112results about How to "Excellent temperature sensitive performance" patented technology

This invention relates to a method for prparing temperature-sensitive polyvinylidene flourine intelligent membrane. The method is: NIPA as grafted monomer, PVDF as macromelocular initiator, cuprous chloride as catalyst,4,4 demethyl 2,2 bipyridine as ligand, using atom transfer free radical process, preparation of temperature-sensitive polyvinylidene flourine intelligent membrane comprising: in reaction kettle, adding 7-13% PVDF(WT%) and solvent N-methyl-2-pyrrolidone,heating to 50 deg. C to make it solve completely; then adding grafted monomer NIPA, its mol ratio with cuprous chloride is 2000:1-2500:1,filling nitrogen gas 30mins. at stirring, and separately adding 0.20-025g ligand 4,4-dimethyl 2,2-bipyridine and 0.04-0.06g catalyst cupous chloride, stirring and heating to 80-120deg.C,constant reaction 19-25 hrs; then washing reaction product using pure water to obtain light brown solid, filtering and 80 C degree drying to obtain finish product.

The invention discloses a preparation method of gel nano particles in a thermosensitivie nuclear shell structure and an application of a product thereof. Thermosensitive microgel is prepared by the preparation method by using polybutadiene nanometer emulsion particles as nucleus, grafting poly(N-isopropyl acrylamide) on the surface of the nucleus by a free radical polymerization method under the effect of a cross-linking agent. The microgel can be used as a nano reactor. Nano silver particles with controllable particle size and distribution are prepared through an in-situ reduction reaction. The microgel carrying the nano silver particles can be used as a high-performance catalyst, a bacteriacide and the like.

The invention discloses a semi-interpenetrating network nano hybrid hydrogel and a preparation method and an application thereof. Firstly, chitosan is modified to prepare water soluble carboxymethyl chitosan (CMCS); then N-isopropylacrylamide (NIPAM), CMCS and (carboxyl functionalized) carbon nanotubes are subjected to in-situ free radical crosslinking polymerization reaction, and the semi-interpenetrating network nano hybrid hydrogel with different composition ratios of NIPAM, CMCS and the nanotubes is obtained. The prepared novel nano hybrid hydrogel has relatively high swelling rate, appropriate volume phase transition temperature and pH phase transition point, and high drug loading amount and continuous controllable drug release behavior. The hydrogel pharmaceutical preparation can be used as a promising hydrophilic oral drug carrier, is used for targeted release of oral vaccines, polypeptides, proteins and anticancer drugs, has low toxicity, and can be used for long-term treatment of colon cancer and the like.

The invention discloses a preparation method of a biological multilayer nerve conduit containing mesenchymal stem cells. The method comprises the following steps: (1) dissolving a photocurable biological hydrogel with a PBS solution containing a photoinitiator to obtain two concentrations of biological ink; (2) collecting mesenchymal stem cells with confluence degree of more than 80%, and resuspending the mesenchymal stem cells with low concentration of biological ink after treatment to obtain cell-loaded biological ink; 3) load that cell-loaded biological ink and the high-concentration biological ink into two nozzles of the biological 3D printing device respectively; (4) setting printing parameters, firstly printing the cell-carrying biological ink on the optical axis rotating uniformly to obtain a first layer of nerve conduit; And then printing high-concentration biological ink to obtain a double-layer hollow tubular nerve conduit; (5) Biological multilayer nerve conduit was obtainedby ultraviolet irradiation. The invention has the advantages of short preparation time, simplicity, mild operation conditions, simple structure, good biocompatibility and degradability of the prepared nerve conduit.

The preparation method includes two steps of dispersing macromolecular monomer solution to be microdroplets under temperature of phase shift for macromolecular monomer solution and then rising temperature to cause polymerization.

The invention discloses a fluorine-containing block graft polymer with thermosensitivity and a preparation method and application thereof. According to the invention, fluorine-containing acrylate monomers are polymerized into a macroinitiator by adopting atom transfer radical polymerization; the macroinitiator and glycidyl methacrylate are copolymerized; and after an azide group is introduced into a side chain epoxide cleavage of the obtained product, a polymer with thermosensibility is grafted by adopting the click chemical reaction so as to obtain the block graft polymer. The fluorine-containing block graft polymer has mild reaction conditions, is easy to operate and has high reaction speed and high conversion rate. The preparation method of the fluorine-containing block graft polymer with thermosensitivity, which is disclosed by the invention, is simple and convenient to operate, and has low toxicity and high product purity; and the prepared fluorine-containing block graft polymer with thermosensitivity not only has the advantages of fluorine-containing materials, but also has excellent performance of thermosensitivity and realizes function combination.

