Huperzine A sustained-release pellet coating granule, sustained-release pellet tablet and preparation method thereof

A technology for slow-release pellets and huperzine A, applied in microcapsules, pill delivery, pharmaceutical formulations and other directions, can solve the problems of layering phenomenon, influence of content uniformity of pressed tablets, small friction, etc., to reduce the The effect of medication frequency, good drug content uniformity, and good medication experience

Active Publication Date: 2020-10-16
GUANGZHOU NEWORLD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of sustained-release pellets is relatively difficult. The main difficulty is that the surface of the pellets is a more regular spherical shape, and the friction with the tableting auxiliary materials is small. In the process of mixing with the tableting auxiliary materials, it is easy Stratification occurs, which greatly affects the content uniformity of compressed tablets

Method used

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  • Huperzine A sustained-release pellet coating granule, sustained-release pellet tablet and preparation method thereof
  • Huperzine A sustained-release pellet coating granule, sustained-release pellet tablet and preparation method thereof
  • Huperzine A sustained-release pellet coating granule, sustained-release pellet tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] The preparation of embodiment 1 huperzine A sustained-release pellets

[0079] The formulation of the huperzine A sustained-release pellets provided in this example is shown in Table 1.

[0080] Table 1

[0081]

[0082] The preparation method of the huperzine A sustained-release pellets of the present embodiment may further comprise the steps:

[0083] Dissolve binder and additives in purified water according to the formula and dosage in Table 1, and the resulting solution is used as wetting agent; then the wetting agent is mixed evenly with huperzine A, slow-release materials and pelleting auxiliary materials, and prepared into soft material; the soft material is prepared into pellets by an extrusion spheronizer, dried and sieved to obtain the product.

Embodiment 2

[0085] 1. Preparation of Huperzine A Sustained-release Pellets Coated Granules

[0086] The formulation of the huperzine A sustained-release pellets coated particles provided in this example is shown in Table 2.

[0087] Table 2

[0088]

[0089] The preparation method of the huperzine A sustained-release pellet coating particle of the present embodiment comprises the following steps:

[0090] (1) dissolving the binder in purified water to obtain a binder solution;

[0091] (2) Mix microcrystalline cellulose PH-302, cornstarch, lactose and sodium carboxymethyl starch;

[0092] (3) Huperzine A sustained-release pellets are placed in a centrifugal granulator, and the rotating speed of the centrifugal granulator is 400rpm, after the huperzine A sustained-release pellets are in a centrifugal state, the huperzine A sustained-release pellets are processed according to the speed of 10g / min The liquid supply speed is sprayed into the binder solution, and at the same time, the un...

Embodiment 3

[0100] 1. Preparation of Huperzine A Sustained-release Pellets Coated Granules

[0101] The formulation of the huperzine A sustained-release pellets coated particles provided in this example is shown in Table 4.

[0102] Table 4

[0103]

[0104] The preparation method of the huperzine A sustained-release pellet coated granule of this embodiment is the same as that of Example 2.

[0105] Two, the preparation of huperzine A sustained-release pellets

[0106] The coated granules of huperzine A sustained-release pellets prepared in this example were further prepared into huperzine A sustained-release pellets, the formulation and preparation method of which were the same as in Example 2.

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Abstract

The invention relates to huperzine A sustained-release pellets coated granules, sustained-release pellets and a preparation method thereof. The huperzine A sustained-release pellets coated granules ofthe present invention are prepared from the following raw materials in parts by weight: 100 parts of huperzine A sustained-release pellets, 5-15 parts of a binder A, and 55-75 parts of coating auxiliary materials. The binder A is hydroxypropyl cellulose; the coating auxiliary materials are composed of the following components in parts by weight: 20-30 parts of microcrystalline cellulose, 10-20 parts of corn starch, 10-20 parts of lactose, and 10 parts of carboxyl methyl starch sodium. The huperzine A sustained-release pellets coated granules of the invention have the high-roughness pellet surface, and have a slow and stable release effect. The huperzine A sustained-release pellets prepared by further preparation of the huperzine A sustained-release pellets coated granules have good drug content uniformity and have the sustained release effect similar to that of the sustained-release pellets coated granules.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a huperzine A sustained-release pellet coated granule, a sustained-release pellet tablet and a preparation method thereof. Background technique [0002] Huperzine A is a drug for the treatment of middle-aged and elderly benign memory impairment and various types of dementia, memory cognitive function and emotional behavior disorders. The drug has high biological activity, high fat solubility, and is easy to pass through the blood-brain barrier. After entering the central nervous system, it is more distributed in the brain area closely related to learning and memory. AchE) has a strong inhibitory effect, which significantly increases the content of acetylcholine (Ach) in the synaptic gap in the distribution area, thereby enhancing the excitatory conduction of neurons, strengthening the excitatory effect of learning and memory brain regions, and improving cognit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K31/4748A61K47/38A61K9/26A61P25/28A61P25/00
CPCA61K9/1652A61K9/2077A61K9/2095A61K9/5042A61K31/4748
Inventor 陈航平李革杨思超张敏敏
Owner GUANGZHOU NEWORLD PHARMA CO LTD
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