48results about How to "Not easy to wrap" patented technology

The invention provides camptothecin-adriamycin prodrug. A structural formula of the prodrug is shown as a formula (I), wherein R1 is camptothecin or derivative group thereof, R2 is one of -CH2- or -O-, R3 is one of -CH2- or -O-, X is one of S or -CH2-, and n1 and n2 are numbers of repeated units, and are integers from 0 to 10. The prodrug can be easily wrapped by amphiphilic polymer to form nanoparticles. The nanoparticles are high in drug carrying efficiency and drug carrying capacity and capable of quickly releasing unmodified camptothecin and adriamycin in the presence of glutathione, and the nanoparticles can be effectively taken in by tumor cells to kill the same. The invention further provides a preparation method of the prodrug, a preparation of the prodrug and application of the prodrug in preparing cancer treating drug.

The invention provides a heterodimer multifunctional prodrug based on camptothecin. The heterodimer multifunctional prodrug is loaded with the camptothecin and 2-(1-hexyloxy ethyl)-2-devinyl-pyropheophorbide-a (HPPH), the prodrug is a camptothecin-HPPH prodrug formed by the camptothecin and the HPPH through a connecting group, and the structural formula of the prodrug is as shown in formula (I), wherein R is the connecting group and is one of -SS-, -CH2CH2- or -S(CH3)C(CH3)S-; R1 is the camptothecin group. The prodrug has the advantages that the prodrug can be easily wrapped by amphiphilic polymer to form nano particles, and the formed nano particles are high in drug loading efficiency and drug loading capacity and can fast release the unmodified camptothecin and HPPH in the presence of glutathione; meanwhile, the nano particles can be effectively absorbed by tumor cells to kill the tumor cells. The invention further provides a preparation method and preparation of the prodrug and application of the prodrug in the preparation of drugs for treating cancer.

The invention discloses a method for preparing a photopolymerizable organosilicon polyurethane acrylate aqueous oligomer and a composition thereof. The method is based on the shortcomings of the current photopolymerizable organosilicon polyurethane acrylate aqueous oligomer, and the method comprises the following steps: synthesizing 2,2-bis(hydroxymethyl) butyl acrylate (HBA), and introducing thematerial into the oligomer molecule to make the polymer side chain is rich in unsaturated carbon-carbon double bonds; synthesizing one-terminated hydroxypolydimethylsiloxane (Si-OH), and introducing the substrate to the end of a main chain of the aqueous polyurethane acrylate oligomer so that the substrates facilitate enrichment on the surface of the material. Through the above molecular design, the problems of poor water resistance and low hardness of the aqueous photocurable material caused by the low double bond content and low crosslink density of the photocurable material are effectivelysolved, and the disadvantages that silicone chain is easily wrapped by the crosslinked network when is in the middle of the main chain so that the silicone is not enriched at the surface of the material, so that the surface hydrophobicity of the material can be effectively increased.

The invention discloses a sealant overflow process of photovoltaic assembly framing. The sealant overflow process comprises the steps of: (1) injecting a sealant into a mounting groove of the frame by an injection head, wherein the injection head is provided with a tip consisting of a platform and a bevel surface on the outlet thereof, the platform and the bevel surface have an included angle beta of 75 to 80 degrees, and the height h of the bevel surface is equal to 7 to 8mm; (2) placing a laminated plate on the lifting platform of a frame loading machine, and pressing the frame from four corners of the frame by using a press block of the frame loading machine to inlay the mounting groove of the frame into the edge of the laminated plate so as to result in sealant overflowing, and framing to obtain the photovoltaic assembly; and (3) continuously conveying the photovoltaic assembly to a sealed chamber through the conveying belt of a plurality of automatic line units to cure the sealant. The sealant overflow process provided by the invention can realize a good sealant overflowing effect, thereby ensuring the insulation sealing property of the photovoltaic assembly, greatly reducing the sealant removal frequency, and improving the photovoltaic assembly production efficiency.

The invention relates to an implanting instrument capable of preventing gastroesophageal reflux. The implanting instrument comprises a magnetic chain and auxiliary lines, the magnetic chain comprises multiple magnetic devices, multiple connecting units and a lock catch device, each magnetic device comprises one or more annular magnets and a shell, and the internal circumferential face of each shell is an internal concave cambered surface; the adjacent magnetic devices are movably connected through one connecting unit, and each connecting unit comprises a connecting part and limiting parts arranged at the ends of the connecting part; the lock catch device comprises a first lock catch device body and a second lock catch device body, the magnetic chain is further provided with a starting magnetic device and a tail end magnetic device, the first lock catch device body and the second lock catch device body are arranged on a shell of the starting magnetic device and a shell of the tail end magnetic device respectively, and when the first lock catch device body and the second lock catch device body are combined, a closed annular magnetic chain ring is formed by the magnetic chain. According to the implanting instrument capable of preventing the gastroesophageal reflux, the design is reasonable, and the shape formed by connecting the magnetic chain in series is closer to a circle, so that the implanting instrument is more attached to the outer wall of esophagus after being implanted to the outer side of lower esophageal sphincter, and the effect of strengthening the LES through the instrument is exerted more sufficiently.

