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190 results about "Pulpa dentis" patented technology

Synonym(s): pulpa dentis [TA], dentinal pulp, pulp (2) , tooth pulp dental pulp a small mass of connective tissue, blood vessels, and nerves located in a chamber within the dentin layer of a tooth.

Acid-tolerant dental composition

A dental composition compatible with acidic dental primers / adhesives, the dental composition comprising (A) 5% (w / w) to 90% (w / w) of at least one polymerizable monomer having at least one ethylenically unsaturated vinyl, acrylate, or methacrylate group; (B) 0.01% (w / w) to 10% (w / w) of at least one compound of structurewhere each of R1, R2, and R3 may be the same or different and is independently selected from H, alkyl, alkoxyl, aryl, acyl, allyl, pyridyl, —OH, alkenyl, aralkyl, cycloalkyl, and heterocyclic structure containing O, S, or N; (C) 0.01% (w / w) to 10% (w / w) of at least one hydroperoxide compound with at least one hydroperoxide groups attached to a tertiary carbon; (D) 5% (w / w) to 95% (w / w) of at least one finely divided filler; (E) 0% (w / w) to 25% (w / w) of one or more components selected from a solvent, a photoinitiator, a stabilizer, and / or an antimicrobial agent. One embodiment of the invention is a dental cementation or core buildup kit that has enhanced compatibility between the acidic primer / adhesive and the cement or core buildup material, and therefore enhanced adhesion to a tooth. The kit includes (I) an acidic primer / adhesive composition having a pH less than 4.5; and (II) a cement or core buildup material having the above described composition comprising components (A)-(E). Another embodiment of the invention is a method for adhering a prosthetic device to a tooth to restore the function and / or appearance of a diseased tooth. Another embodiment of the invention is a method of providing a temporary cement, crown and / or bridge, inlay, onlay, endodontic sealer, and / or an endodontic filling material, using the inventive composition.
Owner:THE KERR

Stem cells for specifically expressing PD-1 as well as identifying and separating method and application of stem cells

The invention discloses stem cells for specifically expressing a programmed death receptor 1 (PD-1), and particularly relates to the stem cells from an organic cavity. The stem cells comprise but notlimited to dental pulp stem cells, gingival mesenchymal steam cells (GMSCs), periodontal ligament stem cells (PDLSCs), stem cells of apical papilla (SCAPs) and dental follicle stem cells (DFSCs) or any combination thereof, and preferably comprise stem cells from human exfoliated deciduous teeth (SHED) and/or dental pulp mesenchymal stem cells for permanent teeth (DPSC); the stem cells also includemesenchymal stem cells from other tissues, which do not express the PD-1 at first and express the PD-1 after being modified by CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats), suchas PD-1 plus bone mesenchymal stem cells (BMMSC) modified by the CRISPR. The invention further discloses an identifying and separating method for the stem cells for specifically expressing the PD-1,a method for preparing the PD-1 plus mesenchymal stem cells modified by the CRISPR as well as application of the mesenchymal stem cells for expressing the PD-1, disclosed by the invention, in tissue regeneration, pain relief and treatment of chronic pain and a series of diseases.
Owner:北京泰盛生物科技有限公司

Injectable tissue engineering building method for regenerating dental pulp dentin

The invention discloses an injectable tissue engineering building method for regenerating dental pulp dentin. The method comprises the following three steps: preparation of an injectable hyaluronic acid gel scaffold material, separation and cultivation of mesenchymal cells of tooth germs, building of cells and injectable scaffold material compounds in different microenvironments, material preparation of implants and histological detection. According to the method disclosed by the invention, the third generation of mesenchymal cells of tooth germs are seed cells for regenerating dentin pulp sample structures by using a tissue engineering method; TGF-beta1 plays a crucial role in building of the dentin pulp sample structures; meanwhile, the hyaluronic acid gel can be an injectable scaffold material and is suitable for injectable dental tissue engineering; the third generation of mesenchymal cells of tooth germs, the TGF-beta1 and the hyaluronic acid gel are combined and injected into an emedullated dental pulp cavity to build the injectable tissue engineering; thus, in situ regeneration of a dentin-pulp complex sample structure can be realized under the micro-trauma condition, and a new possibility is provided for in situ and physiological regeneration of the dentin-pulp complex in clinic.
Owner:SHANGHAI TISSUE ENG LIFE SCI

Dopamine-hyaluronic acid coating material as well as preparation method and application thereof in promoting specific adhesion of dental pulp stem cell to dentin

ActiveCN108192427AGrafting rate controllableGood biocompatibilityPharmaceutical delivery mechanismTissue regenerationFreeze-dryingPulpal Regeneration
The invention discloses a dopamine-hyaluronic acid coating material as well as a preparation method and application thereof in promoting specific adhesion of dental pulp stem cell to dentin, and belongs to the technical field of dental pulp regeneration. The preparation method comprises the following steps: sequentially adding raw materials including hyaluronic acid, 1-(3-dimethylamino propyl)-3-ethyl carbodiimide, N-hydroxyl succinimide and dopamine hydrochloride into deionized water according to a molar ratio of (1 to 10) to 2 to 2 to 1, and mixing uniformly; stirring at room temperature under nitrogen protection; adjusting the pH to 4-5 with hydrochloric acid or sodium hydroxide; reacting for 2-5 hours while keeping the pH value unchanged; reacting overnight at room temperature; finally, performing dialysis and purification on the obtained reaction solution for 3-5 days in an acid deionized water environment; collecting the product; performing vacuum freeze drying for 48-96h, wherein the obtained white flocculent grafted product is a dopamine-hyaluronic acid composite material. The coating thickness is controlled by changing the molar ratio of the raw materials as well as the product concentration, and the coating material can effectively promote specific adhesion of dental pulp stem cell to the root canal wall.
Owner:JILIN UNIV

