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307results about How to "Short dissolution time" patented technology

Synthesis method and application of water soluble chitosan-based flocculant

The invention provides a synthesis method and application of a water soluble chitosan-based flocculant. The method comprises the steps of adding chitosan into acid solution, adding acylated monomer aqueous solution into the acid solution, uniformly stirring and mixing, performing vibration reaction for 1 to 10 h at 5 to 60 DEG C, performing precipitation and purification through ethyl alcohol and acetone, drying, and obtaining N-acylated chitosan; sequentially adding the N-acylated chitosan, deionized water, acrylamide and strong cation functional monomer into a reactor, uniformly stirring, leading nitrogen into homogenous solution to remove oxygen, adding a photoinitiator and a cosolvent, uniformly stirring and mixing, putting the raw materials into an ultraviolet light reaction device to perform polymerization reaction, drying, performing granulation and powder process, and obtaining the water soluble chitosan-based flocculant; the flocculant can be used for the removal treatment of alga in source water. The flocculant is good in solubility property, high in viscosity coefficient and short in synthesis time, does not need temperature reduction control, simplifies the production technology, reduces energy consumption, and reduces the production cost.
Owner:NANJING UNIV OF TECH

Method for extracting andrographolide in andrographis tablets

InactiveCN107746395AAvoid the problems of heat resistance, high temperature and easy decomposition lossChange permeabilityOrganic chemistryBulk chemical productionHydrolysateImpurity
The invention discloses a method for extracting andrographolide in andrographis tablets. The method comprises the following steps: taking a proper amount of andrographis tablets, crushing the tablets,putting the mixture into an enzymolysis tank, adding complex enzyme according to the mass ratio, carrying out vortex mixing, carrying out enzymolysis at 30-50 DEG C for 1-2 hours, filtering to obtainan enzymatic hydrolysate; and rapidly freezing the obtained enzymatic hydrolysate and then naturally unfreezing, so that starch in the extract is aged and precipitated; collecting a supernatant, subjecting the residual part to centrifuging, collecting the centrifugal liquid and combining the centrifugal liquid with the supernatant, carrying out spray drying, and carrying out CO2 supercritical extraction on the obtained powder, wherein the fluid extraction pressure is 20-30 MPa, the extraction temperature is 40-50 DEG C, the CO2 fluid flow is 750-850 L/h, the extraction time is 3-5 hours; collecting the andrographolide. The andrographolide can be efficiently extracted from the andrographis tablets, the operation is convenient, and the impurities in the extracting solution are not increased, expensive equipment is not needed, and the extraction cost of andrographolide is reduced.
Owner:ZHUHAI COLLEGE OF JILIN UNIV

Pioglitazone hydrochloride solid dispersoid and medicinal compound thereof as well as preparation methods and applications thereof

The invention discloses a pioglitazone hydrochloride solid dispersoid and a medicinal compounds thereof as well as preparation methods and applications thereof. The pioglitazone hydrochloride solid dispersoid contains pioglitazone hydrochloride and PEG6000, with the weight ratio of 1:1. 5-9. The preparation method of the pioglitazone hydrochloride solid dispersoid comprises the following steps: A1. heating the PEG6000 to 60-80 DEG C, so as to enable the PEG6000 to be in a liquid state; A2. under the condition of constantly stirring the solution, adding the pioglitazone hydrochloride with proportional amount, stirring and dispersing for 20-40 minutes; and A3. quickly pouring a mixture on a metal panel with fast heat conduction to form a thin solid layer, immediately placing the thin solid layer in an environment with temperature below -20 DEG C, quenching for 50-70 minutes, taking out, smashing and screening with a 100-mesh sieve. The invention has the beneficial effects that the solid dispersoid can greatly improve the dissolution rate of the pioglitazone hydrochloride in a dissolution medium, so as to increase bioavailability. A solid dispersing agent can be further made into the medicinal compounds in forms of tablets and capsules.
Owner:CHENGDU HENGRUI PHARMA
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