The invention relates to a PEG type thermosensitive hydrogel three-dimensional cell scaffold and as well as a preparation method and application thereof. The preparation method of the three-dimensional cell scaffold comprises the steps of mixing acrylate water-soluble macromolecular polymerizable monomer containing a PEG side chain, an initiator, a surfactant, a cross-linking agent and/or comonomer, reacting and obtaining PEG type thermosensitive nano gel; mixing the PEG type thermosensitive nano gel with cells uniformly at room temperature, and forming the PEG type thermosensitive hydrogel three-dimensional cell scaffold by thermally inducing in-situ embedded cells. The preparation method is easy to conduct, is featured by mild conditions, and damages cells slightly. Compared with a traditional PNIPAM type thermosensitive hydrogel scaffold, the PEG type thermosensitive hydrogel scaffold has high biocompatibility, is degradable, is adjustable in nature, prolongs syneresis slightly along with time, and can keep cells growing and proliferating for long time, thereby being an ideal tissue engineering material, and being used in fields like in vitro culture of cells, tissue repair andtumor treatment.

The invention discloses an intelligent graphene nano-material with high chiral selectivity as well as preparation and application thereof. The material is prepared from graphene, a temperature-sensitive component, a magnetic component and the like. The material disclosed by the invention has high chiral selectivity, temperature-sensitive performance and magnetic responsiveness; the material has the advantages of simplicity in operation, high resolution efficiency, convenience for recycling materials, and environment-friendly operation process in chiral resolution of an amino acid enantiomer, and has a good industrial application prospect.

The invention provides temperature-sensitive waterproof moisture-permeable shell fabric and a preparation method thereof. The preparation method includes soaking base cloth in hydrochloric acid for hydrolysis, wherein the base cloth is shell fabric which can contain an amino and/or hydroxy structure after being hydrolyzed; soaking the hydrolyzed base cloth in a glutaric dialdehyde solution for pre-crosslinking reaction, and subjecting the pre-crosslinked base cloth to padding treatment in temperature-sensitive hydrogel so as to obtain crosslinked base cloth; applying the surface of the crosslinked base cloth with a coating agent and baking so as to obtain the temperature-sensitive waterproof moisture-permeable shell fabric. The temperature-sensitive waterproof moisture-permeable shell fabric has the advantages of good temperature-sensitive performance and waterproof moisture-permeable performance as well as excellent washability because of good bonding performance and high bonding firmness between the temperature-sensitive hydrogel and nylon fabric.

The invention discloses an alkoxy ethers temperature-sensitive polymer nanometer microsphere and a preparation method thereof. The method includes the steps of first catalyzing two monomers for copolymerization through rhodium metal to obtain a temperature-sensitive polymer; dissolving the polymer in an acidic aqueous solution, and adding a corresponding cross-linking agent to obtain the intelligent nanometer microsphere. The nanometer microsphere has good dispersibility in an aqueous solution and shows good temperature-sensitive behavior. The size of the nanometer microsphere can be reversibly regulated through external temperature stimuli. The alkoxy ethers temperature-sensitive polymer nanometer microsphere and the preparation method thereof provide a theoretical basis for the construction of the nanometer microsphere through a dynamic keys crosslinked temperature-sensitive polymer, have an important academic value in the preparation of novel intelligent nanometer materials and are instructive for the expansion of the application of the stimulus responsive temperature-sensitive polymer in the fields of materials science, drug sustained release and envelope.

The invention relates to the field of functional macromolecular materials, in particular to novel linear temperature-sensitive type polyurethane and a preparation method thereof. The preparation method of polyurethane comprises steps as follows: polycarbonate diol and dimethylolpropionic acid are added to an organic solvent and are mixed uniformly at the temperature of 75-85 DEG C under the protection of nitrogen, then hexamethylene diisocyanate and a catalyst are added, the mixture is stirred at the temperature of 75-85 DEG C and reacts for more than 3 h to generate linear polyurethane with isocyanato as an end group, ethylenediamine and triethylamine are added, the mixture is stirred to react for 2 h or longer, linear polyurethane with amino as an end group is obtained, N-isopropyl acrylamide is added, the mixture is stirred to react for 12 h or longer, then deionized water is added, an organic solvent is removed through rotary evaporation in a vacuum state, and the novel linear temperature-sensitive type polyurethane is obtained. Two ends of a polyurethane chain segment of the novel linear temperature-sensitive type polyurethane are directly sealed with N-isopropyl acrylamide, no other chain segments are contained, the synthetic method is simple, the synthesis and chemical grafting steps of poly(N-isopropyl acrylamide) are omitted, synthetic raw materials are also saved, and the cost is reduced.

