Compound enrofloxacin injection for animals and preparation thereof

A technology of enrofloxacin and injection, which is applied in the field of veterinary compound enrofloxacin injection and its preparation, and can solve the problems of increasing the dosage and use time, reducing drug resistance and sensitivity, and exceeding the standard of drug residues. , to achieve the effects of reducing excessive drug residues, increasing sensitivity, reducing the frequency and dosage of medication

A technology of enrofloxacin and injection, which is applied in the field of veterinary compound enrofloxacin injection and its preparation, and can solve the problems of increasing the dosage and use time, reducing drug resistance and sensitivity, and exceeding the standard of drug residues. , to achieve the effects of reducing excessive drug residues, increasing sensitivity, reducing the frequency and dosage of medication

CN101301291AInactive Publication Date: 2008-11-12TIANJIN SHENGJI GRP CO LTD
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Weigh 0.01 kg of sodium hydroxide and put it into 20 L of water for injection, stir until completely dissolved, then add 5 kg of enrofloxacin and 1 kg of lincomycin hydrochloride successively, stir and dissolve;

[0024] (2) Take another 5L of water for injection, then add 0.2kg of sodium sulfite and 0.01kg of EDTA-2Na in sequence, and stir until completely dissolved;

[0025] (3) Take 30kg of propylene glycol and heat to dissolve 0.1kg of doxofylline.

[0026] (4) Combine the solutions prepared in step 1, step 2 and step 3, then add water for injection to 100L, stir evenly, keep for 15-20min, after the liquid medicine is clear, adjust the pH value to 9.5-10.5 with hydrochloric acid, that is Make veterinary compound enrofloxacin injection of the present invention. .

Embodiment 2

[0028] (1) Weigh 0.05 kg of sodium hydroxide and put it into 50 L of water for injection, stir until completely dissolved, then add 0.5 kg of enrofloxacin and 10 kg of lincomycin hydrochloride successively, stir and dissolve;

[0029] (2) Take another 5L of water for injection, then add 0.2kg of sodium sulfite and 0.01kg of EDTA-2Na in sequence, and stir until completely dissolved;

[0030] (3) Take 30kg of propylene glycol and heat to dissolve 2kg of doxofylline.

[0031] (4) Combine the solutions prepared in Step 1, Step 2 and Step 3, then add water for injection to 100L, stir evenly, and keep it for 15-20min. After the liquid is clear, adjust the pH value to 9.5-10.5 with sodium hydroxide , promptly make the veterinary compound enrofloxacin injection of the present invention.

Embodiment 3

[0033] (1) Weigh 0.04 kg of sodium hydroxide and put it into 50 L of water for injection, stir until completely dissolved, then add 4 kg of enrofloxacin and 2 kg of lincomycin hydrochloride successively, stir and dissolve;

[0034] (2) Take another 5L of water for injection, then add 0.2kg of sodium sulfite and 0.01kg of EDTA-2Na in sequence, and stir until completely dissolved;

[0035] (3) Take 30kg of propylene glycol and heat to dissolve 0.5kg of doxofylline.

[0036] (4) Combine the solutions prepared in Step 1, Step 2 and Step 3, then add water for injection to 100L, stir evenly, and keep it for 15-20min. After the liquid is clear, adjust the pH value to 9.5-10.5 with sodium hydroxide , promptly make the veterinary compound enrofloxacin injection of the present invention.

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Abstract

The invention discloses a compound enrofloxacin injection for animals and a preparation method thereof, which aims to provide the enrofloxacin injection for the animals and the preparation method thereof, wherein, the enrofloxacin injection for the animals can treat swine enzootic pneumonia, is quick to take effect, decreases drug resistance, and can treat symptoms and root causes; and the preparation method has a simple process and is easy to realize. The injection comprises the following compositions by weight portion: 0.5 to 5kg of enrofloxacin, 1 to 10kg of lincomycin hydrochloride, 0.01 to 0.05kg of sodium hydroxide, 0.1 to 2kg of doxofylline, 0.2kg of sodium sulfite, 0.01kg of EDTA-2Na, 30kg of propanediol, and the balance being water for injection. The injection adopts a compound preparation of an antimicrobial drug and antibiotics; due to the combined use of the enrofloxacin and the lincomycin hydrochloride as well as the doxofylline, the injection is quick to take effect to the swine enzootic pneumonia, is effective and highly efficient, reduces the probability of the drug resistance, can apparently relieve clinical symptoms caused by the swine enzootic pneumonia, can treat symptoms and root causes, and increase the weight of pigs.

Description

technical field [0001] The invention relates to a veterinary compound enrofloxacin injection and a preparation method thereof. Background technique [0002] Pig panting disease is a common disease of pigs, which can cause coughing, wheezing, dyspnea, confluent bronchitis, and shrimp-like changes in the lungs, which can cause poor growth and weight loss of pigs, affecting feed intake. Swine panting disease is mainly caused by mycoplasma, also known as mycoplasma swine pneumonia, which has a high incidence rate and is highly contagious. Usually, whole groups get sick, causing pigs to not grow for a long time. [0003] Most of the drugs currently used to treat swine panting, such as enrofloxacin and lincomycin hydrochloride, are used alone. Because mycoplasma produces drug resistance and sensitivity, the treatment effect will be reduced when used alone, and some even have no treatment effect. Moreover, because the onset of the disease lasts longer and has a greater impact, fa...

Claims

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Application Information

Patent Timeline
12 Nov 2008
Publication
CN101301291A
IPC
A61K31/496; A61K31/7056; A61P11/00; A61P31/00
Inventors
徐克福