26 results about "Controlled-Release Preparations" patented technology

The invention discloses a method for in vitro slow release performance evaluation of a slow and controlled release preparation based on the overflow principle. A container with an upper outlet and a lower outlet is adopted to serve as a release tank, a to-be-detected medicine and a dissolution medium are placed in the release tank, a stirring device is adopted in the release tank to perform stirring, and the dissolution medium is added from the lower outlet of the release tank through a peristaltic pump; the dissolution medium dissolved with the medicine is taken away through the overflow from the upper outlet so as to offset medicine absorption or metabolism, and the slow and controlled release speed of the medicine, the total medicine overflow quantity and the total release amount are calculated by measuring the concentration of the medicine contained in the dissolution medium flowing out, the volume of the release tank and the overflow quantity. According to the method, the releasing degree of the slow and controlled release medicine can be evaluated accurately, the effective medicine release time of the slow and controlled release preparation is evaluated, and slow release performances of the slow and controlled release preparation are evaluated comprehensively.

The invention relates to the technical field of medicines, in particular to a stable drug-loaded microcapsule and a preparation method thereof. According to the method, A-type gelatin and succinic anhydride modified B-type gelatin are adopted to synergistically construct a layered composite shell layer, genipin is added step by step to realize progressive crosslinking, and the interface structure and the controlled release performance are optimized. The microcapsule prepared by the invention has high encapsulation efficiency, controllable release and excellent storage stability, adopts an innovative multi-molecular-weight gelatin layered design and a step-by-step cross-linking strategy, and takes into account the dual requirements of strong encapsulation and slow release and controlled release, so that the vitamin B6 is prevented from being influenced by environmental degradation, and the efficacy and compliance of a preparation are improved. The invention provides a new technical scheme for development of controlled release preparations of water-soluble vitamins and related drugs.

The invention relates to a method for determining a dissolution curve of a brexpiprazole long-acting injection, and belongs to the field of analytical chemistry. According to the method, brexpiprazole long-acting injection and inert beads are added into a sample cup, and the sample cup is placed at the bottom of a dissolution cup for sample feeding. The method disclosed by the invention is good in stability and good in reproducibility, and can meet the release curve requirement of the sustained and controlled release preparation in the dissolution medium, and the device can be recycled, so that the cost is saved.

1. The name of the design product: hot melt machine (JR20). 2. The use of the design product: a new type of drug equipment that uses extrusion mixing technology to uniformly mix active pharmaceutical ingredients (API) in a polymer-based carrier, mainly used to improve the dissolution of poorly soluble drugs and prepare sustained-release preparations. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to an acetate fiber thermoplastic coating film as well as preparation and application thereof. The cellulose acetate thermoplastic coating film is prepared by thermoforming cellulose acetate, triethyl citrate and polyethylene glycol which are uniformly mixed as raw materials. The preparation process is high in automation and scale degree, low in environment and equipment requirements, green and environment-friendly, capable of reducing loss and suitable for industrial production. The sustained and controlled release preparation prepared from the cellulose acetate fiber thermoplastic coating film has a good sustained and controlled release effect, and a new coating direction is provided for preparation of the sustained and controlled release preparation.

The invention belongs to the technical field of mesalazine controlled-release preparations, and particularly relates to a mesalazine oral controlled-release pharmaceutical composition and a preparation method thereof.The mesalazine oral controlled-release pharmaceutical composition comprises a tablet core part and a coating part and is characterized in that the outer layer of the tablet core part is wrapped with the coating part, the tablet core part is composed of mesalazine and auxiliary materials, and the auxiliary materials are added into the tablet core part. The auxiliary material components comprise a matrix material, a filler, an adhesive and a lubricant, and the coating part is composed of an acid-resistant material, a plasticizer and a light shielding agent. According to the tablet core particle screening device, dried tablet core particles can be rapidly screened through the arranged vibration screening assembly, power of the vibration screening assembly can be transmitted through the arranged transmission assembly so that the transverse moving screening assembly can be driven, and the phenomenon that screening holes are blocked can be effectively reduced through the arranged transverse moving screening assembly; and therefore, the screening efficiency of the tablet core particles and the subsequent production efficiency can be improved.

