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Method for extracting andrographolide in andrographis tablets

A technology of andrographolide and Andrographis paniculata, which is applied in the field of chemical extraction, can solve the problems of expensive equipment, increased production costs, and large amount of solvent usage, and achieve the effects of reducing production costs, reducing equipment costs, and being easy to separate and purify

Inactive Publication Date: 2018-03-02
ZHUHAI COLLEGE OF JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many reports on the extraction methods of andrographolide, including water extraction, alcohol extraction, alkaline water extraction, etc. These processes are simple to operate, but have low extraction efficiency, low raw material utilization rate, large solvent usage and Impurities are difficult to remove, and other extraction methods, such as supercritical extraction, ultrasonic-assisted extraction, microwave-assisted extraction, resin adsorption, etc., although high-purity andrographolide can be obtained, the required equipment is expensive and greatly Increased production costs, and difficult to apply to industrial mass production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A method for extracting andrographolide in Chuanxinlian tablets, comprising the steps of:

[0023] S1. Take an appropriate amount of Andrographis paniculata tablets and crush them, put them in an enzymolysis tank, add a compound enzyme at a mass percentage of 1-2%, vortex and mix for 3 minutes, enzymolyze at 35°C for 1.5 hours, and filter to obtain an enzymolysis solution;

[0024] S2. Rapidly freezing the obtained enzymatic solution and then thawing it naturally to age and precipitate the starch in the extract; collect the supernatant, centrifuge the remaining part, collect the centrifuged liquid and merge it into the supernatant, and spray dry to obtain a powder;

[0025] S3, subjecting the obtained powder to CO 2 Supercritical extraction, fluid extraction pressure is 25MPa, extraction temperature is 45°C, CO 2 The fluid flow rate is 800L / h, the extraction time is 4h, and the andrographolide is collected to obtain the product.

Embodiment 2

[0027] A method for extracting andrographolide in Chuanxinlian tablets, comprising the steps of:

[0028] S1. After crushing an appropriate amount of Andrographis paniculata tablets, put them in an enzymolysis tank, add a compound enzyme at a mass percentage of 1-2%, vortex and mix for 1 min, enzymolyze at 50°C for 1 hour, and filter to obtain an enzymolysis solution;

[0029] S2. Rapidly freezing the obtained enzymatic solution and then thawing it naturally to age and precipitate the starch in the extract; collect the supernatant, centrifuge the remaining part, collect the centrifuged liquid and merge it into the supernatant, and spray dry to obtain a powder;

[0030] S3, subjecting the obtained powder to CO 2 Supercritical extraction, fluid extraction pressure is 20MPa, extraction temperature is 40°C, CO 2 The fluid flow rate is 750L / h, the extraction time is 5h, and the andrographolide is collected to obtain the product.

Embodiment 3

[0032] A method for extracting andrographolide in Chuanxinlian tablets, comprising the steps of:

[0033] S1. Take an appropriate amount of Andrographis paniculata tablets and crush them, put them in an enzymatic hydrolysis tank, add a compound enzyme at a mass percentage of 1-2%, vortex and mix for 5 minutes, enzymolyze at 30°C for 2 hours, and filter to obtain an enzymatic hydrolysis solution;

[0034] S2. Rapidly freezing the obtained enzymatic solution and then thawing it naturally to age and precipitate the starch in the extract; collect the supernatant, centrifuge the remaining part, collect the centrifuged liquid and merge it into the supernatant, and spray dry to obtain a powder;

[0035] S3, subjecting the obtained powder to CO 2 Supercritical extraction, fluid extraction pressure is 30MPa, extraction temperature is 50°C, CO 2 The fluid flow rate is 850L / h, the extraction time is 3h, and the andrographolide is collected to obtain the product.

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Abstract

The invention discloses a method for extracting andrographolide in andrographis tablets. The method comprises the following steps: taking a proper amount of andrographis tablets, crushing the tablets,putting the mixture into an enzymolysis tank, adding complex enzyme according to the mass ratio, carrying out vortex mixing, carrying out enzymolysis at 30-50 DEG C for 1-2 hours, filtering to obtainan enzymatic hydrolysate; and rapidly freezing the obtained enzymatic hydrolysate and then naturally unfreezing, so that starch in the extract is aged and precipitated; collecting a supernatant, subjecting the residual part to centrifuging, collecting the centrifugal liquid and combining the centrifugal liquid with the supernatant, carrying out spray drying, and carrying out CO2 supercritical extraction on the obtained powder, wherein the fluid extraction pressure is 20-30 MPa, the extraction temperature is 40-50 DEG C, the CO2 fluid flow is 750-850 L / h, the extraction time is 3-5 hours; collecting the andrographolide. The andrographolide can be efficiently extracted from the andrographis tablets, the operation is convenient, and the impurities in the extracting solution are not increased, expensive equipment is not needed, and the extraction cost of andrographolide is reduced.

Description

technical field [0001] The invention relates to the field of chemical extraction, in particular to a method for extracting andrographolide in Chuanxinlian tablets. Background technique [0002] Chuanxinlian tablet is a heat-clearing agent, which has the effects of clearing heat and detoxifying, cooling blood and reducing swelling. It is mainly used to treat pathogenic toxins, cold and fever, sore throat, sores of the mouth and tongue, sudden cough and overworked cough, diarrhea and dysentery, astringent pain due to hot stranguria, carbuncle sores, and poisonous snake bites. The main ingredient is Andrographis paniculata, and the auxiliary materials are starch and magnesium stearate. There are four lactone components in andrographolide: deoxyandrographolide, andrographolide, neoandrographolide and dehydroandrographolide. Andrographolide and total lactones are clinically commonly used ingredients. Its main pharmacological activities are anti-allergic, anti-HIV virus, anti-i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/60
CPCC07D307/60Y02P20/54
Inventor 张建会杨东生吴丽艳秦书芝耿璐璐赵曦孟凡欣赵成国周慧李晶莹吴威滕利荣
Owner ZHUHAI COLLEGE OF JILIN UNIV
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