The invention belongs to the technical field of medicine, and in particular relates to a process for producing memantine hydrochloride. The process for producing the memantine hydrochloride comprises the steps of performing acetyl amination reaction on 1-bromo-3,5-dimethyladamantane and acetonitrile at 5-10 DEG C under the action of concentrated sulfuric acid to obtain 1-acetamino-3,5-dimethyladamantane; performing hydrolysis reaction on the 1-acetamino-3,5-dimethyladamantane and polyol which does not contain an ether bond under an alkali condition to obtain 1-amino-3,5-dimethyladamantane; and acidifying the 1-amino-3,5-dimethyladamantane with hydrochloric acid, and performing re-crystallization to obtain the high-purity memantine hydrochloride. The process for producing the memantine hydrochloride, disclosed by the invention, has the advantage that the product yield of the memantine hydrochloride is increased by controlling process parameters and changing process conditions based on an existing synthetic process.

The invention discloses an organic silicon modified acrylic acid secondary dispersion and a preparation method thereof. The dispersion is prepared from 15-25 parts by weight of a (methyl) acrylate monomer, 0.5-3 parts by weight of a monomer containing carboxyl, 8-15 parts by weight of hydroxyl (methyl) acrylate and 2-6 parts by weight of an organic silicon modified monomer. The organic silicon modified acrylic acid secondary dispersion is high in organic silicon grafting rate and good in emulsion stability, the phenomena of floating oil, gel, phase separation and the like are avoided after the dispersion is placed for 6 months, and a cured paint film has excellent scratch resistance, weather resistance, aging resistance, hydrophobicity, heat resistance and the like.

The invention discloses a preparation method of cefpiramide sodium, belonging to the field of chemical pharmacy. The preparation method comprises the following steps: preparing a cefpiramide amine salt by using a cefpiramide acid as a raw material, carrying out salt formation and crystallization, drying, and driving atomized water for injection by using gas to blow before drying. The preparation method can reduce the solvent residue in the product, is simple, energy-saving and environmentally-friendly and is suitable for large-scale industrial production; and the prepared cefpiramide sodium has the advantages of high purity and good stability.

The invention relates to a preparation method of high-density nickel-cobalt-manganese hydroxide. The preparation method comprises three stages of reaction systems, each stage of reaction system comprises one or more than one reaction unit, and each reaction unit comprises a reaction kettle, an overflow pipe, an intermediate tank, a diaphragm pump, a thickener and a return pipe which are connectedin sequence; the invention provides the preparation method of high-density nickel-cobalt-manganese hydroxide, and aims to solve the problems that in the current process of preparing a precursor through coprecipitation, small and micro particles cannot be eliminated, particle size distribution is wide, large particles are prone to breakage, morphology consistency is poor, and the impurity sodium-sulfur content is high. The precursor particles prepared by the method have the characteristics of higher consistency, no small-particle and micro-powder phenomena, centralized particle size distribution, higher tap density, extremely compact particles, low possibility of breakage, low sodium-sulfur content and the like, so that the subsequently prepared positive electrode material has higher safetyperformance, cycle performance and higher specific capacity.

The invention provides a prepuce stitching staple. The staple comprises staple legs and a crossbeam, the crossbeam is composed of a staple bridge and an auxiliary piece, and the inner surface of the crossbeam is a non-planar surface. According to the prepuce stitching staple, the staple is formed under the drive of an advancing component of an instrument, tissues can be closed tightly, the stitching can be completed, the area of the crossbeam which is composed of the staple bridge and the auxiliary piece is large, and the inner surface of the crossbeam is the non-planar surface, so that the prepuce stitching staple is not prone to being wrapped by the tissues, therefore after the wound is healed, the prepuce stitching staple can fall off automatically under the action of long-time slow peristalsis of the tissues.

