46results about How to "Enable Personalized Treatment" patented technology

The invention discloses a continuous blood sugar monitoring based method for processing and displaying diabetes management information with intervention information. The method comprises an information processing step and an information displaying step. In the information processing step, blood sugar change information is continuously acquired in all weather through an optical monitoring based noninvasive blood sugar monitoring technology; and in the information displaying step, a blood sugar monitoring result generated by continuous blood sugar monitoring is mapped to a two-dimensional graph to be displayed, and a curve graph of blood sugar changed with time change is formed. The method has the beneficial effects that the optical monitoring based noninvasive blood sugar monitoring technology is adopted, and a displaying method for correlating life intervention information of drug treatment, diet, exercise and the like with blood sugar change is provided, so that patients are helped to understand positive effects of the drugs, the exercise and the diet on the blood sugar change, visual knowledge is provided for the patients, and the patients are promoted to actively perform intervention and management.

The invention belongs to the technical field of medicine, and specifically relates to a primary tumor cell culture medium, culture method and application. The primary tumor cell culture method provided by the invention comprises the steps as follows: preparing a primary cell culture medium which comprises the following components: hydrocortisone, EGF, Insulin, a ROCK inhibitor, but not contains cholera toxin, and is an improvement of the existing primary cell culture medium; culturing tumor tissue epithelial cells on laid-out trophoblast cells by using the primary cell culture medium, and enabling the tumor tissue epithelial cells to proliferate rapidly under the combined action of growth factors secreted by the trophoblast cells and nutrient factors contained in the culture medium; and digesting and sub-culturing the tumor tissue epithelial cells when the tumor tissue epithelial cells grow to a cell density of about 80% to 90%. A convenient primary cell culture method is used to obtain immortalized cells possessing the biological characteristics of a patient's own tumor, and the problem of immortalization of the primary culture of tumor cells is solved, thereby realizing personalized treatment for the patient.

The invention provides a preparation method of a tissue engineering porous extracellular matrix scaffold. The method is characterized in that a nano or micron polymer scaffold is implanted under the skin of or in the abdomen of a host, the polymer scaffold is used as a template to prepare the tissue engineering porous extracellular matrix scaffold with a controllable pore structure and free of immunogenicity after in-vivo implantation by using a host immunoprotection mechanism. The preparation method has the advantages that the problem of hole forming of extracellular matrix scaffold materials is solved; the porous scaffold is animal-source, is used for repairing self-injured tissue or organs, and is free of immunological rejection; since self-repair has no complex decellularization step, the scaffold has significantly better mechanical strength than a decelluarized scaffold material; the extracellular matrix scaffold may be further decelluarized for repairing foreign tissue or organs and has a promising application prospect in the field of organ repairing.

The invention discloses a gradient material for guiding regeneration of periodontal hard and soft tissues, and a preparation method of the gradient material. The gradient material is constructed by combining an electrostatic spinning technology with a biological 3D (three dimensional) technology. A micropore structure of an electrostatic spun fibrous membrane can prevent gingival fibroblasts frommigrating to a root surface to play a mechanical barrier role and facilitate transmission of nutrition and metabolism substances; and individualized repair of alveolar bone can be achieved according to clinical requirements since a structure and a shape of a 3D printing scaffold layer are highly designable. The method is simple and stable in preparation technology, and the gradient material integrates a periodontal guided tissue regeneration membrane and an alveolar bone repair scaffold material and has a potency to achieve clinical customized treatment. The gradient material has a good effectof guiding the repair of the hard and soft tissues in vivo and can be better applied to the synchronous regeneration and repair of the alveolar bone and the periodontal tissues.

The invention relates to a gene group which relates to twelve genes, and the detection for the change of the expression situation of two or more genes in the gene group can be used for the selection and / or the prognostic evaluation of a lung cancer treatment scheme. The gene group can be used for preparing a gene chip and a detection kit. Through the identification for a plurality of gene expression ways, the method is simple and convenient, strong in accuracy, lower in cost and easy to accept by the general patients. The invention has important guide significance for the selection (such as chemotherapy or radiotherapy) of a clinical treatment scheme. Simultaneously, the invention also can effectively predict the treating effect of the treatment scheme and besides, the invention further can find out a new target point in the treatment of lung cancer.

