Tumor targeting drug delivery system loaded with nanometer materials, and construction method and application of tumor targeting drug delivery system

Abstract

The invention discloses a tumor targeting drug delivery system loaded with nanometer materials, and a construction method and application of the tumor targeting drug delivery system. The method comprises the following steps: reconstituting CTAB modified gold nanorods with water, feeding the gold nanorods into a BSA solution, a NaOL solution or an MUDA solution to perform stirring reaction, centrifuging a reaction product, and taking precipitate, so as to obtain BSA, NaOL or MUDA modified gold nanorods, and feeding macrophage to perform incubation together, so as to form the tumor targeting drug delivery system loaded with the nanometer materials. The drug delivery system can effectively improve the tumor targeting and penetrating capacity of the nanometer materials, efficiently converts light energy into heat energy through the nanometer materials and irradiation of near infrared laser, further kills tumor cell, and reduces toxic and side effect during treatment while effectively enhancing targeted therapy of nanometer photothermal conversion materials, thereby constructing a medical strategy for tumor treating through high targeting conveying nanometer photothermal conversion materials by taking macrophage as a carrier.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a tumor-targeted drug delivery system loaded with nanomaterials and its construction method and application. Background technique [0002] Throughout the long history of humanity's struggle with disease, cancer has been one of the diseases we want to fight but don't quite understand. Nowadays cancer has become the number one killer threatening our health. The ever-increasing morbidity and mortality rate make everyone "disgusted when talking about cancer", so the medical demand for effective cure of cancer is becoming more and more urgent. [0003] As early as 1896, William Halsted's surgical resection of tumors has officially opened the most important clinical treatment for tumors. However, surgical resection of tumors cannot prevent the metastasis of cancer cells and cannot eliminate cancer cells in the circulating blood, so However, after the operation, it is s...

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Problems solved by technology

[0006] ① Insufficient ability to target tumors, easy to accumulate in non-treatment areas, causing side effects;

[0007] ②Insufficient ability of nano-drugs to actively penetrate tumor tissue, especially in hypoxic areas of tumors, where nano-drugs are difficult to reach;

[0008] ③ The tumor treatment effect is not good, and the tumor is prone to recurrence and metastasis

[0009] In recent years, the rapid development of nanomaterials research has provided new ideas for the precise cure of tumors. However, due to the complex microenvironment in vivo, tumor cells can continuously adapt and avoid the recognition of nanomaterials, and the tumor tissue structure is dense and lacks lymphatic return. characteristics, making it difficult for nanomaterials to efficiently target tumor tissues to exert anti-tumor effects

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