12results about How to "Excellent temperature sensitive performance" patented technology

The invention belongs to the field of drug-loaded nanoparticles, and provides a targeted drug-loaded nanoparticle with multiple responsiveness and a preparation method thereof. The targeted drug-loaded nano-particle with multiple responsiveness is prepared from poly (N-isopropylacrylamide-co-acrylic acid-co-N-acryloyloxy succinimide) nanogel with temperature and pH response characteristics, an anti-tumor drug and a folic acid layer capable of specifically targeting a folic acid receptor of a tumor cell, wherein the temperature and pH response characteristics are realized by the poly (N-isopropylacrylamide-co-acrylic acid-co-N-acryloyloxy succinimide) nanogel; the anti-tumor drug is loaded in the polymer network structure of the nanogel to form drug-loaded nanoparticles, the folic acid layer is composed of aminated folic acid molecules, the folic acid layer coats the drug-loaded nanoparticles, and amino groups of the aminated folic acid molecules are grafted on the surfaces of the drug-loaded nanoparticles. According to the invention, the preparation method of the existing chemotherapy nano-drug carrier can be simplified, the controllability of the preparation process is improved, the biocompatibility of the existing chemotherapy nano-drug carrier is improved, and the targeting property of the existing chemotherapy nano-drug carrier is enhanced.

The invention provides herbal ointment for relieving limpness, numbness and swelling pain and a preparation method thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition is prepared from the following raw materials: codonopsis pilosula, cinnamon, angelica sinensis, corydalis serrate, paeonia lactiflora, peony root bark, ligusticum chuanxiong hort, liquorice, fructus evodiae, caulis spatholobi, leonurus, rhizoma corydalis, garden balsam stem, radix aconiti carmichaeli, rhizoma atractylodis, lycopodium clavatum, cortex dictamni, ramulus mori, radix clematidis, rhizoma arisaematis, semen brassicae and notopterygium root. The herbal ointment for relieving limp, numb and swelling pain has the effects of promoting blood circulation to remove blood stasis, expelling wind and removing cold, relieving pain and clearing damp, expelling toxin and enhancing immunity, is good in transdermal absorption promoting effect, long in contact time with skin and lasting in acting effect, can well improve toothache and arthralgia caused by shoulder pain, cervical vertebra pain, waist soreness and back pain, stiff neck, dizziness, headache and excessive internal heat, and has the effects of relieving pain, relieving swelling pain, relieving pain and relieving swelling pain. , varicosity, sprain, bruise, limpness, numbness and swelling pain of limbs, and the like, and has a wide application prospect.

The present invention relates to the field of bioengineering technology, and specifically to the construction of a membraneless organelle and its application in regulating metabolic synthesis. By designing an octapeptide basic element, a recombinant disordered protein composed of repeated tandem peptide segments is constructed, which is introduced into an expression host to obtain a biomolecular condensate, i.e., a membraneless organelle. A membraneless organelle with good fluidity, stability, and temperature sensitivity is constructed and verified in Bacillus subtilis cells, proving that the constructed recombinant disordered protein has a high degree of programmability. The function of the membraneless organelle is tested using a visualization experiment. The constructed membraneless organelle can not only allow the extended penetration of small molecule compounds, but also recruit specific targeting proteins, and can be used to regulate the metabolism of target compounds.

The invention discloses fire-extinguishing flame-retardant temperature-sensitive hydrogel as well as a preparation method and application thereof, and belongs to the technical field of high polymer materials. The flame retardant solution and the chitosan solution are mixed and stirred, then a polyethylene glycol solution is added, stirring continues, and chitosan colloid is obtained; adding a heat-sensitive agent, a cross-linking agent and an initiator into water, then adding the obtained mixed solution into the chitosan colloid, carrying out heating reaction, and then filtering to obtain the fire-extinguishing flame-retardant temperature-sensitive hydrogel. The hydrogel prepared by the invention has good thermosensitivity, forms a carbon layer at a high temperature, has dual effects of flame retardance and fire extinguishment, and is suitable for the fields of fire fighting, buildings, textiles, electronics and the like. The materials used for preparing the hydrogel are all biodegradable materials and are environmentally friendly; the preparation method is simple, easy to operate and suitable for large-scale production.