The invention discloses a lower limb spasm mode comprehensive rehabilitation device based on kinesitherapy. The lower limb spasm mode comprehensive rehabilitation device comprises shank protecting equipment, planta pedis protecting equipment and an angle adjusting mechanism for adjusting the included angle between the shank protecting equipment and the planta pedis protecting equipment, the angleadjusting mechanism comprises a drawing adjusting mechanism and an enstrophe / exstrophy adjusting mechanism, and the drawing adjusting mechanism and the enstrophe / exstrophy adjusting mechanism jointlydrive ankle joints of a patient to conduct motion in the four directions of plantar flexion, dorsiflexion, enstrophe and exstrophy. The lower limb spasm mode comprehensive rehabilitation device further comprises electrode patches and an electric heating heat-preservation layer, and thus affected limbs can be subjected to muscle electrical stimulation therapy and thermal therapy. According to the treatment demands of the patients, the three device bodies can be separately used or mutually combined to be used, and personalized treatment can be achieved. After being mutually combined, three treatment methods are synergistic, the treatment effect can be improved to the greatest extent, the effective rate of preventing and treating spasm is increased, the illness condition is relieved in the shortest time, and the treating strength and effect which cannot be achieved when a rehabilitation therapist conducts drawing hand or when the three treatments modes are separately used are provided.

The invention discloses a shape memory hydrogel made of 3D printing and application in a controlled release preparation thereof. The preparing method of the hydrogel comprises the following steps that a substrate modified hydrogel material is mixed and stirred with sodium alginate and a photoinitiator to prepare printing ink after synthesized, hydrogel with a certain internal structure is obtained through 3D printing, and the shape (initial shape) of the hydrogel is fixed by using an ultraviolet lamp immediately after printing is completed; the initial shape is folded manually and then be processed and fixed with a calcium chloride solution, so that a temporary shape is obtained; and then the temporary shape will be unfolded to restore the initial shape after being treated with a sodium carbonate solution. According to the shape memory hydrogel made of 3D printing and the application in the controlled release preparation thereof, compared with existing shape memory hydrogel, the shape memory hydrogel has an internal structure which has a positive effect on medicine releasing and cell culturing; in addition, the memory hydrogel is restored to the initial shape under a certain condition, medicine can be relieved rapidly in a specific environment, and controlled release of the medicine is achieved.

The invention provides a dyskinesia non-intrusive rehabilitative closed-loop brain-computer integrated system based on an FPGA. The FPGA is used as a control core of the system, nuclei basales and thalamic-cortical prosthesis hardware model is set up, data obtained through calculation of a self-adaptation control algorithm based on the FPGA is used as input to control model parameter setting and force feedback and adjustment until an expected control result is achieved, the self-adaptation control algorithm based on the dynamic causal model is realized, force feedback signals are output, and therefore rehabilitation of patients with the dyskinesia nervous system diseases is achieved. Rehabilitation of the patients with dyskinesia nervous system diseases is achieved, and the complex nuclei basales and thalamic-cortical neuron network and the self-adaptation control algorithm of the dynamic causal model are modeled. The platform provides the effective theoretical basis and technical support for rehabilitation of the dyskinesia nervous system diseases and has important practical value in research on control and treatment on nerve diseases such as Parkinson's disease, epilepsia and alzheimer's disease.

The invention discloses a preparation method of an acetabulum guide plate for assisting accurate positioning after hemipelvic resection. The method comprises the steps of firstly, importing thin-layer CT data of a patient into image reconstruction software to carry out three-dimensional reconstruction on an operative region, determining the tumor edge and simulating hemipelvic resection on a computer; secondly, designing the acetabulum guide plate by combining the pelvic morphology after hemipelvic resection according to the spatial position of a contralateral (original) acetabulum; and finally importing an STL file of the designed acetabulum guide plate into a 3D printing device to print the acetabulum guide plate, and then sterilizing and packaging. The acetabulum guide plate is prepared through data reconstruction of the lesion position of the patient; personalized treatment for each patient is achieved; the designed acetabulum guide plate is accurately designed according to the size and the position of the contralateral acetabulum of the patient; the position of the acetabulum can be directly determined by using the acetabulum guide plate after tumor resection in surgery, so that a lot of perspectives in past surgeries are reduced, the operative time is shortened and the patient and an intranperative operator benefit from the acetabulum guide plate.