The invention relates to the field of aluminum alloy manufacturing, and particularly relates to an aluminum alloy and a preparation method thereof. The preparation method of the aluminum alloy comprises the following steps: (A) injecting first molten aluminum with a pressure of 0.6-0.8 MPa and a temperature of 630-650 DEG C into a cooling model at a temperature of 10-25 DEG C to cool, so that a first semisolid blank is formed; (B) after the first semisolid blank is turned, putting the obtained substance into second molten aluminum at a temperature of 650-680 DEG C to stir, so that second semisolid slurry is obtained; and (C) feeding the second semisolid slurry into an injection chamber, so that a product is obtained. Compared with common die casting methods in the prior art, the preparation method of the aluminum alloy disclosed by the invention can obtain fine grain structures without the addition of a grain refiner, and structures of columnar crystals and oversize dendrites in traditional casting are eliminated, so that products are uniform in grain and better in effect, and the moulding temperature of the products is about 100 DEG C lower than the temperature of common die casting materials.

The invention relates to a polystyrene foam filling method for a composite material honeycomb sandwich structure. The polystyrene foam filling method comprises the following steps of paving a layer of strip-shaped polystyrene foam on the die-attaching side of a honeycomb core, heating and extruding the strip-shaped polystyrene foam into a filling cavity of the honeycomb core, and paving a single-layer isolating membrane between the honeycomb core and a die; filling the non-die-attaching side of the honeycomb core with powdery polystyrene foam, and laying multiple layers of isolating membranes; and putting a forming die into curing forming equipment for heating and curing the polystyrene foam. According to the polystyrene foam filling method for the composite material honeycomb sandwich structure, residual stress generated by curing shrinkage of the polystyrene foam due to the fact that a composite material honeycomb sandwich structure workpiece is subjected to the procedures of pre-bonding and foaming in sequence, only the foaming face on one side is bound, and the other side is not bound can be eliminated; air wrapping in the filling cavity of the honeycomb core in the polystyrene foam filling process is avoided, and the filling quality and efficiency are improved; and the honeycomb core is independently formed, a pre-bonding process is cancelled, and the manufacturing cost of the composite material honeycomb sandwich structure is reduced.

The invention discloses a kelp slitter. A bracket in the kelp slitter is fixedly connected into a box; a guide plate is aslant positioned below the bracket; a first blade shaft and a second blade shaft are both rotationally arranged on the box, and are parallel to each other; a plurality of second slitting blades are fixedly connected to the second blade shaft at equal intervals; cutter tanks are formed between two adjacent second slitting blades; a plurality of first slitting blades are fixedly connected to the first blade shaft at equal intervals, and one sides, opposite to the cutter tanks, of all the first slitting blades are positioned in the cutter tanks; a first transmission gear and a second transmission gear are fixedly connected to the first blade shaft and the second blade shaft respectively; the first transmission gear and the second transmission gear are meshed; a transmission belt wheel is fixedly connected to the first blade shaft, and is connected with a motor rotating shaft through a transmission belt; shielding bodies are positioned on the bracket; and one ends of the shielding bodies extend into the cutter tanks. The kelp slitter is simple in structure and safe in use; kelp is not easy to wrap the blades; and the slitting efficiency is high.

The invention provides a prepuce stitching nail. The prepuce stitching nail comprises a nail leg and a beam. The beam is composed of a nail bridge and an auxiliary piece, and the outer surface of the beam is not a plane. The prepuce stitching nail can disengage automatically. The outer surface of the beam is not the plane so that the contact area of the outer surface of the stitching nail can be increased, and the stitching nail can automatically disengage more easily.

The invention relates to a sintering method and system adopting a sintering return ore as an embedded material. The method at least comprises the steps of preparing the embedded material, directly conveying the obtained embedded material to the tail part of a secondary mixing machine in a sintered material pelleting workshop, and uniformly mixing. The system comprises a return ore coarse grain screening unit and a conveying unit, wherein the return ore coarse grain screening unit is used for further screening and grading the separated sintering return ore so as to obtain a coarse grain-gradedreturn ore; and the conveying unit is used for directly feeding the coarse grain-graded return ore obtained through screening to the tail end of a secondary cylinder mixing machine. By adopting the adding system using the sintering return ore as the embedded material designed by the process and the device provided by the invention, the coarse grain-graded return ore is directly added to the tail end of the secondary cylinder mixing machine, so that internal transfer and cycle facility construction and equipment investment can be reduced, and the operation and maintenance cost is further saved;meanwhile, the coarse grain-graded return ore does not participate in the pelleting process, so that mixture pellets are protected, the filling rate of the mixing machine is reduced, the processing efficiency in unit volume is improved, and a mixture pelleting effect is improved; and in addition, the sintering return ore is not easy to be wrapped by adhered particles and is uniformly embedded into the mixture so as to achieve a material layer support effect, so that the air permeability of a material layer can be improved, and a sintering effect can be improved.