The application provides an apatite structure silicate fluorescent powder, a preparation method thereof and application thereof in the field of optical temperature sensing, and relates to the technical field of fluorescent materials. z (SiO4)6O2:0.01Bi 3+ ,xEu 3+ ; 0 < x < 0.12, z = 8(1-0.01-x). The application adjusts Bi 3+ →Eu 3+ energy transfer by controlling Eu 3+ doping concentration in the Mg2Gd8(SiO4)6O2 matrix, realizes tuning of the fluorescent powder from blue light to red light, and particularly, the Bi 3+ →Eu 3+ energy transfer in the process of temperature rise and drop is beneficial to improving the temperature measurement sensitivity of the fluorescent temperature probe based on FIR, and realizes high-sensitivity optical temperature sensing (the maximum relative sensitivity reaches 0.92%K ‑1 (498K)). Meanwhile, the fluorescent powder can also be widely applied in the field of temperature visualization.

This invention relates to a mildly photothermal-releasing, injectable, self-healing hydrogel dressing for wound healing after oral cancer surgery. The hydrogel dressing is prepared by loading NO donor-loaded nanoparticles into a thermosensitive ABA triblock copolymer. This hydrogel dressing possesses thermosensitivity, injectability, self-healing properties, mild photothermal antibacterial activity, controlled NO release, blood compatibility, and biocompatibility. It can promote tissue regeneration, angiogenesis, and cell migration in postoperative wounds after oral cancer surgery, making it an ideal material for postoperative wound management in oral cancer patients.

The invention relates to a thermo-sensitive black phosphorus hydrogel (BP at Gel) for wound healing. The hydrogel is composed of a black phosphorus nanosheet loaded drug sulfadiazine silver and a chitosan thermo-sensitive hydrogel. The hydrogel has the temperature-sensitive characteristic, and can continuously release the medicine silver sulfadiazine under near-infrared irradiation, so that photo-thermal and antibacterial synergistic treatment is achieved. Meanwhile, the antibacterial effect on staphylococcus aureus is achieved. The thermo-sensitive black phosphorus hydrogel is a good wound dressing, and in a rat skin wound model, collagen deposition is promoted, new vessels are increased, and inflammatory factors are inhibited. The preparation method provided by the invention is simple to operate, and the hydrogel has thermosensitivity and good stability and biocompatibility, and can significantly improve the capability of promoting wound healing.

This invention discloses the preparation and application of radiofrequency thermoresponsive platinum ion crosslinked black phosphorus nanogel. The nanogel has a core-shell structure, comprising a core composed of a radiofrequency thermosensitive agent and chemotherapeutic drugs, and a shell constructed from a thermosensitive nanopolymer. The thermosensitive nanogel BP-Pt@PNA prepared using the above components exhibits radiofrequency thermosensitive properties. Simultaneously, the introduction of the thermosensitive nanopolymer improves the stability of the radiofrequency thermosensitive agent and chemotherapeutic drugs, enabling long-term drug retention and fully leveraging the synergistic effect of non-invasive radiofrequency thermotherapy and chemotherapy. This drug-loaded nanogel can achieve multimodal treatment applications, including non-invasive radiofrequency thermotherapy-chemotherapy synergistic antitumor therapy and invasive radiofrequency ablation-chemotherapy-vascular embolization synergistic antitumor therapy, demonstrating significant clinical translational potential.

