The invention discloses a refining method of cyclobenzaprine hydrochloride, and concretely relates to the field of medicines. The refining method comprises the following preparation steps: S1, in an extraction process in the later period of cyclobenzaprine hydrochloride processing, adding dispersed adsorption powder into a mixed solution of cyclobenzaprine hydrochloride, stirring by adopting a paddle stirrer, and precipitating to obtain a cyclobenzaprine hydrochloride crude product; S2, adding an organic solvent into the cyclobenzaprine hydrochloride crude product, performing recrystallization, dissolving and stirring in a steam pressurizing manner, and keeping constant temperature for later use; and S3, filtering and adsorbing the mixed solution obtained in step S2 through vesuvianite, and filtering to obtain a white refined cyclobenzaprine hydrochloride product. By adding the dispersed adsorption powder, crystals can be dispersed and fluffy, impurity byproducts are not wrapped, crystal discharging is fine and uniform, impurities and redundant metal ions can be adsorbed, and the cyclobenzaprine hydrochloride fine product with high purity and extraction rate is obtained.