12 results about "Controlled-Release Preparations" patented technology

The invention discloses a method for in vitro slow release performance evaluation of a slow and controlled release preparation based on the overflow principle. A container with an upper outlet and a lower outlet is adopted to serve as a release tank, a to-be-detected medicine and a dissolution medium are placed in the release tank, a stirring device is adopted in the release tank to perform stirring, and the dissolution medium is added from the lower outlet of the release tank through a peristaltic pump; the dissolution medium dissolved with the medicine is taken away through the overflow from the upper outlet so as to offset medicine absorption or metabolism, and the slow and controlled release speed of the medicine, the total medicine overflow quantity and the total release amount are calculated by measuring the concentration of the medicine contained in the dissolution medium flowing out, the volume of the release tank and the overflow quantity. According to the method, the releasing degree of the slow and controlled release medicine can be evaluated accurately, the effective medicine release time of the slow and controlled release preparation is evaluated, and slow release performances of the slow and controlled release preparation are evaluated comprehensively.

1. The name of the design product: hot melt machine (JR20). 2. The use of the design product: a new type of drug equipment that uses extrusion mixing technology to uniformly mix active pharmaceutical ingredients (API) in a polymer-based carrier, mainly used to improve the dissolution of poorly soluble drugs and prepare sustained-release preparations. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to an acetate fiber thermoplastic coating film as well as preparation and application thereof. The cellulose acetate thermoplastic coating film is prepared by thermoforming cellulose acetate, triethyl citrate and polyethylene glycol which are uniformly mixed as raw materials. The preparation process is high in automation and scale degree, low in environment and equipment requirements, green and environment-friendly, capable of reducing loss and suitable for industrial production. The sustained and controlled release preparation prepared from the cellulose acetate fiber thermoplastic coating film has a good sustained and controlled release effect, and a new coating direction is provided for preparation of the sustained and controlled release preparation.

The invention relates to the technical field of oral sustained-release preparations, in particular to an oil-based protective hard capsule containing sustained-release pellets and a preparation method of the oil-based protective hard capsule. The preparation method comprises the following steps: firstly, preparing a capsule shell: dissolving hydroxypropyl methylcellulose, carrageenan, gellan gum and lauryl sodium sulfate in hot water in stages, aging to obtain a glue solution, dipping the glue solution, drying and cutting to obtain a primary capsule body; secondly, adding hydrophobic modified silica gel nanoparticles and a temperature response type copolymer into linseed oil to form a suspension; preparing an active drug and a sustained-release auxiliary material into a pellet core, and coating to obtain a sustained-release pellet; and finally, filling the sustained-release pellets into a capsule lower shell, filling the suspension, covering the capsule upper shell, sealing by adopting a hydroxypropyl methylcellulose solution, and heating and curing by hot air. The obtained capsule can be used for oral sustained-release medicines or functional foods after leakage detection and sterilization; liquid-solid split charging is achieved, the drug release behavior can be effectively controlled, the stability is improved, and good application prospects are achieved.

The invention discloses a controlled release preparation and application thereof in preparation of a medicine for treating diabetic osteoporosis. The controlled release preparation consists of the following components: empagliflozin, alendronate sodium, an isolation coating material, an enteric controlled release coating material, a filling agent, a disintegrating agent and a lubricating agent. The enteric controlled release coating material comprises a pH sensitive regulator. The invention also discloses a preparation method of the alendronate sodium enteric-coated pellet, which comprises the following steps: preparing the alendronate sodium enteric-coated pellet, totally mixing, and forming the preparation. The preparation reduces gastrointestinal reaction and has higher stability.

The invention discloses a slow-release granule with a water surface floating weeding function and a processing technology of the slow-release granule. According to the preparation method, a micro-capsule which takes imidazolyl ionic liquid in which a difloxysulfone active compound is dissolved as a core and silicon dioxide as a wall material is prepared, and the slow-release granule with the water surface floating weeding function is prepared after tabletting; the microcapsule granules have a good slow-release effect, the utilization rate of pesticide can be effectively increased, the lasting period is prolonged, and then the usage amount of the pesticide is reduced; in the processing process of the granules, the use of an organic solvent is reduced, so that the toxicity of the slow-release granules during preparation and use caused by the use of the organic solvent can be effectively reduced; porous hollow silicon dioxide is used as a difloxysulfone sustained and controlled release preparation, so that the requirement of protecting the difloxysulfone active ingredient to be slowly released in the environment and even accurately delivered to weed seedlings is met, and the degradation time of the difloxysulfone active ingredient in the environment can be prolonged.

