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Chinese medicine granule containing extract of grassleaved sweetflag rhizome and preparation method thereof

A technology of traditional Chinese medicine granules and extracts, which is applied in the field of traditional Chinese medicine granules containing Shichangpu extract and its preparation, which can solve the problems of not having quick release characteristics, unsightly appearance, and easy moisture absorption, etc.

Inactive Publication Date: 2009-05-27
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] 1, the extraction of extractum of the present invention: get Radix Astragali 1600.7g, Salvia Miltiorrhiza 1600.7g, Rhizoma Chuanxiong 1000g, Atractylodes Rhizoma Atractylodis 1000g, Shichangpu 1000g, Coptis Rhizoma 300.3g, Borneolum 6.67g;

[0050] Take astragalus and dandelion and add 10 times the amount of water, reflux and extract twice, 1.5 hours each time, filter the extract, and set aside; add 10 times the amount of water to Chuanxiong, Atractylodes atractylodes, and Shichangpu, extract the volatile oil with a volatile oil extractor for 8 hours, and use the volatile oil for later use. Filter out the water extract, add 10 times the amount of water to extract the dregs of the medicine for 1.5 hours, combine the water extract, filter and combine with the Astragalus miltiorrhiza extract and concentrate under reduced pressure to 1ml approximately equal to 1g crude drug, let cool, add 95% ethanol to make the alcohol Concentration is 60%, after standing overnight, filter,...

Embodiment 2

[0065] The preparation of active ingredient of the present invention: take astragalus membranaceus 2500.5g, salvia miltiorrhiza 2500.5g, chuanxiong 1500g, atractylodes atractylodes 1500g, Shichangpu 1500g, coptis 750g, borneol 80g standby; After 3 hours, filter the extract and set aside; add 12 times the amount of water to Chuanxiong, Atractylodes, and Shichangpu to extract the volatile oil with a volatile oil extractor for 12 hours, set aside the volatile oil, filter the water extract, add 12 times the amount of water to extract the medicinal residues for 3 hours, Combine the water extracts, filter and combine with the Astragalus miltiorrhiza extract and concentrate under reduced pressure to 1ml approximately equal to 1.5g crude drug, let cool, add 98% ethanol to make the alcohol concentration 60%, after standing overnight, filter, and recover the ethanol to 1ml is approximately equal to 4g of crude drug, add 95% ethanol to make the alcohol concentration 70%, let stand overnig...

Embodiment 3

[0069] Preparation of active components of the present invention: take 850g of astragalus, 850g of salvia, 500g of chuanxiong, 500g of atractylodes, 500g of calamus, 200g of coptis, and 1g of borneol for later use; take 8 times the amount of water of astragalus and danshen, and reflux extraction for 2 times, each time for 2 hours , filter the extract, and set aside; Chuanxiong, Atractylodes atractylodes, and Shichangpu add 8 times the amount of water to extract the volatile oil for 4 hours with a volatile oil extractor. extract, filter and combine with Astragalus miltiorrhiza extract and concentrate under reduced pressure to about 0.5g crude drug in 1ml, let it cool, add 90% ethanol to make the alcohol concentration 60%, let stand overnight, filter, and recover ethanol to about 1ml Equal to 3g of crude drug, add 95% ethanol to make the alcohol concentration 80%, let it stand overnight, filter, recover ethanol, concentrate to get a paste, concentrate at 60°C to a relative densit...

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Abstract

The invention provides a traditional Chinese medicine granular preparation containing grass-leaved sweetflag extractive and a preparation method thereof. In the invention, traditional Chinese medicine spheroidized particles are prepared by traditional Chinese medicine extractive and carriers acceptable in pharmacy. The outline of the traditional Chinese medicine spheroidized particles takes sphere shape or round type shape. The density of the preparation is 0.6-1.3 g / ml. The spheroidized particles of the invention have low single dose, are convenient in use, can be served as intermediate products of capsules, and also can be used for developing traditional Chinese medicine controlled release preparation.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing calamus calamus extract and a preparation method thereof. Background technique [0002] Dementia is a common geriatric disease, and it is also recognized as a refractory disease in the medical field today. According to the report of the World Health Organization, among the elderly over 65 years old, 10% of them have mental disorders, and 60% of them develop dementia, and With increasing age, the incidence of dementia showed a sharp upward trend. Dementia that occurs in old age can be divided into two categories: chronic and acute according to the speed of symptom development: Chronic dementia accounts for about 80% of old age dementia, also known as senile chronic brain syndrome. It includes senile dementia, vascular dementia, and mixed dementia in which the two coexist. In addition, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8884A61K9/16A61P25/28A61K31/045
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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