Manufacturing method of biological tooth root bracket material

The invention discloses a manufacturing method of a biological tooth root bracket material. The method comprises the following steps of: flushing teeth with phosphate buffered saline (PBS) in a sterile state for three times; removing dental crown parts by grinding with a carborundum disc, and keeping tooth root parts; pulling pulp tissues out of the tooth roots and repeatedly flushing the inside of root canals with physiological saline; gradually expanding the inside of teeth with a dental expander and repeatedly flushing the inside of the root canals with 5 to 17 percent of ethylene diamine tetraacetic acid (EDTA) solution; grinding outer side tissues of the tooth roots by grinding with a dental turbine and constructing a biological tooth root profile as required so as to obtain a bracket with a specific shape; preserving the teeth in the PBS and treating in an ultrasonic oscillator for 3 to 8 times; performing stepped demineralization on a dentine with EDTA with different concentrations in a magnetic stirrer with the rotating speed of between 100 and 500 revolutions per minute so as to obtain a dentine substrate; and preserving the dentine substrate in double-antibody-containing PBS. The biological tooth root bracket material has a tooth root profile, the thickness of 1mm to 3mm, the length of 1cm to 2.5cm and certain tooth inducing capability, comprises a large number of proteins and factors related to the manufacturing of teeth, can release the proteins and factors continuously, can better solve the problem of induction micro-environment, and contributes to application to tooth socket intra-alveolar orthotopic transplantation.
Owner:成都世联康健生物科技有限公司

Long-acting antibacterial material and preparation method thereof, long-acting antibacterial dental diaphragm and long-acting antibacterial invisible appliance

ActiveCN111484641ALong-lasting and stable antibacterial effectHigh biosecurityOthrodonticsOral diseasePolymer science
The invention belongs to the field of modified materials, and particularly relates to a long-acting antibacterial material and a preparation method thereof, a long-acting antibacterial dental diaphragm and a long-acting antibacterial invisible appliance. The long-acting antibacterial material provided by the invention is prepared by carrying out tertiary amination and in-situ quaternization on a base material of which the surface is polyurethane. According to the invention, tertiary amination and in-situ quaternization treatment are carried out on polyurethane (TPU) on the surface of a base material, so that quaternary ammonium salt antibacterial groups are grafted into a molecular structure on the surface of the base material, and the material has a stable and lasting antibacterial effect. The dental diaphragm and the invisible appliance provided by the invention are both made of the long-acting antibacterial material, so that the dental diaphragm and the invisible appliance have goodbiological safety and stable and lasting antibacterial effect, and can effectively prevent and treat oral diseases such as dental caries, periodontal diseases and dental pulp diseases.
Owner:SHENZHEN TOOLINK TECH CO LTD

Preparation method of super-bionic soft and hard tissue composite scaffold

ActiveCN112791239ATroubleshoot closing difficultiesImplementing functionalized density gradient reconstructionAdditive manufacturing apparatusCulture processDirected differentiationPrinting ink
The invention discloses a preparation method of a super-bionic soft and hard tissue composite scaffold. The preparation method comprises the following steps: designing a bionic bone tissue scaffold, preparing a printing raw material, preparing printing ink, performing DLP photocuring 3D printing, performing freeze drying, extracting dental pulp mesenchymal stem cells of a patient, performing directional differentiation, inoculating and culturing the cells, preparing a soft tissue scaffold and preparing a soft and hard tissue composite scaffold. Through 3D printing of the super-bionic biological material, simultaneous personalized repair of oral clinical soft and hard tissues is achieved, development of a second operation area is avoided, and the treatment time for stage repair of the soft and hard tissues at present is shortened. Meanwhile, the three-dimensional microstructure of the jawbone tissue and the Harvard tube and the Walkman tube simulating the jawbone are inspired to establish good blood supply in the early stage, conditions are provided for layered induction of the bionic jawbone tissue, and a new thought is provided for design, research and development of the bionic scaffold.
Owner:ZHEJIANG UNIV

Method for performing interceptive treatment on osteoarthritis of knee joints through dental pulp stem cells

InactiveCN108042568AHigh pathological indexReduce exudateAntipyreticAnalgesicsTreatment effectKnee Joint
The invention discloses a method for performing interceptive treatment on osteoarthritis of knee joints through dental pulp stem cells (DPSCs). The method comprises the following steps: injecting CFA(Complete Freund's Adjuvant) and MIA (Sodium Iodoacetate) through an articular cavity and performing induction for one week to obtain a rat model of the osteoarthritis of the knee joints; performing intervention and treatment on different groups of rats after one week, wherein a treatment group adopts interceptive treatment in a way of DPSCs cell suspension liquid articular cavity orthotopic injection or intravenous injection; taking materials after treatment for 4 weeks and analyzing a treatment effect, and evaluating the treatment effect of DPSCs on the osteoarthritis of the knee joints. According to the method disclosed by the invention, an experimental result proves that the DPSCs has a treatment effect on bone osteoarthritis induced by combination of CFA and MIA; after treatment for 4weeks, through DPSCs systematic or local injection, a knee joint bone structure induced by the combination of CFA and MIA can be recovered, and exudates of the articular cavity are reduced. Through the DPSCs systematic or local injection, a transparent cartilage arrangement structure and cell forms can be recovered.
Owner:上海卡智生物技术有限公司
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