A kind of levetiracetam 3D printing preparation and preparation method thereof
A 3D printing and preparation technology, applied in the field of levetiracetam 3D printing preparation and its preparation, levetiracetam 3D printing tablet, levetiracetam tablet such as levetiracetam dispersible tablet, It can solve the problems of insufficient mechanical properties such as surface roughness, hardness, and friability of the tablet, failure to coordinate the rapid disintegration and smooth appearance of the tablet, and the rough appearance of the rapidly dispersing tablet, so as to improve drug compliance and improve drug use. Experience and reduce the effect of dosage differences
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preparation example 1
[0142] Preparation Example 1: Preparation of Sample 1-1, Sample 1-2, Sample 1-3 and Sample 1-4
[0143] 1. Preparation of drug powder
[0144]Levetiracetam is pulverized through a 120-mesh sieve, colloidal silicon dioxide is passed through a 40-mesh sieve, and the remaining auxiliary materials are passed through a 120-mesh sieve. Add the raw and auxiliary materials into the hopper mixer, set the speed at 20 rpm, and mix for 20 minutes to ensure that the drug powder is evenly mixed. The drug powder material composition is as follows:
[0145]
[0146] 2. Preparation of printing solution
[0147] A 50% ethanol solution (v / v) was used as base solvent.
[0148] The composition of each printing solution is as follows:
[0149] (1) Transparent printing fluid:
[0150] 50% ethanol solution 95.95% (w / w)
[0151] Povidone K30 0.05% (w / w)
[0152] Glycerin 4% (w / w)
[0153] (2) Cyan printing solution (C):
[0154]
[0155]
[0156] (3) Magenta printing solution (M): ...
preparation example 2
[0174] Preparation Example 2: Preparation of Sample 2-1, Sample 2-2, Sample 2-3 and Sample 2-4
[0175] 1. Preparation of drug powder
[0176] Levetiracetam is pulverized through a 120-mesh sieve, colloidal silicon dioxide is passed through a 40-mesh sieve, and the remaining auxiliary materials are passed through a 120-mesh sieve. Add the raw and auxiliary materials into the hopper mixer, set the speed at 20 rpm, and mix for 20 minutes to ensure that the drug powder is evenly mixed. The drug powder material composition is as follows:
[0177]
[0178] 2. Preparation of printing solution
[0179] A 40% isopropanol solution (v / v) was used as base solvent.
[0180] The composition of each printing solution is as follows:
[0181] (1) Transparent printing fluid:
[0182] 40% isopropanol solution 95.9% (w / w)
[0183] Povidone K30 0.1% (w / w)
[0184] Glycerin 4% (w / w)
[0185] (2) Cyan printing solution (C):
[0186]
[0187]
[0188] (3) Magenta printing solutio...
preparation example 3
[0207] Preparation Example 3: Preparation of Sample 3-1, Sample 3-2, Sample 3-3 and Sample 3-4
[0208] 1. Preparation of drug powder
[0209] With preparation example 2.
[0210] 2. Preparation of printing solution
[0211] With preparation example 2.
[0212] 3. Model design
[0213] With preparation example 1.
[0214] 4. Tablet printing
[0215] Transfer the model data to the 3D printer control software, set the printing quantity and typesetting, and the printing parameters are set as follows:
[0216]
[0217]
[0218] First, spread a certain thickness of drug powder on the printing platform, as a support for the bottom of the printing model and ensure that a single powder layer can be spread evenly during the printing process. The thickness of the powder layer is 2-5mm. During the printing process, the thickness of each powder layer is 150 μm. The print nozzle finely sprays a certain number of droplets on a specific part according to the instructions input ...
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