The invention relates to a dental implant and a preparation method thereof. The dental implant comprises an implant body and a graphene layer, wherein the surface of the implant body is coated with the graphene layer, and the graphene layer is a reduced graphene layer; the dental implant is obtained by dropwise adding a graphene oxide solution onto the surface of a three-dimensional (3D) printing implant body, carrying out spin-coating so as to enable the graphene oxide solution to be evenly distributed, naturally drying the implant body, and then carrying out high temperature reduction treatment on the dried implant body. Compared with the prior art, the method adopts a spin-coating technology to enable the surface of the implant body to be coated with oxidized form graphene, and enables the oxidized form graphene to be reduced by using a high temperature reduction method so as to obtain a reduced graphene coating, so that the coating on the surface of the implant body is firm, does not easily fall off and is higher in mechanical strength; the dental implant has good biological activity and can obtain a good osseointegration effect.

The invention discloses a Parkinson's disease related biomarker and an application of same. A test proves that FGFBP2 shows up-regulated expression in blood of a Parkinson's disease patient, which means that the FGFBP2 can be used for clinical diagnosis of the Parkinson's disease as a detection index. The invention also discloses that proliferation of neurons can be influenced by regulating the expression level of the FGFBP2, which prompts that the FGFBP2 can be used for individual treatment for the Parkinson's disease patients as a medicine target.

The invention relates to a multifunctional regenerative blood purification system. The multifunctional regenerative blood purification system comprises a blood purification mechanism, a dialysate supplementing mechanism and a toxin adsorption mechanism and specifically comprises two high-throughput dialyzers, ultrafiltration pumps, power pumps, arterial pots, a vein pot, dialysis bags, an albumin container, a carbon absorption pillar, a resin absorption pillar and a waste liquid tank. During work, water-insoluble toxins combined with albumin in blood are cleared away through multiple adsorption across a fiber membrane, water-soluble medium molecule and micromolecule toxins in the blood are cleared away through continuous blood purification, electrolyte balance is effectively realized by means of a continuous blood purification technology, and regeneration and repeated use of an adsorbent (such as activated carbon and resin) are realized by the aid of desorption of the adsorbent. By means of the system, a few absorbents are consumed, a variety of toxins are cleared, electrolyte balance is rapid, the edema removal effect is good, the treatment time is short, the system cost is low, the safety is good, and personal treatment can be realized.

The invention discloses a preparation method of anti-tumor macrophages. The method comprises the following steps of obtaining primary bone marrow stem cells or separating mononuclear cells in peripheral blood for primary cell culture, adding a colony stimulating factor, and after 7 days, obtaining macrophages; obtaining in-vitro tumor cells for primary tumor cell culture, and obtaining primary tumor cells; performing radiotherapy irradiation on the obtained primary tumor cells and a culture solution, collecting supernate after radiotherapy, and obtaining a mixture of required microparticles and apoptotic tumor cell debris; centrifuging the obtained mixture to obtain tumor antigen-carrying microparticles; and treating the primary macrophages obtained in the step 1 with the obtained microparticles to obtain the anti-tumor macrophages. According to the preparation method of the anti-tumor macrophages, personalized treatment is realized, and the macrophages capable of aiming at different tumor antigens of patients is prepared; and the preparation process is simple and relatively easy in production.

The invention discloses application of a biomarker in predicting sensitivity of rectal cancer to preoperative chemoradiotherapy and surgical mesorectal resection. The biomarker is S100P, SIGLEC5 and / or SEMA4B, and verification shows that the biomarker has relatively good diagnostic efficiency in predicting sensitivity or reactivity of rectal cancer patients to operative treatment, and is relatively high in AUC value; and the application provides a new strategy and thought for clinically treating the rectal cancer, and also provides a candidate target for developing medicines for improving the treatment sensitivity of the rectal cancer patients to the preoperative chemoradiotherapy and surgical mesorectal resection.