The invention belongs to the technical field of mesalazine controlled-release preparations, and particularly relates to mesalazine colon-targeted controlled-release tablets and a preparation method thereof.The mesalazine colon-targeted controlled-release tablets comprise a tablet core layer and a controlled-release layer, the controlled-release layer wraps the tablet core layer, the tablet core layer is composed of mesalazine and an auxiliary material pyrodextrin, and the auxiliary material pyrodextrin is a mixture of mesalazine and pyrodextrin. The controlled release layer consists of pyrodextrin, a plasticizer and a pore-foaming agent. By arranging the power assembly, the two efficient stirring assemblies and the two cleaning assemblies can be driven at the same time, attachments on the inner wall of the equipment can be treated while efficient stirring is achieved, by arranging the efficient stirring assemblies, a starch aqueous solution and hydrochloric acid can be mixed more sufficiently and evenly, and the efficiency of the equipment is improved. And through the arrangement of the cleaning assembly, materials attached to the inner wall of the equipment can be scraped away, resources are saved, waste is reduced, and meanwhile the labor intensity of follow-up equipment cleaning is reduced.

To provide an economical composition capable of continuing attraction of Setothosea asigna for a long period of time.SOLUTION: There is provided a composition at least including 100 pts.mass of (9E)-9-dodecenal, 1 to 40 pts.mass of (9Z)-9-dodecenal, and 1 to 70 pts.mass of (9E)-9,11-dodecadienal. There is provided a sustained release preparation for controlling Setothosea asigna at least including the composition, and a carrier or a container for carrying or housing the composition and sustainedly releasing at least the (9E)-9-dodecenal, the (9Z)-9-dodecenal and the (9E)-9,11-dodecadienal. There is provided a method of controlling Setothosea asigna at least including a step of setting the sustained release preparation in a field, and releasing at least the (9E)-9-dodecenal, the (9Z)-9-dodecenal and the (9E)-9,11-dodecadienal.SELECTED DRAWING: None

The invention belongs to the technical field of biological medicines, and discloses application of isatin in preparation of a medicine for treating polycystic ovarian syndrome. The medicine for treating the polycystic ovarian syndrome contains isatin or a derivative thereof. The medicine for treating the polycystic ovarian syndrome can be an oral preparation, an injection, a granule, a pill, a capsule, powder, a slow-release or controlled-release preparation, a targeted preparation and other preparations. The preparation method of the medicine for treating the polycystic ovarian syndrome comprises the following steps: S1, purifying isatin, and preparing isatin crystals with the purity greater than 99%; and S2, adding 100 mg of isatin into 10 ml of the 1% sodium carboxymethyl cellulose solution by taking the 1% sodium carboxymethyl cellulose solution as a solvent, and carrying out ultrasonic uniform mixing at 50 DEG C to prepare a 10 mg / ml isatin solution, namely the medicine for treating the polycystic ovarian syndrome. The medicine for treating the polycystic ovarian syndrome is prepared from isatin or the derivative thereof, and reference value is provided for preparing the medicine which is good in effect, small in toxicity and low in side effect.

The invention relates to the technical field of oral sustained-release preparations, in particular to an oil-based protective hard capsule containing sustained-release pellets and a preparation method of the oil-based protective hard capsule. The preparation method comprises the following steps: firstly, preparing a capsule shell: dissolving hydroxypropyl methylcellulose, carrageenan, gellan gum and lauryl sodium sulfate in hot water in stages, aging to obtain a glue solution, dipping the glue solution, drying and cutting to obtain a primary capsule body; secondly, adding hydrophobic modified silica gel nanoparticles and a temperature response type copolymer into linseed oil to form a suspension; preparing an active drug and a sustained-release auxiliary material into a pellet core, and coating to obtain a sustained-release pellet; and finally, filling the sustained-release pellets into a capsule lower shell, filling the suspension, covering the capsule upper shell, sealing by adopting a hydroxypropyl methylcellulose solution, and heating and curing by hot air. The obtained capsule can be used for oral sustained-release medicines or functional foods after leakage detection and sterilization; liquid-solid split charging is achieved, the drug release behavior can be effectively controlled, the stability is improved, and good application prospects are achieved.

