42 results about "Cefpiramide" patented technology

The invention discloses a preparation method of cefpiramide sodium, which belongs to the field of chemical pharmacy, and comprises the steps of preparing cefpiramide salt by using cefpiramide as raw material, forming salt and crystallizing, drying, and using gas to drive the atomized cefpiramide before drying. Purging with water for injection; the invention can reduce the solvent residue in the product, and the prepared cefpiramide sodium has the advantages of high purity and good stability, the preparation method is simple, energy-saving and environment-friendly, and is suitable for large-scale industrial production.

The invention discloses a method for crystallizing and producing cefpiramide sodium crystals. The method comprises the steps that: (a) cefpiramide acid and an transamination agent are dissolved in a solvent I, wherein the transamination agent is any one selected from triethylamine, diisopropylamine, and isopropylamine; and a temperature is controlled, and the materials are stirred until completely dissolved; (b) a salt-forming agent is added into a solvent II, wherein when the salt-forming agent is sodium ethylhexanoate, the solvent II is an acetone solvent, and when the salt-forming agent is sodium hydroxide, the solvent II is any one or a mixture of two selected from methanol and tetrahydrofuran; and the materials are stirred until completely dissolved; (c) the salt-forming agent solution is uniformly added into the solution of cefpiramide amine salt; the temperature is controlled, and crystal seeds are added; curing crystallization is carried out; acetone is added into the crystallization system for regulating the pH value of the crystallization system and for carrying out solvent-out crystallization; and filtering, washing, and drying are carried out, such that the cefpiramide sodium crystals are obtained. The method provided by the invention has the advantages of simple operation, uniform crystals, high purity, low impurity content, good stability, easy storage, and the like.

The invention discloses cephalosporin nucleus derivative compound and cephaene onium salt compound prepared from the cephalosporin nucleus derivative compound, which are respectively intermediates for synthesizing cefpiramide sulfate, and a method for preparing the cefpiramide sulfate from the two intermediates, namely preparing 7beta-[2-(2-alkanol aminothiazol-5-yl)-2-methoxyimino acetamid]]-3-[3-alkanol amino-2-(2-alkanol oxy ethyl)-1-pyrazol onium]methyl-3-cephem-4-carboxylate (IV) by coupling 7beta-[2(2-alkanol aminothiazol-5-yl)-2-methoxyimino acetamid]]-3-(hydrocarbon sulfonate)-3-cephem-4-carboxylic acid (I) serving as a raw material with 5-alkanol amino-2-(2-alkanol oxy ethyl)-1-pyrazol, and then converting to obtain the cefpiramide sulfate. The method has the advantages of mild reaction conditions, short steps, cheap raw materials, industrial production, no special reagents, simple process and easy amplification.