Polylactic acid aquagel and application thereof

A technology of hydrogel and lactic acid, which is applied in the fields of medical science, dentistry, dental preparations, etc., can solve the problems of complex preparation of polymer gels, simple and easy to obtain, unsuitable for wide application, etc., to promote the production of new bone , reduce the number of follow-up visits, and reduce the effect of temporary closure time

Inactive Publication Date: 2014-06-04
韩冰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of the polymer gel is complicated, the cost is high, and it is not suitable for wide application.
[0007] Therefore, none of the prior art relates to a

Method used

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  • Polylactic acid aquagel and application thereof
  • Polylactic acid aquagel and application thereof
  • Polylactic acid aquagel and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1. Polylactic acid-acetate thermosensitive hydrogel containing metronidazole

[0028] Preparation of polylactic acid-acetin hydrogel containing metronidazole: Take a certain amount of polylactic acid and glyceryl acetate hydrogel and add it into a round bottom flask for stirring. After it is completely dissolved, remove the foam and pour it into a certain mold freeze at -25°C for 9-13 hours, and then thaw at room temperature for 3-4 hours. After the aforementioned 2 to 3 cycles, the ears are soaked in distilled water, soaked in distilled water for 3 days, and then taken out to absorb surface floating water, electronic analytical balance precision weighing, adding mass of 0.5wt% metronidazole gel, vacuum Adsorption, 4 ° C standby, wherein polylactic acid accounted for 30wt% of the total weight of the gel, glyceryl acetate 10wt%.

[0029] Determination of minimum inhibitory concentration (MIC):

[0030] The polylactic acid accounts for 30wt%, and glyceryl ace...

Embodiment 2

[0034] Example 2. Polylactic acid-calcium sulfate thermosensitive hydrogel containing clindamycin

[0035] According to the method of Example 1, a hydrogel containing 30 wt% of polylactic acid, 5 wt% of calcium sulfate and 30 wt% of clindamycin was prepared.

[0036] In vitro experiments on animals:

[0037] Add 0.1-0.3g of the hydrogel of Example 2 and 20mL of 0.9% NaCl solution (just add 20mL of 0.9% NaCl solution to the blank, without adding gel) into a 100mL Erlenmeyer flask to swell for 20-30h, and then add Add 0.1mL of initial bacterial solution, place on a shaker (37°C, 150r / min), shake and culture for 20-50min, measure the concentration of viable bacteria by plate counting method, repeat the antibacterial test 5 times, each time 10 petri dishes, and repeat The result shall prevail, and the antibacterial rate of the resin shall be calculated according to the following formula:

[0038] η=(N 0 -N 1 ) / N 0 *100

[0039] where N 0 , N 1 Respectively represent the av...

Embodiment 3

[0043] Embodiment 3.BMP-2-polylactic acid thermosensitive hydrogel material

[0044] Preparation: Recombinant human bone morphogenetic protein-2 (BMP-2) and liquid polylactic acid gel (containing polylactic acid 30wt%) were pressed into the weight ratio of 1:30, and the liquid polylactic acid gel was put into 10wt% BMP-2 in guanidine hydrochloride solution. Dialyze the above mixed solution against double distilled water (50 times volume), 28°C, 4h; change the solution 4 times, after the BMP-2 precipitate is formed, lyophilize the dialyzed retentate to obtain BMP-2-polylactic acid hydrogel Material.

[0045] In vivo experiment:

[0046] Select 16 healthy adult mongrel dogs, both sexes, weighing 15-20kg, and randomly divide them into 2 groups. After intravenous anesthesia with 2% pentobarbital sodium, the 2nd and 4th premolars on both sides of the mandible were extracted. The hydrogel of Example 3 in liquid state was injected into the extraction socket of the experimental gro...

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Abstract

The invention relates to an aquagel material which comprises 3-80 wt% of colloidal particle containing lactic acid polymer, 0.1-40 wt% of pharmaceutical active component, 0-80 wt% of assistant and the balance of water. The aquagel material is applicable to promoting bone healing and new bone formation in tooth cavities after implementation of tooth extraction. The bone healing is wound healing after implementation of tooth extraction; and the new bone formation is new bone formation in a tooth implantation process. The aquagel material can also be used for temporary sealing after cavity preparation and during dental pulp disease treatment in the tooth disease treatment process.

Description

technical field [0001] The invention relates to a hydrogel material and its application, in particular to a polylactic acid-containing hydrogel and its application. Background technique [0002] Tooth extraction is the most common clinical operation in alveolar surgery. Tooth extraction, as a surgical operation, will inevitably cause varying degrees of damage to soft and hard tissues in the operative area, resulting in reactions such as bleeding, pain, and swelling. Trigger different degrees of systemic reactions, which can cause the intensification or aggravation of other systemic diseases, and are also prone to complications such as alveolar infection and pain. The trauma that occurs after surgery is called a tooth extraction wound. The healing process of tooth extraction wounds takes a long time and is often not smooth. At present, clinically, after tooth extraction, cotton balls are used to block the extraction socket to stop bleeding and prevent infection. On the surf...

Claims

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Application Information

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IPC IPC(8): A61K6/087A61K6/891
Inventor 韩冰杨莉李佳方明张海锋王颖
Owner 韩冰
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