5 results about "Doxofylline" patented technology

The utility model belongs to the technical field of medicine production equipment, and discloses a mixing device for doxofylline raw material treatment, which comprises a rectangular box, and the left side and the right side of the top of the rectangular box are respectively and fixedly connected with a first support plate and a second support plate. By arranging the driving motor, the lead screw, the movable block, the toothed plate and the gear, when the driving motor runs, the lead screw rotates to drive the movable block to move back and forth, so that the toothed plate moves back and forth and is meshed with the gear to drive the whole mixing tank to rotate by taking the second movable shaft as the axis; the raw materials at the bottom of the stirring shaft flow in the mixing tank, meanwhile, the stirring motor is started, the stirring shaft drives the stirring blades to rotate to stir and mix the raw materials in the mixing tank, and under the cooperation of rotation of the mixing tank and stirring of the stirring blades, the purpose of more uniform mixing of the doxofylline raw materials in the mixing tank is achieved. And the production quality of doxofylline is ensured.

This application discloses a method for separating and detecting related substances in doxophylline; the separation and detection method adopts high performance liquid chromatography, and the chromatographic conditions include phosphate aqueous solution and acetonitrile as mobile phase, detection wavelengths of 200nm-237nm and 246nm-280nm and gradient elution, so as to comprehensively and effectively separate and detect a variety of key process impurities and degradation products in doxophylline raw materials.

The present application relates to the biomedical detection technical field, disclose the liver reserve function evaluation product and the application of doxofylline in the evaluation product, the method is continuously intravenous infusion doxofylline to the subject, collects at least three time point blood samples during infusion, adopts liquid chromatography-mass spectrometry to detect the concentration of its metabolites theophylline acetaldehyde, theophylline acetic acid, hydroxyethyl theophylline and theophylline acetic acid-2' hydroxyethyl ester, based on the change data of total molar concentration of metabolite with time, the linear slope is calculated in combination with enzyme kinetics principle, and then the liver metabolic reserve function is detected.The present application also provides a complete detection system, the related use and pharmaceutical composition of doxofylline.The scheme is high in liver specificity, fast in detection, convenient in operation, excellent in safety, and superior in sensitivity to classical ICG clearance test, can solve the limitation of existing evaluation method, is suitable for preoperative risk assessment of hepatobiliary surgery, chronic liver disease staging and other scenes, and has important clinical application value.

The application discloses a doxofylline tablet and a preparation method thereof. The doxofylline tablet is prepared from the following raw materials in parts by weight: doxofylline 35-50 parts, a filling agent 10-20 parts, a flow aid 3-9 parts, a binder 1-4.35 parts, a lubricant 0.05-0.4 parts and a disintegrating agent 0.02-0.5 parts. The binder is povidone and / or copovidone; and the disintegrating agent is cross-linked sodium carboxymethyl cellulose. The doxofylline tablet provided by the application has the advantages of similar dissolution as compared with a reference preparation, uniform content, good stability and good compressibility.

The utility model discloses a product detection device for doxofylline injection production, and relates to the technical field of doxofylline injection production. The conveying device comprises a workbench, a supporting frame is fixedly connected to the center of the back face of the top of the workbench, an electric push rod is fixedly connected to the top of the supporting frame, and two conveying assemblies are symmetrically arranged at the top of the workbench. The sealing detection sleeve is arranged, specifically, after a glass bottle moves to the position below the sealing detection sleeve, the electric push rod is started to drive the sealing detection sleeve to move downwards, the rubber sleeve is connected with the glass bottle in a sleeved mode, the sealing effect is achieved, and then gas is conveyed into the sealing detection sleeve from the gas conveying pipe through starting of the electromagnetic valve; a worker observes the condition of liquid in the glass bottle to judge whether sealing is qualified or not, the defective glass bottle can be prevented from being packaged and conveyed through detection in the mode, and the condition that the liquid overflows is prevented.