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A kind of cyclobenzaprine hydrochloride sublingual tablet and preparation method thereof

A technology of cyclobenzaprine hydrochloride and sublingual tablets, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., to achieve stable quality, enhanced drug experience, and remarkable effects

Active Publication Date: 2021-02-26
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Cyclobenzaprine hydrochloride was first developed by Merk Company. In 1978, cyclobenzaprine hydrochloride tablets were launched in the United States, with specifications of 5mg and 10mg. They are used to relieve muscle spasms accompanied by acute painful musculoskeletal diseases. It is still the most popular drug in the United States. One of the commonly used muscle relaxants, which has not been marketed in China

Method used

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  • A kind of cyclobenzaprine hydrochloride sublingual tablet and preparation method thereof
  • A kind of cyclobenzaprine hydrochloride sublingual tablet and preparation method thereof
  • A kind of cyclobenzaprine hydrochloride sublingual tablet and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0025] Weigh each component according to the following ratio: cyclobenzaprine hydrochloride 20%, sucrose-lactose-mannitol 40% with a weight ratio of 3:2:5, microcrystalline cellulose 15%, carboxymethylcellulose calcium C 10%, 3% sodium saccharin, an appropriate amount of orange flavor, an appropriate amount of sorbic acid, and an appropriate amount of distilled water. Weigh the diluent in proportion, mix it evenly, and pass through an 80-mesh sieve; mix the prepared diluent with cyclobenzaprine hydrochloride, disintegrating agent, corrective agent, essence and preservative, add distilled water to granulate, Lubricant is added and compressed into tablets.

Embodiment 2

[0027] Cyclobenzaprine Hydrochloride 25%, Sucrose-Lactose-Mannitol 3:2:5 by weight 40%, Microcrystalline Cellulose 10%, Carmellose Calcium C 10%, Sodium Saccharin 3%, Orange Flavor Appropriate amount, appropriate amount of sorbic acid, appropriate amount of distilled water. Weigh the diluent in proportion, mix it evenly, and pass through an 80-mesh sieve; mix the prepared diluent with cyclobenzaprine hydrochloride, disintegrating agent, corrective agent, essence and preservative, add distilled water to granulate, Lubricant is added and compressed into tablets.

Embodiment 3

[0029] Cyclobenzaprine hydrochloride 30%, sucrose-lactose-mannitol 45% with a weight ratio of 3:2:5, microcrystalline cellulose 10%, carmellose calcium C 12%, sodium saccharin 1%, orange flavor Appropriate amount, appropriate amount of sorbic acid, appropriate amount of distilled water. Weigh the diluent in proportion, mix it evenly, and pass through an 80-mesh sieve; mix the prepared diluent with cyclobenzaprine hydrochloride, disintegrating agent, corrective agent, essence and preservative, add distilled water to granulate, Lubricant is added and compressed into tablets.

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Abstract

The invention relates to a cyclobenzaprine hydrochloride sublingual tablet and a preparation method thereof, belonging to the field of pharmaceutical preparations. Cyclobenzaprine hydrochloride sublingual tablet of the present invention preferably comprises cyclobenzaprine hydrochloride 25%, diluent 40%, disintegrant 20%, correctives 3%, and the present invention adopts special weight ratio and is 3:2: 5 of sucrose, lactose and mannitol as diluents, and microcrystalline cellulose 10‑20% and carboxymethylcellulose calcium C 10‑20% as disintegrants, the disintegration of sublingual tablets thus prepared can meet the time limit Requirements, the novel form of sublingual tablet is adopted, and it is disintegrated in the oral cavity when taking it, and combined with the preferred mint essence, it can enhance the consumer's medication experience, with stable quality and remarkable effect.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a cyclobenzaprine hydrochloride sublingual tablet and a preparation method thereof. Background technique [0002] In a modern society where the pace of life is getting faster and faster, back pain is one of the common diseases. People generally treat it with rest. However, rest cannot solve the fundamental problem. Not being able to work will not only cost a lot of medical expenses, but also long-term and a large number of missed work will affect the gross social product. [0003] Acute pain refers to back and lower back pain that lasts less than 3 months. The initial feeling is muscle spasm, muscle soreness, and limited local activities. The symptoms generally last for several weeks and affect the quality of daily life and work efficiency. If not treated properly , will gradually transform into chronic pain, and further worsen, the situation will become more serious. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/135A61K47/26A61K47/38A61K47/46A61P21/02A61P29/00
CPCA61K9/006A61K9/2018A61K9/2054A61K9/2068A61K31/135
Inventor 王明刚陈阳生刘晓霞孙桂玉臧云龙
Owner CP PHARMA QINGDAO CO LTD
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