The invention discloses a method for preparing a structure controlled temperature-sensitive polyvinylidene fluoride (PVDF) flat separation membrane and a product thereof, belongs to the technical field of membranes, and particularly relates to an intelligent polymeric membrane technology. According to the structure controlled temperature-sensitive polyvinylidene fluoride flat separation membrane, the flat separation membrane has temperature response property at the temperature of between 27 and 32 DEG C, and the flat separation membrane can be prepared by the following method of preparation of the PVDF flat membrane and temperature-sensitive modification of the PVDF flat membrane. The method prepares the temperature response PVDF flat separation membrane, the pure water flux of the membrane is abruptly increased at the temperature of 27 to 32 DEG C, the interception rate of the membrane on bovine serum albumin and the like is abruptly reduced, and the abrupt change amplitude reaches over 40 percent. The product is simple in process and low in cost, does not need special equipment, is easy for industrialized implementation, and has good membrane temperature sensitivity.

The invention discloses composite hydrogel, a preparation method and application thereof, and belongs to the technical field of biology. The preparation method of the composite hydrogel comprises thefollowing steps: dissolving chitin in an alkali and/or urea solution, and carrying out etherification modification on the chitin to obtain hydroxypropyl chitin (HPCH); uniformly mixing the HPCH and hyaluronic acid (HA) to prepare a gel aqueous dispersion, pouring the gel aqueous dispersion in a glass container, placing the glass container in a refrigerator, and performing freeze-drying to obtain gel powder; dissolving the gel powder in a PBS, performing uniform ultrasonic mixing, and then placing the obtained mixture in the refrigerator overnight for swelling; and after swelling, adding powdercontaining Mg<2+>, and performing uniform stirring and then ultrasonic dispersion to obtain Mg<2+>/HA/HPCH composite hydrogel. The composite hydrogel can be used for preparing 3D printing bio-ink, printing in vivo can be realized according to designed shapes and sizes, the sprayed bio-ink can be formed at a specified part, and cartilage defects can be repaired individually.

The invention provides a thermo-sensitive hydrogel and a preparation method thereof. The method comprises the following steps: dissolving a thermo-sensitive monomer and a cross-linking agent in a solvent, and carrying out a polymerization reaction through the irradiation of ultraviolet lights in the presence of a photoinitiator, so as to obtain the thermo-sensitive hydrogel, wherein the photoinitiator has a light bleaching effect, and the cross-linking agent is a substance with a bifunctional degree. According to the method disclosed by the invention, an external heating source is not needed,only the irradiation of the ultraviolet lights is needed, the reaction time is short, the pollution is avoided, the energy is saved, the environment is protected, the preparation method is efficient and controllable, and the prepared hydrogel has good thermal sensitivity, thermal stability and mechanical property. The poly(N-isopropylacrylamide) hydrogel with thermal sensitivity prepared by the embodiment of the invention has a diameter of about 10mm, the length can reach 80mm, the swelling rate at 25 DEG C is 400-1100%, the low critical phase transition temperature is 30-32 DEG C, and obviousthermal sensitivity is achieved.

The invention relates to thermosensitive graphite oxide composite aquagel and a preparation method thereof and belongs to the technical field of chemical engineering in high polymers. The method is specifically implemented according to the following steps: firstly, preparing graphite oxide by an improved Hummers method, then, dispersing the graphite oxide and a polymerization monomer into an aqueous solution under ultrasonic assistance, and carrying out a heat-preserving reaction, thereby obtaining thermosensitive poly(acrylic acid/diacetone acrylamide/acrylamide)/graphite oxide composite aquagel. During the preparation of the aquagel, multi-step reaction is not required, N2 introducing treatment is not required, and the method is easy and feasible. The composite aquagel prepared by the method has the advantages of appropriate water retention property, good thermal shrinkage sensitivity and the like.