The invention discloses a method for extracting
andrographolide in
andrographis tablets. The method comprises the following steps: taking a proper amount of
andrographis tablets, crushing the tablets,putting the mixture into an enzymolysis tank, adding complex
enzyme according to the
mass ratio, carrying out vortex mixing, carrying out enzymolysis at 30-50 DEG C for 1-2 hours, filtering to obtainan enzymatic
hydrolysate; and rapidly freezing the obtained enzymatic
hydrolysate and then naturally unfreezing, so that
starch in the extract is aged and precipitated; collecting a supernatant, subjecting the residual part to centrifuging, collecting the centrifugal liquid and combining the centrifugal liquid with the supernatant, carrying out
spray drying, and carrying out CO2 supercritical extraction on the obtained
powder, wherein the fluid extraction pressure is 20-30 MPa, the extraction temperature is 40-50 DEG C, the CO2 fluid flow is 750-850 L / h, the extraction time is 3-5 hours; collecting the
andrographolide. The
andrographolide can be efficiently extracted from the
andrographis tablets, the operation is convenient, and the impurities in the extracting solution are not increased, expensive equipment is not needed, and the extraction cost of andrographolide is reduced.