The invention discloses a controlled release preparation and application thereof in preparation of a medicine for treating diabetic osteoporosis. The controlled release preparation consists of the following components: empagliflozin, alendronate sodium, an isolation coating material, an enteric controlled release coating material, a filling agent, a disintegrating agent and a lubricating agent. The enteric controlled release coating material comprises a pH sensitive regulator. The invention also discloses a preparation method of the alendronate sodium enteric-coated pellet, which comprises the following steps: preparing the alendronate sodium enteric-coated pellet, totally mixing, and forming the preparation. The preparation reduces gastrointestinal reaction and has higher stability.

The invention discloses a slow-release granule with a water surface floating weeding function and a processing technology of the slow-release granule. According to the preparation method, a micro-capsule which takes imidazolyl ionic liquid in which a difloxysulfone active compound is dissolved as a core and silicon dioxide as a wall material is prepared, and the slow-release granule with the water surface floating weeding function is prepared after tabletting; the microcapsule granules have a good slow-release effect, the utilization rate of pesticide can be effectively increased, the lasting period is prolonged, and then the usage amount of the pesticide is reduced; in the processing process of the granules, the use of an organic solvent is reduced, so that the toxicity of the slow-release granules during preparation and use caused by the use of the organic solvent can be effectively reduced; porous hollow silicon dioxide is used as a difloxysulfone sustained and controlled release preparation, so that the requirement of protecting the difloxysulfone active ingredient to be slowly released in the environment and even accurately delivered to weed seedlings is met, and the degradation time of the difloxysulfone active ingredient in the environment can be prolonged.

The present application relates to the technical field of medicine, in particular to a kind of stability drug-loaded microcapsule and preparation method thereof.The method uses type A gelatin and succinic anhydride modified type B gelatin to cooperatively build layered composite shell, gradually adds genipin to realize progressive crosslinking, and optimizes interface structure and controlled release performance.The microcapsule prepared by the present application has high encapsulation efficiency, controllable release and excellent storage stability, and the innovative layered design of multiple molecular weight gelatin and step-by-step crosslinking strategy meet the dual requirements of strong encapsulation and slow release, so that vitamin B6 is not affected by environmental degradation, and the preparation efficacy and compliance are improved.The present application provides a new technical solution for the development of controlled-release preparations of water-soluble vitamins and related drugs.

The invention discloses a nutrition nursing intervention method and device for tumor chemoradiotherapy patients and a medium, and relates to the technical field of medical nursing, and the method comprises the steps: obtaining patient chemoradiotherapy regimen parameters, collecting tumor metabolism data, muscle metabolism data and serum circulating tumor marker concentration, and obtaining a monitoring data set; the monitoring data set comprises toxicity risk factors and radiation dose distribution; the monitoring data set is input into a tumor nutrition competition model to calculate a sweep coefficient, when the sweep coefficient exceeds a pathological threshold value, a deceptive nutrition starting instruction is generated, a composite risk value is calculated based on the toxicity risk factor and radiation dose distribution, and when the composite risk value exceeds a critical threshold value, a double-blocking protocol is triggered, and a decision instruction is generated; blending and applying a liposome injection, an oral controlled release preparation and a functional patch according to the decision instruction to form an integrated intervention composition; according to the method, the optimization of local intervention parameters is realized, and the local mucous membrane repair efficiency is improved.

