Compound Ofloxacin solution and preparation method thereof

A technology of compound ofloxacin and ofloxacin, which is applied in the direction of medical formula, medical preparations containing active ingredients, digestive system, etc., can solve the problem of inconvenient use, singleness, failure to achieve rapid treatment, and rapid control of the disease and other issues, to achieve the effect of easy realization, convenient use, and avoidance of bacterial resistance

Inactive Publication Date: 2010-11-10
天津市天合力药物研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the disease tends to be mixed and complicated. In addition to long-term breeding, there is no special production and breeding management. The injection is inconvenient for large groups, and a single oral administration cannot meet the needs of rapid treatment and rapid control of the disease.

Method used

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  • Compound Ofloxacin solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Take 50L of water for injection, dissolve 0.01kg of EDTA-2Na, add 0.5L of hydrochloric acid, stir evenly, add 1kg ofloxacin, stir to dissolve, after dissolving, add 15kg of lincomycin hydrochloride and atropine sulfate in sequence 0.5kg was stirred and dissolved.

[0022] (2) Take 10kg of dimethylacetamide and heat to dissolve 0.2kg of doxofylline.

[0023] (3) Combine the solution prepared in step 1 and step 2, add water for injection to 100L, adjust the pH value to 4.00 with a concentration of 40% sodium hydroxide solution or a hydrochloric acid solution with a concentration of 10% by mass percent to get final product The compound ofloxacin solution for poultry of the present invention. After the pH value meets the requirements, fill it with a glass vial, seal it with a butyl rubber stopper and an aluminum cap, and sterilize it by circulating steam at 100°C for 30 minutes.

Embodiment 2

[0025] (1) Take 50L of water for injection, dissolve 0.01kg of EDTA-2Na, add 0.5L of hydrochloric acid, stir evenly, add ofloxacin 10kg, stir to dissolve, after dissolving, add 3kg of lincomycin hydrochloride and atropine sulfate in sequence 0.05kg was stirred and dissolved.

[0026] (2) Take 10kg of dimethylacetamide and heat to dissolve 2kg of doxofylline.

[0027] (3) Combine the prepared solution of step 1 and step 2, add water for injection to 100L, adjust the pH value to 4.20 with 40% sodium hydroxide solution by mass percentage or 10% hydrochloric acid solution by mass percentage to obtain the present invention Compound ofloxacin solution for poultry. After the pH value meets the requirements, fill it with a glass vial, seal it with a butyl rubber stopper and an aluminum cap, and sterilize it by circulating steam at 100°C for 30 minutes.

Embodiment 3

[0029] (1) Take 50L of water for injection, dissolve 0.01kg of EDTA-2Na, add 0.5L of hydrochloric acid, stir evenly, add ofloxacin 2kg, stir to dissolve, after dissolving, add lincomycin hydrochloride 10kg, atropine sulfate in turn 0.3kg was stirred and dissolved.

[0030] (2) Take 10kg of dimethylacetamide and heat to dissolve 1.5kg of doxofylline.

[0031] (3) Combine the prepared solution of step 1 and step 2, add water for injection to 100L, adjust the pH value to 4.51 with 40% by mass percent sodium hydroxide solution or 10% by mass percent concentration of hydrochloric acid solution to obtain the present invention After the pH value of the compound ofloxacin solution for poultry meets the requirements, it is filled with a glass vial, sealed with a butyl rubber stopper and an aluminum cap, and sterilized by circulating steam at 100°C for 30 minutes.

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Abstract

The invention discloses a compound Ofloxacin solution and a preparation method thereof, aiming at providing a solution with the advantages of treating digestive tract infections and respiratory tract infections of birds with rapid effect, treating both principal and secondary aspects of diseases and reducing drug-applied times and a preparation method thereof. The solution can be injected or orally taken and proper treating methods and administration approaches can be adopted according to disease states and the specific conditions of culturists. Every 100L of solutions comprises 1-10 kg of Ofloxacin, 3-15 kg of lincomycin hydrochloride, 0.05-0.5 kg of atropine sulfates, 0.2-2 kg of doxofylline, 0.01 kg of EDTA (Ethylene Diamine Tetraacetic Acid)-2Na, 10 kg of dimethylacetylamide and 0.5 L of hydrochloric acid. Because the Ofloxacin and the lincomycin hydrochloride are adopted as antibacterial components, the compound Ofloxacin solution can effectively solve the problems of bacterial drug resistance and takes effect on common bacteria causing the digestive tract infections and the respiratory tract infections; and meanwhile, the doxofylline can effectively relieve cough and asthma and inhibit respiratory symptoms, and the atropine sulfates have the rapid effects of inhibiting glandular secretion and reducing the liquid contents of digestive tracts and the respiratory tracts.

Description

technical field [0001] The invention relates to a compound ofloxacin solution for treating poultry respiratory and digestive tract infections and a preparation method thereof. Background technique [0002] Poultry respiratory tract and digestive tract infections are common diseases in poultry in recent years. Sick poultry manifests both respiratory symptoms and diarrhea and dysentery. It is mainly caused by mixed infections such as Escherichia coli, Salmonella, and mycoplasma. Sick poultry grow poorly, Rapid onset and high mortality. [0003] At present, the disease tends to be mixed and complicated. In addition to long-term breeding, there is no special production and breeding management. The injection is inconvenient to use in large groups, and a single oral administration cannot meet the needs of rapid treatment and rapid control of the disease. Contents of the invention [0004] The present invention aims to overcome the deficiencies in the prior art and provide a po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61K31/5383A61K31/522A61K31/46A61K9/08A61P11/00A61P1/00A61P31/00A61P31/04A61P11/06A61P11/14
Inventor 徐克福
Owner 天津市天合力药物研发有限公司
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