The invention aims to provide a biliary stent and solves the problems that a biliary stent is non-degradable, poor in matching, prone to moving and poor in biocompatibility in the liver transplantation process. The biliary stent is used for biliary support of an anastomosis part after liver transplantation and comprises a first stent body, a second stent body, a fixing part and a covering film; the first stent body and the second stent body are of a net-shaped hollow structure integrally formed through 3D printing; the outer diameter of the first stent body and the outer diameter of the second stent body are the same as the inner diameter of a donor biliary tract and the inner diameter of a receptor biliary tract respectively; the fixing part is arranged on the outer surface of the joint of the first stent body and the second stent body; and the covering film is arranged on the inner surface of the joint of the first stent body and the second stent body.

The invention provides a vaginal multi-contact electrode. The vaginal multi-contact electrode includes a spindle-shaped shell, two pressure sensing belts, a first contact, a second contact, a third contact and a connection wire; the outer portion of the first contact is provided with a sponge package, the pressure sensing belts are of strip-shaped structures which are made from medical pressure sensors and pass through the two ends of the spindle-shaped shell respectively, the pressure sensing belts are symmetrically distributed on the two sides of the shell, the first contact, the second contact and the third contact are in a ring shape and embedded into the outer wall of the shell sequentially, and the insides of the pressure sensing belts, the first contact, the second contact and the third contact are connected with the connection wire and connected with a signal line of a test instrument through the connection wire. The electrode further includes a tail portion, and sponge is wetwith wetting liquid before use. The vaginal multi-contact electrode is simple in structure and convenient to operate, and the combination of the electrode and an external controller in use can enablea patient to effectively achieve self-diagnosis treatment without medical intervention or guidance of doctors.

The invention provides a DBS closed-loop learning method in a Parkinson's state based on a generalized generative adversarial network. According to the method, a generative network and a basal nucleus-thalamus-cortex neuron network built by MATLAB are creatively defined as the generalized generative network, and a closed-loop DBS deep learning algorithm based on the generalized generative adversarial network is designed. The method comprises the steps that a required data set is obtained through a basal nucleus-thalamus-cortex neuron network built by a field programmable gate array, repeated adversarial training is conducted on a generalized generative network and a discrimination network, when random noise is input to the generalized generative network, the generalized generative networkcan output a data sequence of ''falsifying the truth with the falsification'', so that a control signal capable of effectively inhibiting the Parkinson's state is obtained, and the effective control over the Parkinson state is achieved. The algorithm adopts the idea of deep learning and uses the adversarial network algorithm based on generalized generative network to carry out closed-loop DBS modulation on Parkinson's state, so as to promote the possibility of adaptive DBS technology to improve the Parkinson's state.

The invention discloses an miRNA (microribonucleic acid) diagnosis and treatment marker for endometrial carcinoma. The miRNA marker is miRNA-1266. The experiment proves that the miRNA-1266 is related to generation and development of endometrial carcinoma. The in-vitro experiment detects that the inhibition of the miRNA-1266 expression can inhibit the proliferation and transfer of endometrial carcinoma cells and promote the apoptosis of endometrial carcinoma cells, thereby laying a foundation for molecular treatment of endometrial carcinoma.

The invention relates to application of a detection agent used for detecting the expression quantities of the following genes in preparation of a kit used for recurrence risk assessment, prognosis, treatment or adjuvant therapy of lung cancer: CD1A, CD1B, CD1C, CD1D, MR1, AQP3 and CEACAM3. According to change of the expression quantities of the genes, the marker is used for accurately evaluating prognosis of a patient with lung cancer; and complex and fussy statistical analysis is avoided. A gene group detection result in the invention can provide accurate therapeutic effect evaluation for clinical doctors and patients; simultaneously, a patient, who is not sensitive to a conventional treatment scheme also can be detected; a doctor is helped to select a new effective clinical treatment scheme; and thus, individualized treatment is really realized.