The invention discloses a 3D printing cavernous body organ-like model capable of simulating an erectile physiological process, and belongs to the technical field of tissue engineering and regenerative medicine. The hydrogel is formed by photo-curing 3D printing of a dual-network hydrogel material formed by blending a pig cavernous body acellular extracellular matrix pregel solution and polyethylene glycol diacrylate, and has a bionic sine curve expansion structure; micron-sized grooves for guiding the directional arrangement of smooth muscle cells are formed in the surface of the micro-sphere, and an elliptical cavity for providing structural support is formed in the micro-sphere. A pig cavernous body dECM pre-gel solution is used as a base material, so that a microenvironment for living of cells in a body can be effectively simulated; by regulating and controlling the proportion of PEGDA, the mechanical property of the model is matched with that of a natural cavernous body tissue. The organ model can reproduce the NO-mediated smooth muscle cell relaxation and tissue expansion physiological process in vitro, and provides an effective in-vitro platform for researching the pathological mechanism of erectile dysfunction, screening drugs and developing a novel treatment method.

The invention provides silicate fluorescent powder with an apatite structure, a preparation method of the silicate fluorescent powder and application of the silicate fluorescent powder in the field of optical temperature sensing, and relates to the technical field of fluorescent materials. The chemical formula of the fluorescent powder is Mg2Gdz (SiO4) 6O2: 0.01 Bi < 3 + >, xEu < 3 + >, 0 lt; x is less than or equal to 0.12, and z is 8 (1-0.01-x). In a Mg2Gd8 (SiO4) 6O2 matrix, Bi < 3 + >-Eu < 3 + > energy transfer is adjusted by controlling the doping concentration of Eu < 3 + >, and tuning of the fluorescent powder from blue light to red light is achieved; especially, energy transfer from Bi < 3 + > to Eu < 3 + > in the heating and cooling process is beneficial for improving the temperature measurement sensitivity of the FIR-based fluorescent temperature probe, and high-sensitivity optical temperature sensing (the maximum relative sensitivity reaches 0.92% K <-1 > (498K)) is realized. Meanwhile, the fluorescent powder can also be widely applied to the field of temperature visualization.

The present application belongs to the technical field of thermoelectric conversion, and particularly relates to a self-repairing thermoelectric hydrogel based on lignin, a thermoelectric conversion device, and a preparation method and application thereof. The present application successfully prepares a self-repairing thermoelectric hydrogel based on lignin by compounding specific inorganic small-molecule thermoelectric materials with cyclodextrin-modified lignin sulfonate and adamantane acrylate. In the formation process of the thermoelectric hydrogel, the inorganic small-molecule thermoelectric materials are uniformly dispersed in the network structure of the hydrogel, so that the hydrogel has excellent mechanical properties; the host-guest interaction introduced by the cyclodextrin-modified lignin sulfonate enables the hydrogel to have excellent self-repairing ability; the hydrogel also has good temperature sensitivity; the above characteristics greatly improve the thermal effect, thermoelectric conversion performance and electrochemical performance of the thermoelectric conversion device prepared based on the above thermoelectric hydrogel; and the preparation method of the above thermoelectric hydrogel is simple and easy to operate, the conditions are mild, the raw materials are easy to obtain, and the thermoelectric hydrogel has a wide application prospect.

The present invention belongs to the field of polymer compounds and mercury ion detection, and provides mercury ion responsive linear polymers and polymer smart gels and preparation methods thereof. The mercury ion responsive linear polymer of the present invention is poly(N-isopropylacrylamide-co-allylbarbituric acid), which is formed by one-step copolymerization of N-isopropylacrylamide monomers and allylbarbituric acid monomers. The mercury ion responsive linear polymer of the present invention has excellent specific recognition ability for mercury ions, which can solve the problem that the selective recognition ability of existing mercury ion recognition polymer materials for mercury ions and trivalent ions is not high. The mercury ion responsive polymer smart gel of the present invention is polymerized by N-isopropylacrylamide monomers, allylbarbituric acid monomers and cross-linking agents. The operation of detecting mercury ions or adsorbing and removing mercury ions in water based on the smart gel is simple, and has good application prospects.