula 1), a composition containing the peptide, and uses thereof are disclosed. In General Formula 1, R1 is arginine (R), lysine (K), or glutamine (Q); R2 is arginine (R) or glutamine (Q); R3, R4, and R5 are each arginine (R) or lysine (K); R6 is asparagine (N) or serine (S); and R7 and R8 are lysine (K) or tyrosine (Y). The composition is applied to the treatment of damaged dentin, such as dental caries or fractures, and thus can prevent possible dentin necrosis, dental extraction, or dental loss after treatment.

The invention relates to the technical field of medical instruments, in particular to an oral cavity tooth pulp disease treatment auxiliary device which comprises a handle, a sleeve is fixedly connected to the handle, and a lighting mechanism used for providing lighting and a saliva suction mechanism used for sucking saliva in the oral cavity are arranged at the end, away from the handle, of the sleeve. The saliva suction mechanism is communicated with a suction mechanism for assisting in sucking liquid; a linkage mechanism is also arranged in the handle and is used for driving the illumination mechanism to change the illumination angle and driving the saliva suction mechanism to change the aperture of the saliva suction port; the linkage mechanism is further used for driving the suction mechanism to operate synchronously so as to assist in saliva suction. When a doctor rotates the handle linkage mechanism, the light angle can automatically adapt to the current treatment area, the saliva suction opening is synchronously adjusted to the corresponding size, the suction mechanism is started accordingly to assist in cleaning oral liquid, the doctor can always concentrate on instrument operation, through cooperative linkage of the illumination function and the saliva suction function, the treatment view blind area can be reduced, and the treatment effect is improved. And the operation precision is improved.