The invention relates to a manufacturing method of a medium-carbon CrMo steel wire rod free of annealing and drawing, and belongs to the field of wire rod production. Raw materials are prepared and smelted according to chemical compositions, and KR hot metal pretreatment, converter smelting, LF and RH refining, steel blank machining, warm supply or heat supply, steel blank heating and cogging, middle blank surface clearing, reheating, high-pressure water descaling, rolling control and temperature control, cooling control and wire rod forming are carried out in sequence. Rolling comprises roughrolling, medium finish rolling and reducing and sizing. In the medium finish rolling process, in the later period, rolled parts are subjected to water cooling to be below phase change temperature, and the compression ratio of the last two passes is set to be larger than or equal to 35%; coils are slowly cooled online; and the roller speed is constant, a heat preservation cover is closed for heatpreservation, and the rolled parts are discharged out of the cover to be subjected to air cooling to room temperature. The wire rod needs no annealing before drawing, large-draft drawing can be directly carried out, the production cost is reduced, and energy saving and environment protection are achieved.