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Chinese medicine granular containing notoginseng extract and preparation method thereof

A technology of traditional Chinese medicine granules and extracts, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, drug combinations, etc., can solve problems such as lack of immediate release characteristics, low drug loading of granules, and unsightly appearance, and achieve physical Good properties, small specific surface area, regular particle size distribution

Active Publication Date: 2009-05-27
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The preparation of active ingredient of the present invention: get astragalus 860.5g (65.6%), salvia miltiorrhiza 210.3g (16.1%), notoginseng 30.5g (2.7%), radish 20.6g (15.6%); , water decoction 2 times, add 7 times the amount of water each time, 2 hours each time, combine the decoction liquid, filter, concentrate the filtrate to 900ml, add 95% ethanol to make the alcohol concentration reach 70%, let it stand for 12-24 hours, filter, recover ethanol, and concentrate into an extract with a relative density of 1.32-1.38 (50-60°C); decoct the crushed Astragalus membranaceus with water twice, add 6 times the amount of water each time, and extract for 2 hours in sequence , 1 hour, combine the filtrate, when concentrated to about 1500ml, add 95% ethanol to make the alcohol concentration 60%, let stand for 12 to 24 hours, filter, reclaim the ethanol from the filtrate, when concentrated to about 400ml, add 95% ethanol to make the alcohol The concentration is 80%, let it stand ...

Embodiment 2

[0053] Preparation of the active ingredient of the present invention: get 400.6g (30.0%) of Radix Astragali, 440.8g (33.1%) of Salvia Miltiorrhiza, 110.2g (8.3%) of Radix Notoginseng, 380.6g (28.6%) of Radix Dalbergia, and prepare the cost according to the method of Example 1. Invention of active ingredients;

[0054] Preparation of masterbatch: Take a mixture of micropowder silica gel and chitosan with a weight ratio of 1:1 to pass through a 200-mesh sieve, 65% of which is used as a base material and put into the side spray pot of the fluidized bed, and another PVP K30 is added with water, extract, and prepared Adhesive forming agent-spray in as slurry, and sieve out small particles with a particle size of 120-180μ as the mother nucleus, then put the mother nucleus into the pot, continue to spray starch slurry, and at the same time, spray the remaining 35% from the powder gun The fine powder of micronized silica gel and chitosan is sprinkled in to make the particle size of th...

Embodiment 3

[0057] Preparation of the active ingredient of the present invention: take 770.3g (57.1%) of Radix Astragali, 220.8g (16.8%) of Salvia Miltiorrhiza, 40.8g (3.6%) of Radix Notoginseng, 300.5g (22.5%) of Dalbergia, and prepare the cost according to the method of Example 1. Invention of active ingredients;

[0058] Preparation of masterbatch: take a mixture of dextrin and starch with a weight ratio of 1:1 and pass through a 200-mesh sieve, 65% of which is put into the side spray pot of the fluidized bed as the bottom material, and starch and extract (after being folded and dried to account for the mother batch) 15% of the grain weight) and water to make a slurry and spray it in, and sieve out small particles (180-250μ) as the mother nucleus, then put the mother nucleus into the pot, continue to spray the starch slurry, and at the same time, spray it from the powder gun Sprinkle the remaining 35% dextrin and starch fine powder to make the particle size of the mother core grow, and...

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PUM

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Abstract

The invention provides a traditional Chinese medicine granular preparation with notoginseng extract and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using a traditional Chinese medicine extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g / ml to 1.3 g / ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing Panax notoginseng extract and a preparation method thereof. Background technique [0002] Coronary heart disease is a common disease, and it is also one of the diseases that seriously harm the middle-aged and elderly people. In recent years, due to social development, changes in work, life, diet and environment, the number of patients with coronary heart disease is on the rise. According to relevant statistics, the incidence rate of coronary heart disease patients over middle age is 2.47%-3.18%. At present, the western medicines for treating coronary heart disease are mainly nitrate compounds, beta-receptor blockers and calcium antagonists, etc. These medicines can only relieve symptoms, but are difficult to cure the root cause, and have certain toxic and side effects. Although the si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K36/537A61K9/16A61P9/10
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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