Sucrose acetate isobutyrate gel and application thereof

A technology of isobutyric acid and sucrose esters, which is applied in the fields of medical science, dentistry, dental preparations, etc., can solve the problems of complex polymer gel preparation, unsuitable for wide application, simple and easy to obtain, etc., and achieve the prevention of infection and Occurrence of complications, promotion of healing and new bone production, effects of reducing the number of follow-up visits

Inactive Publication Date: 2014-06-04
韩冰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of the polymer gel is complicated, the cost is high, and it is not suitable for wide application.
[0007] Therefore, none of the prior art relates to a

Method used

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  • Sucrose acetate isobutyrate gel and application thereof
  • Sucrose acetate isobutyrate gel and application thereof
  • Sucrose acetate isobutyrate gel and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1. contains the sucrose acetate isobutyrate-glyceryl acetate gel (solvent: ethanol) containing metronidazole

[0028] Preparation of sucrose acetate isobutyrate-glyceryl acetate gel containing metronidazole: add a certain amount of sucrose acetate isobutyrate and glyceryl acetate into a round-bottomed flask, heat in a water bath, stir, and after they are completely dissolved, defoam , pour it into a certain mold, freeze it at -25°C for 9-13 hours, and then thaw it at room temperature for 3-4 hours. After the aforementioned 2 to 3 cycles, take it out and soak it in ethanol, soak it in glyceryl acetate for 3 days, take it out and absorb the floating ethanol on the surface, weigh it accurately with an electronic analytical balance, add 0.5wt% metronidazole with a mass of gel, Adsorbed in vacuum, set aside at 4°C, wherein sucrose acetate isobutyrate accounts for 60wt% of the total weight of the gel, and glyceryl acetate accounts for 10wt%.

[0029] Determination...

Embodiment 2

[0034] Embodiment 2. Sucrose acetate isobutyrate-calcium sulfate gel containing clindamycin (solvent: ethyl lactate)

[0035] According to the method of Example 1, a gel containing 40 wt% of sucrose acetate isobutyrate, 5 wt% of calcium sulfate and 30 wt% of clindamycin was prepared.

[0036] In vitro experiments on animals:

[0037] Add 0.1-0.3g of the gel of Example 2 and 20mL of ethyl lactate solution (just add 20mL of 0.9% NaCl solution for the blank, without gel) into a 100mL Erlenmeyer flask to swell for 20-30h, and then add Place 0.1mL of initial bacterial solution on a shaker (37°C, 150r / min), shake and culture for 20-50min, measure the concentration of viable bacteria by plate counting method, repeat the antibacterial test 5 times, 10 petri dishes each time, take the repeated results as Standard, calculate the antibacterial rate of resin according to the following formula:

[0038] η=(N 0 -N 1 ) / N 0 *100

[0039] where N 0 , N 1 Respectively represent the aver...

Embodiment 3

[0043] Embodiment 3.BMP-2-sucrose acetate isobutyrate gel material (solvent: ethanol)

[0044] Preparation: Recombinant human bone morphogenetic protein-2 (BMP-2) and liquid sucrose acetate isobutyrate gel (containing 70wt% sucrose acetate isobutyrate and 30wt% ethanol) were mixed with liquid acetic acid in a weight ratio of 1:30. The sucrose isobutyrate gel was put into 10wt% BMP-2 guanidine hydrochloride solution. Dialyze the above mixed solution against ethanol (50 times the volume), 28°C, 4h; change the solution 4 times, after the BMP-2 precipitate is formed, lyophilize the dialyzed retentate to obtain BMP-2-sucrose acetate isobutyrate coagulated glue material.

[0045] In vivo experiment:

[0046] Select 16 healthy adult mongrel dogs, both sexes, weighing 15-20kg, and randomly divide them into 2 groups. After intravenous anesthesia with 2% pentobarbital sodium, the 2nd and 4th premolars on both sides of the mandible were extracted. The gel of Example 3 in the liquid st...

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Abstract

The invention relates to a gel material which comprises 3-80 wt% of sucrose acetate isobutyrate colloidal particle, 0.1-30 wt% of pharmaceutical active component, 0-60 wt% of assistant and the balance of water. The gel material is applicable to promoting bone healing and new bone formation in tooth cavities after implementation of tooth extraction. The bone healing is wound healing after implementation of tooth extraction; and the new bone formation is new bone formation in a tooth implantation process. The gel material can also be used for temporary sealing after cavity preparation and during dental pulp disease treatment in the tooth disease treatment process.

Description

technical field [0001] The invention relates to a gel material and its use, in particular to a gel containing sucrose acetate isobutyrate and its use. Background technique [0002] Tooth extraction is the most common clinical operation in alveolar surgery. Tooth extraction, as a surgical operation, will inevitably cause varying degrees of damage to soft and hard tissues in the operative area, resulting in reactions such as bleeding, pain, and swelling. Trigger different degrees of systemic reactions, which can cause the intensification or aggravation of other systemic diseases, and are also prone to complications such as alveolar infection and pain. The trauma that occurs after surgery is called a tooth extraction wound. The healing process of tooth extraction wounds takes a long time and is often not smooth. At present, clinically, after tooth extraction, cotton balls are used to block the extraction socket to stop bleeding and prevent infection. On the surface of the too...

Claims

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Application Information

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IPC IPC(8): A61L15/20A61L15/44A61L15/42A61K6/02A61L31/14A61L31/16
Inventor 韩冰杨莉李佳方明张海锋王颖
Owner 韩冰
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