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Dexlansoprazole enteric-coated slow controlled-release pellet tablets

A technology of lansoprazole enteric and pellet tablets, applied in the preparation of dexlansoprazole sustained and controlled release preparations, dexlansoprazole enteric-coated sustained and controlled release pellets, dexlansoprazole sustained and controlled release In the field of pellet preparation, it can solve problems such as low cost, large output, and difficult swallowing of capsules

Inactive Publication Date: 2014-02-12
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dexlansoprazole pellets prepared by the present invention have lower requirements for production equipment, are easy to industrialize products of domestic enterprises, have large output and low cost, and can solve the problem that some patients have difficulty swallowing capsules

Method used

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  • Dexlansoprazole enteric-coated slow controlled-release pellet tablets
  • Dexlansoprazole enteric-coated slow controlled-release pellet tablets
  • Dexlansoprazole enteric-coated slow controlled-release pellet tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation of drug-containing pill core I (blank pill core medicine method):

[0035]

[0036] Preparation Process:

[0037] 90g dexlansoprazole, 45g magnesium oxide, 75g HPMC K4M, 30g lactose are uniformly dissolved or dispersed in 1500ml water, and the blank sugar ball core (sucrose, made by starch) is filled in the fluidized bed coater, adjusted Coating parameters: Spray the drug-containing suspension on the blank pellet core. After the drug application is completed, continue to dry until the moisture content of the pellets is below 3%.

Embodiment 2

[0039] Preparation of drug-containing pill core I (blank pill core medicine method):

[0040]

[0041] The preparation process is the same as in Example 1.

Embodiment 3

[0043] Preparation of drug-containing pill core I (blank pill core medicine method):

[0044]

[0045] The preparation process is the same as in Example 1.

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PUM

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Abstract

The invention discloses dexlansoprazole enteric-coated slow controlled-release pellet tablets belonging to the field of slow controlled-release preparations, and in particular relates to a preparation method of acid-sensitive proton pump inhibitor (PPI) slow controlled-release pellet tablets. The pellet tablets are prepared by tabletting and coating two types of pellets with different release speeds as well as a filler, a disintegrating agent and a lubricant, and release active ingredients at different release speeds, wherein one type of the pellets are enteric-coated quick-release pellets, and the other type of the pellets are enteric-coated slow-release pellets.

Description

technical field [0001] The present invention is a kind of dexlansoprazole enteric-coated sustained and controlled release micropellet tablet, specifically relates to the preparation method of dexlansoprazole sustained and controlled release preparation, more specifically a kind of dexlansoprazole sustained and controlled release micropellet A method for preparing pills belongs to the technical field of sustained and controlled release preparations. Background technique [0002] Dexlansoprazole is another optically pure proton pump inhibitor (PPIs) anti-ulcer drug developed after esomeprazole. Belonging to the benzimidazole class of drugs that inhibit gastric acid secretion, it is an optically pure drug of racemic lansoprazole, which acts on the H of gastric parietal cells + / K + -ATPase, clinically used for the treatment of duodenal ulcer, gastric ulcer, reflux esophagitis, and Zollinger-Ellison syndrome, has remarkable curative effect and has inhibitory effect on Helicoba...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K31/4439A61P1/04A61P31/04
Inventor 不公告发明人
Owner FUKANGREN BIO PHARMA
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