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Application of etoposide and cytarabine combined mobilization technology to lymphomas/myelomas

A technology of cytarabine and etoposide, which is applied in the field of medicine, can solve the problem of high recurrence rate, achieve the effect of improving curative effect, increasing compliance and tolerance, and good safety

Inactive Publication Date: 2016-02-03
FUJIAN MEDICAL UNIV UNION HOSPITAL
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Problems solved by technology

[0006] The disadvantage of autologous hematopoietic stem cell transplantation compared with allogeneic transplantation is its high recurrence rate

Method used

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  • Application of etoposide and cytarabine combined mobilization technology to lymphomas/myelomas
  • Application of etoposide and cytarabine combined mobilization technology to lymphomas/myelomas
  • Application of etoposide and cytarabine combined mobilization technology to lymphomas/myelomas

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Embodiment Construction

[0017] The present invention will be further described in detail below in conjunction with the embodiments and the accompanying drawings. It should be noted that the protection scope of the present invention shall include but not be limited to the technical content disclosed in this embodiment.

[0018] 1. In 16 patients (12 cases of myeloma, 4 cases of lymphoma, see Table 1 for details), the mobilization regimen of etoposide combined with cytarabine (etoposide 0.1 / m 2 , d1-3, cytarabine 0.5 / m 2 , bid, d1-3, G-CSF5ug / kgd5), monitor the blood picture and the number of CD34+ cells after chemotherapy, when the peripheral blood CD34+>10( / ul) (up to the standard), use the COBESpectra blood cell separator with version 6.1 software and double Fill the plate at the level, install the AutoPBSC pipeline according to the flow path of the collection liquid, and input the height, weight, hematocrit, white blood cell count, and percentage of mononuclear cells after initialization. The har...

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Abstract

The invention discloses application of an etoposide and cytarabine combined mobilization technology to lymphomas / myelomas. The etoposide and cytarabine combined mobilization chemotherapy technology is applied to lymphoma / myeloma peripheral blood autotransplantation for autologous hematopoietic stem cell mobilization. The application of the etoposide and cytarabine combined mobilization technology to the lymphomas / myelomas has the advantages that the etoposide and cytarabine combined mobilization technology is good in use effect, so that patients' compliance on and tolerance to chemotherapy / transplantation are enhanced, chemotherapy effect and transplantation effect are improved, cost is reduced for patients, survival time of the patients is prolonged, cure ratio is increased, and the application is good in social and economic benefits and has promising clinical application prospect; the efficient safety mobilization technology can be used for lymphoma / myeloma autologous stem cell transplantation, so that tumor treatment effect is improved.

Description

technical field [0001] The invention belongs to the field of medicine, especially the application of etoposide combined with cytarabine mobilization technology in lymphoma / myeloma, and mainly relates to the autologous hematopoietic stem cell mobilization scheme, which is mainly carried out by etoposide combined with cytarabine Mobilization not only increases patients' compliance and tolerance to chemotherapy / transplantation, but also improves the curative effect of chemotherapy and transplantation. Background technique [0002] Hematopoietic stem cell transplantation (HSCT) is pretreated with high-dose radiotherapy and chemotherapy or other immunosuppressants to remove tumor cells and abnormal clone cells in the recipient, block the pathogenesis, and then transplant autologous or allogeneic hematopoietic stem cells to the recipient to make Receptor reconstruction of normal hematopoietic immunity, and a therapeutic approach to achieve therapeutic purposes. Autologous stem ce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7068A61P35/00A61K31/7048
Inventor 李乃农李晓帆付海英
Owner FUJIAN MEDICAL UNIV UNION HOSPITAL
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