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Shape memory hydrogel made of 3D printing and application in controlled release preparation thereof

A hydrogel and printing ink technology, applied in 3D object support structures, additive manufacturing, manufacturing tools, etc., can solve the problems of insufficient holes and insufficient shape memory function, so as to reduce drug toxicity, avoid degradation and drug efficacy loss , enhance the effect of treatment

Inactive Publication Date: 2017-12-01
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the defects of insufficient internal holes (or pores) of existing shape memory hydrogels, and the problem that the shape memory function is not strong enough, the primary purpose of the present invention is to provide a method for preparing shape memory hydrogels, the hydrogel Glue is 3D printed

Method used

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  • Shape memory hydrogel made of 3D printing and application in controlled release preparation thereof
  • Shape memory hydrogel made of 3D printing and application in controlled release preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A method for preparing a shape memory hydrogel, comprising the following steps:

[0038] (1) Synthetic base hydrogel

[0039] Add the hydrogel material (Pluronic), acryloyl chloride, and triethylamine into dichloromethane, react for 12 hours under ice bath, and react for 12 hours at room temperature, then wash the reaction product with a saturated solution of sodium bicarbonate, and then rotary evaporate The solvent is used to obtain a modified hydrogel material; every 100mL of dichloromethane contains 0.6-13.0g of hydrogel material, 3-6mL of acryloyl chloride, and 3-6mL of triethylamine;

[0040] (2) Preparation of printing ink

[0041] With deionized water as solvent, add the modified hydrogel material (final concentration 0.12g / mL), sodium alginate (final concentration 0.04g / mL) and photoinitiator (2,2-dimethoxy base-2-phenylacetophenone) (final concentration 0.2mg / mL), stir evenly, and put it in a 4°C refrigerator for defoaming.

[0042] (3) 3D model design and l...

Embodiment 2

[0051] A method for preparing a shape memory hydrogel, comprising the following steps:

[0052] (2) Preparation of printing ink

[0053] Using deionized water as a solvent, add the modified hydrogel material (final concentration 0.14g / mL), sodium alginate (final concentration 0.03g / mL) and photoinitiator (2,2-dimethoxy base-2-phenylacetophenone) (final concentration 0.3mg / mL), stir evenly, and put it in a 4°C refrigerator for defoaming.

[0054] Steps (1), (3), (4) are the same as in Example 1.

[0055] The printed mesh was folded diagonally and placed in a 1% calcium chloride solution for 3 minutes to fix the temporary shape; the hydrogel was transferred to a 10% sodium carbonate solution for 30 minutes to return to its original shape.

Embodiment 3

[0057] A method for preparing a shape memory hydrogel, comprising the following steps:

[0058] (2) Preparation of printing ink

[0059] With deionized water as solvent, add the modified hydrogel material (final concentration 0.13g / mL) of step (1), sodium alginate (final concentration 0.03g / mL) and photoinitiator (2,2-dimethoxy base-2-phenylacetophenone) (final concentration 0.4mg / mL), stir evenly, and put it in a 4°C refrigerator for defoaming.

[0060] Steps (1), (3), (4) are the same as in Example 1.

[0061] The printed mesh was folded diagonally and placed in a 1% calcium chloride solution for 3 minutes to fix the temporary shape; the hydrogel was transferred to a 10% sodium carbonate solution for 30 minutes to return to its original shape.

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Abstract

The invention discloses a shape memory hydrogel made of 3D printing and application in a controlled release preparation thereof. The preparing method of the hydrogel comprises the following steps that a substrate modified hydrogel material is mixed and stirred with sodium alginate and a photoinitiator to prepare printing ink after synthesized, hydrogel with a certain internal structure is obtained through 3D printing, and the shape (initial shape) of the hydrogel is fixed by using an ultraviolet lamp immediately after printing is completed; the initial shape is folded manually and then be processed and fixed with a calcium chloride solution, so that a temporary shape is obtained; and then the temporary shape will be unfolded to restore the initial shape after being treated with a sodium carbonate solution. According to the shape memory hydrogel made of 3D printing and the application in the controlled release preparation thereof, compared with existing shape memory hydrogel, the shape memory hydrogel has an internal structure which has a positive effect on medicine releasing and cell culturing; in addition, the memory hydrogel is restored to the initial shape under a certain condition, medicine can be relieved rapidly in a specific environment, and controlled release of the medicine is achieved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a shape-memory hydrogel made by 3D printing and its application in controlled-release preparations. Background technique [0002] Shape memory hydrogels are a class of polymers that can return to their original shape in response to external conditions. When used as an implant material, it can be fixed into a temporary shape suitable for surgery, and it can be restored to its original shape by responding after surgery, reducing the pain of the patient and reducing the damage to the material caused by surgical instruments during implantation. Improves the effectiveness of the treatment. [0003] The studies on hydrogels are all focused on the external morphology, and there is no research report on its internal configuration. The internal structure has an important impact on drug loading, drug release, cell culture and other aspects. Shape memory hydrogels with different inter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/52A61L27/50A61L27/54C08F283/06C08F220/02C08F2/48B29C64/135B33Y10/00
CPCA61L27/18A61L27/20A61L27/50A61L27/52A61L27/54A61L2300/602A61L2400/16B33Y10/00C08F2/48C08F283/06C08L71/02C08L5/04C08F220/02
Inventor 薛巍王永周马栋张洁玲
Owner JINAN UNIVERSITY
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