The invention belongs to the technical field of biological medicines, and discloses application of isatin in preparation of a medicine for treating hyperandrogenemia. The medicine for treating the hyperandrogenemia contains isatin or a derivative thereof. The medicine for treating the hyperandrogenemia has the following preparation forms: an oral preparation, an injection, a granule, a pill, a capsule, powder, a slow-release or controlled-release preparation, a targeted preparation and preparations of other administration routes. The preparation method of the medicine for treating hyperandrogenemia comprises the following steps: S1, purifying isatin to obtain isatin crystals with the purity of more than 99%; s2, taking 0.5% tragacanth solution as a solvent, adding 100mg of isatin into 10ml of 0.5% tragacanth solvent, and magnetically stirring at 37 DEG C to prepare 1mg / ml of isatin solution. According to the invention, the isatin or the derivative thereof is used for preparing the medicine for treating hyperandrogenemia, so that reference value is provided for preparing the medicine with good effect, low toxicity and low side effect.

The present invention relates to the field of pharmaceutical engineering technology, and specifically to a drug assembly and a preparation method and application thereof. The drug assembly provided by the present invention is obtained by self-assembly of a protein polypeptide calcium channel blocking drug and an amide local anesthetic; the protein polypeptide calcium channel blocking drug includes conotoxin or its derivatives. The present invention can not only quickly block nerve conduction to achieve rapid analgesia, but also prolong the analgesic time, and minimize systemic toxicity. The drug preparation can maintain long-term analgesia, providing a powerful tool for the use of biological toxin molecular sustained / controlled release preparations as non-addictive drugs to control severe pain.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a sustained and controlled release preparation process and formula of a compound paracetamol and amantadine hydrochloride capsule. The preparation consists of three functional units, namely quick-release particles, slow-release particles and regulation particles. Wherein the quick-release particles contain a pretreated disintegrating agent so as to realize quick drug release; the slow-release particles realize delayed release on the basis of an ionic cross-linked gel matrix constructed by sodium alginate and chitosan; and regulating and controlling a buffering and stabilizing system in the particles to maintain the internal microenvironment. The preparation method comprises the following steps: constructing slow-release particles by adopting dry rolling and a unique ion gradient spray activation process, preparing quick-release particles by combining with airflow impact molding, and finally mixing and filling. The preparation disclosed by the invention can realize sequential controlled release of the compound medicine components, ensure stable exertion of the medicine effect and improve the medication compliance; the preparation process is mild in conditions, is beneficial to protecting heat-sensitive components, and has good process reproducibility.

The invention relates to the technical field of drug sustained and controlled release preparation preparation, in particular to a drug sustained and controlled release preparation preparation device based on a microencapsulation technology, which comprises a stirring component, a precipitation component, a circulating hose, a capsule material storage component and a capsule material output hose, the stirring component comprises a stirring tank, the upper side of the stirring tank is provided with a core material feeding pipe, and the lower side of the stirring tank is provided with a core material discharging pipe; and a first overflow port is formed in one side of the stirring tank, a capsule material output component is installed at the lower end of the stirring tank, and a first discharging pipe is arranged at the lower end of the stirring tank. The capsule wall material output component rotates and conveys materials in the stirring tank, the uniformity of the prepared drug sustained and controlled release preparation is facilitated, materials stirred in the stirring tank are guided into the settling tank through the first overflow opening and the second overflow opening to be subjected to settling operation, the preparation efficiency of the drug sustained and controlled release preparation is improved, and the production cost is reduced. And liquid precipitated in the precipitation tank is circulated through the first liquid pumping pipe, the first liquid pump and the circulating hose, so that the microencapsulation completeness is improved.