The invention discloses a self-emulsified nano-multi-emulsion as well as a preparation method and application thereof, relating to the technical field of medical treatment. The preparation method comprises the following steps: mixing a proper amount of Span 80 and polyoxyethylene hydrogenated castor oil in a mass ratio of 10 to 8, and mixing a proper amount of a mixture and a co-emulsifier in a mass ratio of 8 to 2, so as to obtain a mixed surfactant; mixing 12-15 parts by weight of the mixed surfactant with 75 parts of an oil phase, heating to 60 DEG C, maintaining the temperature, simultaneously carrying out magnetic stirring so as to completely dissolve the co-emulsifier in the mixed surfactant, adding a water phase at 60 DEG C, cooling to the room temperature under a magnetic stirringstate, so as to obtain a W / O type nano-primary emulsion; mixing a proper amount of polyoxyethylene hydrogenated castor oil with the co-emulsifier in a mass ratio of 8 to 2, so as to obtain a mixed emulsifier; and mixing a proper amount of the W / O type nano-primary emulsion with the mixed emulsifier in mass ratio of 8 to 2, so as to obtain the self-emulsified nano-multi-emulsion.

The invention provides a method for preparing a porous extracellular matrix scaffold for tissue engineering. In the method, a nanometer or micrometer polymer scaffold is implanted into the subcutaneous or peritoneal cavity of a host, and the polymer scaffold is used as a template to prepare a tissue-engineered porous extracellular matrix scaffold using the immune protection mechanism of the host. Controlled pore structure, and non-immunogenic tissue engineered extracellular matrix scaffold implanted in vivo. The invention solves the problem of pore formation of extracellular matrix scaffold materials; the porous scaffold is derived from the animal itself and is used for repairing autologous damaged tissues or organs without immune rejection; at the same time, since there is no complicated decellularization step for autologous repair, the scaffold The mechanical strength of the cell matrix is ​​obviously better than that of the decellularized scaffold material; the cell matrix porous scaffold can be further decellularized for allogeneic tissue or organ repair, and has a good application prospect in the field of organ repair.

The invention discloses a field-adaptive segmentation method and system for OCT retinal images. The method comprises the following steps: step 1, acquiring OCT retinal image data, and performing image preprocessing; step 2, combining feature extraction network, feature classification network and feature identification The network respectively constructs the intra-domain segmentation model and the cross-domain segmentation model; step 3, obtains the pseudo-label of the target domain according to the intra-domain segmentation model and the cross-domain segmentation model respectively; step 4, uses the self-selection active learning strategy to select effective pseudo-labels and original images, Add rich image data from the source domain, and train the cross-domain segmentation model again; step 5, use the trained cross-domain segmentation model to segment the OCT retinal image in the target domain. Through the technical solution of the invention, the generalization performance of the segmentation model can be effectively improved, reliable quantitative data can be provided for clinical ophthalmic disease diagnosis, and computer-aided personalized treatment can be realized.

The invention relates to a gene group which relates to twelve genes, and the detection for the change of the expression situation of two or more genes in the gene group can be used for the selection and / or the prognostic evaluation of a lung cancer treatment scheme. The gene group can be used for preparing a gene chip and a detection kit. Through the identification for a plurality of gene expression ways, the method is simple and convenient, strong in accuracy, lower in cost and easy to accept by the general patients. The invention has important guide significance for the selection (such as chemotherapy or radiotherapy) of a clinical treatment scheme. Simultaneously, the invention also can effectively predict the treating effect of the treatment scheme and besides, the invention further can find out a new target point in the treatment of lung cancer.

The invention discloses an miRNA (microribonucleic acid) diagnosis and treatment marker for endometrial carcinoma. The miRNA marker is miRNA-1266. The experiment proves that the miRNA-1266 is related to generation and development of endometrial carcinoma. The in-vitro experiment detects that the inhibition of the miRNA-1266 expression can inhibit the proliferation and transfer of endometrial carcinoma cells and promote the apoptosis of endometrial carcinoma cells, thereby laying a foundation for molecular treatment of endometrial carcinoma.

