A kind of levetiracetam 3D printing preparation and preparation method thereof

A 3D printing and preparation technology, applied in the field of levetiracetam 3D printing preparation and its preparation, levetiracetam 3D printing tablet, levetiracetam tablet such as levetiracetam dispersible tablet, It can solve the problems of insufficient mechanical properties such as surface roughness, hardness, and friability of the tablet, failure to coordinate the rapid disintegration and smooth appearance of the tablet, and the rough appearance of the rapidly dispersing tablet, so as to improve drug compliance and improve drug use. Experience and reduce the effect of dosage differences
CN111840243BActive Publication Date: 2021-11-30ACADEMY OF MILITARY MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ACADEMY OF MILITARY MEDICAL SCI
Publication Date
2021-11-30

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Abstract

The invention belongs to the field of medicines and preparations, and relates to a levetiracetam 3D printing preparation and a preparation method thereof. Specifically, the present invention relates to a levetiracetam 3D printing preparation, including levetiracetam accounting for 40%-70% of the weight of the preparation, as well as fillers, disintegrants, flavoring agents, glidants, anti- Oxygen and binder; wherein, the roughness characteristic value root mean square height (Sq) of the levetiracetam 3D printing preparation is not higher than 45 μm, the arithmetic mean height (Sa) is not higher than 40 μm, and the maximum height ( Sz) is not higher than 350 μm. The preparation of the invention has excellent surface smoothness, can realize rapid drug release within a few seconds, can realize flexible adjustment of drug dosage, and greatly improves children's drug compliance.
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Description

technical field

[0001] The invention belongs to the field of medicines and preparations, and relates to a levetiracetam 3D printing preparation and a preparation method thereof. Specifically, the present invention relates to a levetiracetam tablet such as levetiracetam dispersible tablet, and a method for preparing the levetiracetam tablet such as levetiracetam dispersible tablet using 3D printing technology . In particular, it relates to 3D printed tablets of levetiracetam suitable for administration to children. Background technique

[0002] Levetiracetam is a pyrrolidone derivative and one of the most widely used broad-spectrum antiepileptic drugs in clinical practice. Levetiracetam is easily soluble and highly permeable, rapidly absorbed after oral administration, with an absolute bioavailability close to 100%, linear metabolism, small intra-individual and inter-individual differences, no gender, racial or circadian rhythm differences. Due to the complete and linear a...

Claims

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