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Cyclobenzaprine sustained-release preparation

A technology of cyclobenzaprine and sustained-release tablets, applied in the field of medicine, can solve the problems of affecting the curative effect, slow elimination, poor patient compliance, etc., and achieve the effects of stable product quality, reduced dosage, and uniform drug release.

Inactive Publication Date: 2020-08-07
CP PHARMA QINGDAO CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, cyclobenzaprine is eliminated slowly in the body (the elimination half-life is 32 hours), so the long-release preparations are administered multiple times in small doses during the day to avoid adverse reactions, resulting in poor patient compliance and affecting the curative effect

Method used

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  • Cyclobenzaprine sustained-release preparation
  • Cyclobenzaprine sustained-release preparation
  • Cyclobenzaprine sustained-release preparation

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0023] A preparation method of cyclobenzaprine sustained-release tablet, comprising the following steps:

[0024] (1) get cyclobenzaprine and filler to mix evenly by weight percentage, take 85% ethanol as binding agent, make soft material, 20-24 mesh sieve granulation;

[0025] (2) Add surfactants and lubricants to the granules prepared in step (1), mix well, press into tablets, and dry to obtain cyclobenzaprine sustained-release tablets.

Embodiment 1-6

[0026] The preparation of embodiment 1-6 cyclobenzaprine sustained release tablet

[0027] According to the raw and auxiliary materials in the following prescription, the cyclobenzaprine sustained-release tablet is prepared according to the above-mentioned preparation method. Among them, " / " means not used.

[0028]

Embodiment 7-11

[0034] Example 7-11 Preparation of Cyclobenzaprine Sustained Release Tablets

[0035] According to the raw and auxiliary materials in the following prescription, the cyclobenzaprine sustained-release tablet is prepared according to the above-mentioned preparation method.

[0036]

[0037] Test Example 2 The Cyclobenzaprine Sustained-release Tablet Release Determination of Embodiment 7-11 Gained

[0038] The measurement method is the same as that of Test Example 1, and the measurement results are shown in Table 2.

[0039] Table 2 The release investigation table of cyclobenzaprine sustained-release tablets obtained in Examples 7-11

[0040]

[0041] As can be seen from Table 2, the cyclobenzaprine sustained-release tablet of embodiment 9 releases slowly within 24 hours, indicating that when hydrogenated vegetable oil and carnauba wax are used as sustained-release materials, and the weight ratio is 1:1, the prepared Cyclobenzaprine sustained-release tablets have the best...

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PUM

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Abstract

The invention discloses a cyclobenzaprine sustained-release tablet and a preparation method thereof. The cyclobenzaprine sustained-release tablet comprises cyclobenzaprine, a sustained-release skeleton matrix, a filler, a surfactant and a lubricant. The medicine provided by the invention can be slowly and uniformly released, achieves the purposes of long acting and curative effect increasing, canalso reduce the dosage and reduce side effects while maintaining the same efficacy, and is simple in preparation process, stable in quality of obtained products and suitable for large-scale production.

Description

technical field [0001] The invention relates to a western medicine preparation technology, in particular to a cyclobenzaprine sustained-release tablet, which belongs to the technical field of medicine. Background technique [0002] Musculoskeletal system diseases are more common in clinical practice, involving bones, intervertebral discs, nerves, muscles, joints, soft tissues and other diseases. There are also many causes of musculoskeletal pain, such as inflammation, mechanical injury, immune reasons, tumors, etc. The International Society for Pain (IASP) pointed out that musculoskeletal pain is the pain with the highest incidence and the largest range of impact among all pains, and even about half of the population suffers from musculoskeletal pain for more than 3 months in a year. Musculoskeletal pain occurs frequently and is classified into neck pain, back and lower back pain, joint pain, etc. depending on the site of attack. Often cause long-term, chronic injury to the...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/135A61K47/44A61K47/32A61P21/02
CPCA61K9/2013A61K9/2027A61K9/2054A61K31/135A61P21/02
Inventor 袁航臧云龙陈阳生孙桂玉刘晓霞王明刚王清亭牛建兴朱锐张丽敏
Owner CP PHARMA QINGDAO CO LTD
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