2 results about "Doxofylline" patented technology

This application discloses a method for separating and detecting related substances in doxophylline; the separation and detection method adopts high performance liquid chromatography, and the chromatographic conditions include phosphate aqueous solution and acetonitrile as mobile phase, detection wavelengths of 200nm-237nm and 246nm-280nm and gradient elution, so as to comprehensively and effectively separate and detect a variety of key process impurities and degradation products in doxophylline raw materials.

The present application relates to the biomedical detection technical field, disclose the liver reserve function evaluation product and the application of doxofylline in the evaluation product, the method is continuously intravenous infusion doxofylline to the subject, collects at least three time point blood samples during infusion, adopts liquid chromatography-mass spectrometry to detect the concentration of its metabolites theophylline acetaldehyde, theophylline acetic acid, hydroxyethyl theophylline and theophylline acetic acid-2' hydroxyethyl ester, based on the change data of total molar concentration of metabolite with time, the linear slope is calculated in combination with enzyme kinetics principle, and then the liver metabolic reserve function is detected.The present application also provides a complete detection system, the related use and pharmaceutical composition of doxofylline.The scheme is high in liver specificity, fast in detection, convenient in operation, excellent in safety, and superior in sensitivity to classical ICG clearance test, can solve the limitation of existing evaluation method, is suitable for preoperative risk assessment of hepatobiliary surgery, chronic liver disease staging and other scenes, and has important clinical application value.