Dyskinesia non-intrusive rehabilitative closed-loop brain-computer integrated system based on FPGA

Abstract

The invention provides a dyskinesia non-intrusive rehabilitative closed-loop brain-computer integrated system based on an FPGA. The FPGA is used as a control core of the system, nuclei basales and thalamic-cortical prosthesis hardware model is set up, data obtained through calculation of a self-adaptation control algorithm based on the FPGA is used as input to control model parameter setting and force feedback and adjustment until an expected control result is achieved, the self-adaptation control algorithm based on the dynamic causal model is realized, force feedback signals are output, and therefore rehabilitation of patients with the dyskinesia nervous system diseases is achieved. Rehabilitation of the patients with dyskinesia nervous system diseases is achieved, and the complex nuclei basales and thalamic-cortical neuron network and the self-adaptation control algorithm of the dynamic causal model are modeled. The platform provides the effective theoretical basis and technical support for rehabilitation of the dyskinesia nervous system diseases and has important practical value in research on control and treatment on nerve diseases such as Parkinson's disease, epilepsia and alzheimer's disease.

Description

technical field [0001] The invention relates to biomedical engineering technology, in particular to a closed-loop brain-machine-body interface hardware system for non-invasive rehabilitation of movement disorders based on FPGA. Background technique [0002] In recent years, movement disorder neurological diseases have seriously endangered human health, and have had a great impact on patients' work and life, and because nerve cells are not easy to regenerate after injury, the rehabilitation treatment of these neurological diseases is still unclear . Movement-impairing neurological diseases such as Parkinson's and dystonia are generally considered to be disorders of the neurobasal ganglia, and this simplified mapping does not capture the pathophysiology of this movement-impairing neurological disease, which involves complex interacting processes and numerous The path problem of neuroanatomy requires a system-level description and understanding of the dynamic mechanism and neu...

AI Technical Summary

Problems solved by technology

At present, dopamine replacement drugs are the main means of drug treatment, however, such as depression, dementia, hallucinations and other diseases are dopamine resistant, long-term use of dopamine replacement therapy may induce a variety of serious side effects, such as deterioration of lower limb proprioception, induced Dopamine dysregulation syndrome; the invasive method of DBS treatment will bring additional risks and complications to the operation, and the high cost of treatment also limits its use, and the non-invasive method will reduce the risks due to the operation; Symptoms can vary through factors such as individual genetics and disease progression

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