Cyclobenzaprine hydrochloride sustained release pellets and preparation method thereof

Abstract

The invention discloses cyclobenzaprine hydrochloride sustained release pellets and a preparation method thereof. The cyclobenzaprine hydrochloride sustained release pellets comprise coating layers and medicine-containing pellets, wherein the medicine-containing pellets are externally coated with the coating layers; the coating layers comprise Eudragit NE30D, talcum powder and sodium dodecyl sulfate or polyethylene glycol; the medicine-containing pellets comprise cyclobenzaprine hydrochloride, hollow pellet cores, filling agents, lubricating agents and adhesives. The cyclobenzaprine hydrochloride sustained release pellets and the preparation method have the beneficial effects that the cyclobenzaprine hydrochloride sustained release pellets are mainly used as adjuvant medicines for treating painful local muscle spasms, adopt more novel sustained release preparations and pellet preparations and have the characteristics that the distribution areas of the medicines on the surfaces of the gastrointestinal tracts are enlarged, so that the irritation can be reduced, the bioavailability can be improved, and meanwhile, the medicines are not affected by the factor of gastric emptying, are uniform in internal absorption and have small individual difference; the technological advantages of the medicines are further enhanced by simultaneously applying the two types of advanced technologies; compared with oral liquids, the cyclobenzaprine hydrochloride sustained release pellets have the advantages of good medicine stability, convenience in packaging, transportation and storage, and the like; the preparation method is simple and practicable and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of chemical drug sustained-release preparations, and in particular relates to cyclobenzaprine hydrochloride sustained-release pellets and a preparation method thereof. Background technique [0002] In the era of the industrial revolution, back pain was considered to be a manifestation of fatigue. It was generally not called a "disease" and was usually treated with rest. However, rest could not solve the fundamental problem. You can't work at all, not only costing a lot of medical expenses, but also long-term and large-scale missed work will affect the gross social product. According to statistics, 50% to 80% of adults will experience back pain in their lifetime, and 12% to 15% of adults will suffer from it every year. [0003] Acute pain refers to back and lower back pain that lasts less than 3 months. The initial feeling is muscle spasm, muscle soreness, and limited local activities. The symptoms generally last for ...

AI Technical Summary

Problems solved by technology

At present, the medical market has not adapted to this new trend, and the treatment of back pain is still limited to the category of rest and physical therapy, and the development of central muscle relaxant drugs with exact curative effects has a good prospect

[0009] At present, the existing products on the market have low drug release stability, high irritation to the gastrointestinal tract, low bioavailability, and inconvenient packaging, transportation, and storage. and complex preparation methods