A kind of cyclobenzaprine hydrochloride sustained-release preparation

A technology for cyclobenzaprine hydrochloride and sustained-release preparations, which is applied in the direction of pill delivery, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of short half-life of cyclobenzaprine hydrochloride, frequent medication, Affect the patient's medication compliance and other issues, to achieve the effect of good stability and ideal release speed
CN109248153BActive Publication Date: 2021-07-13CP PHARMA QINGDAO CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
CP PHARMA QINGDAO CO LTD
Publication Date
2021-07-13

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Abstract

The invention relates to a sustained-release preparation of cyclobenzaprine hydrochloride, which belongs to the field of pharmaceutical preparations. The invention provides a cyclobenzaprine hydrochloride coated chip, the inner chip is composed of active ingredient cyclobenzaprine hydrochloride, sustained release agent, diluent, adhesive, disintegrating agent and lubricant, and the middle layer is sustained release agent The composition of the coating layer and the outer layer is the same as that of the inner chip. The cyclobenzaprine package chip of the present invention adopts cross-linked sodium alginate and chitosan as sustained-release agents, the release speed is ideal, the release is gentle within 24 hours, and the release is basically completed within 24 hours. The influencing factors test, accelerated test and The test results of the long-term sample retention test at room temperature all show that its stability is very good. The cyclobenzaprine hydrochloride package chip of the present invention well solves the problem that the cyclobenzaprine hydrochloride is frequently used due to its short half-life in the body, thus affecting the drug compliance of patients.
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Description

technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to a sustained-release preparation of cyclobenzaprine hydrochloride. Background technique

[0002] Cyclobenzaprine hydrochloride (cyclobenzaprine hydrochloride, 1), the chemical name is 5 ~ (3 ~ dimethylaminopropylene) dibenzo [a, d] cycloheptene hydrochloride, is a muscle drug developed by Merck Company of the United States. The relaxant is now on the market in many countries, and the trade name is Flexeril.

[0003] Cyclobenzaprine hydrochloride is a central muscle relaxant, and its action site may be in the brainstem, not a ganglion muscle blocking agent. After administration, skeletal muscle relaxation occurs. Cyclobenzaprine hydrochloride also has an anticholinergic effect. It can relieve the symptoms of local muscle spasms without interfering with the normal function of muscles, and is ineffective for muscle spasms caused by central nervous system diseases. Clinica...

Claims

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