The invention provides a vaginal multi-contact electrode containing graphene oxide-silver nanocomposite. The vaginal multi-contact electrode containing the graphene oxide-silver nanocomposite comprises a spindle-shaped shell, two pressure sensing strips, a first contact, a second contact and a connecting wire. The shell is prepared from a graphene oxide material, and the first contact and the second contact are made of materials containing the graphene oxide-silver nanocomposites; the pressure sensing strips are of belt-shaped structures prepared from medical pressure sensors and penetrating through the two ends of the spindle-shaped shell; the pressure sensing strips are symmetrically distributed on two sides of the shell, and the first contact and the second contact are annular and are embedded on the outer wall of the shell; and the insides of the pressure sensing strips, the first contact and the second contact are connected with the connecting wire, and are connected with a signalwire of a test instrument through the connecting wire. The vaginal multi-contact electrode disclosed by the invention is simple in structure and convenient to operate, and can be used together with an external source controller to realize effective self-diagnosis and treatment of patients without medical intervention or guidance of physicians.

The invention relates to a conditioning instrument used for preventing motion sickness. The conditioning instrument adopts a conveniently worn earphone structure, and is characterized in that the conditioning instrument comprises a treatment earmuff used for being attached to the auricle and a wearing mechanism, the wearing mechanism is connected with the treatment earmuff, the treatment earmuff is a device capable of outputting a treatment light beam used for stimulating auricular points, the treatment earmuff is attached to the auricle of the human body after being worn through the wearing mechanism, and the treatment light beam outputted by the treatment earmuff just covers a specified position, namely, a radiation region, of the ear. The conditioning instrument is convenient to carry, simple to operate and use, good in effect and safe in use, and has no injury or side effect for the human body.

The invention relates to an anti-infection coating capable of realizing immediate construction in an operation as well as a preparation method and application of the anti-infection coating. The anti-infection coating comprises an anti-infection drug coating covering the surface of a main body structure and a high polymer material coating covering the surface of the anti-infection drug coating, and the high polymer material comprises chitosan and beta-sodium glycerophosphate. The temperature-sensitive phase-change high polymer material coating can be subjected to rapid phase change under a heating condition, and the surface of the main body structure is covered with an anti-infection drug, so that immediate construction in an operation is realized, the defect that in the prior art, an antibacterial coating needs to be prepared before the operation, and then the storage problem needs to be considered is overcome. Meanwhile, the content of the anti-infection drug can be adjusted according to the infection degree of the focus in the operation, and personalized treatment is achieved. Meanwhile, the biocompatibility of the anti-infection coating is good, the local slow release behavior of the anti-infection drug can be achieved, and the action time of the drug is remarkably prolonged.

The invention discloses a maxillofacial region postoperative drainage system. The system comprises a drainage device and a mobile terminal. The drainage device comprises a drainage unit and a controlunit. The drainage unit comprises a drainage tube, a control valve, a three-way quick connector and a negative pressure bottle which are sequentially communicated; the control unit comprises a negative pressure adjusting piece, a pressure measurer and a wireless transmitting module. The pressure measurer is used for obtaining a pressure signal; the wireless transmitting module is used for transmitting the pressure signal to the mobile terminal; the mobile terminal comprises a communication part, a control part and a processing part. The control part is at least used for controlling the pressure measurer to measure; the wireless transmitting module is used for transmitting a pressure signal; the communication part receives a pressure signal from the drainage device, the processing part is used for processing and converting the pressure signal into a numerical value or an image and displaying the numerical value or the image on the mobile terminal, the negative pressure adjusting piece adjusts the negative pressure in the negative pressure bottle to determine the optimal negative pressure suction value, and the drainage tube pumps out hydrops of a patient through the negative pressure.

The invention discloses a reverse design and manufacturing method of a personalized total knee joint implant prosthesis, which includes: (1) reconstructing a three-dimensional digital model of the knee joint bone based on the standard medical image CT / MRI scan raw data of the patient's knee joint; (2) Design the 3D CAD data model of the knee implant; (3) Process the above 3D CAD data model of the knee implant to obtain a multi-layer sliced ​​2D CAD data model of the knee implant ; (4) Import the multi-layer sliced ​​two-dimensional CAD data model file into the laser selective melting 3D printing device to obtain the knee joint implanted prosthesis wax model; (5) Obtain the cast of the knee joint implanted prosthesis. The present invention is designed according to the shape and structure of Chinese knee joints, combined with rapid prototyping technology to realize casting production and manufacturing, which can not only greatly improve production efficiency and reduce costs, but also improve the design of the implanted prosthesis at any time according to the doctor's treatment opinion, and realize customization Personalized design, personalized treatment.