Bambutero hydrochloride and doxofylline-contained compound preparation and preparation method thereof

A technology for bambuterol hydrochloride and doxofylline, which is applied in the directions of ester active ingredients, heterocyclic compound active ingredients, respiratory system diseases, etc., can solve problems such as less side effects, and achieves convenient administration, reasonable formula, and preparation technology. easy effect

Inactive Publication Date: 2012-05-09
岳阳新华达制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug has shown similar efficacy to theophylline in animal and human studies, but with significantly fewer side effects

Method used

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  • Bambutero hydrochloride and doxofylline-contained compound preparation and preparation method thereof
  • Bambutero hydrochloride and doxofylline-contained compound preparation and preparation method thereof
  • Bambutero hydrochloride and doxofylline-contained compound preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0041] The compound tablet of bambuterol hydrochloride and doxofylline comprises main ingredients and auxiliary materials, and is characterized in that it is formulated according to the following weight percentages: main ingredients: 42%, auxiliary materials: 58%.

[0042]

[0043] Among them, corn starch and lactose are fillers; gelatin and talc are effervescent agents; magnesium stearate is a lubricant.

[0044] The preparation method of bambuterol hydrochloride and doxofylline compound tablet of the present invention, comprises raw material pulverizing, weighing, the direct tabletting operation after mixing, is characterized in that concrete process step is as follows:

[0045] Step 1: Pulverize bambuterol hydrochloride, doxofylline and the above-mentioned various auxiliary materials respectively, then pass through a 100-mesh sieve, and store them separately for later use;

[0046] Step 2: Weigh each component according to the above-mentioned prescription amount, and mix...

example 2

[0049] The compound tablet of bambuterol hydrochloride and doxofylline includes main ingredients and auxiliary materials, and is characterized in that it is formulated according to the following weight percentages: main ingredients: 84%, auxiliary materials: 16%.

[0050]

[0051] Among them, corn starch and lactose are fillers; gelatin and talc are effervescent agents; magnesium stearate is a lubricant.

[0052] The preparation method of bambuterol hydrochloride and doxofylline compound tablet of the present invention, comprises raw material pulverizing, weighing, the direct tabletting operation after mixing, is characterized in that concrete process step is as follows:

[0053] Step 1: Pulverize bambuterol hydrochloride, doxofylline and the above-mentioned various auxiliary materials respectively, then pass through a 100-mesh sieve, and store them separately for later use;

[0054] Step 2: Weigh each component according to the above-mentioned prescription amount, and mix ...

Embodiment 3

[0057] The compound syrup of bambuterol hydrochloride and doxofylline includes main ingredients and auxiliary materials, and is characterized in that it is formulated according to the following weight percentages: main ingredients: 1.26%, auxiliary materials: 98.74%.

[0058] Compound syrup of the present invention is formulated from the raw materials of following weight ratio:

[0059]

[0060] Among them, liquid glucose and sucrose are sweet additives; vitamin C is an antioxidant; sodium metabisulfite is a preservative; edetate disodium is a complexing agent; purified water is a diluent.

[0061]The preparation method of bambuterol hydrochloride and doxofylline compound syrup of the present invention comprises the steps of pulverizing raw materials, weighing, mixing, stirring, filtering and sterilizing, and is characterized in that the specific process steps are as follows:

[0062] Step 1: Pulverize bambuterol hydrochloride, doxofylline and the above-mentioned various au...

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Abstract

The invention discloses a bambutero hydrochloride and doxofylline-contained compound preparation, which comprises tablet and syrup, wherein main medicines are bambutero hydrochloride and doxofylline, auxiliary materials comprise corn starch, lactose, gelatin, talcum powder, magnesium stearate, liquid glucose, cane sugar, vitamin C, sodium metabisulfite, edetate disodium, orange juice flavouring agent, edible toner and purified water. The compound preparation has good co-therapy function to bronchial asthma, chronic bronchitis, emphysema and other lung diseases which are relevant to concurrent bronchospasm.

Description

Technical field: [0001] The invention relates to an oral drug compound preparation for treating asthma and a preparation method thereof, in particular to a compound preparation of two main drug formulations and a preparation method thereof. Background technique [0002] Bambuterol hydrochloride is a long-acting beta 2 receptor agonist. The drug is a new generation of bronchodilator developed by Swiss company Astra in 1989. It is used for the treatment of bronchial asthma and is one of the main drugs for the treatment of asthma, emphysema and bronchitis. Babuterol is a dicarbamate prodrug of terbutaline, with strong lipophilicity, it can be preferentially distributed in the lung tissue after oral administration, reducing the first-dose effect, and can be slowly hydrolyzed in the lung tissue to produce terbutaline , so as to produce a stable and continuous terbutaline concentration in the blood, the effect can reach 24 hours, take once a night, easy to use, it is currently t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K31/27A61P11/06A61P11/00
Inventor 张长利郭凌云随裕敏刘岳彪
Owner 岳阳新华达制药有限公司
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