Huperzine A sustained-release pellet coating granule, sustained-release pellet tablet and preparation method thereof
A technology for slow-release pellets and huperzine A, applied in microcapsules, pill delivery, pharmaceutical formulations and other directions, can solve the problems of layering phenomenon, influence of content uniformity of pressed tablets, small friction, etc., to reduce the The effect of medication frequency, good drug content uniformity, and good medication experience
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Embodiment 1
[0078] The preparation of embodiment 1 huperzine A sustained-release pellets
[0079] The formulation of the huperzine A sustained-release pellets provided in this example is shown in Table 1.
[0080] Table 1
[0081]
[0082] The preparation method of the huperzine A sustained-release pellets of the present embodiment may further comprise the steps:
[0083] Dissolve binder and additives in purified water according to the formula and dosage in Table 1, and the resulting solution is used as wetting agent; then the wetting agent is mixed evenly with huperzine A, slow-release materials and pelleting auxiliary materials, and prepared into soft material; the soft material is prepared into pellets by an extrusion spheronizer, dried and sieved to obtain the product.
Embodiment 2
[0085] 1. Preparation of Huperzine A Sustained-release Pellets Coated Granules
[0086] The formulation of the huperzine A sustained-release pellets coated particles provided in this example is shown in Table 2.
[0087] Table 2
[0088]
[0089] The preparation method of the huperzine A sustained-release pellet coating particle of the present embodiment comprises the following steps:
[0090] (1) dissolving the binder in purified water to obtain a binder solution;
[0091] (2) Mix microcrystalline cellulose PH-302, cornstarch, lactose and sodium carboxymethyl starch;
[0092] (3) Huperzine A sustained-release pellets are placed in a centrifugal granulator, and the rotating speed of the centrifugal granulator is 400rpm, after the huperzine A sustained-release pellets are in a centrifugal state, the huperzine A sustained-release pellets are processed according to the speed of 10g / min The liquid supply speed is sprayed into the binder solution, and at the same time, the un...
Embodiment 3
[0100] 1. Preparation of Huperzine A Sustained-release Pellets Coated Granules
[0101] The formulation of the huperzine A sustained-release pellets coated particles provided in this example is shown in Table 4.
[0102] Table 4
[0103]
[0104] The preparation method of the huperzine A sustained-release pellet coated granule of this embodiment is the same as that of Example 2.
[0105] Two, the preparation of huperzine A sustained-release pellets
[0106] The coated granules of huperzine A sustained-release pellets prepared in this example were further prepared into huperzine A sustained-release pellets, the formulation and preparation method of which were the same as in Example 2.
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