The present application relates to the technical field of medicine, in particular to a kind of stability drug-loaded microcapsule and preparation method thereof.The method uses type A gelatin and succinic anhydride modified type B gelatin to cooperatively build layered composite shell, gradually adds genipin to realize progressive crosslinking, and optimizes interface structure and controlled release performance.The microcapsule prepared by the present application has high encapsulation efficiency, controllable release and excellent storage stability, and the innovative layered design of multiple molecular weight gelatin and step-by-step crosslinking strategy meet the dual requirements of strong encapsulation and slow release, so that vitamin B6 is not affected by environmental degradation, and the preparation efficacy and compliance are improved.The present application provides a new technical solution for the development of controlled-release preparations of water-soluble vitamins and related drugs.

The invention discloses a nutrition nursing intervention method and device for tumor chemoradiotherapy patients and a medium, and relates to the technical field of medical nursing, and the method comprises the steps: obtaining patient chemoradiotherapy regimen parameters, collecting tumor metabolism data, muscle metabolism data and serum circulating tumor marker concentration, and obtaining a monitoring data set; the monitoring data set comprises toxicity risk factors and radiation dose distribution; the monitoring data set is input into a tumor nutrition competition model to calculate a sweep coefficient, when the sweep coefficient exceeds a pathological threshold value, a deceptive nutrition starting instruction is generated, a composite risk value is calculated based on the toxicity risk factor and radiation dose distribution, and when the composite risk value exceeds a critical threshold value, a double-blocking protocol is triggered, and a decision instruction is generated; blending and applying a liposome injection, an oral controlled release preparation and a functional patch according to the decision instruction to form an integrated intervention composition; according to the method, the optimization of local intervention parameters is realized, and the local mucous membrane repair efficiency is improved.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a sustained and controlled release preparation process and formula of a compound paracetamol and amantadine hydrochloride capsule. The preparation consists of three functional units, namely quick-release particles, slow-release particles and regulation particles. Wherein the quick-release particles contain a pretreated disintegrating agent so as to realize quick drug release; the slow-release particles realize delayed release on the basis of an ionic cross-linked gel matrix constructed by sodium alginate and chitosan; and regulating and controlling a buffering and stabilizing system in the particles to maintain the internal microenvironment. The preparation method comprises the following steps: constructing slow-release particles by adopting dry rolling and a unique ion gradient spray activation process, preparing quick-release particles by combining with airflow impact molding, and finally mixing and filling. The preparation disclosed by the invention can realize sequential controlled release of the compound medicine components, ensure stable exertion of the medicine effect and improve the medication compliance; the preparation process is mild in conditions, is beneficial to protecting heat-sensitive components, and has good process reproducibility.

The present application relates to the technical field of pharmaceutical preparations, and provides a diclofenac sodium pharmaceutical preparation, a preparation method and application thereof.The diclofenac sodium pharmaceutical preparation comprises, in terms of weight fraction, 1-10 parts of diclofenac sodium, 5-10 parts of cationic lipids, 1-5 parts of PEGylated lipids and 0.1-5 parts of a surfactant.The active ingredient diclofenac sodium in the pharmaceutical preparation is delivered by liposomes, which endows the preparation with better transdermal absorption effect;at the same time, the pharmaceutical preparation also has excellent controlled release effect, so that the blood drug concentration is more stable, and the diclofenac sodium is encapsulated in the liposome microcapsules, which effectively reduces the stimulation to the gastrointestinal tract and can effectively improve the patient compliance; the pharmaceutical preparation can be prepared into not only an external transdermal patch, but also an oral controlled release preparation, and has wide application.

A controlled-release preparation and a preparation method therefor. Specifically, the controlled-release preparation comprises a drug crystal and a polymer coating wrapping same. The method for preparing the controlled-release preparation comprises the following steps: subjecting a monomer to a polymerization reaction on the surface of the drug crystal to form a polymer coating, or subjecting a polymer to a cross-linking reaction on the surface of the drug crystal to form a polymer coating. The controlled-release preparation has high drug loading capacity and long drug release time, can achieve long-acting zero-level release of a drug, the preparation method is simple, and the encapsulation efficiency is high.