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Tebuconazole nano controlled release preparation and preparation method thereof

A technology of tebuconazole and sustained-release agent, applied in the field of tebuconazole nano sustained-release agent and preparation thereof, can solve the problems of uneven application, poor biodegradability, environmental pollution and the like, and achieves good sustained-release effect, strong The effect of adsorption capacity

Active Publication Date: 2014-03-19
JIANGSU ESSENCE AGROCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional slow-release pesticides have their own shortcomings. For example, most of the slow-release agents are synthetic polymer materials, and most of them have poor biodegradability and are easy to pollute the environment; Environmental pollution; in addition, the particles of polymer controlled release agent are generally relatively large, and the particles are large during application, which is easy to be unevenly applied and easy to fall off, and ultimately cannot achieve the purpose of protecting the environment and reducing the amount of pesticides used

Method used

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  • Tebuconazole nano controlled release preparation and preparation method thereof
  • Tebuconazole nano controlled release preparation and preparation method thereof
  • Tebuconazole nano controlled release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Mesoporous SiO 2 Preparation of microspheres.

[0033] Dissolve CTAB in a mixed solution of ethanol and water, add ammonia and TEOS to the above-mentioned mixed solution containing CTAB under stirring conditions, react at 35°C for 24 hours, centrifuge, and wash with ethanol to obtain SiO 2 White powder. The molar ratio of ethyl orthosilicate: cetyltrimethylammonium bromide: 25wt% ammonia: water: ethanol is 1:0.0922:2.96:621:115.

[0034] The resulting SiO 2 SiO is obtained by transferring the powder to water 2 Dispersion liquid, placed for 150h, centrifuged, washed with a mixed solution of hydrochloric acid and ethanol several times. The concentration of hydrochloric acid is 36wt%, and the volume ratio of hydrochloric acid to ethanol is 1:500.

[0035] SiO 2 The white powder is dried and calcined at 500℃ for 5h to obtain ordered mesoporous SiO with hollow structure 2 Microspheres.

[0036] figure 1 Mesoporous SiO 2 The TEM image of the microspheres shows that the pr...

Embodiment 2

[0037] Example 2: Preparation of Pentanolol Nano Sustained Release Agent.

[0038] A saturated toluene solution of pentotholol is added to the silica microspheres, shaken in a constant temperature shaker at 25° C. for 24 hours, and centrifuged to obtain a pentotholol nano sustained release agent.

[0039] figure 2 Is pentanol and hollow mesoporous SiO 2 The thermogravimetric analysis results of the nano drug-loading system showed that the sample weight loss was not obvious before 300℃. When the temperature was higher than 300℃, the pentanolol began to decompose, and the weight loss was obvious. The mass was constant at 600~700℃, indicating that the pentanolol had completely decomposed. . It can be concluded from the figure that the drug loading amount of pentanolol in the nano drug loading system is about 46wt%.

Embodiment 3

[0040] Example 3: Determination of the sustained-release performance of the pentanolol nano sustained-release agent.

[0041] Precisely weigh 40mg pentoxolol and 1.3g pendoxolol nano drug-loaded particles, place them in a cylindrical dialysis bag, clamp the two ends with dialysis clips, and suspend them in 800mL ethanol solution containing 50(v / v)% by volume In the Erlenmeyer flask, perform magnetic stirring at room temperature, take out a small amount of liquid regularly, and supplement it with the same amount of liquid to keep the total volume of the liquid unchanged. The content of pentoxolol in the solution was measured by ultraviolet-visible spectrophotometer, and the curve of pentoxolol over time was drawn, and compared with the dissolution curve of pentoxolol original drug to characterize the sustained release effect.

[0042] image 3 It is the release kinetic curve of pentozolol technical drug and nano drug delivery system in 50% (v / v) ethanol / water solution. It can be s...

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Abstract

The invention discloses a tebuconazole nano controlled release preparation which takes tebuconazole as an active ingredient of a pesticide, and takes a hollow mesoporous nano-silica microsphere as a carrier. The invention further discloses a preparation method of the nano controlled release preparation. According to the tebuconazole nano controlled release preparation disclosed by the invention, the hollow mesoporous SiO2 nano-particles have stronger adsorption ability to the tebuconazole, and has adsorption drug loading capacity of 46%; the prepared tebuconazole nano controlled release preparation can control release time to over 100 hours in a continuously-stirred dissolution medium, and therefore, the novel tebuconazole nano controlled release preparation is indicated to have a very good controlled release effect.

Description

Technical field [0001] The invention belongs to the technical field of pesticide slow-release, and specifically relates to a pentanolol nano slow-release agent and a preparation method thereof. Background technique [0002] Pentoxolol is a high-efficiency, low-toxicity, systemic fungicide, and its chemical name is (RS)-1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2 ,-Triazole-1-ylmethyl)pentan-3-ol, a triazole fungicide, was listed in the American Wood Protection Association (AWPA) standard in 1994 [1] . Pentanolol is widely used in the prevention and control of agricultural and forestry diseases and insect pests. By the end of 2006, the global usage reached 1.3×10. 6 t [2,3] , But the main dosage form of pentanolol is emulsifiable concentrate, which has a relatively short duration, and the use of a large amount of organic solvents is likely to cause environmental pollution and waste of resources. In order to improve the use efficiency of pentanolol, reduce residues, and reduce envir...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/08A01N43/653A01P3/00
Inventor 徐鹏
Owner JIANGSU ESSENCE AGROCHEM
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