The present invention provides a controlled-release preparation for treating ulcerative colitis based on an extract composition of Oudemansiella raphanipes, and the controlled-release preparation is nanoparticles comprising the extract composition of Oudemansiella raphanipes as an active ingredient; the preparation method of the nanoparticles comprises the steps of: ultrasonically dispersing the extract composition of Oudemansiella raphanipes uniformly in ethanol; adding an aqueous solution of ferric sulfate heptahydrate with konjac glucomannan oxidized and gelatin as solutes, stirring evenly, and then performing ultrasonic dispersion treatment in a mixed solution composed of span80 and liquid paraffin; centrifuging, discarding the supernatant, blowing the precipitate with anhydrous methanol, discarding the supernatant after centrifugation, and taking the precipitate to obtain the nanoparticles. The extract composition of Oudemansiella raphanipes provided by the present invention has good curative effects on ulcerative colitis and can reduce side effects, having certain advantages compared with traditional typical western medicines; the present invention lays a certain foundation for the related research of Oudemansiella raphanipes and improves the medicinal value of Oudemansiella raphanipes.

The present application relates to the technical field of pharmaceutical preparations, and provides a diclofenac sodium pharmaceutical preparation, a preparation method and application thereof.The diclofenac sodium pharmaceutical preparation comprises, in terms of weight fraction, 1-10 parts of diclofenac sodium, 5-10 parts of cationic lipids, 1-5 parts of PEGylated lipids and 0.1-5 parts of a surfactant.The active ingredient diclofenac sodium in the pharmaceutical preparation is delivered by liposomes, which endows the preparation with better transdermal absorption effect;at the same time, the pharmaceutical preparation also has excellent controlled release effect, so that the blood drug concentration is more stable, and the diclofenac sodium is encapsulated in the liposome microcapsules, which effectively reduces the stimulation to the gastrointestinal tract and can effectively improve the patient compliance; the pharmaceutical preparation can be prepared into not only an external transdermal patch, but also an oral controlled release preparation, and has wide application.

The osmotic pump controlled release preparation comprises a tablet core containing a drug layer and a boosting layer, a controlled release coating layer with drug release holes and an optional water-soluble coating film which are sequentially arranged from inside to outside, wherein the drug release hole is communicated with the drug-containing layer and the exterior of the osmotic pump controlled release preparation; the boosting layer is positioned on one side, far away from the medicine release holes, of the medicine-containing layer; the drug-containing layer comprises active pharmaceutical ingredients, the boosting layer comprises a permeation promoting polymer, and the permeation promoting polymer comprises hydroxyethyl cellulose and alginate.

A controlled-release preparation and a preparation method therefor. Specifically, the controlled-release preparation comprises a drug crystal and a polymer coating wrapping same. The method for preparing the controlled-release preparation comprises the following steps: subjecting a monomer to a polymerization reaction on the surface of the drug crystal to form a polymer coating, or subjecting a polymer to a cross-linking reaction on the surface of the drug crystal to form a polymer coating. The controlled-release preparation has high drug loading capacity and long drug release time, can achieve long-acting zero-level release of a drug, the preparation method is simple, and the encapsulation efficiency is high.

The invention discloses a method for determining the content of glucose in star-shaped PLGA and a pretreatment method, a mixed solution of triethylamine and methanol is adopted as a hydrolysis solvent to perform pretreatment on PLGA or PLA in a polyester compound so as to form a stable hydrolysis solution, and the hydrolysis method is adopted to rapidly extract the bonded glucose in the star-shaped PLGA, so that the content of the glucose in the star-shaped PLGA is determined. Then, HPLC-ELSD is used for detection, and the content of glucose is calculated according to the linear regression equation and the logarithm value of the glucose peak area in the chromatogram of the sample to be detected. The detection method is easy and convenient to operate, rapid in detection and high in sensitivity, quantitative detection of trace glucose in the star-shaped PLGA caused by glucose can be achieved, characterization methods and quality control methods of the quality attribute of the star-shaped PLGA are enriched, research on performance parameters of a sustained and controlled release preparation with the star-shaped PLGA as a carrier is facilitated, and the application prospect is wide. And a reference is provided for evaluating process change and quality difference of the sustained and controlled release preparation.