A kind of Huanglong cough and asthma syrup and its preparation method

Abstract

The invention belongs to the technical field of medicines, and in particular relates to a Huanglong Kechuan syrup and a preparation method thereof. Contains the following effective ingredients: astragaloside IV, icariin, irisin, calycosin glucoside; the syrup has a simple preparation process, low cost, high recovery rate, less organic solvent residue, less solvent consumption, and leaching The mention time is short. The prepared Huanglong cough and asthma syrup has the advantages of easy absorption, high bioavailability, fast curative effect, and convenient administration.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a Huanglong Kechuan syrup and a preparation method thereof. Background technique [0002] Cough and asthma is a syndrome name in traditional Chinese medicine. It is a series of respiratory diseases including asthma and bronchitis. It is a common disease and difficult disease. Difficulty, palpitations, hyperhidrosis, severe irritability, wheezing, irregular heartbeat, drop in blood pressure, and even death from suffocation. Improper care of long-term cough and asthma can easily turn into chronic obstructive pulmonary disease or cor pulmonale. In recent years, cough and asthma has become a global public health problem, affecting more than 300 million people. Due to the increasing pollution of the ecological environment, the morbidity and mortality of cough and asthma are increasing year by year. Cough and asthma damage the circulatory system, nervous system, digest...

AI Technical Summary

Problems solved by technology

However, capsules have certain defects. Capsules account for a relatively large proportion of solid preparations of traditional Chinese medicine. Due to the concept of multi-particle drug release and the convenience of taking them, they are increasingly favored by consumers.

Compared with western medicine, the dose of traditional Chinese medicine is large, and the amount of general excipients in the preparation is less. In recent years, with the development of hypoglycemic and sugar-free dosage forms, there are more and more varieties without adding excipients. At present, the preparation of domestic traditional Chinese medicine capsules is affected by equipment. Very large, its workmanship is not ideal

The main problems of traditional Chinese medicine capsules: (1) Moisture absorption: most traditional Chinese medicines have strong moisture absorption performance, so the relative humidity requirements of the production environment are strict, and the filling measurement varies greatly

Due to mildew, the warranty period is short, and the requirements for such as aluminum-plastic packaging are high

(2) Viscosity: During the preparation process, it is sticky after being wetted. Although ethanol is mostly used as a wetting agent, it has not fundamentally overcome the adhesion, and it is also accompanied by safety and cost issues.

(3) Particle specific gravity: In the process of GMP transformation, one-step granulator is widely used, but when preparing capsule granules, the particle strength is generally low and the specific gravity is small, which brings difficulties to filling dosage

(4) Difficulty in the preparation of granules and pills: Traditional Chinese medicine has complex ingredients, large doses, and a small amount or even no auxiliary materials for adjustment of the preparation process. Therefore, the use of fluidized bed granulation has little room for adjustment of the physical properties of the particles.

(5) Easy to decompose when exposed to heat or high temperature

[0006] In addition, capsules are taken by different groups of people. Soft capsules are generally not suitable for infants and patients with digestive tract ulcers.

In the treatment of children with cough and asthma, it is difficult to swallow and inconvenient to take, and the effect is also limited.

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